Compounds exhibiting thrombopoietin receptor agonism

ABSTRACT

Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism:
 
X 1 —Y 1 -Z 1 -W 1   (I)
 
wherein X 1  is optionally substituted aryl, optionally substituted heteroaryl or the like; Y 1  is —NR A CO—(CH 2 ) 0-2 — or the like (wherein R A  is a hydrogen or the like); Z 1  is optionally substituted phenylene or the like; and W 1  is a group represeted by the below formula:
 
                         
wherein R 1 , R 2 , R 3 , and R 4  are each independently a hydrogen atom, optionally substituted lower alkyl or the like, a broken line ( - - - ) represents the presence or absence of bond.

TECHNICAL FIELD

The present invention relates to compounds exhibiting thrombopoletinreceptor agonism.

BACKGROUND ART

Thrombopoietin, polypeptide cytokine composed of 332 amino acids,activates the production of platelets by stimulating the differentiationand proliferation of megakaryocytes through the receptor and is expectedas a medicine for hemopathy accompanied with the unusual number ofplatelets, for example, thrombocytopenia and the like. DNA sequencesencoding the thrombopoietin receptor have been described in Proc. Natl.Acad. Sci., 89, 5640-5644 (1992). Low molecular peptides having anaffinity for the thrombopoietin receptor is also known (JP98/72492A andWO96/40750), but these peptide derivatives are not generally practicalfor oral administration.

1,4-Benzodiazepine derivatives as a low molecule compound having anaffinity to the thrombopoietin receptor is described in JP99/1477A andJP99/152276A.

The compounds having a similar structure of the present inventioncompound are described in JP98/287634A and the like, but the affinityfor thrombopoietin receptor is not described therein.

DISCLOSURE OF INVENTION

The object of the present invention is to prepare pharmaceuticalcompositions exhibiting thrombopoietin receptor agonism and provideorally administrable platelet production modifiers.

In the above situation, the inventors of the present invention havefound that the following compounds exhibit strong thrombopoietinreceptor agonism.

The present invention relates to:

I) A pharmaceutical composition exhibiting thrombopoietin receptoragonism which contains as an active ingredient a compound of the generalformula (I):X¹—Y¹-Z¹-W¹  (I)wherein X¹ is optionally substituted aryl, optionally substitutedaralkyl, optionally substituted heteroaryl, or optionally substitutedheteroarylalkyl; Y¹ is —NR^(A)CO—(CR^(C)R^(D))₀₋₂—,—NR^(A)CO—(CH₂)₀₋₂—V—, —NR^(A)CO—CR^(C)═CR^(D)—,—V—(CH₂)₁₋₅—NR^(A)CO—(CH₂)₀₋₂—, —V—(CH₂)₁₋₅—CONR^(A)—(CH₂)₀₋₂—,—CONR^(A)—(CH₂)₀₋₂—, —(CH₂)₀₋₂—NR^(A)—SO₂-(CH₂)₀₋₂—,—(CH₂)₀₋₂—SO₂—NR^(A)—(CH₂)₀₋₂—, —NR^(A)—(CH₂)₀₋₂—, —NR^(A)—CO—NR^(A)—,—NR^(A)—CS—NR^(A)—, —N═C(—SR^(A))—NR^(A)—, —NR^(A)CSNR^(A)CO—,—N═C(—SR^(A))—NR^(A)CO—, —NR^(A)—(CH₂)₁₋₂—NR^(A)—CO—,—NR^(A)CONR^(A)NR^(B)CO—, or —N═C(—NR^(A)R^(A))—NR^(A)—CO—,wherein R^(A) is each independently a hydrogen atom or lower alkyl;R^(B) is a hydrogen atom or phenyl; R^(C) and R^(D) are eachindependently a hydrogen atom, halogen atom, optionally substitutedlower alkyl, optionally substituted lower alkyloxy, optionallysubstituted lower alkylthio, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted aryl,optionally substituted heteroaryl, optionally substituted cycloalkyl,optionally substituted aralkyl, optionally substituted heteroarylalkyl,optionally substituted non-aromatic heterocyclic group, or optionallysubstituted amino; V is an oxygen atom or a sulfur atom;Z¹ is optionally substituted phenylene, optionally substitutedmonocyclic heteroarylene, optionally substituted monocyclic non-aromaticheterocycle-diyl, or optionally substituted monocyclic cycloalkane-diyl;

W¹ is a group represented by the formula:

wherein R¹, R², R³, R⁴, R⁷, and R⁸ are each independently a hydrogenatom, halogen atom, optionally substituted lower alkyl, optionallysubstituted lower alkyloxy, optionally substituted lower alkylthio,optionally substituted lower alkenyl, optionally substituted loweralkynyl, optionally substituted aryl, optionally substituted heteroaryl,optionally substituted cycloalkyl, optionally substituted aralkyl,optionally substituted heteroarylalkyl, optionally substitutednon-aromatic heterocyclic group, or optionally substituted amino;R⁵, R⁶, and R⁹ are each independently a hydrogen atom, optionallysubstituted lower alkyl, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted aryl,optionally substituted heteroaryl, optionally substituted cycloalkyl,optionally substituted aralkyl, optionally substituted heteroarylalkyl,or optionally substituted non-aromatic heterocyclic group;A¹ is a optionally substituted aryl or optionally substitutedheteroaryl;

a broken line ( - - - ) represents the presence or absence of a bond,its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.

In more detail, the invention relates to the following II) to XXIX).

II) A pharmaceutical composition exhibiting thrombopoictin receptoragonism of I), wherein X¹ is optionally substituted heteroaryl.

III) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of I), wherein X¹ is a group represented by the formula:

wherein R¹⁰ and R¹¹ are each independently a hydrogen atom, optionallysubstituted lower alkyl, carboxy, lower alkyloxycarbonyl, halogen atom,optionally substituted aminocarbonyl, optionally substituted heteroaryl,or optionally substituted aryl;R¹² is a hydrogen atom or lower alkyl.

IV) A pharmaceutical composition exhibiting thrombopoietin receptoragonism which contains a compound of I), wherein X¹ is a grouprepresented by the formula:

V) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to IV), wherein Y¹ is —NHCO—, —CONH—, —NHCH₂—,—NHCO—CH═CH—, or —NHSO₂—.VI) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to IV), wherein Y¹ is —NHCO—.VII) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to VI), wherein Z¹ is 1,4-phenylene optionallysubstituted with halogen atom or lower alkyl.VIII) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to VII), wherein R¹ is a hydrogen atom or loweralkyl.IX) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to VIII), wherein R² is a hydrogen atom, loweralkyl, halogen atom, lower alkyloxy, lower alkylthio, or optionallysubstituted amino.X) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to IX), wherein W¹ is a group represented bythe formula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthio, or halogen atom;R¹⁴ and R¹⁵ are each independently a hydrogen atom, or optionallysubstituted lower alkyl, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted cycloalkyl,optionally substituted aryl, optionally substituted heteroaryl, oroptionally substituted heteroarylalkyl, each substituted by one or moresubstituent(s) selected from substituent group A;a broken line ( - - - ) is as defined in I);substituent group A consisits of a halogen atom, halo(lower)alkyl,optionally substituted amino, carboxy, lower alkylthio, loweralkylsilyl, or lower alkyloxy.XI) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to IX), wherein W¹ is a group represented bythe formula:

R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, lower alkylthio, orhalogen atom;R²⁶ is a hydrogen atom or lower alkyl;a broken line ( - - - ) is as defined in I);XII) A pharmaceutical composition exhibiting thrombopoietin receptoragonism of any one of I) to XI), which is a platelet productionmodifier.XIII) Use of a compound of any one of I) to XI), for preparation of amedicine for modifiering a platelet production.XIV) A method for modifiering a platelet production of a mammal,including a human, which comprises administration to said mammal of acompound of any one of I) to XI) in a pharmaceutically effective amount.XV) A compound represented by the general formula (II):X²—Y²-Z²-W²  (II)wherein X² is optionally substituted 5-member heteroaryl or optionallysubstituted pyridyl:Y² is —NR^(A)CO—(CR^(C)R^(D))₀₋₂—, —NR^(A)CO—(CH₂)₀₋₂—V—,—NR^(A)CO—CR^(C)═CR^(D)—, —V—(CH₂)₁₋₅—NR^(A)CO—(CH₂)₀₋₂—,—V—(CH₂)₁₋₅—CONR^(A)—(CH₂)₀₋₂—, —CONR^(A)—(CH₂)₀₋₂—,—(CH₂)₀₋₂—NR^(A)—SO₂—(CH₂)₀₋₂—, —(CH₂)₀₋₂—SO₂—NR^(A)—(CH₂)₀₋₂—,—NR^(A)—(CH₂)₀₋₂—, —NR^(A)—CO—NR^(A)—, —NR^(A)—CS—NR^(A)—,—N═C(—SR^(A))—NR^(A)—, —NR^(A)CSNR^(A)CO—, —N═C(—SR^(A))—NR^(A)CO—,—NR^(A)—(CH₂)₁₋₂—NR^(A)—CO—, —NR^(A)CONR^(A)NR^(B)CO—, or—N═C(—NR^(A)R^(A))—NR^(A)—CO—,wherein R^(A) is each independently a hydrogen atom or lower alkyl;R^(B) is a hydrogen atom or phenyl; R^(C) and R^(D) are eachindependently a hydrogen atom, halogen atom, optionally substitutedlower alkyl, optionally substituted lower alkyloxy, optionallysubstituted lower alkylthio, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted aryl,optionally substituted heteroaryl, optionally substituted cycloalkyl,optionally substituted aralkyl, optionally substituted heteroarylalkyl,optionally substituted non-aromatic heterocyclic group, or optionallysubstituted amino; V is an oxygen atom or a sulfur atom;Z² is optionally substituted phenylene, optionally substituted2,5-pyridine-diyl, optionally substituted 2,5-thiophene-diyl, oroptionally substituted 2,5-furan-diyl;W² is a group represented by the formula:

wherein R¹, R², R³, R⁴, R⁷, and R⁸ are each independently a hydrogenatom, halogen atom, optionally substituted lower alkyl, optionallysubstituted lower alkyloxy, optionally substituted lower alkylthio,optionally substituted lower alkenyl, optionally substituted loweralkynyl, optionally substituted aryl, optionally substituted heteroaryl,optionally substituted cycloalkyl, optionally substituted aralkyl,optionally substituted heteroarylalkyl, optionally substitutednon-aromatic heterocyclic group, or optionally substituted amino;R⁵, R⁶, and R⁹ are each independently a hydrogen atom, optionallysubstituted lower alkyl, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted aryl,optionally substituted heteroaryl, optionally substituted cycloalkyl,optionally substituted aralkyl, optionally substituted heteroarylalkyl,or optionally substituted non-aromatic heterocyclic group;A² is a optionally substituted aryl or optionally substitutedheteroaryl;a broken line ( - - - ) represents the presence or absence of a bond,its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XVI) A compound described in XV), wherein X² is a group represented bythe formula:

wherein R¹⁰ and R¹¹ are each independently a hydrogen atom, optionallysubstituted lower alkyl, carboxy, lower alkyloxycarbonyl, halogen atom,optionally substituted aminocarbonyl, optionally substituted heteroaryl,or optionally substituted aryl,its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XVII) A compound described in XV) or XVI), wherein X² is a grouprepresented by the formula:

wherein R¹⁶ is a hydrogen atom, optionally substituted lower alkyl,carboxy, lower alkyloxycarbonyl, halogen atom, or optionally substitutedaminocarbonyl;R¹⁷, R¹⁸, R¹⁹, R²⁰, R²¹, R²², and R²³ are each independently a hydrogenatom, optionally substituted lower alkyl by one or more substituent(s)selected from substituent group B, cycloalkyl, optionally substitutedalkyoxy by one or more substituent(s) selected from substituent group B,alkylthio, halogen atom, optionally substituted phenyl by one or moresubstituent(s) selected from substituent group C, optionally substitutedheteroaryl by one or more substituent(s) selected from substituent groupC, or optionally substituted nonaromatic heterocyclic group by one ormore substituent(s) selected from substituent group C;substituent group B consists of hydroxy, alkyloxy, halogen atom,carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally substitutedamino, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, non-aromatic heterocyclic group, orheteroaryl;substituent group C consisits of hydroxy, alkyl, halogen atom,halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy, optionallysubstituted amino, non-aromatic heterocyclic group, or heteroaryl;R¹⁶ and R¹⁷ taken together may form —CH₂—, —CH₂CH₂—, —CH₂CH₂CH₂—,—OCH₂—, or —SCH₂—;its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XVIII) A compound of any one of XV) to XVII), wherein Y₂ is —NHCO—;its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.

XIX) A compound of any one of XV) to XVIII), wherein Z² is 1,4-phenyleneoptionally substituted with halogen atom or lower alkyl;

its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.

XX) A compound of any one of XV) to XIX), wherein R¹ is a hydrogen atomor lower alkyl;

its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.

XXI) A compound of any one of XV) to XX), wherein R² is a hydrogen atom,lower alkyl, halogen atom, lower alkyloxy, lower alkylthio, oroptionally substituted amino;

its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.

XXII) A compound of any one of XV) to XXI), wherein W² is a grouprepresented by the formula:

wherein, R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸ and A² are as defined in claimXV); provided that R² is not imidazolyl, triazolyl, or tetrazolyl;its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XXIII) A compound of any one of XV) to XXII), wherein W² is a grouprepresented by the formula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthio, or halogen atom;R¹⁴ and R¹⁵ are each independently a hydrogen atom, or optionallysubstituted lower alkyl, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted cycloalkyl,optionally substituted aryl, optionally substituted heteroaryl, oroptionally substituted heteroarylalkyl, each substituted by one or moresubstituent(s) selected from substituent group A;substituent group A consists of a halogen atom, halo(lower)alkyl,optionally substituted amino, carboxy, lower alkylthio, loweralkylsilyl, or lower alkyloxy;its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XXIV) A compound of any one of XV) to XXII), wherein W² is a grouprepresented by the formula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthio, or halogen atom;R²⁶ is a hydrogen atom or lower alkyl;a broken line ( - - - ) as defined in XV);its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XXV) A compound represented by the general formula (III):

wherein R¹⁶ is a hydrogen atom, optionally substituted lower alkyl,carboxy, lower alkyloxycarbonyl, halogen atom, or optionally substitutedaminocarbonyl;R¹⁷, R¹⁸, R¹⁹, R²⁰, and R²¹ are each independently a hydrogen atom,optionally substituted lower alkyl by one or more substituent(s)selected from substituent group B, cycloalkyl, optionally substitutedalkyoxy by one or more substituent(s) selected from substituent group B,alkylthio, halogen atom, optionally substituted phenyl by one or moresubstituent(s) selected from substituent group C, optionally substitutedheteroaryl by one or more substituent(s) selected from substituent groupC, or optionally substituted nonaromatic heterocyclic group by one ormore substituent(s) selected from substituent group C;substituent group B consists of hydroxy, alkyloxy, halogen atom,carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally substitutedamino, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, non-aromatic heterocyclic group, orheteroaryl;substituent group C consists of hydroxy, alkyl, halogen atom,halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy, optionallysubstituted amino, non-aromatic heterocyclic group, or heteroaryl;R¹⁶ and R¹⁷ taken together may form —CH₂—, —CH₂CH₂—, —CH₂CH₂CH₂ —,—OCH₂—, or —SCH₂—;R³¹ and R³² are each independently a hydrogen atom, lower alkyl, halogenatom, halo(lower)alkyl, lower alkyloxy, halo(lower)alkyloxy, or hydroxy;W³ is represented by the formula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthio, or halogen atom;R¹⁴ and R¹⁵ are each independently a hydrogen atom, or optionallysubstituted lower alkyl, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted cycloalkyl,optionally substituted aryl, optionally substituted aralkyl, optionallysubstituted heteroaryl, optionally substituted heteroarylalkyl, oroptionally substituted non-aromatic heterocyclic group, each substitutedby one or more substituent(s) selected from substituent group A;substituent group A consists of a halogen atom, halo(lower)alkyl,optionally substituted amino, carboxy, lower alkylthio, loweralkylsilyl, or lower alkyloxy;R²⁴ is a hydrogen atom or lower alkyl;R²⁵ is lower alkyl, optionally substituted aryl, or optionallysubstituted non-aromatic heterocyclic group;A³ is heteroaryl;its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XXVI) A compound represented by the general formula (IV-A):

wherein R²⁷ is a hydrogen atom, C1-C3 alkyl, trifluoromethyl, or halogenatom;R²⁸, R²⁹, and R³⁰ are independently a hydrogen atom, optionallysubstituted lower alkyl by one or more substituent(s) selected fromsubstituent group B, cycloalkyl, optionally substituted alkyoxy by oneor more substituent(s) selected from substituent group B, alkylthio,halogen atom, optionally substituted phenyl by one or moresubstituent(s) selected from substituent group C, optionally substitutedheteroaryl by one or more substituent(s) selected from substituent groupC, or optionally substituted nonaromatic heterocyclic group by one ormore substituent(s) selected from substituent group C;substituent group B consists of hydroxy, alkyloxy, halogen atom,carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally substitutedamino, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, non-aromatic heterocyclic group, orheteroaryl;substituent group C consists of hydroxy, alkyl, halogen atom,halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy, optionallysubstituted amino, non-aromatic heterocyclic group, or heteroaryl;R³¹ and R³² are each independently a hydrogen atom, lower alkyl, halogenatom, haro(lower)alkyl, lower alkyloxy, halo(lower)alkyloxy, or hydroxy;W⁴ is a group represented by the formula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthio, or halogen atom;R¹⁴ and R¹⁵ are each independently a hydrogen atom, optionallysubstituted lower alkyl, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted cycloalkyl,optionally substituted aryl, optionally substituted aralkyl, optionallysubstituted heteroaryl, optionally substituted heteroarylalkyl, oroptionally substituted non-aromatic heterocyclic group, each substitutedby one or more substituent(s) selected from substituent group A;substituent group A consists of a halogen atom, halo(lower)alkyl,optionally substituted amino, carboxy, lower alkylthio, loweralkylsilyl, or lower alkyloxy;R²⁴ is a hydrogen atom or lower alkyl;its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XXVII) A compound represented by the general formula (IV-B):

wherein R²⁸, R²⁹, and R³⁰ are each independently a hydrogen atom,optionally substituted lower alkyl by one or more substituent(s)selected from substituent group B, cycloalkyl, optionally substitutedalkyoxy by one or more substituent(s) selected from substituent group B,alkylthio, halogen atom, optionally substituted phenyl by one or moresubstituent(s) selected from substituent group C, optionally substitutedheteroaryl by one or more substituent(s) selected from substituent groupC, or optionally substituted nonaromatic heterocyclic group by one ormore substituent(s) selected from substituent group C;substituent group B consists of hydroxy, alkyloxy, halogen atom,carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally substitutedamino, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, non-aromatic heterocyclic group, orheteroaryl;substituent group C consists of hydroxy, alkyl, halogen atom,halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy, optionallysubstituted amino, non-aromatic heterocyclic group, or heteroaryl;R³¹ and R³² are each independently a hydrogen atom, lower alkyl, halogenatom, haro(lower)alkyl, lower alkyloxy, halo(lower)alkyloxy, or hydroxy;W⁴ is a group represented by the formula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthio, or halogen atom;R¹⁴ and R¹⁵ are each independently a hydrogen atom, optionallysubstituted lower alkyl, optionally substituted lower alkenyl,optionally substituted lower alkynyl, optionally substituted cycloalkyl,optionally substituted aryl, optionally substituted aralkyl, optionallysubstituted heteroaryl, optionally substituted heteroarylalkyl, oroptionally substituted non-aromatic heterocyclic group, each substitutedby one or more substituent(s) selected from substituent group A;substituent group A consists of a halogen atom, halo(lower)alkyl,optionally substituted amino, carboxy, lower alkylthio, loweralkylsilyl, or lower alkyloxy;R²⁴ is a hydrogen atom or lower alkyl;T is —CH₂—, —CH₂CH₂—, —CH₂CH₂CH₂—, —OCH₂—, or —SCH₂—;its prodrug, or their pharmaceutically acceptable salt, or solvatethereof.XXVIII) A pharmaceutical composition containing as the active ingredienta compound of any one of XV) to XXVII).XXIX) A pharmaceutical composition containing as the active ingredient acompound of any one of XV) to XXVII), which is exhibiting thrombopoietinreceptor agonism.XXX) A platelet production modifier which contains as the activeingredient a compound of any one of XV) to XXVII).XXXI) Use of a compound of any one of XV) to XXVII) for preparation of apharmaceutical composition for modifiering a platelet production.XXXII) A method for modifiering a platelet production of a mammal,including a human, which comprises administration to said mammal of acompound of any one of XV) to XXVII) in a pharmaceutically effectiveamount.

In the present specification, the term “halogen” means fluoro, chloro,bromo, and iodo.

In the present specification, the term “alkyl” employed alone or incombination with other terms means a straight- or branched chainmonovalent hydrocarbon group having 1 to 15 carbon atom(s). Examples ofalkyl include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl,sec-butyl, tert-butyl, n-pentyl, isopentyl, neo-pentyl, n-hexyl,isohexyl, n-heptyl, n-octyl, n-nonanyl, n-decanyl, n-undecanyl,n-dodecanyl, n-tridecanyl, n-tetradecanyl, n-pentadecanyl, and the like.C1 to C10 alkyl is preferred. C1 to C6 alkyl is more preferred.

In the present specification, the term “lower alkyl” employed alone orin combination with other terms means a straight- or branched chainmonovalent hydrocarbon group having 1 to 8 carbon atom(s). Examples ofalkyl include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl,sec-butyl, tert-butyl, n-pentyl, isopentyl, neo-pentyl, n-hexyl,isohexyl, n-heptyl, n-octyl, and the like. C1 to C6 alkyl is preferred.C1 to C3 alkyl is more preferred.

In the present specification, the term “C1 to C3 alkylene” includemethylene, ethylene, propylene, and the like.

In the present specification, the term “cycloalkane” employed alone orin combination with other terms means a mono cycloalkane having 3 to 8carbon atom. Examples of cycloalkane include cyclopropane, cyclobutane,cyclopentane, cyclohexane, cycloheptane, cyclooctane, and the like. C3to C6 cycloalkane is preferred.

In the present specification, the term “cycloalkyl” employed alone or incombination with other terms means a mono cycloalkane having 3 to 8carbon atom. Examples of cycloalkyl include cyclopropyl, cyclobutyl,cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, and the like. C3 to C6cycloalkyl is preferred.

The term “lower alkenyl” in the present specification means a straight-or branched chain monovalent hydrocarbon group having 2 to 8 carbonatoms and one or more double bond. Examples of the alkenyl includevinyl, allyl, 1-propenyl, 2-propenyl, a variety of butenyl isomers andthe like. C2 to C6 alkenyl is preferred. C2 to C4 alkenyl is morepreferred.

The term “lower alkynyl” used in the present specification means astraight or branched chain monovalent hydrocarbon group having 2 to 8carbon atoms and one or more than two triple bond. Examples of thealkynyl include ethynyl, 1-propynyl, 2-propynyl, 1-propenyl, 2-propenyl,crotonyl, isopentenyl, a variety of butenyl isomers and the like. C2 toC6 alkynyl is preferred. C2 to C4 alkynyl is more preferred.

In the present specification, the term “aryl” employed alone or incombination with other terms means monocyclic or condensed ring aromatichydrocarbons. Examples of aryl include phenyl, 1-naphtyl, 2-naphtyl,anthryl, and the like.

The term “aralkyl” herein used means the above mentioned “lower alkyl”substituted with the above mentioned “aryl” at any possible position.Examples of the aralkyl are benzyl, phenethyl (e.g., 2-phenethyl),phenylpropyl (e.g., 3-phenylpropyl), naphthylmethyl (e.g.,1-naphthylmethyl and 2-naphthylmethyl), anthrylmethyl (e.g.,9-anthrylmethyl), and the like. Benzyl and phenylethy are preferred.

In the present specification, the term “non-aromatic heterocyclic group”employed alone or in combination with other terms means a 5 to 7membered non-aromatic ring which contains one or more hetero atomsselected from the group consisting of oxygen, sulfur, and nitrogen atomsin the ring and the 5 to 7 membered non-aromatic ring may be condensedwith two or more rings. Examples of the non-aromatic heterocyclic groupare pyrrolidinyl (e.g., 1-pyrrolidinyl, 2-pyrrolidinyl), pyrrolinyl(e.g., 3-pyrrolinyl), imidazolidinyl (e.g., 2-imidazolidinyl),imidazolinyl (e.g., imidazolinyl), pyrazolidinyl (e.g., 1-pyrazolidinyl,2-pyrazolidinyl), pyrazolinyl (e.g., pyrazolinyl), piperidinyl (e.g.,piperidino, 2-piperidinyl), piperazinyl (e.g., 1-piperazinyl), indolynyl(e.g., 1-indolynyl), isoindolinyl (e.g., isoindolinyl), morpholinyl(e.g., morpholino, 3-morpholinyl), tetrahydrofuranyl, tetrahydropyranyl,and the like.

Preferable are morpholino, piperazino, pyrrolidino, teterahydrofuranyl,tetrahydropyranyl, and the like as “non-aromatic heterocyclic group” ofR¹⁷, R¹⁸, R¹⁹, R²⁰, R²¹, R²², R²³, R²⁸, R²⁹, and R³⁰.

Preferable are morpholino, piperazino, piperidino, teterahydrofuranyl,tetrahydropyranyl, and the like as “non-aromatic heterocyclic group” ofsubstituent group B.

Preferable are morpholino, piperazino, piperidino, pyrrolidino,teterahydrofuranyl, tetrahydropyranyl, and the like as “non-aromaticheterocyclic group” of substituent group C.

In the present specification, the term “heteroaryl” employed alone or incombination with other terms means a 5 to 6 membered aromaticheterocyclic group which contains one or more hetero atoms selected fromthe group consisting of oxygen, sulfur, and nitrogen atoms in the ringand may be fused with above mentioned cycloalkyl, above mentioned aryl,above mentioned non-aromatic heterocyclic group, and other heteroaryl atany possible position. Examples of the heteroaryl are pyrrolyl (e.g.,1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl), furyl (e.g., 2-furyl, 3-furyl),thienyl (e.g., 2-thienyl 3-thienyl), imidazolyl (e.g., 2-imidazolyl,4-imidazolyl), pyrazolyl (e.g., 1-pyrazolyl, 3-pyrazolyl), isothiazolyl(e.g., 3-isothiazolyl), isoxazolyl (e.g., 3-isoxazolyl), oxazolyl (e.g.,2-oxazolyl), thiazolyl (e.g., 2-thiazolyl), pyridyl (e.g., 2-pyridyl,3-pyridyl, 4-pyridyl), pyrazinyl (e.g., 2-pyrazinyl), pyrimidinyl (e.g.,2-pyrimidinyl, 4-pyrimidinyl), pyridazinyl (e.g., 3-pyridazinyl),tetrazolyl(e.g., 1H-tetrazolyl), oxadiazolyl (e.g., 1,3,4-oxadiazolyl),thiadiazolyl (e.g., 1,3,4-thiadiazolyl), indolizinyl (e.g.,2-indolizinyl, 6-indolizinyl), isoindolyl (2-isoindolyl), indolyl (e.g.,1-indolyl, 2-indolyl, 3-indolyl), indazolyl (e.g., 3-indazolyl), puriyl(e.g., 8-puriyl), quinolizinyl ( e.g., 2-quinolizinyl), isoquinolyl(e.g., 3-isoquinolyl), quinolyl (e.g., 3-quinolyl, 5-quinolyl),phthalazinyl (e.g., 1-phthalazinyl), naphthyridinyl (e.g.,2-naphthyridinyl), quinolanyl (2-quinolanyl), quinazolinyl (e.g.,2-quinazolinyl), cinnolinyl (e.g., 3-cinnolinyl), pteridinyl (e.g.,2-pteridinyl), carbazolyl (e.g., 2-carbazolyl, 4-carbazolyl),phenanthridinyl (e.g., 2-phenanthridinyl, 3-phenanthridinyl), acridinyl(e.g., 1-acridinyl, 2-acridinyl), dibenzofuranyl (e.g.,1-dibenzofuranyl, 2-dibenzofuranyl), benzimidazolyl (e.g.,2-benzimidazolyl), benzisoxazolyl (e.g., 3-benzisoxazolyl), benzoxazolyl(e.g., 2-benzoxazolyl), benzoxadiazolyl (e.g., 4-benzoxadiazolyl),benzisothiazolyl (e.g., 3-benzisothiazolyl), benzothiazolyl (e.g.,2-benzothiazolyl), benzofuryl (e.g., 3-benzofuryl), benzothienyl (e.g.,2-benzothienyl), 4,5-dihydronaphtho[1,2-d]thiazolyl,4H-chromeno[4,3-d]thiazolyl, 4H-thiochromeno[4,3-d]thiazolyl,4,5-dihydrothiazo[5,4-c]quinolyl, 8H-indeno[1,2-d]thiazolyl,5,6-dihydro-4H-3-thia-1-aza-benzo[e]azurenyl and the like.

Preferable are thiazolyl, isoxazolyl, thienyl, carbazolyl,benzothiazolyl, pyridyl, pyrazolyl, and the like as “heteroaryl” for X¹.More preferable are thiazolyl, pyridyl, and the like.

Preferable are pyridyl, thiazolyl, benzothiazolyl, and the like as“heteroaryl” for R¹, R², R³, R⁴, R⁷, and R⁸.

Preferable are pyridyl, thienyl, furyl, pyrimidinyl, imidazolyl,thiazolyl, oxazolyl, triazolyl, and the like as “heteroaryl” for R¹⁰ andR¹¹.

Preferable are imidazolyl, triazolyl, tetrazolyl, pyridyl, pyrimidinyl,and the like as “heteroaryl” for A¹, A²,and A³.

Preferable are pyridyl, thienyl, furyl, pyrimidinyl, imidazolyl,thiazolyl, oxazolyl, triazolyl, and the like as “heteroaryl” for R¹⁷,R¹⁸, R¹⁹, R²⁰, R²¹, R²², R²³, R²⁸, R¹⁹, and R³⁰.

Preferable are pyridyl, pyrazolyl, pyrimidinyl, imidazolyl, oxazolyl,triazolyl, furyl, thienyl and the like as “heteroaryl” for substituentgroup B.

Preferable are pyridyl, pyrazolyl, imidazolyl, and the like as“heteroaryl” for substituent group C.

In the present specification, the term “5-membered heteroaryl” measns a5 membered aromatic heterocyclic group which contains one or more heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogenatoms. Examples of the 5-membered heteroaryl are thienyl, furyl,pyrrolyl, imidazolyl, pyrazolyl, isothiazolyl, isoxazolyl, thiazolyl,oxazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,4-thiadiazolyl,1,3,4-thiadiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, and the like.Preferable is thiazolyl.

The term “heteroarylalkyl” herein used means the above-mentioned “loweralkyl” substituted with the above-mentioned “heteroaryl” at any possibleposition. Examples of the heteroarylalkyl are thienylmethyl (e.g.,2-thienylmethyl), thienylethyl (e.g., 2-(thiophen-2-yl)ethyl),furylmethyl (e.g., 2- furylmethyl), furylethyl (e.g.,2-(furan-2-yl)ethyl), pyrrolylmethyl (e.g., 2-pyrrolylmethyl),pyrrolylethyl (e.g., 2-(pyrrol-2-yl)ethyl), imidazolylmethyl (e.g.,2-imidazolylmethyl, 4-imidazolylmethyl), imidazolylethyl (e.g.,2-(imidazol-2-yl)ethyl), pyrazolylmethyl (e.g., 3-pyrazolylmethyl),pyrazolylethyl (e.g., 2-(pyrazol-3-yl)ethyl), thiazolylmethyl (e.g.,2-thiazolylmethyl), thiazolylethyl (e.g., 2-(thiazol-2-yl)ethyl),isothiazolylmethyl (e.g., 3-thiazolylmethyl), isoxazolylmethyl (e.g.,3-isoxazolylmethyl), oxazolylmethyl (e.g., 2-oxazolylmethyl),oxazolylethyl (e.g., 2-(oxazol-2-yl)ethyl), pyridylmethyl (e.g.,2-pyridylmethyl , 3-pyridylmethyl, 4-pyridylmethyl), pyridylethyl (e.g.,2-pyridylethyl) and the like.

Preferable are 2-thienylmethyl, 2-furylmethyl, and the like as“heteroarylalkyl” for R¹, R², R³, R⁴, R⁷, and R⁸.

The term “phenylene” herein used means a divalent group of theabove-mentioned “phenyl”. Examples of the phenylene are 1,2-phenylene,1,3-phenylen, 1,4-phenylene, and the like. Preferable is 1,4-phenylene.

The term “monocyclic heteroarylene” herein used means a monocyclicheteroaryl divalent group of the above-mentioned “heteroaryl”. Examplesof the heteroarylene are thionphene-diyl, furan-diyl, pyridine-diyl, andthe like. Mentioned in more detail, it is exemplified by2,5-thionphene-diyl, 2,5-furan-diyl, 2,5-pyridine-diyl,2,5-thiazole-diyl, 2,5-(1,3,4-thiadiazole)-diyl, 2,5-piridine-diyl,2,5-pirazine-diyl, 3,6-pyridazine-diyl, 2,5-(4H-pyrane)-diyl, and thelike. Preferable are 2,5-thionphene-diyl, 2,5-furan-diyl,2,5-pyridine-diyl.

The term “monocyclic non-aromatic heterocycle-diyl” herein used means adivalent group of an above-mentioned “monocyclic non-aromaticheterocyclic group”. Examples of the non-aromatic heterocycle-diyl arepyrrolidine-diyl, piperidine-diyl, pyrazine-diyl and the like.

The term “monocyclic cycloalkane-diyl” herein used means a divalentgroup of the above-mentioned “monocyclic cycloalkyl”. Examples of thecycloalkyl-diyl are 1,4-cylopentane-diyl, 1,4-cyclohexane-diyl and thelike.

The term “alkyloxy” herein used are methyloxy, ethyloxy, n-propyloxy,i-propyloxy, n-butyloxy, i-butyloxy, sec-butyloxy, tert-butyloxy,n-pentyloxy, n-hexyloxy, n-heptyloxy, n-octyloxy, n-nonanyloxy,n-decanyloxy, and the like. Methyloxy, ethyloxy, n-propyloxy,i-propyloxy and n-butyloxy are preferred.

The term “lower alkyloxy” herein used are methyloxy, ethyloxy,n-propyloxy, i-propyloxy, n-butyloxy, i-butyloxy, sec-butyloxy,tert-butyloxy, and the like. Methyloxy, ethyloxy, n-propyloxy,i-propyloxy and n-butyloxy are preferred.

The term “lower alkylthio” herein used are methylthio, ethylthio, andthe like.

The term “lower alkyloxycarbonyl” herein used are methyloxycarbonyl,ethyloxycarbonyl, n-propyloxycarbonyl, isopropyloxycarbonyl,n-butyloxycarbonyl, t-butyloxycarbonyl, n-pentyloxycarbonyl and thelike.

The term “aryloxycarbonyl” herein used are phenyloxycarbonyl,1-naphthyloxycarbonyl, 2-naphthyloxycarbonyl, and the like.

In the present specification, the term “acyl” employed alone or incombination with other terms means alkylcarbonyl in which alkyl group isthe above-mentioned “lower alkyl” and arylcarbonyl in which aryl groupis the above-mentioned “aryl”. Examples of the acyl are acetyl,propyonyl, benzoyl, and the like. “Lower alkyl” and “aryl” may besubstituted respectively with substituents mentioned below.

In the present specification, the term “halo(lower)alkyl” employed aloneor in combination with other terms means the above-mentioned “loweralkyl” which is substituted with the above mentioned “halogen” at 1 to 8positions, preferably, at 1 to 5. Examples of the halo(lower)alkyl aretrifluoromethyl, trichloromethyl, difluoroethyl, trifluoroethyl,dichloroethyl, trichloroethyl, and the like. Preferable istrifluoromethyl.

The term “halo(lower)alkyl” herein used are trifluoromethyl,trichloromethyl, difluoroethyl, trifluoroethyl, dichloroethyl,trichloroethyl, and the like. Preferable is trifluoromethyl.

Examples of the term “acyloxy” herein used are acetyloxy, propionyloxy,benzoyloxy and the like.

Examples of the term “lower alkylsilyl” herein used are triethylsilyl,t-butyldimethylsilyl, and the like.

In the present specification, the term “optionally substituted amino”employed alone or in combination with other terms includes aminosubstituted with one or two of the above mentioned “lower alkyl”,“aralkyl”, “heteroarylalkyl” or “acyl”. Examples of the optionallysubstituted amino are amino, methylamino, dimethylamino,ethylmethylamino, diethylamino, benzylamino, acetylamino, benzoylaminoand the like. Preferable are amino, methylamino, dimethylamino,ethylmethylamino, diethylamino and acetylamino.

Examples of the term “optionally substituted aminocarbonyl” herein usedare aminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl,ethylmethylaminocarbonyl, diethylaminocarbonyl and the like. Preferableare aminocarbonyl, methylaminocarbonyl, and dimethylaminocarbonyl.

In the present specification, the term “optionally substituted ureide”includes ureide substituted with one or more than two of the abovementioned “lower alkyl”, “aryl”, “aralkyl”, “heteroaryl”,“heteroarylalkyl” or “acyl”.

The substituents of “optionally substituted lower alkyl” are cycloalkyl,lower alkenyl, lower alkyliden, hydroxy, lower alkyloxy, mercapto, loweralkylthio, halogen, nitro, cyano, carboxy, lower alkyloxycarbonyl,halo(lower)alkyl, halo(lower)alkyloxy, optionally substituted amino,optionally substituted aminocarbonyl, acyl, acyloxy, optionallysubstituted non-aromatic heterocyclic group, aryloxy (e.g., phenyloxy),aralkyloxy (e.g., benzyloxy), lower alkylsulfonyl, guanidino, azo group,optionally substituted ureide, ═N—O— (acyl) and the like. Thesesubstituents are able to locate at one or more of any possiblepositions.

Preferable are halogen atom, or halo(lower)alkyl, as substituents of“optionally substituted lower alkyl” for R^(C) and R^(D).

Preferable are hydroxy, carboxy, halogen atom, alkyloxy, alkylthio,alkylsilyl, optionally substituted amino, cyano, acyl, and the like assubstituents of “optionally substituted lower alkyl” for R¹, R², R³, R⁴,R⁵, R⁶, R⁷, R⁸, and R⁹.

Preferable are lower alkyloxycarbonyl and halogen atom as substituentsof “optionally substituted lower alkyl” for R¹⁰, R¹¹, and R¹⁶.

Preferable are cycloalkyl, lower alkenyl, lower alkylidene assubstituents of “optionally substituted lower alkyl” for R¹².

The substituents of “optionally substituted lower alkyloxy” and“optionally substituted lower alkylthio” are cycloalkyl, lower alkenyl,lower alkyliden, hydroxy, lower alkyloxy, mercapto, lower alkylthio,halogen, nitro, cyano, carboxy, lower alkyloxycarbonyl,halo(lower)alkyl, halo(lower)alkyloxy, optionally substituted amino,optionally substituted aminocarbonyl, acyl, acyloxy, optionallysubstituted non-aromatic heterocyclic group, aryloxy (e.g., phenyloxy),aralkyloxy (e.g., benzyloxy), lower alkylsulfonyl, guanidino, azo group,optionally substituted ureide, ═N—O— (acyl) and the like. Thesesubstituents are able to locate at one or more of any possiblepositions.

The substituents of “optionally substituted lower alkenyl” and“optionally substituted lower alkylthio” are cycloalkyl, lower alkenyl,lower alkyliden, hydroxy, lower alkyloxy, mercapto, lower alkylthio,halogen, nitro, cyano, carboxy, lower alkyloxycarbonyl,halo(lower)alkyl, halo(lower)alkyloxy, optionally substituted amino,optionally substituted aminocarbonyl, acyl, acyloxy, optionallysubstituted non-aromatic heterocyclic group, aryloxy (e.g., phenyloxy),aralkyloxy (e.g., benzyloxy), lower alkylsulfonyl, guanidino, azo group,optionally substituted ureide, and the like. These substituents are ableto locate at one or more of any possible positions.

The substituents of “optionally substituted phenylene”, “optionallysubstituted heteroarylene”, “optionally substituted 2,5-pyridine-diyl”,“optionally substituted 2,5-thiophene-diyl”, “optionally substituted2,5-furan-diyl”, “optionally substituted monocyclic non-aromaticheterocycle-diyl”, “optionally substituted monocyclic cycloalkane-diyl”,“optionally substituted aryl”, “optionally substituted phenyl”,“optionally substituted heteroaryl”, “optionally substituted 5-memberedheteroaryl”, “optionally substituted pyridyl”, “optionally substitutednon-aromatic heterocyclic group”, “optionally substituted cycloalkyl”,“optionally substituted aralkyl”, and “optionally substitutedheteroarylalkyl” herein used are optionally substituted alkyl,cycloalkyl, lower alkenyl, lower alkynyl, hydroxy, alkyloxy,aralkyloxy,mercapto, lower alkylthio, halogen, nitro, cyano, carboxy, loweralkyloxycarbonyl, halo(lower)alkyl, halo(lower)alkyloxy, optionallysubstituted amino, optionally substituted aminocarbonyl, acyl, acyloxy,optionally substituted aryl (which is substituted by halogen atom,carboxy, alkyl, or alkyloxy, and the like), optionally substitutedheteroaryl (which is substituted by halogen atom, carboxy, alkyl, oralkyloxy, and the like), optionally substituted non-aromaticheterocyclic group, optionally substituted aralkyl, lower alkylsulfonyl,guanidino, azo group, —N═N— (optionally substituted phenyl) oroptionally substituted ureide and the like. These substituents are ableto locate at one or more of any possible positions.

Preferable are halogen, nitro, cyano, lower alkyl, lower alkyloxy, andthe like as substituents of “optionally substituted phenylene”,“optionally substituted heteroarylene”, “optionally substituted2,5-pyridine-diyl”, “optionally substituted 2,5-thiophene-diyl”,“optionally substituted 2,5-furan-diyl”, “optionally substitutedmonocyclic non-aromatic heterocycle-diyl”, “optionally substitutedmonocyclic cycloalkyl-diyl”. Their unsubstituted one is preferred.

The examples of substituents of “optionally substituted aryl” and“optionally substituted aralkyl” for X¹ are lower alkyl, hydroxy loweralkyl, hydroxy, lower alkyloxy, lower alkylthio, halogen, nitro, cyano,carboxy, lower halo(lower)alkyl, halo(lower)alkyloxy, aralkyloxy,unsubstituted or substituted amino, unsubstituted or substitutedaminocarbonyl, aryl, heteroaryl, non-aromatic heterocyclic group,arylazo (e.g., phenylazo), and the like. Preferable substituents arelower alkyl, hydroxy, lower alkyloxy, lower alkylthio, halogen,halo(lower)alkyl, halo(lower)alkyloxy, aralkyloxy, —N═N— (phenyl),alkylendioxy, and the like.

The examples of “optionally substituted aryl” for X¹ are phenyl,3-methylphenyl, 4-methylphenyl, 3,4-dimethylphenyl, 4-ethylphenyl,4-t-buylphenyl, 4-n-buylphenyl, 4-n-hexylphenyl, 4-n-octylphenyl,3,5-di-t-butyl-4-hydroxyphenyl, 4-ethyloxyphenyl, 4-fluorophenyl,3,4-dichlorophenyl, 3,5-dichlorophenyl, 4-iodophenyl,4-trifluoromethylphenyl, 4-methylthiophenyl, 4-phenylmethyloxyphenyl,4-phenyazophenyl, 4-phenylphenyl, 2-naphtyl, benzodioxoryl (e.g.,1,3-benzodioxoryl), and the like.

The substituents of “optionally substituted aryl” for R¹⁰ and R¹¹ arehalogen atom, optionally substituted alkyl, cycloalkyl, lower alkenyl,lower alkynyl, hydroxy, lower alkyloxy, mercapto, lower alkylthio,nitro, cyano, carboxy, lower alkyloxycarbonyl, halo(lower)alkyl,halo(lower)alkyloxy, optionally substituted amino, optionallysubstituted aminocarbonyl, acyl, formyl, acyloxy, optionally substitutedaryl, optionally substituted heteroaryl (e.g., pyridyl, imidazolyl),non-aromatic heterocyclic group (e.g., morpholino, piperazinyl),aralkyl, and the like. Preferable are optionally substituted alkyl byone or more substituent(s) selected from substituent group B,cycloalkyl, optionally substituted alkyloxy by one or moresubstituent(s) selected from substituent group B, alkylthio, halogenatom, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, optionally substituted heteroaryl byone or more substituent(s) selected from substituent group C, optionallysubstituted non-aromatic heterocyclic group by one or moresubstituent(s) selected from substituent group C, and the like.

Substituent group B consists of hydroxy, alkyloxy, halogen atom,carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally substitutedamino, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, non-aromatic heterocyclic group, andheteroaryl.

Substituent group C consists of hydroxy, alkyl, halogen atom,halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy, optionallysubstituted amino, non-aromatic heterocyclic group, and heteroaryl.

The aryl may be fused with C5-C7 cycloalkane (e.g., cyclopentane,cyclohexane) and non-aromatic heterocyclic group (e.g.,tetrahydrofuranyl, 1,3-dioxolyl, 1,4-dioxynyl, pyrrolidinyl) to formindane, 1,2,3,4-tetrahydronaphthalene, 1,2,3,4-tetrahydroquinoline,2,3-dihydrobenzo[1,4]dioxyine, benzo[1,3]dioxsole,2,3-dihydrobenzofuran, 2,3-dihydro-1H-indole.

The substituents of “optionally substituted heteroaryl” and “optionallysubstituted heteroarylalkyl” for X¹ are optionally substituted alkyl,lower alkenyl (e.g., ═CH—CH₃), lower alknyl, hydroxy, lower alkyloxy,mercapto, lower alkylthio, halogen, nitro, cyano, carboxy, loweralkyloxycarbonyl, halo(lower)alkyl, halo(lower)alkyloxy, optionallysubstituted amino, optionally substituted aminocarbonyl, acyl (e.g.,optionally substituted aryloxycarbonyl by halogen atom nitro, cyano, andthe like) acyloxy, optionally substituted aryl, optionally substitutedheteroaryl (e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl, 3-thienyl,5-methylpyridin-2-yl, 3-quinolyl, 5-chlorothiophen-2-yl,5-bromothiophen-2-yl), non-aromatic heterocyclic group, aralkyl, ═N—O—(acyl) and the like. Preferable are optionally substituted lower alkyl,lower alkenyl, lower alkyloxycarbonyl, optionally substituted phenyl,heteroaryl, ═N—O— (acyl) and the like.

In the case of heteroatom is nitrogen atom, the nitrogen atom may besubstituted by alkyl, oxo, and the like.

The substituents of “optionally substituted 5-membered heteroaryl” forX² are optionally substituted lower alkyl, lower alkenyl (e.g.,═CH—CH₃), lower alkynyl, hydroxy, lower alkyloxy, mercapto, loweralkylthio, halogen, nitro, cyano, carboxy, lower alkyloxycarbonyl,halo(lower)alkyl, halo(lower)alkyloxy, optionally substituted amino,optionally substituted aminocarbonyl, acyl (e.g., aryloxycarbonyloptionally substituted with halogen, nitro, cyano and the like),acyloxy, optionally substituted phenyl, aryl, optionally substitutedheteroaryl (e.g., 2-pyridyl, 3-pyridyl, 4-pyridyl, 3-thienyl,5-methylpyridine-2-yl, 3-quinolyl, 5-chlorothiophene-2-yl,5-bromothiophene-2-yl), non-aromatic heterocyclic group, aralkyl, ═N—O—(acyl), and the like. Preferable are optionally substituted alkyl by oneor more substituent(s) selected from substituent group B, cycloalkyl,optionally substituted alkyloxy by one or more substituent(s) selectedfrom substituent group B, alkylthio, halogen atom, optionallysubstituted phenyl by one or more substituent(s) selected fromsubstituent group C, optionally substituted heteroaryl by one or moresubstituent(s) selected from substituent group C, or optionallysubstituted non-aromatic heterocyclic group by one or moresubstituent(s) selected from substituent group C, and the like.

Substituent group B consists of hydroxy, alkyloxy, halogen atom,carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally substitutedamino, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, non-aromatic heterocyclic group, andheteroaryl,Substituent group C consists of hydroxy, alkyl, halogen atom,halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy, optionallysubstituted amino, non-aromatic heterocyclic group, and heteroaryl,

The substituents of “optionally substituted aryl” for R¹⁰ and R¹¹ arehalogen atom, optionally substituted alkyl, cycloalkyl, lower alkenyl,lower alkynyl, hydroxy, lower alkyloxy, mercapto, lower alkylthio,nitro, cyano, carboxy, lower alkyloxycarbonyl, halo(lower)alkyl,halo(lower)alkyloxy, optionally substituted amino, optionallysubstituted aminocarbonyl, acyl, formyl, acyloxy, optionally substitutedaryl, optionally substituted heteroaryl (e.g., pyridyl, imidazolyl),non-aromatic heterocyclic group (e.g., morpholino, piperazinyl),aralkyl, and the like. Preferable are optionally substituted alkyl byone or more substituent(s) selected from substituent group B,cycloalkyl, optionally substituted alkyloxy by one or moresubstituent(s) selected from substituent group B, alkylthio, halogenatom, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, optionally substituted heteroaryl byone or more substituent(s) selected from substituent group C, optionallysubstituted non-aromatic heterocyclic group by one or moresubstituent(s) selected from substituent group C, and the like,

Substituent group B consists of hydroxy, alkyloxy, halogen atom,carboxy, lower alkyloxycarbonyl, aryloxycarbonyl, optionally substitutedamino, optionally substituted phenyl by one or more substituent(s)selected from substituent group C, non-aromatic heterocyclic group, andheteroaryl.Substituent group C consists of hydroxy, alkyl, halogen atom,halo(lower)alkyl, carboxy, lower alkyloxycarbonyl, alkyloxy, optionallysubstituted amino, non-aromatic heterocyclic group, and heteroaryl.

In the present specification, the term “(α)_(β-γ)” means that α ispresent of number of β to γ. Examples of “(α)_(β-γ)” are(CR^(C)R^(D))₀₋₂, (CH₂)₀₋₂, (CH₂)₀₋₅ mean that CR^(C)R^(D) is present ofnumber of 0 to 2, CH₂ is present of number of 0 to 2, CH₂ is present ofnumber of 0 to 5, respectively.

In the present specification, the term “hemopathy” means hemopathyaccompanied with the unusual number of platelet. For example thehemopathy is thrombocytopenia (after bone marrow transplantation, afterchemotherapy, anaplastic anemia, bone marrow dysplasia syndrome,acquired thrombopenia of intractable sudden thrombocy topenic purpuraand the like, congenital thrombopenia of thrombopoietin deficiency andthe like) and the like. For example this medicine can be used astreating agent in the case of decreacing number of platelet byadministrating antitumor agent, or as protecting agent in the case ofexpecting the decreace of number of platelet by administrating antitumoragent.

In the present specification, the term “modifiering a plateletproduction” means 1) increasing a number of platelet decreased byadministrating antitumor agent and the like. 2) maintaining a number ofplatelet which may be decreased by administrating antitumor agent andthe like. 3) reducing the ratio of the platelet number of decreasecaused by administrating antitumor agent and the like.

BRIEF DESCRIPTION OF THE DRAWING

FIG. 1: The chart shows the stimulation activity of a present inventionfor the proliferation and differentiation of megakaryocyte precursorcells, by counting megakaryocyte colonies formed from human bone marrowcells.

FIG. 2: The chart represents proliferation of the human TPO dependentcells bearing human TPO receptors by the present invention compound,wherein the x-axis is concentration of the present invention compound,and the y-axis is the absorbance as an indicator of cell proliferation.Open circles indicate a response of human TPO, and closed circlesindicate a response of the compound (B-1).

FIG. 3: The chart represents proliferation of the human TPO independentcells bearing no human TPO receptor by the present invention compound,wherein the x-axis is a concentration of the present invention compound,and the y-axis is absorbance as an indicator of cell proliferation. Opentriangles indicate a response of human TPO, and closed circles indicatea response of the compound (B-1).

BEST MODE CARRYING OUT THE INVENTION

Compounds (I) of the invention can be synthesized by the followingmethods A to B and the similar process.

wherein R¹, R², R³, and X are as defined above mentioned.(Step 1)

This step is a process of protecting of carboxylic acid of4-formyl-substituted or 4-acyl-substitutedbenzoic acid derivatives byR^(E). In step 3 combination of R^(E) and R^(F) is important in order toremove selectively protecting group of two carboxylic acid. In the caseof R^(F) is protecting group such as methyl and ethyl, which can beremoved by basic condition, it is necessary that protecting group ofR^(E) can be removed by another condition except basic condition.Examples of R^(E) are allyl (removed by palladium (0) complex),tert-butyl, p-methoxybenzyl, triphenylmethyl, diphenylmethyl (removed byacidic condition), trimethylsilylethyl, trimethylsilylethoxymethyl,tert-butyldimethylsilyl (removed by fluoride ion) and the like.

Esterification condition can be used the method of reacting withconsiderable halo-compound in the presence of suitable base. And it canbe synthesized by condensation reaction using a alcohol derivative asstarting material.

(Step 2)

This step is a process of converting aldehyde or ketone to olefin. Forexamples, the olefin can be syntesized by the reaction usingphosphineylide such as Wittig reaction, Horner-Emmons reaction, or bydehydrated condensation reaction such as Knoevenagel reaction.

(Step 3)

This step is a process of removing the protecting group R^(E). Theremoval of protecting group R^(E) is carried out under suitable reactioncondition as described in Protective Groups in Organic Synthesis,Theodora W Green (John Wiley & Sons).

(Step 4)

This step is a process of preparing amide derivative (VIII) fromcarboxylic acid derivative (VII) and amine derivative (X¹—NH₂) by themethod such as active esterification, acid chloride, mixed acidanhydride. This step is reacted in the solvent such as tetrahydrofuran,dioxane, dichloromethane, toluene, benzene. At active esterificationmethod it can be carried out by using 1-hydroxybenzotriazole,hydroxysuccinimide, dimethylaminopyridine, and the like anddicyclohexylcarbodiimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimidehydrochloride salt, and the like as condensation reagent. At acid halidemethod it can be carried out by converting free carboxylic acid which isreacted with thionyl chloride or oxalyl chloride to acid chloride. Atmixed acid anhydride method it can be carried out by convertingcarboxylic acid which is reacted with ethylchloroformate,isobutylchloroformate or the like to mixed acid anhydride.Triethylamine, pyridine or the like are used as base in these reactionaccording to be necessary.

(Step 5)

This step is a process of removing protecting group R^(F). Theprotecting group R^(F) is removed under suitable reaction condition byusing the method as described in Protective Groups in Organic Synthesis,Theodora W Green (John Wiley & Sons).

(Step 6)

This step is a process of preparing amide derivative (I-A) fromcarboxylic acid derivative (IX) and amine derivative (R³—NH₂) by themethod such as active esterification, acid chloride, mixed acidanhydride method. This step is reacted in the solvent such astetrahydrofuran, dioxane, dichloromethane, toluene, benzene. At activeesterification method it can be carried out by using1-hydroxybenzotriazole, hydroxysuccinimide, dimethylaminopyridine, andthe like and dicyclohexylcarbodiimide,1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride salt, andthe like as condensation reagent. At acid halide method it can becarried out by converting free carboxylic acid which is reacted withthionyl chloride or oxalyl chloride to acid chloride. At mixed acidanhydride method it can be carried out by converting carboxylic acidwhich is reacted with ethylchloroformate, isobutylchloroformate or thelike to mixed acid anhydride. Triethylamine, pyridine or the like areused as base in these reaction according to be necessary.

(Method B)

This method is another method for preparing compound (VIII) as describedmethod A.

wherein R¹, R² and X¹ are as defined above mentioned.(Step 1)

This step is a process of preparing carboamide derivative (XI) in amanner similar to Step 4 of Method A.

(Step 2)

This step is a process of converting aldehyde derivative (XI) to olefinderivative (XII) in a manner similar to Step 2 of Method A. Compound(XII) can be converted to compound (I-A) in a manner similar to Step 5and 6 of Metod A.

A compound is represented by the formula wherein Y¹ is —N(-alkyl)-CO—;Z¹ is optionally substituted thiazole or the like:

wherein W¹ and Z¹ are as defined above mentioned; Alk is lower alkyl.

Under alkylation condition for preparing the above mentioned compoundmay be obtained below mentioned compound.

wherein W¹, Z¹ and Alk are as defined above mentioned.

Compound in formula (I), (II) and (III) wherein a broken line ( - - - )represents the presence of a bond, contains cis-isomer, trans-isomer andtheir mixture. For example, compound wherein W¹ is amide type possessescisisomer and trans-isomer blow mentioned.

wherein R¹, R², R³, R⁴, X¹, Y¹, and Z¹ are as defined above mentioned.

The term “solvate” includes, for example, solvates with organicsolvents, hydrates, and the like.

The term “compound of the present invention” herein used includes apharmaceutically acceptable salt or solvate thereof. The salt isexemplified by a salt with alkali metals (e.g., lithium, sodium,potassium, and the like), alkaline earth metals (e.g., magnesium,calcium, and the like), ammonium, organic bases, amino acids, mineralacids (e.g., hydrochloric acid, hydrobromic acid, phosphoric acid,sulfuric acid, and the like), or organic acids (e.g., acetic acid,citric acid, maleic acid, fumaric acid, benzenesulfonic acid,p-toluenesulfonic acid, and the like). These salts can be formed by theusual method. These hydrates can coordinate with any water moleculeswhen hydrates are formed.

Prodrug is a derivative of the compound having a group which can bedecomposed chemically or metabolically, and such prodrug is a compoundaccording to the present invention which becomes pharmaceutically activeby means of solvolysis or by placing the compound in vivo under aphysiological condition. The method of both selection and manufacture ofappropriate prodrug derivatives is described in, for example. Design ofProdrugs, Elsevier, Amsterdam, 1985). For instance, prodrugs such as anester derivative which is prepared by reacting a basal acid compoundwith a suitable alcohol, or an amide derivative which is prepared byreacting a basal acid compound with a suitable amine are exemplifiedwhen the compounds according to present invention have a carboxylicgroup. Particularly preferred esters as prodrugs are methyl, ethyl,n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, morpholinoethyl, andN,N-diethylglycolamido, and the like. For instance, prodrugs such as anacyloxy derivative which is prepared by reacting a basal hydroxycompound with a suitable acyl halide or a suitable acid anhydride, or anamide derivative which is prepared by reacting a basal acid compoundwith a suitable amine are exemplified when the compounds according topresent invention have a hydroxy group. Particularly preferred acyloxyderivatives as prodrugs —OCOC₂H₅, —OCO(t-Bu), —OCOC₁₅H₃₁,—OCO(m-COONa—Ph), —COCH₂CH₂COONa, —OCOCH(NH₂)CH₃, —OCOCH₂N(CH₃)₂, andthe like. For instance, prodrugs such as an amide derivative which isprepared by reacting a basal amino compound with a suitable acid halideor a suitable acid anhydride are exemplified when the compoundsaccording to present invention have an amino group. Particularlypreferred amide as prodrugs are —NHCO(CH₂)₂₀CH₃, —NHCOCH(NH₂)CH₃, andthe like.

The compound of the present invention is not restricted to anyparticular isomers but includes all possible isomers and racemicmodifications.

The present invention compounds show excellent thrombopoietin receptoragonism as described in examples mentioned later, and may be used as apharmaceutical composition (platelet production modifier) for hemopathyaccompanied with the unusual number of platelet, for examplethrombocytopenia and the like. And the present compound may be used as aperipheral blood stem cell releasing promoter, a differetiation-inducerof megakaryocytic leukemic cell, a platelet increasing agent of aplatelet donor and the like.

When the compound of the present invention is administered to a personfor the treatment of the above diseases, it can be administered orallyas powder, granules, tablets, capsules, pilulae, and liquid medicines,or parenterally as injections, suppositories, percutaneous formulations,insufflation, or the like. An effective dose of the compound isformulated by being mixed with appropriate medicinal admixtures such asexcipient, binder, penetrant, disintegrators, lubricant, and the like ifnecessary. Parenteral injections are prepared by sterilizing thecompound together with an appropriate carrier.

The dosage varies with the conditions of the patients, administrationroute, their age, and body weight. In the case of oral administration,the dosage can generally be between 0. 1 to 100 mg/kg/day, andpreferably 1 to 20 mg/kg/day for adult.

The following examples are provided to further illustrate the presentinvention and are not to be constructed as limiting the scope thereof.

Abbreviations described below are used in the following examples.

-   Me: methyl-   Et: ethyl-   n-Pr: n-propyl-   i-Pr: isopropyl-   c-Pr: cyclopropyl-   n-Bu: n-butyl-   i-Bu: i-butyl-   sec- Bu:sec-butyl-   t-Bu: tert-butyl-   i-Bu: i-butyl-   n-Pen: n-pentyl-   c-Pen: cyclopentyl-   n-Hex: n-hexyl-   c-Hex: cyclohexyl-   i-Hex: i-hexyl-   Ph: phenyl-   Bn: benzyl-   Bz: benzoyl-   Py: pyridyl-   Th: thienyl-   Ac: acetyl-   Z: benzyloxycarbonyl-   DMF: N,N-dimethylformamide-   THF: tetrahydrofuran proppargyl, allyl, pyrazole, pyrimidine,    piperidine, methyl, cyclohexylmethyl

EXAMPLE Example 1 The Preparation of Compound (A-1, A-2, and B-1)

(Step 1)

A solution of terephthaladehydic acid (7.5 g), allyl bromide (4.41 ml),and potassium carbonate (7.0 g) in DMF (100 ml) was stirred at 60° C.for 16 h. The reaction solvent was removed under reduced pressure, andthe residue was partitioned between ethyl acetate and water. The ethylacetate layer was washed with sodium bicarbonate aqueous solution,water, and brine, and dried over magnesium sulfate. The solvent wasremoved under reduced pressure to obtain compound (2) 9.2 g as colorlessclear oil.

1H NMR(CDCl₃, δ ppm): 4.87 (2H, dt, J=1.2, 5.7 Hz), 5.30-5.47 (2H, m),5.99-6.12 (1H, m), 7.94-7.98 (2H, m), 8.20-8.25 (2H, m), 10.11 (1H, s).

(Step 2)

A solution of compound (2) (4.37 g) and ethyl2-(triphenylphosphoranilidene)propionate (10.63 g) in toluene (100 ml)was heated with stirring at 70° C. for 1 h. The reaction solvent wasconcentrated to ca. 30 to 40 ml, the precipitatedtriphenylphosphineoxide was filtered off. The filtrate was concentrated,and the residue was purified by silica gel column chromatography (ethylacetate/n-hexane=1/10) to obtain compound (3) 6.9 g as colorless clearoil.

¹H NMR (CDCl₃, δ ppm): 1.36 (3H, t, J=7.2 Hz), 2.11 (3H, d, J=1.5 Hz),4.29 (2H, q, J=7.2 Hz), 4.84 (2H, dt, J=1.2, 5.7 Hz), 5.28-5.46 (2H, m),5.98-6.11 (1H, m), 7.43-7.47 (2H, m), 7.69 (1H, d, J=1.5 Hz), 8.06-8.10(2H, m).

(Step 3)

A solution of compound (3) (6 g), tetrakistriphenylphosphinpalladium(1.27 g), and morpholine (2.68 g) in THF (100 ml) was stirred at 60° C.for 30 min. The reaction solvent was concentrated to ca. 30 to 40 ml,and ethyl acetate was added to the residue. The mixture was extractedwith sodium bicarbonate aqueous solution three times. The combinedsodium bicarbonate extract was acidified with 3M hydrocholic acid, andthe precipitated crystals were extracted with ethyl acetate. The ethylacetate layer was washed with brine, dried over magnesium sulfate. Thesolvent was removed under reduced pressure to obtain compound (4) 4.5 gas white crystals.

¹H NMR (CDCl₃, δ ppm): 1.37 (3H, t, J=7.2 Hz), 2.13 (3H, d, J=1.2 Hz),4.30 (2H, q, J=7.2 Hz), 7.49 (2H, d, J=8.4 Hz), 7.71 (1H, s), 8.14 (2H,d, J=8.4 Hz).

(Step 4)

To a solution of compound (4) (5.67 g), oxalyl chloride (1.3 ml) in THF(100 ml) was added catalytic amount of DMF, and then the reactionmixture was stirred at room temperature for 2 h. The reaction solutionwas removed under reduced pressure, toluene was added to the resultingresidue, and toluene was removed under reduced pressure. The obtainedcarboxylic acid chloride was dissolved with dioxane (70 ml), was added2-amino-4-(3,4-dichlorophenyl)thiazole (1 g), and pyridine (970 μl) tothe mixture. The reaction solution was heated with stirring at 100° C.for 16 h, and partitioned between ethyl acetete and water. The ethylacetate layer was washed with sodium bicarbonate aqueous solution,water, and brine, and drided over magnesium sulfate. The solvent wasremoved under reduced pressure to obtain compound (A-1) 1.5 g as whitecrystals.

¹H NMR (DMSO-d₆, δ ppm): 1.29 (3H, t, J=7.2 Hz), 2.10 (3H, d, J=1.2 Hz),4.23 (2H, q, J=7.2 Hz), 7.62-7.68 (3H, m), 7.72 (1H, d, J=8.4 Hz), 7.91(1H, s), 7.94 (1H, dd, J=1.8, 8.4 Hz), 8.15-8.20 (2H, m), 8.21 (1H, d,J=1.8 Hz), 12.84 (1H, br).

(Step 5)

A solution of compound (A-1) (1.7 g), 4M sodium hydroxide aqueoussolution (5.5 ml) in THF (150 ml) was heated with stirring 85° C. for 18h. The reacton solution was acidified with diluted hydrochloric acid,and the precipitated crystals were filtered. The obtained powder waswashed methanol and ethyl acetate to obtain compound (A-2) (1.5 g) aswhite powder.

¹H NMR (DMSO-d₆, δ ppm): 2.08 (3H, d, J=0.9 Hz), 7.62-7.68 (3H, m), 7.72(1H, d, J=8.7 Hz), 7.92 (1H, s), 7.95 (1H, dd, J=2.1, 8.7 Hz), 8.16-8.20(2H, m), 8.22 (1H, d, J=1.8 Hz), 12.84 (1H, br).

(Step 6)

To a solution of compound (A-2) (690 mg), oxalyl chloride (420 μl) inTHF (150 ml) was added catalytic amount of DMF, and then the reactionsolution was stirred at 70° C. for 1 h. The reaction solution wasremoved under reduced pressure, toluene was added to the resultingresidue, and toluene was removed under reduced pressure. To the obtainedcarboxylic acid chloride was added THF (100 ml), and cooled atice-cooling. To a solution of 28% ammonia aqueous solution (20 ml) wasadded ether and sodium hydroxide (5 g) at ice-cooling, and stirred for10 min, and standed. This ether solution was added to a THF solution ofthe acid chloride, and sitrred at ice-cooling for 1 h. The reactionsolution was partitioned between ethyl acetete and water. The organiclayer was successively washed with sodium bicarbonate aqueous solution,water, and brine, and drided over magnesium sulfate. The solvent wasremoved under reduced pressure, the residue was purified by silica gelcolumn chromatography (ethyl acetate/n-hexane=10/1 to ethyl acetate) toobtain compound (B-1) (400 mg) as colorless crystals.

¹H NMR (DMSO-d₆, δ ppm): 2.04 (3H, d, J=1.5 Hz), 7.18 (1H, br), 7.32(1H, s), 7.52-7.58 (2H, m), 7.60 (1H, br), 7.72 (1H, d, J=8.1 Hz), 7.91(1H, s), 7.94 (1H, dd, J=2.1, 8.4 Hz), 8.14-8.19 (2H, m), 8.22 (1H, d,J=2.4 Hz), 12.81 (1H, br).

Example 2 The Preparation of Compound (A-7)

(Step 1)

To a solution of 4-acetylbenzoic acid (1.64 g), oxalyl chloride (1.31ml) in THF (100 ml) was added catalytic amount of DMF, and then thereaction mixture was stirred at room temperature for 2 h. The reactionsolution was removed under reduced pressure, toluene was added to theresulting residue, and toluene was removed under reduced pressure. Tothe obtained carboxylic acid chloride was added THF (50 ml), tert-butylalchol (1.15 ml), and pyridine (1.21 ml), and the reaction mixture washeated under reflux for 40 h, and partitioned between ice-wateracidified with hydrochloric acid and ethyl acetate. The ethyl acetatelayer was washed with sodium bicarbonate aqueous solution, water, andbrine, and drided over magnesium sulfate. The solvent was removed underreduced pressure, the residue was purified by silica gel columnchromatography (ethyl acetate/n-hexane=/1/5) to obtain compound (7) (2.0g) as white crystals.

¹H NMR(CDCl₃, δ ppm): 1.61 (9H, s), 2.64 (3H, s), 7.96-7.00 (2H, m),8.04-8.09 (2H, m).

(Step 2)

To a suspension of 60% sodium hydride (360 mg) in THF (100 ml) was added2-phosphonopropionic acid triethyl (2.14 g) at ice-cooling. After thereacton mixture was stirred for 30 min, added dropwise a solution ofcompound (7) (1.9 g) in THF (15 ml) at ice-cooling. The reactionsolution was stirred at 50° C. for 3 h, and partitioned betweenice-water acidified with hydrochloric acid and ethyl acetate. The ethylacetate layer was washed with sodium bicarbonate aqueous solution,water, and brine, and drided over magnesium sulfate. The solvent wasremoved under reduced pressure, the residue was purified by silica gelcolumn chromatography (ethyl acetate/n-hexane=1/15) to obtain compound(8) (1.0 g) as a colorless oil.

¹H NMR(CDCl₃, δ ppm): 1.35 (3H, t, J=7.2 Hz), 1.60 (9H, s), 1.74 (3H, q,J=1.5 Hz), 2.24 (3H, q, J=1.5 Hz), 4.27 (2H, q, J=6.9 Hz), 7.18-7.22(2H, m), 7.97-8.10 (2H, m).

(Step 3)

A solution of compound (8) (900 mg) in formic acid (98-100%, 10 ml) wasstirred at room temperature for 3 h. The reaction solution wasconcentrated, toluene was added to the residure, and concentrated again.The obtained residure was washed with n-hexane to obtain compound (9)(680 mg) as white crystals.

¹H NMR(CDCl₃, δ ppm): 1.36 (3H, t, J=7.2 Hz), 1.74 (3H, q, J=1.5 Hz),2.26 (3H, q, J=1.5 Hz), 4.28 (2H, q, J=7.2 Hz), 7.25-7.29 (2H, m),8.10-8.14 m).

(Step 4)

Compound (A-7) was synthsized from compound (9) as starting material ina manner similar to Step 4 of Example 1.

¹H NMR(CDCl₃, δ ppm): 1.36 (3H, t, J=7.2 Hz), 1.74 (3H, q, J=1.5 Hz),2.25 (3H, q, J=1.5 Hz), 4.28 (2H, q, J=7.2 Hz), 7.26-7.29 (2H, m), 7.44(1H, d, J=8.4 Hz), 7.61 (1H, dd, J=2.1, 8.4 Hz), 7.91 (1H, d, J=2.1 Hz),7.91-7.95 (2H, m), 10.09 (1H, br).

Compound (A-3) to (A-6), (A-8) to (A-107), (B-2) to (B-46), (C-1) to(C-5), (D-1), (E-1) to (E-2), (F-1) to (F-3), (G-1) to (G-8), (H-1) to(H-8) and (I-1) to (I-6) were synthsized in a manner similar to Example1 and 2.

Their physical data of compound group A were shown in Tables 1 to 10,compound group B in Tables 11 to 17, compound group C in Tables 18,compound group D in Tables 19, compound group E in Tables 20, compoundgroup F in Tables 21, compound group G in Tables 22 to 23, compoundgroup H in Tables 24 to 25, and compound group I in Tables 26.

TABLE 1

Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-3

H H Et 1.28(3H, t, J=7.2Hz), 4.22(2H, q, J=7.2Hz), 6.80(1H, d,J=16.5Hz), 7.72(1H, d, J=8.4Hz), 7.73(1H, d, J=15.9Hz), 7.88-7.93(3H,m), 7.94(1H, dd, J=2.1, 8.7Hz), 8.12-8.18(2H, m), 8.21(1H, d, J=1.8Hz),12.84(1H, s). A-4

H H H 6.70(1H, d, J=15.9Hz), 7.67(1H, d, J=15.9Hz), 7.72(1H, d,J=8.7Hz), 7.84(2H, m), 7.92(1H, s), 7.95(1H, dd, J=1.8, 8.1Hz),8.12-8.18(2H, m), 8.21(1H, d, J=2.1Hz). 12.57(1H, br), 12.84(1H, s). A-5

H Et Et 1.13(3H, t, J=7.2Hz), 1.30(3H, t, J=7.2Hz), 2.50(2H, q,J=7.2Hz), 4.24(2H, q, J=7.2Hz), 7.577(1H, s), 7.60-7.63(2H, m), 7.72(1H,d, J=8.7Hz), 7.92(1H, s), 7.95(1H, dd, J=1.8, 8.4Hz), 8.16-8.20(2H, m),8.21(1H, d, J=1.8Hz) 12.85(1H, br). A-6

H Et H 1.13(3H, t, J=7.5Hz), 2.47(2H, q, J=7.2Hz), 7.55-7.60(2H, m),7.61(1H, s), 7.72(1H, d, J=8.4Hz), 7.91(1H, s), 7.95(1H, dd, J=2.1,8.4Hz), 8.15-8.20(2H, m), 8.21(1H, d, J=2.1Hz), 12.76(1H, br). A-8

Me Me H 1.71(3H, d, J=1.5Hz), 2.22(3H, d, J=1.2Hz), 7.37-7.42(2H, m),7.73(1H, d, J=8.4Hz), 7.92(1H, s), 7.95(1H, dd, J=2.1, 8.4Hz),8.13-8.18(2H, m), 8.22(1H, d, J=2.1Hz), 12.77(1H, br). A-9

H Me Et 1.29(3H, t, J=6.9Hz), 2.10(3H, d, J=1.8Hz), 4.23(2H, q,J=6.9Hz), 7.48-7.57(1H, m), 7.62-7.68(3H, m), 7.78-7.85(2H, m),7.93-8.10(1H, m), 8.15-8.20(2H, m), 12.85(1H, br).  A-10

H Me H 2.07(3H, d, J=1.5Hz), 7.47-7.57(1H, m), 7.62-7.67(3H, m),7.79-7.85(2H, m), 7.93-8.01(1H, m), 8.15-8.20(2H, m), 12.81(1H, br). A-11

H Cl Et 1.33(3H, t, J=7.2Hz), 4.33(2H, q, J=7.2Hz), 7.72(1H, d,J=8.1Hz), 7.93(3H, s), 7.94(1H, dd, J=2.1, 8.1Hz), 8.04(2H, d, J=8.7Hz),8.08(1H, s), 8.21(1H, d, J=2.4Hz), 8.21(2H, d, J=8.7Hz), 12.91(1H, s). A-12

H F Et 1.26(3H, t, J=7.5Hz), 4.27(2H, q, J=7.5Hz), 6.91(1H, d, J=21Hz),7.22(1H, s), 7.42(1H, d, J=8.1Hz), 7.55(2H, d, J=8.1Hz), 7.69(1H, dd,J=1.8Hz, 8.1Hz), 7.87(1H, d, J=2.1Hz), 7.87(2H, d, J=8.1Hz), 10.15(1H,s)

TABLE 2 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-13

H NHZ Me 3.64(1H, s), 5.12(2H, s), 6.55(1H, s), 7.32(2H, d, J=8.4Hz),7.35-7.42(5H, m), 7.72(1H, d, J=8.7Hz), 7.94(1H, dd, J=1.8Hz, 8.7Hz),8.06(2H, d, J=8.4Hz), 8.21(1H, d, J=1.8Hz), 9.39(1H, s), 9.39(1H, s),12.86(1H, s) A-14

H Cl H 7.73(1H, d, J=8.4Hz), 7.94(1H, s), 7.95(1H, dd, J=2.1, 8.4Hz),8.04(2H, d, J=8.1Hz), 8.05(1H, s), 8.21(2H, d, J=8.1Hz), 8.22(1H, d,J=2.1Hz), 12.90(1H, s), 13.84(1H, bs) A-15

H Br Me 3.55(3H, s), 6.84(1H, s), 7.56(2H, d, J=8.4Hz), 7.72(1H, d,J=8.1Hz), 7.93(1H, s), 7.95(1H, dd, J=8.4, 2.1Hz), 8.15(2H, d, J=8.4Hz),8.22(1H, d, J=2.1Hz), 12.90(1H, s) A-16

H Br H 6.72(1H, s), 7.58(2H, d, J=8.4Hz), 7.72(1H, d, J=8.4Hz), 7.93(1H,s), 7.95(1H, dd, J=8.4Hz, 1.8Hz), 8.12(2H, d, J=8.4Hz), 8.22(1H, d,J=2.4Hz), 12.88(1H, bs) A-17

H Me Et 7.15-7.21(1H, m), 7.26-7.84(6H, m), 7.47-7.54(1H, m), 7.87(1H,s), 8.24(2H, d, J=8.5Hz), 12.97(1H, s), 13.97(1H, bs) A-18

H Me H 2.07(3H, d, J=1.4Hz), 7.12-7.21(1H, m), 7.47-7.54(1H, m),7.64(2H, d, J=8.5Hz), 7.66(1H, s), 7.74-7.78(1H, m), 7.80-7.84(1H, m),7.85(1H, s), 8.18(2H, d, J=8.5Hz), 12.63(1H, bs), 12.85(1H, s) A-19

H Me Et 1.30(3H, t, J=7.1Hz), 2.10(3H, d, J=1.4Hz), 4.23(2H, q,J=7.1Hz), 7.33-7.36(1H, m), 7.58(1H, t, J=8.0Hz), 7.65(2H, d, J=8.5Hz),7.67(1H, s), 7.91(1H, s), 7.93(1H, bs), 7.99-8.02(1H, m), 8.19(2H, d,J=8.5Hz), 12.85(1H, s) A-20

H Me H 2.07(3H, d, J=1.4Hz), 7.33-7.36(1H, m), 7.57-7.66(4H, m),7.91(1H, s), 7.94(1H, m), 7.99-8.02(1H, m), 8.18(2H, d, J=8.5Hz),12.68(1H, bs), 12.85(1H, s) A-21

H Me Et 1.29(3H, t, J=7.1Hz), 2.10(3H, d, J=1.7Hz), 3.89(3H, s),4.23(2H, q, J=7.1Hz), 7.22-7.28(1H, m), 7.63-7.66(4H, m), 7.74-7.80(2H,m), 8.18(2H, d, J=8.5Hz), 12.80(1H, bs) A-22

H Me H 2.07(3H, d, J=1.4Hz), 3.89(3H, s), 7.22-7.28(1H, m),7.63-7.67(4H, m), 7.75-7.81(2H, m), 8.18(2H, d, J=8.5Hz), 12.80(1H, bs)A-23

H Me Et 1.29(3H, t, J=7.1Hz), 2.10(3H, d, J=1.4Hz), 4.23(2H, q,J=7.1Hz), 7.26-7.32(4H, m), 7.63-7.66(3H, m), 7.69(1H, s), 7.97-8.02(2H,m), 8.18(2H, d, J=8.5Hz), 12.83(1H, bs) A-24

H Me H 2.08(3H, d, J=1.1Hz), 7.26-7.32(2H, m), 7.64(2H, d, J=8.5Hz),7.66(1H, s), 7.704(1H, s), 7.98-8.03(2H, m), 8.18(2H, d, J=8.5Hz),12.85(1H, bs)

TABLE 3 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-25

H Me Et 1.29(3H, t, J=7.1Hz), 2.10(3H, d, J=1.4Hz), 4.23(2H, q,J=7.1Hz), 7.64-7.67(3H, m), 7.83(2H, d, J=8.5Hz), 7.95(1H, s),8.17-8.20(4H, m), 12.93(1H, bs) A-26

H Me H 2.07(3H, d, J=1.1Hz), 7.65(2H, d, J=8.2Hz), 7.66(1H, s), 7.83(2H,d, J=8.5Hz), 7.96(1H, s), 8.17(2H, d, J=8.2Hz), 8.18(2H, d, J=8.5Hz),12.93(1H, s) A-27

H Me Et 1.29(3H, t, J=7.1Hz), 2.10(3H, d, J=1.4Hz), 4.23(2H, q,J=7.1Hz), 7.64-7.72(5H, m), 7.97(1H, s), 8.19(2H, d, J=8.5Hz),8.25-8.28(1H, m), 8.33(1H, s), 12.80(1H, bs) A-28

H Me H 2.08(3H, d, J=1.1Hz), 7.68(2H, d, J=8.2Hz), 7.66(1H, s), 7.71(1H,d, J=5.2Hz), 7.91(1H, s), 8.18(2H, d, J=8.2Hz), 8.26-8.28(1H, m),8.33(1H, bs), 12.87(1H, s) A-29

H Cl Et 1.33(3H, t, J=7.1Hz), 4.32(2H, q, J=7.1Hz), 7.15-7.21(1H, m),7.47-7.54(1H, m), 7.81-7.83(1H, m), 7.86(1H, s), 8.05(2H, d, J=8.5Hz),8.09(1H, s), 8.22(2H, d, J=8.5Hz), 12.92(1H, bs) A-30

H Cl H 7.16-7.21(1H, m), 7.47-7.54(1H, m), 7.75-7.78(1H, m),7.81-7.84(1H, m), 7.86(1H, s), 8.04(2H, d, J=8.2Hz), 8.06(1H, s),8.21(2H, d, J=8.2Hz), 12.91(1H, s) A-31

H Cl Et 1.33(3H, t, J=7.1Hz), 4.33(2H, q, J=7.1Hz), 7.34-7.36(1H, m),7.57-7.63(1H, m), 7.92(1H, s), 7.94(1H, s), 7.99-8.02(1H, m), 8.05(2H,d, J=8.5Hz), 8.08(1H, s), 8.22(2H, d, J=8.5Hz), 12.92(1H, bs) A-32

H Cl H 7.33-7.36(1H, m), 7.57-7.63(1H, m), 7.93(1H, s), 7.93(1H, m),8.04-8.06(4H, m), 8.21(2H, d, J=8.2Hz), 12.92(1H, s) A-33

H Cl Et 1.33(3H, t, J=7.1Hz), 3.88(3H, s), 4.33(2H, q, J=7.1Hz),7.22-7.28(1H, m), 7.67(1H, s), 7.74-7.80(2H, m), 8.05(2H, d, J=8.5Hz),8.09(1H, s), 8.21(2H, d, J=8.5Hz), 12.88(1H, bs) A-34

H Cl H 3.89(3H, s), 7.22-7.28(1H, m), 7.67(1H, s), 7.76-7.81(2H, m),8.04(2H, d, J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.87(1H, bs)A-35

H Cl Et 1.33(3H, t, J=7.1Hz), 4.32(2H, q, J=7.1Hz), 7.48-7.57(1H, m),7.80-7.85(1H, m), 7.83(1H, s), 7.94-8.01(1H, m), 8.05(2H, d, J=8.5Hz),8.08(1H, s), 8.21(2H, d, J=8.5Hz), 12.91(1H, bs) A-36

H Cl H 7.48-7.58(1H, m), 7.80-7.85(1H, m), 7.83(1H, s), 7.94-8.01(1H,m), 8.04(2H, d, J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.92(1H,bs)

TABLE 4 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-37

H Cl Et 1.33(3H, t, J=7.1Hz), 4.32(2H, q, J=7.1Hz), 7.26-7.32(2H, m),7.71(1H, s), 7.98-8.02(2H, m), 8.04(2H, d, J=8.5Hz), 8.09(1H, s),8.21(2H, d, J=8.5Hz), 12.91(1H, bs) A-38

H Cl H 7.26-7.33(2H, m), 7.72(1H, s), 7.98-8.03(2H, m), 8.04(2H, d,J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.92(1H, bs) A-39

H Cl Et 1.33(3H, t, J=7.1Hz), 4.32(2H, q, J=7.1Hz), 7.83(2H, d,J=8.4Hz), 7.97(1H, s), 8.05(2H, d, J=8.5Hz), 8.09(1H, s), 8.18(2H, d,J=8.4Hz), 8.22(2H, d, J=8.5Hz), 13.00(1H, s) A-40

H Cl H 7.83(2H, d, J=8.5Hz), 7.96(1H, s), 8.04(2H, d, J=8.5Hz), 8.06(1H,s), 8.18(2H, d, J=8.5Hz), 8.22(2H, d, J=8.5Hz), 12.97(1H, bs) A-41

H Cl Et 1.33(3H, t, J=7.1Hz), 4.33(2H, q, J=7.1Hz), 7.70-7.72(2H, m),7.98(1H, s), 8.05(2H, d, J=8.5Hz), 8.09(1H, s), 8.22(2H, d, J=8.5Hz),8.25-8.28(1H, m), 8.33(1H, bs), 12.92(1H, s) A-42

H Cl H 7.70-7.72(2H, m), 7.98(1H, s), 8.04(2H, d, J=8.5Hz), 8.06(1H, s),8.22(2H, d, J=8.5Hz), 8.24-8.28(1H, m), 8.33(1H, bs), 12.92(1H, bs) A-43

H F H 7.15(1H, d, J=36.3Hz), 7.73(1H, d, J=8.4Hz), 7.86(2H, d, J=8.7Hz),7.97-7.94(2H, m), 8.18(2H, d, J=8.4Hz), 8.22(1H, d, J=2.1Hz), 12.89(1H,s) A-44

H F H 7.20(1H, d, J=23.1Hz), 7.68(2H, d, J=8.5Hz), 7.70(1H, s), 7.97(1H,s), 8.12(2H, d, J=8.5Hz), 8.25-8.28(1H, m), 8.33(1H, bs), 12.84(1H, bs)A-45

H F H 7.19(1H, d, J=22.8Hz), 7.33-7.56(1H, m), 7.57-7.63(1H, m),7.68(2H, d, J=8.5Hz), 7.91(1H, s), 7.94(1H, bs), 7.99-8.02(1H, m),8.11(2H, d, J=8.5Hz), 12.83(1H, bs) A-46

H F H 7.20(1H, d, J=22.9Hz), 7.68(2H, d, J=8.5Hz), 7.83(2H, d, J=8.5Hz),7.96(1H, s), 8.12(2H, d, J=8.5Hz), 8.18(2H, d, J=8.5Hz), 12.91(1H, s),13.87(1H, bs) A-47

H Cl H 7.39-7.45(1H, m), 7.48-7.54(2H, m), 7.67-7.73(3H, m),7.77-7.81(2H, m), 8.03-8.07(3H, m), 8.19-8.25(3H, m) A-48

H Cl H 1.32(9H, s), 7.47(2H, d, J=9.0Hz), 7.64(1H, s), 7.89(2H, d,J=9.0Hz), 8.01-8.06(3H, m), 8.22(2H, d, J=8.1Hz), 12.89(1H, s),13.90(1H, bs) A-49

H Cl H 0.87(3H, t, J=7.2Hz), 1.26-1.36(4H, m), 1.60(2H, quint, J=7.8Hz),2.60(2H, t, J=7.5Hz), 7.27(2H, d, J=8.4Hz), 7.64(1H, s), 7.87(2H, d,J=8.1Hz), 8.02-8.05(3H, m), 8.21(2H, d, J=8.4Hz), 12.88(1H, s),13.79(1H, bs)

TABLE 5 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-50

H Cl H 7.30-7.46(3H, m), 7.63(1H, d, J=2.4Hz), 8.03-8.07(3H, m),8.12(1H, td, J=1.8Hz, 7.8Hz), 8.22(2H, d, J=8.7Hz), 12.93(1H, s),13.85(1H, bs) A-51

H Cl H 7.19-7.28(2H, m), 7.47-7.57(2H, m), 8.01-8.05(3H, m), 8.21(2H, d,J=8.4Hz), 12.97(1H, s), 13.80(1H, bs) A-52

H Cl H 3.82(3H, s), 6.89-6.94(1H, m), 7.36(1H, t, J=8.1Hz),7.53-7.56(2H, m), 7.75(1H, s), 8.02-8.06(3H, m), 8.21(2H, d, J=8.4Hz),12.88(1H, s), 13.82(1H, bs) A-53

H Cl H 6.60(1H, dd, J=1.8Hz, 3.3Hz), 6.75(1H, d, J=3.3Hz), 7.44(1H, s),7.75(1H, d, J=1.8Hz), 8.01-8.04(3H, m), 8.21(2H, d, J=8.7Hz) A-54

H Cl H 7.37(1H, m), 7.49-7.58(3H, m), 7.65(1H, dt, J=1.8Hz, 8.1Hz),7.71-7.76(2H, m), 7.88(1H, s), 7.97(1H, dt, J=1.8Hz, 7.5Hz),8.03-8.06(3H, m), 8.23(2H, d, J=7.8Hz), 8.28(1H, t, J=1.8Hz), 12.90(1H,s), 13.82(1H, bs) A-55

H Cl H 0.92(3H, t, J=7.5Hz), 1.34(2H, sext, J=7.5Hz), 1.60(2H, quint,J=7.5Hz), 2.64(2H, t, J=7.5Hz), 7.17(1H, d, J=7.8Hz), 7.35(1H, t,J=7.5Hz), 7.70(1H, s), 7.76(1H, d, J=7.8Hz), 7.81(1H, s), 8.02-8.05(3H,m), 8.22(2H, d, J=8.4Hz) 12.86(1H, s), 13.84(1H, bs) A-56

H Cl H 7.24(1H, dt, J=5.8Hz, 2.5Hz), 7.40(1H, ddd, J=11.9Hz, 9.4Hz,2.5Hz), 7.59(1H, d, J=2.5Hz), 8.04(2H, d, J=8.5Hz), 8.05(1H, s),8.09-8.20(1H, m), 8.21(2H, d, J=8.5Hz), 12.93(1H, s), 13.82(1H, bs) A-57

H Cl H 7.55(1H, t, J=8.0Hz), 7.77-7.81(2H, m), 8.04(2H, d, J=8.5Hz),8.06(1H, s), 8.22(2H, d, J=8.5Hz), 8.37-8.42(1H, m), 12.99(1H, s),13.85(1H, bs) A-58

H Cl H 7.22-7.30(1H, m), 7.37-7.46(1H, m), 7.72(1H, d, J=2.5Hz),8.04(2H, d, J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.92(1H, s),13.82(1H, bs) A-59

H Cl H 0.92-0.97(3H, m), 1.41-1.49(2H, m), 1.67-1.75(2H, m), 4.01(2H, t,J=6.3Hz), 7.00(2H, d, J=8.5Hz), 7.54(1H, s), 7.87(2H, d, J=8.5Hz),8.04(2H, d, J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.85(1H, s),13.76(1H, bs) A-60

H Cl H 7.74-7.76(1H, m), 7.82(1H, d, J=2.7Hz), 7.80-7.84(1H, m),8.03-8.05(3H, m), 8.22(2H, d, J=8.5Hz), 8.31(1H, t, J=7.6Hz), 13.01(1H,s), 13.79(1H, bs) A-61

H Cl H 3.83(3H, s), 6.91-6.98(2H, m), 7.45(1H, d, J=2.5Hz), 8.00(4H, m),8.21(2H, d, J=8.5Hz), 12.88(1H, s), 13.81(1H, bs)

TABLE 6 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-62

H Cl H 7.68(1H, d, J=2.5Hz), 7.68-7.76(1H, m), 7.80-8.07(4H, m),8.20(2H, d, J=8.5Hz), 12.92(1H, s) A-63

H Cl H 7.48(1H, t, J=8.8Hz), 7.85(1H, s), 7.98-8.03(1H, m), 8.04(2H, d,J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 8.30(1H, dd, J=6.9Hz,2.2Hz), 12.88(1H, s), 13.82(1H, bs) A-64

H Cl H 0.89(′6H, d, J=6.7Hz), 1.87(1H, seven, J=6.7Hz), 2.48(2H, d,J=7.3Hz), 7.23(2H, d, J=8.2Hz), 7.64(1H, s), 7.87(2H, d, J=8.2Hz),8.04(2H, d, J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.88(1H, s),13.79(1H, bs) A-65

H Cl H 8.02-8.05(4H, m), 8.05(1H, s), 8.22(2H, d, J=8.5Hz), 8.27(1H, s),8.64(2H, s), 12.94(1H, s), 13.84(1H, bs) A-66

H Cl H 3.86(3H, s), 7.17(1H, t, J=7.5Hz), 7.25(1H, t, J=7.5Hz), 7.38(1H,s), 7.50(1H, d, J=8.4Hz), 7.78(1H, s), 8.03-8.06(3H, m), 8.17(1H, d,J=7.8Hz), 8.22(2H, d, J=8.4Hz), 12.79(1H, bs) A-67

H Cl H 2.85(6H, s), 3.52(2H, t, J=5.4Hz), 4.41(2H, t, J=5.4Hz), 7.09(2H,d, J=8.7Hz), 7.60(1H, s), 7.93(2H, d, J=8.7Hz), 8.01-8.05(3H, m),8.21(2H, d, J=8.7Hz), 12.84(1H, bs) A-68

H F H 7.15(1H, d, J=36Hz), 7.24-7.33(2H, m), 7.70(1H, s), 7.86(2H, d,J=8.4Hz), 7.96-8.03(2H, m), 8.18(2h, d, J=8.7Hz), 12.86(1H, s) A-69

H Cl H 7.57(1H, dd, J=8.7Hz, 1.8Hz), 7.67(1H, d, J=2.4Hz), 7.70(1H, dd,J=11.4Hz, 2.1Hz), 8.02-8.09(4H, m), 8.21(2H, d, J=8.7Hz), 12.97(1H, s),13.69(1H, bs) A-70

H Cl H 2.36(3H, s), 7.13-7.19(2H, m), 7.54-7.55(1H, m), 7.98-8.06(4H,m), 8.22(2H, d, J=8.4Hz), 12.89(1H, s), 13.80(1H, bs) A-71

H Cl H 7.39-7.45(1H, m), 7.51(2H, t, J=7.8Hz), 7.67-7.72(3H, m),7.79(2H, d, J=8.4Hz), 8.03-8.07(3H, m), 8.19-8.25(3H, m), 12.97(1H, s),13.86(1H, bs) A-72

H Cl H 7.30-7.48(2H, m), 7.72(1H, d, J=2.4Hz), 7.88-7.93(1H, m),8.04(2H, d, J=8.5Hz), 8.05(1H, s), 8.22(2H, d, J=8.5Hz), 12.96(1H, s),13.83(1H, bs) A-73

H Cl H 2.00-2.10(2H, m), 2.86-2.94(4H, m), 7.29(1H, d, J=7.7Hz),7.61(1H, s), 7.72-7.75(1H, m), 7.82(1H, s), 8.04(2H, d, J=8.5Hz),8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.84(1H, s), 13.84(1H, bs)

TABLE 7 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-74

H Cl H 3.24(2H, t, J=8.5Hz), 4.57(2H, t, J=8.8Hz), 6.83(1H, d, J=8.2Hz),7.49(1H, s), 7.73(1H, dd, J=8.2Hz, 1.6Hz), 7.82(1H, s), 8.04(2H, d,J=8.5Hz), 8.05(1H, s), 8.20(2H, d, J=8.5Hz), 12.83(1H, bs) A-75

H Cl H 7.51(1H, t, J=9.1Hz), 7.86(1H, s), 7.95-8.00(1H, m), 8.04(2H, d,J=8.5Hz), 8.05(1H, s), 8.16(1H, dd, J=7.4Hz, 2.2Hz), 8.22(2H, d,J=8.5Hz), 12.90(1H, bs) A-76

H Cl H 7.46(2H, d, J=8.8Hz), 7.72(1H, s), 8.04(2H, d, J=8.5Hz), 8.06(1H,s), 8.09(2H, d, J=8.8Hz), 8.22(2H, d, J=8.5Hz), 12.96(1H, s), 13.86(1H,bs) A-77

H Cl H 7.76(1H, d, J=2.4Hz), 7.81-7.91(1H, m), 8.03(2H, d, J=8.5Hz),8.04(1H, s), 8.20(2H, d, J=8.5Hz), 12.95(1H, s), 13.81(1H, s) A-78

H Cl H 2.52(3H, s), 7.34(2H, d, J=8.5Hz), 7.69(1H, s), 7.91(2H, d,J=8.5Hz), 8.04(2H, d, J=8.8Hz), 8.06(1H, s), 8.21(2H, d, J=8.5Hz),12.91(1H, bs) A-79

H Cl H 7.58-7.64(1H, m), 7.79(1H, d, J=2.5Hz), 7.79-7.83(1H, m),8.04(2H, d, J=8.5Hz), 8.06(1H,s), 8.22(2H, d, J=8.5Hz), 8.52(1H, dd,J=6.9Hz, 2.2Hz), 12.93(1H, s), 13.72(1H, bs) A-80

H Cl H 7.39-7.55(5H, m), 7.56-7.62(2H, m), 8.05(2H, d, J=8.5Hz),8.06(1H, s), 8.13(1H, td, J=7.8Hz, 1.8Hz), 8.23(2H, d, J=8.5Hz),12.96(1H, s), 13.82(1H, bs) A-81

H Cl H 7.30(1h, t, J=8.1Hz), 7.68-7.74(2H, m), 8.02-8.05(3H, m),8.10(1H, td, J=7.8Hz, 1.8Hz), 8.21(2H, d, J=8.7Hz), 12.96(1H, s),13.82(1h, bs) A-82

H Cl H 3.89(2H, s), 7.14-7.27(2H, m), 7.60-7.68(2H, m), 8.02-8.06(3H,m), 8.21(2H, d, J=8.4Hz), 12.92(1H, s), 13.80(1H, bs) A-83

H Cl H 2.32(3H, d, J=1.8Hz), 7.21(1H, t, J=7.5Hz), 7.25-7.31(1H, m),7.61(1H, d, J=2.7Hz), 7.94(1H, td, J=7.5Hz, 1.8Hz), 8.02-8.06(3H, m),8.21(2H, d), 12.91(1H, s), 13.80(1H, bs) A-84

H Cl H 0.84-0.90(3H, m), 1.30-1.37(4H, m), 1.56-1.66(2H, m), 2.68(2H, t,J=7.3Hz), 7.20-7.30(2H, m), 7.61(1H, d, J=2.7Hz), 7.95(1H, td, J=7.3Hz,2.1Hz), 8.04(2H, d, J=8.5Hz), 8.06(1H, s), 8.21(2H, d, J=8.5Hz),12.88(1H, s), 13.89(1H, bs)

TABLE 8 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A85

H Cl H 0.86-0.90(3H, m), 1.30-1.37(4H, m), 1.56-1.66(2H, m), 2.65(2H, t,J=7.6Hz), 7.18-7.24(1H, m), 7.69(1H, s), 7.79-7.84(1H, m), 7.87-7.91(1H,m), 8.03(2H, d, J=8.5Hz), 8.06(1H, s), 8.22(2H, d, J=8.5Hz), 12.92(1H,s), 14.00(1H, bs) A-86

H Cl H 7.28(1H, td, J=9.1Hz, 1.8Hz), 7.64(1H, s), 7.81-7.89(1H, m),8.04(2H, d, J=8.5Hz), 8.05(1H, s), 8.20(2H, d, J=8.5Hz), 13.01(1H, s),13.93(1H, bs) A-87

H Cl H 2.31(3H, s), 2.41(3H, s), 7.08(1H, dd, J=7.7Hz, 1.4Hz), 7.18(1H,d, J=7.7Hz), 7.33(1H, s), 7.49(1H, d, J=1.4Hz), 8.05(2H, d, J=8.5Hz),8.20(2H, d, J=8.5Hz), 12.85(1H, bs) A-88

H Cl H 7.31-7.44(3H, m), 7.49(td, J=7.5Hz, 1.8Hz), 7.62-7.68(3H, m),8.03-8.06(3H, m), 8.12(1H, td, J=7.5Hz, 1.8Hz), 8.22(2H, d, J=8.4Hz),12.96(1H, s), 13.81(1H, bs) A-89

H Cl H 7.31-7.37(1H, m), 7.41-7.66(7H, m), 8.03(2H, d, J=8.5Hz),8.05(1H, s), 8.21(2H, d, J=8.5Hz), 13.00(1H, bs) A-90

H Cl H 7.49(1H, s), 7.70(1H, d, J=8.5Hz), 8.02-8.10(4H, m), 8.19(2H, d,J=8.5Hz), 12.97(1H, s), 13.82(1H, bs) A-91

H Cl H 7.48(1H, t, J=7.9Hz), 7.69(1H, dd, J=7.9Hz, 1.5Hz), 7.74(1H, s),7.81(1H, dd, J=7.9Hz, 1.8Hz), 8.04(2H, d, J=8.5Hz), 8.06(1H, s),8.21(2H, d, J=8.5Hz), 12.99(1H, s), 13.87(1H, bs) A-92

H Cl H 7.47(1H, dd, J=8.6Hz, 2.7Hz), 7.62(1H, d, J=8.4Hz), 7.88(1H, s),8.02-8.05(4H, m), 8.21(2H, d, J=8.4Hz), 12.93(1H, s), 13.88(1H, bs) A-93

H Cl H 0.86(3H, t, J=6.9Hz), 1.27-1.30(6H, m), 1.55-1.62(2H, m),2.68(2H, t, J=7.5Hz), 7.19-7.30(2H, m), 7.61(1H, d, J=2.7Hz), 7.94(1H,dt, J=7.0Hz, 2.0Hz), 8.03(2H, d, J=8.5Hz), 8.05(1H, s), 8.21(2H, d,J=8.5Hz), 12.92(1H, s), 13.86(1H, bs) A-94

H Cl H 13.70(bs, 1H), 12.93(bs, 1H), 8.21(d, 2H, J=8.2Hz), 8.06(s, 1H),8.04(d, 2H, J=8.2Hz), 7.94(dt, 1H, J=7.5, 2.0Hz), 7.61(d, 1H, J=2.7Hz),7.32(m, 1H), 7.25(t, 1H, J=7.5Hz), 2.90(m, 1H), 1.20-1.90(m, 10H) A-95

H Cl H 0.85-0.89(3H, m), 1.27-1.35(4H, m), 1.53-1.60(2H, m), 2.63(2H, t,J=7.7Hz), 7.11-7.17(1H, m), 7.34-7.41(1H, m), 7.51(1H, s), 8.03(2H, d,J=8.5Hz), 8.05(1H, s), 8.20(2H, d, J=8.5Hz), 12.96(1H, s), 13.78(1H, bs)

TABLE 9 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-96 

H Cl H 0.96(3H, t, J=7.4Hz), 1.41-1.54(2H, m), 1.70-1.78(2H, m),4.08(2H, t, J=6.4Hz), 7.13-7.24(2H, m), 7.61-7.66(2H, m), 8.03(2H, d,J=8.6Hz), 8.05(1H, s), 8.21(2H, d, J=8.6Hz), 12.92(1H, s), 13.81(1H, bs)A-97 

H Cl H 1.23(3H, t, J=7.5Hz), 2.72(2H, q, J=7.5Hz), 7.21-7.33(2H, m),7.61(1H, d, J=2.5Hz), 7.95(1H, dd, J=7.5Hz, 2.0Hz), 8.04(2H, d,J=8.5Hz), 8.05(1H, s), 8.21(2H, d, J=8.5Hz), 12.92(1H, s), 13.85(1H, bs)A-98 

H Cl H 0.88(6H, d, J=6.6Hz), 1.19-1.26(2H, m), 1.53-1.66(3H, m),2.66(2H, t, J=7.7Hz), 7.20-7.30(2H, m), 7.61(1H, d, J=2.7Hz), 7.95(1H,dd, J=7.5Hz, 2.2Hz), 8.04(2H, d, J=8.4Hz), 8.05(1H, s), 8.21(2H, d,J=8.4Hz), 12.92(1H, s), 13.86(1H, bs) A-99 

H Cl H 0.94(3H, t, J=7.5Hz), 1.63(2H, sext, J=7.5Hz), 2.67(2H, t,J=2.67Hz), 7.20-7.31(2H, m), 7.61(1H, d, J=2.7Hz), 7.95(1H, td, J=7.5Hz,2.4Hz), 8.02-8.06(3H, m), 8.22(2H, d, J=8.4Hz), 12.92(1H, s), 13.79(1H,bs) A-100

H Cl H 0.92(3H, t, J=7.5Hz), 1.35(2H, sext, J=7.5Hz), 1.59(2H, quint,J=7.5Hz), 2.69(2H, t, J=7.5Hz), 7.19-7.30(2H, m), 7.61(1H, d, J=2.7Hz),7.94(1H, td, J=8.2Hz, 2.4Hz), 7.99-8.06(3H, m), 8.21(2H, d, J=8.4Hz),12.92(1H, s), 13.80(1H, bs) A-101

H Cl H 0.98(1H, t, J=7.5Hz), 1.60(2H, sext, J=7.5Hz), 2.77-2.83(2H, m),7.59(1H, d, J=8.4Hz), 7.66(1H, d, J=3.0Hz), 7.91(1H, t, J=8.4Hz),8.01-8.07(3H, m), 8.21(2H, d, J=8.7Hz), 12.94(1H, s), 13.80(1H, bs)A-102

H Cl H 7.46(1H, t, J=8.1Hz), 7.54-7.60(2H, m), 7.70(1H, d, J=2.7Hz),7.99-8.07(4H, m), 8.17(1H, dd, J=8.2Hz, 1.8Hz), 8.21(2H, d, J=8.4Hz),8.66(1H, bs), 8.83(1H, bs), 12.97(1H, s) A-103

H Cl H 1.39(3H, t, J=7.0Hz), 4.15(2H, q, J=7.0Hz), 7.13-7.25(2H, m),7.62-7.67(2H, m), 8.04(2H, d, J=8.5Hz), 8.06(1H, s), 8.22(2H, d,J=8.5Hz), 12.94(1H, s), 13.86(1H, bs) A-104

H Cl H 2.89-2.98(4H, m), 7.17-7.61(7H, m), 7.61(1H, d, J=2.5Hz),7.95(1H, dt, J=7.4Hz, 2.2Hz), 8.04(2H, d, J=8.6Hz), 8.05(1H, s),8.21(2H, d, J=8.6Hz), 12.92(1H, s), 13.86(1H, bs) A-105

H Cl H 0.97(9H, s), 1.45-1.50(2H, m), 2.62-2.68(2H, m), 7.19-7.30(2H,m), 7.62(1H, d, J=2.4Hz), 7.94(1H, dt, J=7.5Hz, 2.1Hz), 8.04(2H, d,J=8.5Hz), 8.06(1H, s), 8.22(2H, d, J=8.5Hz), 12.92(1H, s), 13.85(1H, bs)

TABLE 10 Compound No. R⁶ R¹ R² R⁵ ¹H-NMR(DMSO d-6) A-106

H Cl H 1.10(3H, t, J=6.9Hz), 2.93(2H, t, J=6.9Hz), 3.46(2H, q, J=6.9Hz),3.62(2H, t, J=6.9Hz), 7.24(1H, t, J=7.5Hz), 7.33(1H, td, J=7.2Hz,1.8Hz), 7.61(1H, d, J=2.7Hz), 7.97(1H, td, J=7.2Hz, 1.8Hz),8.02-8.06(3H, m), 8.21(2H, d, J=8.4Hz), 12.93(1H, s), 13.89(1H, bs)A-107

H Cl H 4.06(2H, s), 7.18-7.35(7H, m), 7.61(1H, d, J=2.7Hz), 7.98(1H, td,J=7.5Hz, 2.1Hz), 8.02-8.05(3H, m), 8.21(2H, d, J=8.7Hz), 12.92(1H, s),13.86(1H, bs)

TABLE 11

Compound No. R⁶ R¹ R² R ¹H-NMR (DMSO d-6) B-2

H H —NH₂ 6.77 (1H, d, J=15.9 Hz), 7.20 (1H, br), 7.50 (1H, d, J=15.9Hz), 7.60 (1H, br), 7.72 (1H, d, J=8.7 Hz), 7.72-7.76 (2H, m), 7.91 (1H,s), 7.95 (1H, dd, J=1.8, 8.4 Hz), 8.14-8.18 (2H, m), 8.22 (1H, d, J=1.8Hz), 12.82 (1H, br). B-3

H H —NHMe 2.73 (3H, d, J=4.8 Hz), 6.75 (1H, d, J= 15.6 Hz), 7.50 (1H, d,J=15.6 Hz), 7.72 (1H, d, J=8.1 Hz), 7.72-7.75 (2H, m), 7.91 (1H, s),7.95 (1H, dd, J=2.1, 8.4 Hz), 8.09-8.18 (3H, m), 8.21 (1H, d, J=2.1 Hz),12.81 (1H, br). B-4

H Me —NHme 2.06 (3H, d, J=1.5 Hz), 2.72 (3H, t, J= 4.5 Hz), 7.27 (1H,s), 7.53-7.58 (2H, m), 7.72 (1H, d, J=8.7Hz), 7.92 (1H, s), 7.95 (1H,dd, J=1.8, 8.1 Hz), 8.07 (1H, q, J=4.2Hz), 8.13-8.18 (2H, m), 8.22 (1H,d, J=2.1 Hz), 12.81 (1H, s). B-5

H Me —N(Me)₂ 2.05 (3H, d, J=1.5 Hz), 3.32 (6H, s), 6.57 (1H, s),7.54-7.58 (2H, m), 7.72 (1H, d, J=8.4 Hz), 7.91 (1H, s), 7.95 (1H, dd,J=1.8, 8.4 Hz), 8.13-8.18 (2H, m), 8.22 (1H, d, J 1.8 Hz), 12.79 (1H,br). B-6

H Me —NHEt 1.10 (3H, t, J=7.2 Hz), 2.05 (3H, d, J= 1.2 Hz), 3.17-3.26(1H, m), 7.25 (1H, s), 7.54-7.58 (2H, m), 7.72 (1H, d, J= 8.4 Hz), 7.91(1H, s), 7.95 (1H, dd, J= 2.1, 8.1 Hz), 8.09 (1H, t, J=5.4 Hz), 8.13-8.18 (2H, m), 8.21 (1H, d, J=2.1 Hz), 12.80 (1H, s). B-7

H Me —NH(n-Pr) 0.89 (3H, t, J=7.2 Hz), 1.51 (2H, sextet, d=7.2 Hz), 2.06(3H, d,J=1.5 Hz), 3.11- 3.18 (2H, m), 7.25 (1H, s), 7.54-7.59 (2H, m),7.72 (1H, d, J=8.4 Hz), 7.92 (1H, s), 7.95 (1H, dd, J=2.1, 8.4 Hz), 8.10(1H, t, J=5.4 Hz), 8.14-8.19 (2H, m), 8.22 (1H, d, J=2.1 Hz), 12.82 (1H,s). B-8

H Me

2.06 (3H, d, J=1.2 Hz), 3.53-3.58 (4H, m), 3.60-3.64 (4H, m), 6.60 (1H,s), 7.54- 7.61 (2H, m), 7.72 (1H, d, J=8.7 Hz), 7.91 (1H, s), 7.95 (1H,dd, J=2.1, 8.7 Hz), 8.13-8.19 (2H, m), 8.22 (1H, d, J=2.1 Hz), 12.80(1H, br).

TABLE 12 Compound No. R⁶ R¹ R² R ¹H-NMR (DMSO d-6) B-9 

H Me —NHBn 2.10 (3H, d, J=1.5 Hz), 4.41 (2H, d, J= 6.0 Hz), 7.52-7.38(6H, m), 7.56-7.61 (2H, m), 7.72 (1H, d, J=8.4 Hz), 7.92 (1H, s), 7.95(1H, dd, J=2.1, 8.4 Hz), 8.14-8.20 (2H, m), 8.22 (1H, d, J= 2.4 Hz),12.82 (1H, br). B-10

H Me

2.22 (3H, t, J=1.2 Hz), 7.34 (1H, dt, J= 1.2, 8.1 Hz), 7.47 (1H, dt,Jz=1.2, 8.4 Hz), 7.65-7.71 (3H, m), 7.73 (1H, d, J= 8.4 Hz), 7.78 (1H,d, J=7.8 Hz), 7.94 (1H, s), 7.96 (1H, dd, J=2.1, 8.4 Hz), 8.02 (1H, d,J=8.2 Hz), 8.19-8.24 (3H, m), 12.63 (1H, br), 12.89 (1H, br). B-11

H Me

2.18 (3H, d, J=1.5 Hz), 7.27 (1H, d, J= 2.4 Hz), 7.56 (1H, d, J=3.3 Hz),7.59 (1H, br), 7.63-7.68 (2H, m), 7.73 (1H, d, J=8.4 Hz), 7.93 (1H, s),7.96 (1H, dd, J= 2.1, 8.4 Hz), 8.17-8.22 (2H, m), 8.23 (1H, d, J=2.1Hz), 12.36 (1H, br), 12.87 (1H, br). B-12

H Me

2.18 (3H, d, J=1.2 Hz), 7.37-7.43 (2H, m), 7.64-7.69 (2H, m), 7.73 (1H,d, J= 8.4 hz), 7.94 (1H, s), 7.96 (1H, dd, J= 1.8, 8.4 Hz), 8.15 (1H,td, J=1.5, 6.9 Hz), 8.18-8.24 (3H, m), 8.31(1H, dd, J=1.5, 4.5 Hz)8.89(1H, d, J=2.4 Hz), 12.87 (1H, br). B-13

H Me

2.11 (3H, d, J=1.2 Hz), 4.49 (2H, d, J= 6.0 Hz), 7.36 (1H, br),7.52-7.62 (4H, m), 7.69-7.74 (3H, m), 7.92 (1H, s), 7.95 (1H, dd, J=2.1,8.1 Hz), 8.15-8.20 (2H, m), 8.22 (1H, d, J=2.1 Hz), 8.79 (1H, t, J= 6.3Hz), 12.83 (1H, br). B-14

H Me

2.09 (3H, d, J=1.2 Hz), 4.38 (2H, d, J= 5.7 Hz), 7.13-7.20 (2H, m),7.32-7.39 (3H, m), 7.55-7.61 (2H, m), 7.73 (1H, d, J=8.4 Hz), 7.92 (1H,s), 7.95 (1H, dd, J= 2.1, 8.4 Hz), 8.14-8.19 (2H, m), 8.22 (1H, d, J=2.1Hz), 8.71 (1H, t, J= 6.0 Hz), 12.84 (1H, br). B-15

H Me

2.08 (3H, d, J=1.5 Hz), 4.55 (2H, d, J= 5.7 Hz), 6.96-7.03 (2H, m), 7.31(1H, br), 7.40 (1H, dd, J=1.5, 5.4 Hz), 7.55- 7.60 (2H, m), 7.73 (1H, d,J=8.4 Hz), 7.92 (1H, s), 7.95 (1H, dd, J=2.1, 8.4 Hz), 8.14-8.19 (2H,m), 8.22 (1H, d, J=2.1 Hz), 8.80 (1H, t, J=6.0 Hz), 12.84 (1H, br).

TABLE 13 Compound No. R⁶ R¹ R² R ¹H-NMR (DMSO d-6) B-16

H Me

2.07 (3H, d, J=1.2 Hz), 4.39 (2H, d, J= 5.7 Hz), 6.28 (1H, d, J=3.6 Hz),6.41 (1H, dd, J=1.8, 3.3 Hz), 7.30 (1H, br), 7.55-7.61 (3H, m), 7.73(1H, d, J= 8.1 Hz), 7.92 (1H, s), 7.95 (1H, dd, J= 2.1, 8.4 Hz),8.14-8.18 (2H, m), 8.22 (1H, d, J=2.1 Hz), 8.63 (1H, t, J= 6.0 Hz),12.84 (1H, br). B-17

H Et —NH₂ 1.07 (3H, t, J=7.2 Hz), 2.47 (2H, q, J= 7.2 Hz), 7.20 (2H,br), 7.48-7.53 (2H, m), 7.65 (1H, br), 7.73 (1H, d, J= 8.1 Hz), 7.93(1H, s), 7.95 (1H, dd, J= 2.1, 8.4 Hz), 8.13-8.18 (2H, m), 8.22 (1H, d,J=2.1 Hz), 12.83 (1H, br). B-18

H Et —NHMe 1.05 (3H, t, J=7.5 Hz), 2.48 (2H, q, J= 7.5 Hz), 2.72 (2H, d,J=4.5 Hz), 7.11 (1H, s), 7.48-7.53 (2H, m), 7.73 (1H, d, J=8.4 Hz), 7.92(1H, s), 7.95 (1H, dd, J= 2.4, 8.1 Hz), 8.08-8.18 (3H, m), 8.22 (1H, d,J=2.4 Hz), 12.82 (1H, br). B-19

H Et —NHEt 1.05 (3H, t, J=7.5 Hz), 1.10 (3H, t, J= 7.2 Hz), 2.48 (2H, q,J=7.2 Hz), 3.16- 3.26 (2H, m), 7.09 (1H, s), 7.48-7.53 (2H, m), 7.73(1H, d, J=8.4 Hz), 7.93 (1H, s), 7.95 (1H, dd, J=2.1, 8.4 Hz), 8.14-8.20(2H, m), 8.22 (1H, d, J = 2.1 Hz), 12.84 (1H, br). B-20

H Et —NHBn 1.08 (3H, t, J=7.5 Hz), 2.52 (2H, q, J=7.8 Hz), 4.41 (2H, d,J=6.3 Hz), 7.18 (1H, s), 7.22-7.40 (5H, m), 7.50-7.54 (2H, m), 7.73 (1H,d, J=8.4 Hz), 7.93 (1H, s), 7.95 (1H, dd, J=1.8, 8.4 Hz), 8.14-8.18 (2H,m), 8.22 (1H, d, J= 1.8 Hz), 8.75 (1H, t, J=6.0 Hz), 12.84 (1H, br).B-21

Me Me —NH₂ 1.70 (3H, d, J=1.2 Hz), 2.04 (3H, d, J= 1.2 Hz), 7.21 (1H,br), 7.35-7.41 (2H, m), 7.52 (1H, br), 7.73 (1H, d, J= 8.4 Hz), 7.92(1H, s), 7.95 (1H, dd, J= 2.1, 8.4 Hz), 8.13-848 (2H, m), 8.22 (1H, d,J=1.8 Hz), 12.80 (1H, br). B-22

Me Me —NHMe 1.69 (3H, d, J=1.2 Hz), 1.99 (3H, d, J= 1.5 Hz), 2.69 (3H,d, J=4.5 Hz), 7.36- 7.41 (2H, m), 7.73 (1H, d, J=8.4 Hz), 7.92 (1H, s),7.95 (1H, dd, J=2.1, 8.4 Hz), 7.99 (1H, q, J=4.8 Hz), 8.13- 8.18 (2H,m), 8.22 (1H, d, J=2.1 Hz), 12.80 (1H, br).

TABLE 14 Compound No. R⁶ R¹ R² R ¹H-NMR (DMSO d-6) B-23

Me Me —NHEt 1.10 (3H, t, J=7.2 Hz), 1.69 (3H, d, J= 1.2 Hz), 2.00 (3H,d, J=1.5 Hz), 3.14- 3.23 (2H, m), 7.36-7.41 (2H, m), 7.73 (1H, d, J=8.4Hz), 7.92 (1H, s), 7.95 (1H, dd, J=2.1, 8.4 Hz), 8.06 (1H, t, J= 5.4Hz), 8.13-8.17 (2H, m), 8.22 (1H, d, J=2.1 Hz), 12.80 (1H, br). B-24

Me Me —NHBn 1.73 (3H, d, J=1.5 Hz), 2.00 (3H, d, J= 1.5 Hz), 4.39 (2H,d, J=5.7 Hz), 7.22- 7.42 (7H, m), 7.73 (1H, d, J=8.4 Hz), 7.92 (1H, s),7.95 (1H, dd, J=1.8, 8.4 Hz), 8.12-8.18 (2H, m), 8.22 (1H, d, J=1.8 Hz),8.62 (1H, t, J=6.3 Hz), 12.80 (1H, br). B-25

H Me —NH₂ 2.04 (3H, d, J=1.2 Hz), 7.20 (1H, br), 7.32 (1H, br),7.48-7.64 (4H, m), 7.79- 7.86 (2H, m), 7.94-8.02 (1H, m), 8.14- 8.18(2H, m), 12.83 (1H, br). B-26

H Me —NHMe 2.06 (3H, d, J=1.2 Hz), 2.72 (3H, d, J= 4.8 Hz), 7.26 (1H,s), 7.47-7.58 (3H, m), 7.78-7.87 (2H, m), 7.94-8.02 (1H, m), 8.08 (1H,q, J=4.5 Hz)8.13-8.18 (2H, m), 12.82 (1H, br). B-27

H Me —NH(CH₂)₂-N(CH₃)₂ 2.05 (3H, d, J=1.2 Hz), 2.19 (6H, s), 2.39 (2H,t, J=6.9 Hz), 3.28 (2H, q, J= 6.9 Hz), 7.26 (1H, br), 7.55 (2H, d, J=8.7 Hz), 7.72 (1H, d, J=8.1 Hz), 7.91(1H, s), 7.95 (1H, dd, J=2.1 Hz,8.1 Hz), 8.01 (1H, t, J=5.7 Hz), 8.16 (2H, d, J =8.7 Hz),. 8.22 (1H, d,J=2.1 Hz), 12.83 (1H, br) B-28

H Me —NH(CH₂)₂-COOH 2.05 (3H, d, J=1.5 Hz), 2.49 (3H, t, J= 7.5 Hz),3.39 (2H, q, J=6.0 Hz), 7.26 (1H, br), 7.56 (2H, d, J=8.7 Hz), 7.73 (1H,d, J=8.4 Hz), 7.93 (1H, s), 7.95 (1H, dd, J=1.8 Hz, 8.4 Hz), 8.16 (2H,d, J=8.7 Hz),. 8.22 (1H, d, J=1.8 Hz), 12.90 (2H, br) B-29

H Me —NHN(CH₃)₂ 2.05 (3H, s), 2.56 (6H, s), 7.14 (1H, s), 7.56 (2H, d,J=8.1 Hz), 7.73(1H, d, J= 8.1 Hz), 7.93 (1H, s), 7.95 (1H, dd, J= 1.8Hz, 8.1 Hz), 8.16 (2H, d, J=8.1 Hz),. 8.22 (1H, d, J=1.8 Hz), 9.08 (1H,s), 12.83 (1H, br) B-30

H Me —NHPh 2.17 (3H, d, J=1.1 Hz), 7.07-7.11 (1H, m), 7.32-7.37 (3H, m),7.65 (2H, d, J= 8.5 Hz), 7.73 (3H, d, J=8.5 Hz), 7.93(1H, s), 7.96 (1H,dd, J=2.2 Hz, 8.5 Hz), 8.20 (2H, d, J=8.5 Hz), 8.22 (1H, d, J=2.2 Hz),10.01 (1H, s), 12.85 (1H, s)

TABLE 15 Compound No. R⁶ R¹ R² R ¹H-NMR (DMSO d-6) B-31

H Me —NHCH₂CF₃ 2.09 (3H, d, J=1.1 Hz), 4.02 (2H, m), 7.34 (1H, s), 7.60(2H, d, J=8.4 Hz), 7.73 (1H, d, J=8.5 Hz), 7.93 (1H, s), 7.95 (1H, dd,J=2.2 Hz, 8.5 Hz), 8.18 (2H, d, J=8.4 Hz),. 8.22 (1H, d, J=2.2 Hz), 8.75(1H, t, J=6.0 Hz), 12.85 (1H, s) B-32

H Me —NH(CH₂)₃—SCH₃ 1.76 (2H, qn, J=6.9 Hz), 2.06 (6H, s), 2.49-2.53(2H, m), 3.26 (2H, q, J=5.7 Hz), 7.26 (1H, s), 7.57 (2H, d, J=8.4 Hz),7.73 (1H, d, J=8.4 Hz), 7.92(1H, s), 7.95(1H, dd, J=2.1 Hz, 8.4 Hz),8.15 (1H, t, J=4.8 Hz), 8.16 (2H, d, J=8.4 Hz), 8.22 (1H, d, J=2.1 Hz),12.83 (1H, br) B-33

H Me —NHCH(CH₃)-Ph 1.46 (3H, d, J=7.2 Hz), 2.08 (2H, d, J= 1.5 Hz), 5.08(1H, qn, J =7.2 Hz), 7.21- 7.41 (6H, m), 7.69 (2H, d, J=8.4 Hz), 7.72(1H, d, J=8.4 Hz), 7.92 (1H, s), 7.95 (1H, dd, J=2.1 Hz, 8.4 Hz), 8.17(2H, d, J=8.4 Hz), 8.22 (1H, d, J=2.1 Hz), 8.48 (1H, d, J=8.4 Hz), 12.83(1H, br) B-34

H Me —NHCH₂Si-(CH₃)₃ 0.06 (9H, s), 2.06 (3H, d, J=1.2 Hz), 2.72 (2H, d,J=5.4 Hz), 7.18 (1H, s), 7.57 (2H, d, J=8.4 Hz), 7.73(1H, d, J= 8.4 Hz),7.93 (1H, s), 7.95 (1H, dd, J= 2.1 Hz, 8.4 Hz), 7.99(1H, t, J=5.4 Hz),8.16 (2H, d, J=8.4 Hz), 8.22 (1H, d, J= 2.1 Hz), 12.83 (1H, s) B-35

H Me —NH(i-Bu) 0.87 (3H, t, J=7.1 Hz), 1.11 (3H, d, J= 6.6 Hz),1.41-1.57 (2H, m), 2.06 (3H, d, J=1.4 Hz), 3.83 (1H, sexth, J=6.6 Hz),7.21 (1H, s), 7.57 (2H, d, J=8.4 Hz), 7.72 (1H, d, J=8.4 Hz), 7.80 (1H,d, J= 8.1 Hz), 7.92 (1H, s), 7.95 (1H, dd, J= 2.1 Hz, 8.4 Hz), 8.17 (2H,d, J=8.4 Hz), 8.22 (1H, d, J=2.1 Hz), 12.82 (1H, s) B-36

H Me —NH(c-Pr) 0.52-0.70 (4H, m), 2.04 (3H, d, J=0.8 Hz), 2.74-2.80 (1H,m), 7.56 (2H, d, J= 8.1 Hz), 7.72 (1H, d, J=8.4 Hz), 7.92 (1H, s), 7.95(1H, dd, J=2.1 Hz, 8.4 Hz), 8.11 (1H, d, J=4.2 Hz), 8.16(2H, d, J= 8.1Hz), 8.22 (1H, d, J=2.1 Hz), 12.82 (1H, s)

TABLE 16 Compound No. R⁶ R¹ R² R ¹H-NMR (DMSO d-6) B-37

H Me —NH(CH₂)₃O—CH₃ 0.87 (3H, t, J=7.1 Hz), 1.11 (3H, d, J= 6.6 Hz),1.41-1.57 (2H, m), 2.06 (3H, d, J=1.4 Hz), 3.83 (1H, sexth, J=6.6 Hz),7.25 (1H, s), 7.57 (2H, d, J=8.7 Hz), 7.73 (1H, d, J=8.1 Hz), 7.95 (1H,dd, J= 2.1 Hz, 8.1 Hz), 8.11 (1H, t, J=6.0 Hz), 8.16 (2H, d, J=8.7 Hz),8.22 (1H, d, J=2.1 Hz), 12.83 (1H, s) B-38

H Me —NH(c-Pen) 1.46-1.58 (4H, m), 1.63-1.71 (2H, m), 1.81-1.90 (2H, m),2.05 (3H, s), 4.10- 4.15 (1H, m), 7.20 (1H, s), 7.57 (2H, d, J= 8.4 Hz),7.73 (1H, d, J=8.1 Hz), 7.92- 7.96 (3H, m), 8.16 (2H, d, J=8.4 Hz), 8.22(1H, d, J=1.8 Hz, 12.82 (1H, s) B-39

H Me —NH(t-Bu) 1.35 (9H, s), 2.03 (3H, d, J=1.5 Hz), 7.13 (1H, s), 7.56(2H, d, J=8.4 Hz), 7.72 (1H, d, J=8.4 Hz), 7.92 (1H, s), 7.95 (1H, dd,J=2.1 Hz, 8.4 Hz), 8.16 (2H, d, J=8.4 Hz), 8.22 (1H, d, J=2.1 Hz), 12.82(1H, s) B-40

H Me —NHpropargyl 2.06 (3H, d, J=1.2 Hz), 3.12 (1H, t, J= 2.4 Hz), 3.98(2H, dd, J=5.4 HZ, 2.4 Hz), 7.30 (1H, s), 7.58 (2H, d, J=8.4 Hz), 7.73(1H, d, J=8.4 Hz), 7.20 (1H, s), 7.95 (1H, dd, J=8.4 Hz, 2.1 Hz), 8.16(2H, d, J=8.4 Hz), 8.22 (1H, d, J=2.1 Hz), 8.57 (1H, t, J=5.4 Hz), 12.83(1H, s) B-41

H Me —NHallyl 2.08 (3H, d, J=1.2 Hz), 3.83 (2H, t, J= 5.7 Hz), 5.07-5.21(2H, m), 5.94-5.81 (1H, m), 7.29 (1H, s), 7.58 (2H, d, J=8.4 Hz), 7.73(1H, d, J=8.7 Hz), 7.92 (1H, s), 7.94 (1H, dd, J=8.4 Hz, 1.8 Hz), 8.17(2H, d, J=8.4 Hz), 8.22 (1H, d, J=1.8 Hz), 8.31 (1H, t, J=5.7 Hz), 12.83(1H, s) B-42

H Me —NH(CH₂)₂O—CH₃ 2.06 (3H, d, J=1.2 Hz), 3.28 (3H, s), 3.37-3.46 (4H,m), 7.27 (1H, s), 7.57 (2H, d, J=8.7 Hz), 7.72 (1H, d, J=8.4 Hz), 7.92(1H, s), 7.95 (1H, dd, J=8.4 Hz, 2.1 Hz), 8.15 (1H, s), 8.17 (2H, d, J=8.7 Hz), 8.22 (1H, d, J=2.1 Hz), 12.83 (1H, s) B-43

H Me —NHNHAc 1.91 (3H, s), 2.08 (3H, d, J=1.5 Hz), 7.32 (1H, s), 7.59(2H, d, J=8.4 Hz), 7.73 (1H, d, J=8.4 Hz), 7.95 (1H, dd, J= 8.4 Hz, 1.8Hz), 8.18 (2H, d, J=8.4 Hz), 8.22 (1H, d, J=1.8 Hz), 9.81(1H, s), 9.95(1H, s), 12.85 (1H, s)

TABLE 17 Compound No. R⁶ R¹ R² R ¹-NMR (DMSO d-6) B-44

H Me —NHNHPh 2.13 (3H, d, J=1.2 Hz), 6.73 (1H, t, J= 7.5 Hz), 6.80 (2H,d, J=7.8 Hz), 7.17 (2H, t, J=8.1 Hz), 7.38 (1H, s), 7.63 (2H, d,J=8.4Hz), 7.73 (1H, d,J=8.1 Hz), 7.82 (1H, d, J=2.7 Hz), 7.93 (1H, s), 7.96(1H, dd, J=8.1 Hz, 1.8 Hz), 8.19 (2H, d, J=8.4 Hz), 8.23 (1H, d, J=1.8Hz), 10.04 (1H, d, J=2.7 Hz), 12.86 (1H, s) B-45

H Me —N(CH₃)NH₂ 2.10 (3H, s), 3.11 (3H, s), 4.84 (2H, bs), 6.59(1H, s),7.53 (2H, d, J=8.1 Hz), 7.71 (1H, d, J=8.1 Hz), 7.85 (1H, s), 7.94 (1H,dd, J=8.1 Hz, 1.8 Hz), 8.15 (2H, d, J=8.1 Hz), 8.21 (1H, d, J=1.8 Hz),12.63 (1H, br) B-46

H Me —NHOCH₃ 2.03 (3H, d, J=1.5 Hz), 3.68 (3H, s), 7.20 (1H, s), 7.57(2H, d, J=8.4 Hz), 7.72 (1H, d, J=8.1 Hz), 7.95 (1H, dd, J= 8.1 Hz, 2.1Hz), 8.16 (2H, d, J=8.4 Hz), 8.22 (1H, d, J=2.1 Hz), 11.43 (1H, s),12.84 (1H, s)

TABLE 18

Compound No. R¹⁰ R¹ R² R⁵ ¹H-NMR (DMSO d-6) C-1

H Me Me 2.08 (3h, d, J=1.2 Hz), 3.64 (3H, s), 6.87 (1H, s), 7.38 (2H, d,J=8.7 Hz), 7.72 (1H, d, J=8.7 Hz), 7.91 (1H, s), 7.95 (1H, dd, J=8.7 Hz,2.1 Hz), 8.08 (2H, d, J=8.4 Hz), 8.21 (1H, d, J=2.1 Hz), 12.79 (1H, s)C-2

H Me H 2.06 (3H, d, J=1.2 Hz), 6.69 (1H, s), 7.46 (2H, d, J=9.0 Hz),7.72 (1H, d, J= 8.7 Hz), 7.92 (1H, s), 7.94 (1H, dd, J= 8.4 Hz, 1.8 Hz),8.08 (2H, d, J=8.7 Hz), 8.22 (1H, d, J=2.1 Hz), 12.77 (1H, s), 12.91(1H, s) C-3

H Br Me 3.76 (3H, s), 7.48 (2H, d, J=8.7 Hz), 7.69 (1H, s), 7.72 (1H, d,J=8.4 Hz), 7.93 (1H, s), 7.95 (1H, dd, J=8.4 Hz, 2.1 Hz), 8.11 (2H, d,J=8.4 Hz), 8.21 1H, d, J=2.1 Hz), 12.86 (1H, s) C-4

H Br H 7.47 (1H, s), 7.54 (2H, d, J=8.7 Hz), 7.92 (1H, s), 7.95 (1H, dd,J=8.4 Hz, 2.1 Hz), 8.11 (2H, d, J=8.4 Hz), 8.21 (1H, d, J=1.8 Hz), 12.83(1H, s) C-5

H F H 7.19 (1H, d, J=23.1 Hz), 7.68 (2H, d ,J= 8.4 Hz), 7.73 (1H, d,J=8.1 Hz), 7.93 (1H, s), 7.95 (1H, dd, J=8.1 Hz, 2.1 Hz), 8.11 (2H, d,J=8.1 Hz), 8.22 (1H, d, J= 1.8 Hz), 12.84 (1H, s)

TABLE 19

Compound No. R¹⁰ R¹ R² Het ¹H-NMR (DMSO d-6) D-1

H Me

2.35 (3H, d, J=0.9 Hz), 7.12 (2H, bs), 7.32 (1H, s), 7.58 (2H, d, J=8.1Hz), 7.72 (1H, d, J=7.8 Hz), 7.92 (1H, s), 795 (1H, dd, J= 8.4 Hz, 2.1Hz), 8.17 (2H, d, J=8.4 Hz), 8.22(1H, d, J=1.8 Hz), 12.31 (1H, s), 12.79(1H, s)

TABLE 20

Compound No. R¹⁰ R¹ R² R ¹H-NMR (d-6) E-1

H Me anti OH 12.80(bs, 1H), 11.20(s, 1H), 8.21(s, 1H), 815(d, 2H, J=8.3Hz), 7.95(m, 1H), 7.93(s, 1H), 7.90(s, 1H), 7.72(d, 1H, J=8.5 Hz),7.57(d, 2H, J=8.3 Hz), 6.83(s, 1H), 2.10(s, SH) E-2

H Me syn OH 10.60(bs, 1H), 8.12(d, 1H, J=1.9 Hz), 8.03(d, 2H, J=8.5 Hz),7.87(dd, 1H, J=8.5, 1.9 Hz), 7.58(d, 1H, J=8.5 Hz), 7.26(s, 1H), 7.16(d,2H, J=8.2 Hz), 6.56(d, 1H,J=7.1 Hz), 3.20(m, 1H), 2.51-2.80(m, 2H),0.98(d, 3H, J=6.9 Hz)

TABLE 21

Compound No. R¹⁰ R¹ R² R ¹H-NMR (DMSO d-6) F-1

H Me —N(Me)₂ (CDCl3) 2.24(d, 3H, J=1.5 Hz), 2.92(s, 6H), 7.24(s, 1H),7.47(d, 1H, J=8.2 Hz), 7.52 (s, 1H), 7.53(d, 2H, J=8.5 Hz), 7.64(dd, 1H,J=8.2, 1.8 Hz), 7.93(d, 1H, J=1.8 Hz), 8.00(d, 2H, J=8.5 Hz), 9.85(brs,1H). F-2

H Me —NH(t-Bu) (CDCl3) 1.38(s, 9H), 2.28(d 3H, J=1.4 Hz), 4.19(s, 1H),7.24(s, 1H), 7.49(d, 1H, J= 8.2 Hz), 7.53(d, 2H, J=8.5 Hz), 7.62(brs,1H), 7.66(dd, 1H, J=8.2, 1.9 Hz), 7.96(d, 1H, J=1.9 Hz), 8.03(d, 2H,J=8.5 Hz), 9.80(brs, 1H). F-3

H Me —NH₂ 2.25(d, 3H, J=1.2 Hz), 7.17(s, 2H), 7.42(brs, 1H), 7.64(d, 2H,J=8.2 Hz), 7.73(d, 2H, J=8.2 Hz), 7.92(s, 1H), 7.95(dd, 1H, J= 8.2, 2.1Hz), 8.18(d, 2H, J= 8.2 Hz), 8.22(d, 1H, J=2.1 Hz), 12.90(brs, 1H).

TABLE 22

Compound No. R¹⁰ R¹ R² R³ ¹H-NMR (DMSO d-6) G-1

H H Me 2.67 (2H, t, J=7.7 Hz), 3.02 (2H, t, J= 7.7 Hz), 3.69 (3H, s),7.20 (1H, s), 7.26 (1H, s), 7.29 (2H, d, J=8.2 Hz), 7.41 (1H, d, J = 8.5Hz), 7.58 (1H, dd, J=8.5 Hz, 2.2 Hz), 7.82 (2H, d, J= 8.2 Hz), 7.86 (1H,d, J=2.2 Hz), 10.15 (1H, bs) (CDCl3) G-2

H H H 2.61 (2H, t, J=7.3 Hz), 2.92 (2H, t, J= 7.3 Hz), 7.42 (2H, d,J=8.5 Hz), 7.41(1H, d, J=8.5 Hz), 7.92 (1H, s), 7.95 (1H, dd, J=8.5 Hz,2.1 Hz), 8.05 (2H, d, J=8.5 Hz), 8.22 (1H, d, J=2.1 Hz), 12.27 (1H, bs),14.73 (1H, bs) G-3

H Me H 1.07 (3H, d, J=6.6 Hz), 2.68-2.77 (2H, m), 2.94-3.03 (1H, m),7.39 (2H, d, J=8.5 Hz), 7.72(1H, d, J= 8.5 Hz), 7.95 (1H, dd, J=8.5 Hz,2.2 Hz), 8.06 (2H, d, J=8.5 Hz), 8.21 (1H, d, J=2.2 Hz), 12.19 (1H, bs),12.69 (1H, bs) G-4

H Cl H 3.19 (1H, dd, J=14.3 Hz, 8.2 Hz), 3.42 (1H, dd, J=14.3 Hz, 6.3Hz), 4.83 (1H, dd, J=8.2 Hz, 6.3 Hz), 7.48 (2H, d, J=8.2 Hz), 7.72 (1H,d, J=8.5 Hz), 7.92 (1H, s), 7.95 (1H, dd, J=8.5 Hz, 1.9 Hz), 8.08 (2H,d, J= 8.2 Hz), 8.22 (1H, d, J=1.9 Hz), 12.77 (1H, bs), 13.46 (1H, bs)G-5

H Cl Me 3.21 (1H, dd, J=14.3 Hz, 8.0 Hz), 3.41 (1H, dd, J=14.3 Hz, 6.6Hz), 3.77 (3H, s), 4.46 (1H, dd, J=8.0 Hz, 6.6 Hz), 7.20 (1H, s), 7.26(2H, d, J=8.5 Hz), 7.35 (1H, d, J=8.5 Hz), 7.52 (1H, dd, J=8.5 Hz, 2.2Hz), 7.78-7.81 (3H, m), 10.71 (1H, bs) (CDCl3) G-6

H F H 3.11-3.39 (2H, m), 5.23-5.44 (1H, m), 7.46 (2H, d, J=8.2 Hz), 7.72(1H, d, J=8.2 Hz), 7.92 (1H, s), 7.95 (1H, dd, J=8.2 Hz, 2.1 Hz), 8.09(2H, d, J=8.2 Hz), 8.22 (1H, d, J= 2.1 Hz), 13.45 (1H, bs)

TABLE 23 Compound No. R¹⁰ R¹ R² R⁵ ¹H-NMR (DMSO d-6) G-7

H F Et 1.20 (3H, t, J=7.1 Hz), 3.14-3.39 (2H, m), 4.17 (2H, q, J=7.1Hz), 5.36-5.56 (1H, m), 7.45 (2H, d, J= 8.5 Hz), 7.72 (1H, d, J=8.2 Hz),7.92 (1H, s), 7.95 (1H, dd, J=8.2 Hz, 1.9 Hz), 8.08 (2H, d, J=8.2 Hz),8.22 (1H, d, J=1.9 Hz), 12.78 (1H, bs) G-8

Me Cl G 1.39 (3H, d, J=7.1 Hz), 3.41-3.49 (1H, m), 4.78 (1H, d, J=8.5Hz), 7.52 (2H, d, J=8.5 Hz), 7.72 (1H, d, J=8.5 Hz), 7.92 (1H, s), 7.95(1H, dd, J=8.5 Hz, 1.9 Hz), 8.09 (2H, d, J=8.2 Hz), 8.22 (1H, d, J=1.9Hz), 12.76 (1H, bs)

TABLE 24

Compound No. R¹⁰ Z R¹ R² R⁵ ¹H-NMR (DMSO d-6) H-1

H H Et (CDCl₃) 10.10(bs, 1H), 8.06(s, 1H), 7.91(d, 1H, J=8.0 Hz),7.89(d, 1H, J=2.0 Hz), 7.72(d, 1H, J=8.0 Hz), 7.69(d, 1H, J=16.0 Hz),7.61(dd, 1H, J=8.5, 2.0 Hz), 7.53(t, 1H, J= 8.0 Hz), 7.43(d, 1H, J=8.5Hz), 7.23(s, 1H), 6.51(d, 1H, J=16.0 Hz), 4.30(q, 2H, J=7.0 Hz), 1.35(t,3H, J=7.0 Hz) H-2

H H H 12.90(s, 1H), 12.50(s, 1H), 8.57(s, 1H), 8.23(d, 1H, J=2.0 Hz),8.10(d, 1H, J=8.0 Hz), 7.96(dd, 1H, J= 8.5, 2.0 Hz), 7.94(s, 1H),7.92(d, 1H, J=8.0 Hz), 7.73(d, 1H, J=8.0 Hz), 7.68(d, 1H, J=16.0 Hz),7.62(t, 1H, J=8.0 Hz), 6.76(d, 1H, J=16.0 Hz) H-3

H H Me 2.22 (3H, s), 2.42 (3H, s), 3.85 (3H, s), 6.37 (1H, d, J=15.9Hz), 7.10 (1H, s), 7.18 (1H, s), 7.25 (1H, s), 7.31 (1H, d, J=8.5 Hz),7.40 (1H, dd, J=8.5 Hz, 1.9 Hz), 7.63 (1H, d, J=1.9 Hz), 7.82 (1H, d,J=15.9 Hz), 11.30 (1H, bs) (CDCl3) H-4

H H H 2.41 (6H, s), 6.55 (1H, d, J=15.9 Hz), 7.53 (1H, s), 7.69 (1H, s),7.72 (1H, d, J=8.4Hz), 7.79 (1H, d, J= 15.9 Hz), 7.73 (1H, dd, J=8.4 Hz,1.9 Hz), 8.18 (1H, d, J=1.9 Hz), 12.70 (1H, s) H-5

H Cl Et 1.42 (3H, t, J=6.9 Hz), 2.16 (3H, s), 2.43 (3H, s), 4.39 (q, 2H,J=6.9 Hz), 7.17 (1H, s), 7.19 (1H, s), 7.26 (1H, s), 7.34 (1H, d, J=8.7Hz), 7.45 (1H, dd, J=8.7 Hz, 2.1 Hz), 7.47 (1H, s), 7.69 (1H, d, J=2.1Hz), 7.91 (1H, s), 11.09 (1H, s) (CDCl3) H-6

H Cl H 2.31 (3H, s), 2.42 (3H, s), 7.56 (1H, s), 7.57 (1H, s), 7.72 (1H,d, J=8.5 Hz), 7.91-7.94 (2H, m), 8.04 (1H, s), 8.18 (1H, d, J=1.9 Hz),12.71 (1H, s)

TABLE 25 Compound No. R¹⁰ Z R¹ R² R⁵ ¹H-NMR (DMSO d-6) H-7

H Cl H 7.73(d, 1H, J=8.6 Hz), 7.95(dd, 1H, J=8.6, 1.8 Hz), 7.97(s, 1H),8.03(s, 1H), 8.04-8.10(m, 2H), 8.17(t, 1H, J=7.7 Hz), 8.02(d, 1H, J=1.8Hz), 13.01(s, 1H), 14.09(s, 1H) H-8

H Cl H 7.55(t, 1H, J=7.7 Hz), 7.78(m, 1H), 7.79(d, 1H, J =2.7 Hz),7.86(d, 1H, J=4.5 Hz), 8.32(s, 1H), 8.35(d, 1H, J=4.5 Hz), 8.39(t, 1H,J=7.7 Hz), 13.18(s, 1H), 13.87(br, 1H)

TABLE 26

Compound No. R¹⁰ Y R¹ R² R⁵ ¹H-NMR (DMSO d-6) I-1

—NHCH₂— H Me Et (CDCl₃) 7.91(d, 1H, J=1.9 Hz), 7.67(d, 1H, J=1.3 Hz),7.62(dd, 1H, J=8.3, 1.9 Hz), 7.43(d, 1H, J= 8.3 Hz), 7.41(s, 4H),6.73(s, 1H), 5.57(m, 1H), 4.57(d, 2H, J=5.8 Hz), 4.27(q, 2H, J=7.1 Hz),2.11(d, 3H, J=1.3 Hz), 1.35(t, 3H, J=7.1 Hz) I-2

—NHCH₂— H Me H 12.50(bs, 1H), 8.29(t, 1H, J=5.5 Hz), 8.03(d, 1H, J=2.0Hz), 7.80(dd, 1H, J=8.5, 2.0 Hz), 7.61(d, 1H, J=8.5 Hz), 7.57(s, 1H),7.45(s, 4H), 7.30(s, 1H), 4.54(d, 2H, J=5.5 Hz), 2.02(d, 3H, J=0.5 Hz)I-3

—NHCOCH₂— H Me Et (CDCl₃) 8.82(bs, 1H), 7.88(d, 1H, J= 2.0 Hz), 7.68(s,1H), 7.58(dd, 1H, J=8.0, 2.0 Hz), 7.45(d, 2H, J=8.2 Hz), 7.44(d, 1H,J=8.5 Hz), 7.35(d, 1H, J=8.2 Hz), 7.15(s, 1H), 4.29(q, 2H, J=7.0 Hz),3.85(s, 2H), 2.14(d, 3H, J=1.4 Hz), 1.36(t, 3H, J=7.0 Hz) I-4

—NHCOCH₂— H Me H 12.60(bs, 1H), 12.50(bs, 1H), 8.14(d, 1H, J=2.0 Hz),7.88(dd, 1H, J=8.5, 2.0 Hz), 7.84(s, 1H), 7.70(d, 1H, J=8.5 Hz), 7.58(s,1H), 7.45(d, 2H, J=8.5 Hz), 7.40(d, 2H, J=8.5 Hz), 3.84(s, 2H), 2.03(d,3H, J=1.5 Hz) I-5

—NHSO₂— H Me Et (CDCl3) 1.35(t, 3H, J = 7.2 Hz), 2.06(d, 3H, J=1.5 Hz),4.27(q, 2H, J=7.2 Hz), 6.64(s, 1H), 7.35(dd, 1H, J=8.2, 2.1 Hz), 7.42(d, 2H, J= 8.2 Hz), 7.44(d, 1H, J=8.2 Hz), 7.58(d, 1H, J=2.1 Hz),7.62(s, 1H), 7.98(d, 2H, J=8.2 Hz). I-6

—NHSO₂— H Me H (CDCl3+CD3OD) 2.09(d, 3H, J = 1.5 Hz), 6.66(s, 1H),7.40(dd, 1H, J= 8.2, 2.4 Hz), 7.49 (d, 2H, J=8.5 Hz), 7.52(d, 1H, J=8.2Hz), 7.66(d, 1H, J=2.4 Hz), 7.69(s, 1H), 7.97(d, 2H, J=8.5 Hz).

Example 3 The Preparation of Compound (A-15)

To a suspension of methoxy-methoxycarbonylmethyl-triphenylphosphoniumchloride (152 mg) and2-(4-formylbenzoylamino)-4-(3,4-dichlorophenyl)thiazole (57 mg) inmethylene chloride (3 ml) was added triethylamine (38 mg), and thereaction mixture was stirred at room temperature for overnight. Themixture was concentrated, purified by silica gel column chromatographyto obtain compound (A-15) 30 mg.

Melting point: 203˜205° C. ¹H-NMR (CDCl₃) δ ppm: 3.85 (s, 3H), 3.89 (s,3H), 6.96 (s, 1H), 7.22 (s, 1H), 7.46 (dd, 1H, J=8.2, 1.9 Hz), 7.63 (d,1H, J=8.2 Hz) 7.86 (d, 2H, J=8.6 Hz), 7.92 (d, 1H, J=1.9 Hz), 7.94 (d,2H, J=8.6 Hz), 9.82 (brs, 1H).

Example 4 The Preparation of Compound (J-3)

A solution of (E)-3-(4-iodophenyl)-2-methylacrylic acid ethyl ester (200mg), dichlorobis(triphenylphosphine)palladium (II) (22 mg),2-amino-4-(4′-chlorophenyl)-1H-imidazole (277 mg), and triethylamine(0.27 ml) in DMF (7 ml) was stirred under carbon monooxide atmosphere at90° C. for 15 min. The reaction mixture was cooled, poured into water.The precipitated crystals were filterd, recrystalaized with DMF toobtain compound (J-3) 117 mg as light yellow crystals.

Example 5 The Preparation of Compound (J-16)

To a solution of ethyl ester of compound (A-53) (300 mg) inacetonitrile/tetrahydrofuran (1/1, 80 ml), was added1-fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane bistetrafluoroborate(50% on alumina 1.24 g), was stirred at 80° C. for 30 min. Alumina wasfiltered off, the filtrate was concentrated under reduced pressure, andadded chloroform. The insoluble materials was filtered off again, andthe filtrate was concentrated. The residure was purified by preparativeTLC plate to obtain fluoro derivative 20 mg as yellow crystals. Theobtained ester derivative was solvolized in a manner similar topreparing compound (A-2) to obtain compound (J-16).

Compound (J-1) to (J-2), (J-4) to (J-15), and (J-17) were synthsized ina manner similar to Example 4 and 5. Their physical data of compoundwere shown in Tables 27 to 28.

TABLE 27

Compound No. X R¹ R² R⁵ ¹H-NMR (DMSO d-6) J-1

H Cl Et 1.33 (3H, t, J=7.2 Hz), 4.32 (2H, q, J=7.2 Hz), 6.13 (1H, s),7.24 (1H, t, J=7.5 Hz), 7.46 (2H, t, J=8.1 Hz), 7.76 (2H, d, J=7.8 Hz),7.98-8.12 (5H, m), 11.02 (1H, s), 11.89(1H, s) J-2

H Cl H 6.13 (1H, s), 7.24(1H, t, J=7.2 Hz), 7.46 (2H, t, J=8.1 Hz), 7.75(2H, d, J=8.4 Hz), 7.96-8.12 (5H, m), 11.01 (1H, s), 11.86 (1H, s),13.80 (1H, bs) J-3

H Me Et 12.07(bs, 1H), 11.74(bs, 1H), 8.13(d, 2H, J= 8.5 Hz), 7.79(d,2H, J =8.5 Hz), 7.67(s, 1H), 7.63(d, 2H, J=8.5 Hz), 7.44(s, 1H), 7.40(d,2H, J=8.5 Hz), 4.22(q, 2H, J=7.0 Hz), 2.09(d, 3H, J=1.2 Hz), 1.29(t, 3H,J = 7.0 Hz) J-4

H Me H 12.10(bs, 3H), 8.12(d, 2H, J=8.5 Hz), 7.80(d, 2H, J=8.5 Hz),7.65(s, 1H), 7.62(d, 2H, J=8.5 Hz), 7.45(s, 1H), 7.40(d, 2H, J= 8.5 Hz),2.07(d, 3H, J=1.5 Hz) J-5

H Me Et 14.00(bs, 1H), 12.20(bs, 1H), 8.10-8.20(m, 3H), 7.95(dd, 1H,J=8.2, 1.9 Hz), 7.77(d, 1H, J=8.2 Hz), 7.60-7.70(m, 3H), 4.23(q, 2H,J=7.0 Hz), 2.10(s, 3H), 1.29(t, 3H, J= 7.0 Hz) J-6

H Me H 13.95(bs, 1H), 12.69(bs, 1H), 12.22(bs, 1H), 8.10-8.18(m, 3H),7.95(dd, 1H, J= 8.2, 2.0 Hz), 7.77(d, 1H, J=8.2 Hz), 7.61- 7.68(m, 3H),2.07(d, 3H, J=1.2 Hz) J-7

H Me Et 13.24(bs, 1H), 8.20(d, 2H, J=8.2 Hz), 7.96-8.04(m, 2H),7.64-7.70(m, 3H), 7.52- 7.60(m, 3H), 4.23(q, 2H, J=7.0 Hz), 2.10(d, 3H,J=1.4 Hz), 1.29(t, 3H, J=7.0 Hz) J-8

H Me Et 13.72(bs, 1H), 8.20-8.30(m, 4H), 7.66- 7.74(m, 3H), 7.50-7.58(m,3H), 4.23(q, 2H, J=7.0 Hz), 2.10(s, 3H), 1.30(t, 3H, J=7.0 Hz) J-9

H Me Et 10.50(s, 1H), 8.06(d, 2H, J=8.2 Hz), 7.79(d, 2H, J=7.1 Hz),7.62-7.70(m, 3H), 7.41(t, 2H, J=7.5 Hz), 7.30(t, 1H, J=7.5 Hz), 6.74(s,1H), 4.23(q, 2H, J=7.1 Hz), 3.77(s, 3H), 2.09(d, 3H, J=1.1 Hz), 1.29(t,3H, J=7.1 Hz)

TABLE 28 Compound No. X R¹ R² R⁵ ¹H-NMR (DMSO d-6) J-10

H Me H 12.64(bs, 1H), 7.99(d, 2H, J=8.2 Hz), 7.72(d, 2H, J=8.5 Hz),7.66(s, 1H), 7.28- 7.38(m, 5H), 6.95(s, .1H), 2.07(d, 3H, J = 1.2 Hz)J-11

H Cl H 2.31 (3H, d, J=1.9 Hz), 7.18-7.24 (1H, m), 7.35-7.42 (1H, m),7.56-7.64 (1H, m), 8.03 (2H, d, J=8.5 Hz), 8.04 (1H, s), 8.18 (2H, d,J=8.5 Hz), 12.79 (1H, bs) J-12

H Cl H 2.35 (3H, d, J=1.6 Hz), 7.51-7.56 (1H, m), 7.84-7.92 (1H, m),8.03 (2H, d, J=8.5 Hz), 8.04 (1H, s), 8.19 (2H, d, J=8.5 Hz), 12.83 (1H,s), 13.84 (1H, bs) J-13

H Cl H 2.53 (3H, s), 7.44(1H, t, J=7.9 Hz), 7.55- 7.59 (1H, m),7.69-7.72 (1H, m), 7.92 (1H, t, J=1.8 Hz), 8.02 (2H, d, J=8.5 Hz), 8.04(1H, s), 8.19 (2H, d, J=8.5 Hz), 12.76 (1H, bs), 13.80 (1H, bs) J-14

H Cl H 2.56 (3H, s), 7.72-7.74 (2H, m), 8.00-8.06 (5H, m), 8.20 (2H, d,J=8.5 Hz), 12.77 (1H, s), 13.75 (1H, bs) J-15

H Cl H 0.86-0.90 (3H, m), 1.33-1.35 (4H, m), 1.48-1.58 (2H, m),. 2.64(2H, t, J=7.5 Hz), 2.98 (4H, s), 7.07-7.09 (1H, m), 7.20 (1H, t, J=7.6Hz), 7.63-7.66(1H, m), 8.03 (2H, d, J=8.5 Hz), 8.05 (1H, s), 8.20 (2H,d, J=8.5 Hz), 12.81 (1H, s), 13.79 (1H, bs) J-16

H Cl H 13.80(bs, 1H), 13.20(s, 1H), 8.20(d, 2H, J= 8.5 Hz), 8.06(s, 1H),8.04(d, 2H, J=8.0 Hz), 7.75(m, 1H), 7.68(m, 1H), 7.42(dd, 1H, J=8.2, 7.6Hz), 7.26(d, 1H, J=7.6 Hz), 2.65(t, 2H, J=7.8 Hz), 1.50-1.70(m, 2H),1.20-1.40(m, 2H), 0.92(t, 3H, J=7.3 Hz) J-17

H Cl H 13.88(bs, 1H), 13.01(s, 1H), 8.10-8.24(m, 4H), 8.00-8.08(m, 3H),7.74-7.80(m, 2H)

Example 6

A solution of compound (11) (1.1 g), compound (12) (760 mg), potassiumcarbonate (1.44 g), tetrakistriphenylphosphinepalladium (250 mg) in DMFwas stirred at 110° C. for 2 h. The reaction solution was poured intoethyl acetate, and the mixture was washed with water four times andbrine, dried over magnesium sulfate. The solvent was concentrated, theresidue was purified by silica gel column chromatography (ethylacetate/n-hexane=2/3) to obtain compound (13) (870 mg) as a amorphous.

¹H NMR(CDCl₃, δ ppm): 4.06 (3H, s), 7.16 (1H, s), 7.28-7.50 (10H, m),7.72 (1H, dd, J=4.8 Hz, 1.8 Hz), 7.75-7.80 (2H, m), 8.25-8.30 (2H, m),8.40 (1H, d, J=2.1 Hz).

(Step 2)

A solution of compound (13) (870 mg) in formic acid (98-100%, 20 ml) wasstirred at 50° C. for 3 h. The reaction solution was concentrated,toulene was added to the residure, and concentrated again. The obtainedresidure was washed with isopropyl ether to obtain compound (4) (473 mg)as white crystals.

¹H NMR(CDCl₃, δ ppm): 3.93 (3H, s), 7.97-8.02 (2H, m), 8.04 (1H, dd,J=7.8 Hz, 1.8 Hz), 8.07-8.12 (2H, m), 8.35 (1H, d, J=1.5 Hz), 8.82 (1H,d, J=4.8 Hz).

(Step 3)

Compound (K-14) was synthesized form compound (4) as starting materialin a manner similar to Step 4 of Example 1. Its physical data was shownin Table 29.

(Step 4)

Compound (K-15) was synthesized form compound (K-14) as startingmaterial in a manner similar to Step 5 of Example 1. Its physical datawas shown in Table 29.

(Step 5)

A solution of compound (K-15) (100 mg), diphenylphosporoazide (55 μl),triethylamine (351 μl), and tert-butanol (1 ml) in DMF (15 ml) wasstirred at 100° C. for 1 h. The reaction solution was poured into ethylacetate, THF was added according to necessity when the precipitate wasproduced, and the mixture was washed with water two times, sodiumbicarbonate aqueous solution and brine, dried over magnesium sulfate.The solvent was concentrated, the residue was purified by silica gelcolumn chromatography (ethyl acetate/n-hexane=1/1) to obtain compound(K-18) (60 mg) as white crystals.

Compound (K-16) to (K-17), and (K-19) were synthesized in a mannersimilar to Example 6 and compound (K-1) to (K-13) in a manner similar toExample 1. Their physical date were shown in Table 29 to 31.

TABLE 29

Compound No. R¹⁰ Y W ¹H-NMR (DMSO d-6) K-1

—CONHMe 2.80 (3H, d, J=4.5 Hz), 7.00 (1H, d, J=15.8 Hz), 7.70-7.81 (4H,m), 7.89-7.93 (4H, m),. 8.16 (1H, d, J=2.0 Hz), 8.53 (1H, q, J=4.5 Hz),12.62 (1H, bs) K-2

—CONHMe 2.81 (3H, d, J=4.4 Hz), 7.02 (1H, d, J=15.8 Hz), 7.47-7.56 (1H,m), 7.71-7.81 (5H, m),. 7.90- 7.97 (3H, m), 8.54 (1H, q, J=4.5 Hz),12.60 (1H, bs) K-3

—COOMe 3.88 (3H, s), 7.03 (1H, d, J=15.9 Hz), 7.71 (1H, d, J=8.2 Hz),7.76-7.83 (3H, m), 7.89-7.92 (2H, m),. 8.03 (2H, d, J=8.2 Hz), 8.15 (1H,d, J=1.8 Hz), 12.66 (1H, bs) K-4

—CONHMe 2.17 (3H, d, J=1.1 Hz), 2.80 (3H, d, J=4.5 Hz), 7.58 (2H, d, J =8.3 Hz), 7.62 (1H, bs), 7.72 (1H, d, J=8.4 Hz),. 7.89-7.95 (4H, m), 8.20(1H, d, J=2.0 Hz), 8.53 (1H, q, J=4.5 Hz), 12.46 (1H, bs) K-5

—CONHMe 2.79 (3H, d, J=4.5 Hz), 7.16 (1H, d, J=24.2 Hz), 7.64 (2H, d, J=8.3 Hz), 7.71 (1H, d, J=8.5 Hz),. 7.81-7.83 (m, 2H), 7.90-7.97 (m, 2H),8.18 (1H, d,J=1.7 Hz), 8.49 (1H, q, J=4.5 Hz), 13.01 (1H, bs) K-6

—COOH 7.11 (1H, d, J=15.8 Hz), 7.69- 7.82 (4H, m), 7.89-7.93 (2H, m),.8.02 (2H, d, J=8.1 Hz), 8.16 (1H, d, J=1.6 Hz), 12.72 (1H, bs) K-7

—COOMe 2.59 (2H, t, J=7.5 Hz), 3.04 (2H, t, J=7.5 Hz), 3.91(3H, s),7.14- 7.17 (3H, m), 7.43 (2H, d, J=8.7 Hz), 7.58 (1H, dd, J=8.7 Hz, 2.0Hz), 7.87 (1H, d, J=2.0 Hz), 7.94 (2H, d, J=8.7 Hz),. 9.87 (1H, s)(CDCl3)

TABLE 30 Compound No R¹⁰ Y W ¹H-NMR (DMSO d-6) K-8 

—COOH 2.82 (2H, t, J=7.2 Hz), 3.02 (2H, t, J=7.2 Hz), 7.38 (2H, d, J=8.5Hz), 7.68 (1H, d, J=8.4 Hz), 7.83-7.89 (4H, m), 8.12 (1H, d, J= 2.0Hz),. 12.33 (1H, s), 12.82 (1H, s) K-9 

—SO₂NH(t-Bu) (CDCl3) 1.26(s, 911), 2.25(d, 3H, J=1.5 Hz), 4.61(s, 1H),7.21(s, 1H), 7.45(d, 2H, J=8.5 Hz), 7.47(d, 1H, J=8.2 Hz), 7.60(brs,1H), 7.63(dd, 1H, J=8.2, 1.8 Hz), 7.94(d, 1H, J=1.8 Hz), 7.95(d, 2H,J=8.5 Hz), 9.58(brs, 1H). K-10

—SO₂NH₂ 2.14(d, 3H, J=1.5 Hz), 7.42(brs, 2H), 7.59(brs, 1H), 7.65(d, 2H,J= 8.2 Hz), 7.69(d, 1H, J=8.2 Hz), 7.86(s, 1H), 7.87(d, 2H, J= 8.2Hz),7.91(dd, 1H,J=8.2, 2.1 Hz), 8.18(d, 1H, J=2.1 Hz), 12.47(brs, 1H).K-11

—SO₂NH(t-Bu) 1.11(s, 9H), 7.03(d, 1H, J=16.2 Hz), 7.65(s, 1H), 7.67(d,1H, J= 8.5 Hz), 7.80(d, 1H, J=16.2 Hz), 7.81(d, 2H, J=8.5 Hz), 7.89-7.93(m, 4H), 8.17(d, 1H, J=1.8 Hz), 12.67(s, 1H). K-12

—SO₂NH₂ 7.03(d, 1H, J=16.0 Hz), 7.47(2H, s), 7.72(d, 1H, J=8.5 Hz),7.81(d, 1H, J=16.0 Hz), 7.83(d, 2H, J=8.4 Hz), 7.89(d, 2H, J=8.4 Hz),7.91(s, 1H), 7.91(dd, 1H, J=8.5, 2.1 Hz), 8.17(d, 2H, J=2.1 Hz),12.67(s, 1H). K-13

—SO₃H 6.94(d, 1H, J=15.8 Hz), 7.60(d, 2H, J=8.2 Hz), 7.67(d, 2H, J= 8.2Hz), 7.72(d, 1H, J=8.2 Hz), 7.74(d, 1H, J=15.8 Hz), 7.89(s, 1H),7.91(dd, 1H, J=8.2, 1.9 Hz), 8.16(d, 1H, J=1.9 Hz), 12.57(brs, 1H). K-14

—NHCO—

3.94 (3H, s), 7.72 (1H, d, J=8.7 Hz), 7.93 (1H, s), 7.95 (1H, dd, J= 8.4Hz, 1.8 Hz), 8.04-8.10 (3H, m), 8.22 (1H, d, J=2.4 Hz), 8.30 (2H, d,J=8.4 Hz), 8.39 (1H, d, J = 1.2 Hz), 12.93 (1H, s) K-15

—NHCO—

7.71 (1H, d, J=8.4 Hz), 7.82 (1H, bs), 7.89 (1H, s), 7.93-8.01 (3H, m),8.22 (1H,d, J=2.1 Hz), 8.26-8.34 (3H, m), 8.65 (1H, bs)

TABLE 31 Com- pound No. R¹⁰ Y W ¹H-NMR (DMSO d-6) K-16

—NHCO—

3.53(3H, s), 5.26(s, 1H), 7.10 (1H, ddd, J=8.2Hz, 2.5Hz, 0.9 Hz),7.21(1H, s), 7.22-7.28(2H, m), 7.36-7.40(2H, m), 7.55(1H, dd, J=8.4Hz,2.0Hz), 7.63(2H, d, J=8.4Hz), 7.83(1H, d, J= 2.0Hz), 7.93(2H, d,J=8.4Hz), 10.86(1H, bs) (CDCl3) K-17

—NHCO—

6.82-6.86(1H, m), 7.12-7.13 (1H, m), 7.17-7.20(1H, m), 7.28- 7.37(1H,m), 7.73(1H, d, J= 8.2Hz), 7.89(2H, d, J=8.5Hz), 7.93(1H, s), 7.95(1H,dd, J=8.2 Hz, 2.0Hz), 8.21(2H, d, J=8.5 Hz), 8.23(1H, d, J=2.0Hz),9.62(1H, s), 12.83(1H, s) K-18

—NHCO—

6.06(2H, s), 6.79(1H, s), 6.87 (1H, d, J=4.8Hz), 7.73(1H, d, J= 8.4Hz),7.82(2H, d, J=8.4 Hz), 7.93(1H, s), 7.96(1H, dd, J= 8.1Hz, 1.5Hz),8.02(1H, d, J= 5.1Hz), 8.21-8.27(3H, m), 12.88(1H, s) K-19

—NHCO—

3.06(2H, s), 7.28(1H, dt, 7.2Hz, 2.1Hz), 7.45-7.57(3H, m), 7.73 (1H, d,J=8.1Hz), 7.81(2H, d, J= 8.4Hz), 7.93(1H, s), 7.96(1H, dd, J=8.4Hz,2.1Hz), 8.21- 8.27(3H, m), 9.88(1H, bs), 12.84 (1H, bs)

Example 7 The Preparation of Compounds (L-1, L-2)

(Step 1)(Step 1)

A solution of compound (15) (6.3 g), compound (16) (2.0 ml),triethylamine (6.3 ml), tetrakistriphenylphosphinepalladium (870 mg),and copper (I) iodide (290 mg) in DMF (70 ml) was stirred at 90° C. for4 h. The reaction solution was poured into ethyl acetate, and themixture was washed with water four times and brine, dried over magnesiumsulfate. The solvent was concentrated, the residue was purified bysilica gel column chromatography (ethyl acetate/n-hexane=1/4) to obtaincompound (17) (2.25 g) as a amorphous.

¹H NMR(CDCl₃, δ ppm): 3.81 (3H, s), 7.06 (1H, s), 7.28-7.42 (6H, m),7.51-7.55 (4H, m), 7.85 (2H, d, J=8.7 Hz), 8.17 (2H, d, J=8.7 Hz).

(Step 2)

A solution of compound (17) (180 mg) and formic acid (98-100%, 4 ml) inTHF (4 ml) was stirred at room temperature for 18 h. The reactionsolution was concentrated, toulene was added to the residure, andconcentrated again. The obtained residure was washed with isopropylether to obtain compound (18) (95 mg) as white needles.

¹H NMR(CDCl₃, δ ppm): 3.80 (3H, s), 7.79 (2H, d, J=8.1 Hz), 8.00 (2H, d,J=8.1 H z), 13.33 (1 H, bs).

(Step 3)

Compound (L-1) was synthesized form compound (4) as starting material ina manner similar to Step 4 of Example 1. Its physical data was shown inTable 32.

(Step 4)

Compound (L-2) was synthesized form compound (L-1) as starting materialin a manner similar to Step 5 of Example 1. Its physical data was shownin Table 32.

Compound (L-3) to (L-4) were synthesized in a manner similar to Example.Their physical date were shown in Table 32.

TABLE 32

Com- pound No. R¹⁰ Z R⁵ ¹H-NMR (DMSO d-6) L-1

Me 3.82(3H, s), 7.72(1H, s), 7.85(2H, d, J= 8.7Hz), 7.94(1H, dd,J=8.4Hz, 2.1Hz), 7.94(1H, s), 8.16-8.22(3H, m), 12.97 (1H, s) L-2

H 7.72(1H, d, J=8.4Hz), 7.81(2H, d, J= 8.4Hz), 7.95(1H, dd, J=8.4Hz,2.1Hz), 7.94(1H, s), 8.18(2H, d, J=8.4Hz), 8.21(1H, d, J=2.1Hz),12.96(1H, s) L-3

Me 3.80(3H, s), 4.01(3H, s), 7.70-7.74(3H, m), 7.88(1H, s),7.92-7.96(2H, m), 8.21 (1H, d, J=1.8Hz), 12.99(1H, s) L-4

H 4.01(3H, s), 7.70-7.74(3H, m), 7.88 (1H, s), 7.93-7.97(2H, m),8.22(1H, d, J= 2.1Hz), 12.98(1H, s), 13.75(1H, bs)

The below mentioned compounds were synthesized in a manner similar toabove described method.

(Compound No., R^(a), R^(b), R^(c), R^(d), R^(e))=(M-1, H, H, H, H, H),(M-2, H, H, H, H, Cl), (M-3, H, H, H, H, F), (M-4, H, H, H, H, CF₃),(M-5, H, H, H, H, Br), (M-6, H, H, H, H, CH₃), (M-7, H, H, H, F, H),(M-8, H, H, H, F, Cl), (M-9, H, H, H, F, F), (M-10, H, H, H, F, CF₃),(M-11, H, H, H, F, Br), (M-12, H, H, H, F, CH₃), (M-13, H, H, H, Cl, H),(M-14, MeO, H, H, Cl, Cl), (M-15, H, H, H, Cl, F), (M-16, H, H, H, Cl,CF₃), (M-17, H, H, H, Cl, Br), (M-18, H, H, H, Cl, CH₃), (M-19, H, H, H,CH₃, H), (M-20, H, H, H, CH₃, Cl), (M-21, H, H, H, CH₃, F), (M-22, H, H,H, CH₃, CF₃), (M-23, H, H, H, CH₃, Br), (M-24, H, H, H, CH₃, CH₃),(M-25, H, H, H, Et, H), (M-26, H, H, H, Et, Cl), (M-27, H, H, H, Et, F),(M-28, H, H, H, Et, CF₃), (M-29, H, H, H, Et, Br), (M-30, H, H, H, Et,CH₃), (M-31, H, H, H, n-Pr, H), (M-32, H, H, H, n-Pr, Cl), (M-33, H, H,H, n-Pr, F), (M-34, H, H, H, n-Pr, CF₃), (M-35, H, H, H, n-Pr, Br),(M-36, H, H, H, n-Pr, CH₃), (M-37, H, H, H, c-Pr, H), (M-38, H, H, H,c-Pr, Cl), (M-39, H, H, H, c-Pr, F), (M-40, H, H, H, c-Pr, CF₃), (M-41,H, H, H, c-Pr, Br), (M-42, H, H, H, c-Pr, CH₃), (M-43, H, H, H, i-Pr,H), (M-44, H, H, H, i-Pr, Cl), (M-45, H, H, H, i-Pr, F), (M-46, H, H, H,i-Pr, CF₃), (M-47, H, H, H, i-Pr, Br), (M-48, H, H, H, i-Pr, CH₃),(M-49, H, H, H, n-Bu, H), (M-50, H, H, H, n-Bu, Cl), (M-51, H, H, H,n-Bu, F), (M-52, H, H, H, n-Bu, CF₃), (M-53, H, H, H, n-Bu, Br), (M-54,H, H, H, n-Bu, CH₃), (M-55, H, H, H, i-Bu, H), (M-56, H, H, H, i-Bu,Cl), (M-57, H, H, H, i-Bu, F), (M-58, H, H, H, i-Bu, CF₃), (M-59, H, H,H, i-Bu, Br), (M-60, H, H, H, i-Bu, CH₃), (M-61, H, H, H, sec-Bu, H),(M-62, H, H, H, sec-Bu, Cl), (M-63, H, H, H, sec-Bu, F), (M-64, H, H, H,sec-Bu, CF₃), (M-65, H, H, H, sec-Bu, Br), (M-66, H, H, H, sec-Bu, CH₃),(M-67, H, H, H, n-Pen, H), (M-68, H, H, H, n-Pen, Cl), (M-69, H, H, H,n-Pen, F), (M-70, H, H, H, n-Pen, CF₃), (M-71, H, H, H, n-Pen, Br),(M-72, H, H, H, n-Pen, CH₃), (M-73, H, H, H, c-Pen, H), (M-74, H, H, H,c-Pen, Cl), (M-75, H, H, H, c-Pen, F), (M-76, H, H, H, c-Pen, CF₃),(M-77, H, H, H, c-Pen, Br), (M-78, H, H, H, c-Pen, CH₃), (M-79, H, H, H,n-Hex, H), (M-80, H, H, H, n-Hex, Cl), (M-81, H, H, H, n-Hex, F), (M-82,H, H, H, n-Hex, CF₃), (M-83, H, H, H, n-Hex, Br), (M-84, H, H, H, n-Hex,CH₃), (M-85, H, H, H, c-Hex, H), (M-86, H, H, H, c-Hex, Cl), (M-87, H,H, H, c-Hex, F), (M-88, H, H, H, c-Hex, CF₃), (M-89, H, H, H, c-Hex,Br), (M-90, H, H, H, c-Hex, CH₃), (M-91, H, H, H, OH, H), (M-92, H, H,H, OH, Cl), (M-93, H, H, H, OH, F), (M-94, H, H, H, OH, CF₃), (M-95, H,H, H, OH, Br), (M-96, H, H, H, OH, CH₃), (M-97, H, H, H, EtO, H), (M-98,H, H, H, EtO, Cl), (M-99, H, H, H, EtO, F), (M-100, H, H, H, EtO, CF₃),(M-101, H, H, H, EtO, Br), (M-102, H, H, H, EtO, CH₃), (M-103, H, H, H,n-PrO, H), (M-104, H, H, H, n-PrO, Cl), (M-105, H, H, H, n-PrO, F),(M-106, H, H, H, n-PrO, CF₃), (M-107, H, H, H, n-PrO, Br), (M-108, H, H,H, n-PrO, CH₃), (M-109, H, H, H, PhO, H), (M-110, H, H, H, PhO, Cl),(M-111, H, H, H, PhO, F), (M-112, H, H, H, PhO, CF₃), (M-113, H, H, H,PhO, Br), (M-114, H, H, H, PhO, CH₃), (M-115, H, H, H, BnO, H), (M-116,H, H, H, BnO, Cl), (M-117, H, H, H, BnO, F), (M-118, H, H, H, BnO, CF₃),(M-119, H, H, H, BnO, Br), (M-120, H, H, H, BnO, CH₃), (M-121, H, H, H,PhCH₂CH₂O, H), (M-122, H, H, H, PhCH₂CH₂O, Cl), (M-123, H, H, H,PhCH₂CH₂O, F), (M-124, H, H, H, PhCH₂CH₂O, CF₃), (M-125, H, H, H,PhCH₂CH₂O, Br), (M-126, H, H, H, PhCH₂CH₂O, CH₃), (M-127, H, H, H, CF₃O,H), (M-128, H, H, H, CF₃O, Cl), (M-129, H, H, H, CF₃O, F), (M-130, H, H,H, CF₃O, CF₃), (M-131, H, H, H, CF₃O, Br), (M-132, H, H, H, CF₃O, CH₃),(M-133, H, H, H, Ph, H), (M-134, H, H, H, Ph, Cl), (M-135, H, H, H, Ph,F), (M-136, H, H, H, Ph, CF₃), (M-137, H, H, H, Ph, Br), (M-138, H, H,H, Ph, CH₃), (M-139, H, H, H, 4-F-Ph, H), (M-140, H, H, H, 4-F-Ph, Cl),(M-141, H, H, H, 4-F-Ph, F), (M-142, H, H, H, 4-F-Ph, CF₃), (M-143, H,H, H, 4-F-Ph, Br), (M-144, H, H, H, 4-F-Ph, CH₃), (M-145, H, H, H,4-CF₃-Ph, H), (M-146, H, H, H, 4-CF₃-Ph, Cl), (M-147, H, H, H, 4-CF₃-Ph,F), (M-148, H, H, H, 4-CF₃-Ph, CF₃), (M-149, H, H, H, 4-CF₃-Ph, Br),(M-150, H, H, H, 4-CF₃-Ph, CH₃), (M-151, H, H, H, 4-(Me)₂N-Ph, H),(M-152, H, H, H, 4-(Me)₂N-Ph, Cl), (M-153, H, H, H, 4-(Me)₂N-Ph, F),(M-154, H, H, H, 4-(Me)₂N-Ph, CF₃), (M-155, H, H, H, 4-(Me)₂N-Ph, Br),(M-156, H, H, H, 4-(Me)₂N-Ph, CH₃), (M-157, H, H, H, 4-OH-Ph, H),(M-158, H, H, H, 4-OH-Ph, Cl), (M-159, H, H, H, 4-OH-Ph, F), (M-160, H,H, H, 4-OH-Ph, CF₃), (M-161, H, H, H, 4-OH-Ph, Br), (M-162, H, H, H,4-OH-Ph, CH₃), (M-163, H, H, H, 3,4-di-F-Ph, H), (M-164, H, H, H,3,4-di-F-Ph, Cl), (M-165, H, H, H, 3,4-di-F-Ph, F), (M-166, H, H, H,3,4-di-F-Ph, CF₃), (M-167, H, H, H, 3,4-di-F-Ph, Br), (M-168, H, H, H,3,4-di-F-Ph, CH₃), (M-169, H, H, H, 4-COOH-Ph, H), (M-170, H, H, H,4-COOH-Ph, Cl), (M-171, H, H, H, 4-COOH-Ph, F), (M-172, H, H, H,4-COOH-Ph, CF₃), (M-173, H, H, H, 4-COOH-Ph, Br), (M-174, H, H, H,4-COOH-Ph, CH₃), (M-175, H, H, H, Bn, H), (M-176, H, H, H, Bn, Cl),(M-177, H, H, H, Bn, F), (M-178, H, H, H, Bn, CF₃), (M-179, H, H, H, Bn,Br), (M-180, H, H, H, Bn, CH₃), (M-181, H, H, H, 4-F-Bn, H), (M-182, H,H, H, 4-F-Bn, Cl), (M-183, H, H, H, 4-F-Bn, F), (M-184, H, H, H, 4-F-Bn,CF₃), (M-185, H, H, H, 4-F-Bn, Br), (M-186, H, H, H, 4-F-Bn, CH₃),(M-187, H, H, H, 2-Py, H), (M-188, H, H, H, 2-Py, Cl), (M-189, H, H, H,2-Py, F), (M-190, H, H, H, 2-Py, CF₃), (M-191, H, H, H, 2-Py, Br),(M-192, H, H, H, 2-Py, CH₃), (M-193, H, H, H, 3-Py, H), (M-194, H, H, H,3-Py, Cl), (M-195, H, H, H, 3-Py, F), (M-196, H, H, H, 3-Py, CF₃),(M-197, H, H, H, 3-Py, Br), (M-198, H, H, H, 3-Py, CH₃), (M-199, H, H,H, 4-Py, H), (M-200, H, H, H, 4-Py, Cl), (M-201, H, H, H, 4-Py, F),(M-202, H, H, H, 4-Py, CF₃), (M-203, H, H, H, 4-Py, Br), (M-204, H, H,H, 4-Py, CH₃), (M-205, H, H, H, 2-Th, H), (M-206, H, H, H, 2-Th, Cl),(M-207, H, H, H, 2-Th, F), (M-208, H, H, H, 2-Th, CF₃), (M-209, H, H, H,2-Th, Br), (M-210, H, H, H, 2-Th, CH₃), (M-211, H, H, H, 3-Th, H),(M-212, H, H, H, 3-Th, Cl), (M-213, H, H, H, 3-Th, F), (M-214, H, H, H,3-Th, CF₃), (M-215, H, H, H, 3-Th, Br), (M-216, H, H, H, 3-Th, CH₃),(M-217, H, H, H, pyrrazol-2-yl, H), (M-218, H, H, H, pyrrazol-2-yl, Cl),(M-219, H, H, H, pyrrazol-2-yl, F), (M-220, H, H, H, pyrrazol-2-yl,CF₃), (M-221, H, H, H, pyrrazol-2-yl, Br), (M-222, H, H, H,pyrrazol-2-yl, CH₃), (M-223, H, H, H, pyrrazol-3-yl, H), (M-224, H, H,H, pyrrazol-3-yl, Cl), (M-225, H, H, H, pyrrazol-3-yl, F), (M-226, H, H,H, pyrrazol-3-yl, CF₃), (M-227, H, H, H, pyrrazol-3-yl, Br), (M-228, H,H, H, pyrrazol-3-yl, CH₃), (M-229, H, H, H, pyrimidin-2-yl, H), (M-230,H, H, H, pyrimidin-2-yl, Cl), (M-231, H, H, H, pyrimidin-2-yl, F),(M-232, H, H, H, pyrimidin-2-yl, CF₃), (M-233, H, H, H, pyrimidin-2-yl,Br), (M-234, H, H, H, pyrimidin-2-yl, CH₃), (M-235, H, H, H,pyrimidin-4-yl, H), (M-236, H, H, H, pyrimidin-4-yl, Cl), (M-237, H, H,H, pyrimidin-4-yl, F), (M-238, H, H, H, pyrimidin-4-yl, CF₃), (M-239, H,H, H, pyrimidin-4-yl, Br), (M-240, H, H, H, pyrimidin-4-yl, CH₃),(M-241, H, H, H, pyrimidin-5-yl, H), (M-242, H, H, H, pyrimidin-5-yl,Cl), (M-243, H, H, H, pyrimidin-5-yl, F), (M-244, H, H, H,pyrimidin-5-yl, CF₃), (M-245, H, H, H, pyrimidin-5-yl, Br), (M-246, H,H, H, pyrimidin-5-yl, CH₃), (M-247, H, H, H, HOOCCH₂CH₂CH₂, H), (M-248,H, H, H, HOOCCH₂CH₂CH₂, Cl), (M-249, H, H, H, HOOCCH₂CH₂CH₂, F), (M-250,H, H, H, HOOCCH₂CH₂CH₂, CF₃), (M-251, H, H, H, HOOCCH₂CH₂CH₂, Br),(M-252, H, H, H, HOOCCH₂CH₂CH₂, CH₃), (M-253, H, H, H, HOOCCH₂CH₂CH₂CH₂,H), (M-254, H, H, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-255, H, H, H,HOOCCH₂CH₂CH₂CH₂, F), (M-256, H, H, H, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-257,H, H, H, HOOCCH₂CH₂CH₂CH₂, Br), (M-258, H, H, H, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-259, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-260, H, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-261, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-262, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-263, H, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-264, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃),(M-265, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-266, H, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-267, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,F), (M-268, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-269, H, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-270, H, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CH₃), (M-271, H, H, H, MeOCH₂, H), (M-272, H, H, H, MeOCH₂, Cl), (M-273,H, H, H, MeOCH₂, F), (M-274, H, H, H, MeOCH₂, CF₃), (M-275, H, H, H,MeOCH₂, Br), (M-276, H, H, H, MeOCH₂, CH₃), (M-277, H, H, H, EtOCH₂, H),(M-278, H, H, H, EtOCH₂, Cl), (M-279, H, H, H, EtOCH₂, F), (M-280, H, H,H, EtOCH₂, CF₃), (M-281, H, H, H, EtOCH₂, Br), (M-282, H, H, H, EtOCH₂,CH₃), (M-283, H, H, H, EtOCH₂CH₂, H), (M-284, H, H, H, EtOCH₂CH₂, Cl),(M-285, H, H, H, EtOCH₂CH₂, F), (M-286, H, H, H, EtOCH₂CH₂, CF₃),(M-287, H, H, H, EtOCH₂CH₂, Br), (M-288, H, H, H, EtOCH₂CH₂, CH₃),(M-289, H, H, H, MeOCH₂CH₂OCH₂CH₂, H), (M-290, H, H, H,MeOCH₂CH₂OCH₂CH₂, Cl), (M-291, H, H, H, MeOCH₂CH₂OCH₂CH₂, F), (M-292, H,H, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-293, H, H, H, MeOCH₂CH₂OCH₂CH₂, Br),(M-294, H, H, H, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-295, H, H, H, MeOCH₂CH₂, H),(M-296, H, H, H, MeOCH₂CH₂, Cl), (M-297, H, H, H, MeOCH₂CH₂, F), (M-298,H, H, H, MeOCH₂CH₂, CF₃), (M-299, H, H, H, MeOCH₂CH₂, Br), (M-300, H, H,H, MeOCH₂CH₂, CH₃), (M-301, H, H, H, HOCH₂, H), (M-302, H, H, H, HOCH₂,Cl), (M-303, H, H, H, HOCH₂, F), (M-304, H, H, H, HOCH₂, CF₃), (M-305,H, H, H, HOCH₂, Br), (M-306, H, H, H, HOCH₂, CH₃), (M-307, H, H, H,HOCH₂CH₂, H), (M-308, H, H, H, HOCH₂CH₂, Cl), (M-309, H, H, H, HOCH₂CH₂,F), (M-310, H, H, H, HOCH₂CH₂, CF₃), (M-311, H, H, H, HOCH₂CH₂, Br),(M-312, H, H, H, HOCH₂CH₂, CH₃), (M-313, H, H, H, HOCH₂CH₂CH₂, H),(M-314, H, H, H, HOCH₂CH₂CH₂, C), (M-315, H, H, H, HOCH₂CH₂CH₂, F),(M-316, H, H, H, HOCH₂CH₂CH₂, CF₃), (M-317, H, H, H, HOCH₂CH₂CH₂, Br),(M-318, H, H, H, HOCH₂CH₂CH₂, CH₃), (M-319, H, H, H, HOCH₂CH₂CH₂CH₂, H),(M-320, H, H, H, HOCH₂CH₂CH₂CH₂, Cl), (M-321, H, H, H, HOCH₂CH₂CH₂CH₂,F), (M-322, H, H, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-323, H, H, H,HOCH₂CH₂CH₂CH₂, Br), (M-324, H, H, H, HOCH₂CH₂CH₂CH₂, CH₃), (M-325, H,H, H, HOCH₂CH₂CH₂CH₂CH₂, H), (M-326, H, H, H, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-327, H, H, H, HOCH₂CH₂CH₂CH₂CH₂, F), (M-328, H, H, H,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-329, H, H, H, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-330, H, H, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-331, H, H, H,HOCH₂CH₂OCH₂CH₂, H), (M-332, H, H, H, HOCH₂CH₂OCH₂CH₂, Cl), (M-333, H,H, H, HOCH₂CH₂OCH₂CH₂, F), (M-334, H, H, H, HOCH₂CH₂OCH₂CH₂, CF₃),(M-335, H, H, H, HOCH₂CH₂OCH₂CH₂, Br), (M-336, H, H, H, HOCH₂CH₂OCH₂CH₂,CH₃), (M-337, H, H, H, (Me)₂N, H), (M-338, H, H, H, (Me)₂N, Cl), (M-339,H, H, H, (Me)₂N, F), (M-340, H, H, H, (Me)₂N, CF₃), (M-341, H, H, H,(Me)₂N, Br), (M-342, H, H, H, (Me)₂N, CH₃), (M-343, H, H, H,piperidin-4-yl-methyl, H), (M-344, H, H, H, piperidin-4-yl-methyl, Cl),(M-345, H, H, H, piperidin-4-yl-methyl, F), (M-346, H, H, H,piperidin-4-yl-methyl, CF₃), (M-347, H, H, H, piperidin-4-yl-methyl,Br), (M-348, H, H, H, piperidin-4-yl-methyl, CH₃), (M-349, H, H, H,cyclohexylmethyl, H), (M-350, H, H, H, cyclohexylmethyl, Cl), (M-351, H,H, H, cyclohexylmethyl, F), (M-352, H, H, H, cyclohexylmethyl, CF₃),(M-353, H, H, H, cyclohexylmethyl, Br), (M-354, H, H, H,cyclohexylmethyl, CH₃), (M-355, H, H, F, H, H), (M-356, H, H, F, H, Cl),(M-357, H, H, F, H, F), (M-358, H, H, F, H, CF₃), (M-359, H, H, F, H,Br), (M-360, H, H, F, H, CH₃), (M-361, H, H, F, F, H), (M-362, H, H, F,F, Cl), (M-363, H, H, F, F, F), (M-364, H, H, F, F, CF₃), (M-365, H, H,F, F, Br), (M-366, H, H, F, F, CH₃), (M-367, H, H, F, Cl, H), (M-368, H,H, F, Cl, Cl), (M-369, H, H, F, Cl, F), (M-370, H, H, F, Cl, CF₃),(M-371, H, H, F, Cl, Br), (M-372, H, H, F, Cl, CH₃), (M-373, H, H, F,CH₃, H), (M-374, H, H, F, CH₃, Cl), (M-375, H, H, F, CH₃, F), (M-376, H,H, F, CH₃, CF₃), (M-377, H, H, F, CH₃, Br), (M-378, H, H, F, CH₃, CH₃),(M-379, H, H, F, Et, H), (M-380, H, H, F, Et, Cl), (M-381, H, H, F, Et,F), (M-382, H, H, F, Et, CF₃), (M-383, H, H, F, Et, Br), (M-384, H, H,F, Et, CH₃), (M-385, H, H, F, n-Pr, H), (M-386, H, H, F, n-Pr, Cl),(M-387, H, H, F, n-Pr, F), (M-388, H, H, F, n-Pr, CF₃), (M-389, H, H, F,n-Pr, Br), (M-390, H, H, F, n-Pr, CH₃), (M-391, H, H, F, c-Pr, H),(M-392, H, H, F, c-Pr, Cl), (M-393, H, H, F, c-Pr, F), (M-394, H, H, F,c-Pr, CF₃), (M-395, H, H, F, c-Pr, Br), (M-396, H, H, F, c-Pr, CH₃),(M-397, H, H, F, i-Pr, H), (M-398, H, H, F, i-Pr, Cl), (M-399, H, H, F,i-Pr, F), (M-400, H, H, F, i-Pr, CF₃), (M-401, H, H, F, i-Pr, Br),(M-402, H, H, F, i-Pr, CH₃), (M-403, H, H, F, n-Bu, H), (M-404, H, H, F,n-Bu, Cl), (M-405, H, H, F, n-Bu, F), (M-406, H, H, F, n-Bu, CF₃),(M-407, H, H, F, n-Bu, Br), (M-408, H, H, F, n-Bu, CH₃), (M-409, H, H,F, i-Bu, H), (M-410, H, H, F, i-Bu, Cl), (M-411, H, H, F, i-Bu, F),(M-412, H, H, F, i-Bu, CF₃), (M-413, H, H, F, i-Bu, Br), (M-414, H, H,F, i-Bu, CH₃), (M-415, H, H, F, sec-Bu, H), (M-416, H, H, F, sec-Bu,Cl), (M-417, H, H, F, sec-Bu, F), (M-418, H, H, F, sec-Bu, CF₃), (M-419,H, H, F, sec-Bu, Br), (M-420, H, H, F, sec-Bu, CH₃), (M-421, H, H, F,n-Pen, H), (M-422, H, H, F, n-Pen, Cl), (M-423, H, H, F, n-Pen, F),(M-424, H, H, F, n-Pen, CF₃), (M-425, H, H, F, n-Pen, Br), (M-426, H, H,F, n-Pen, CH₃), (M-427, H, H, F, c-Pen, H), (M-428, H, H, F, c-Pen, Cl),(M-429, H, H, F, c-Pen, F), (M-430, H, H, F, c-Pen, CF₃), (M-431, H, H,F, c-Pen, Br), (M-432, H, H, F, c-Pen, CH₃), (M-433, H, H, F, n-Hex, H),(M-434, H, H, F, n-Hex, Cl), (M-435, H, H, F, n-Hex, F), (M-436, H, H,F, n-Hex, CF₃), (M-437, H, H, F, n-Hex, Br), (M-438, H, H, F, n-Hex,CH₃), (M-439, H, H, F, c-Hex, H), (M-440, H, H, F, c-Hex, Cl), (M-441,H, H, F, c-Hex, F), (M-442, H, H, F, c-Hex, CF₃), (M-443, H, H, F,c-Hex, Br), (M-444, H, H, F, c-Hex, CH₃), (M-445, H, H, F, OH, H),(M-446, H, H, F, OH, Cl), (M-447, H, H, F, OH, F), (M-448, H, H, F, OH,CF₃), (M-449, H, H, F, OH, Br), (M-450, H, H, F, OH, CH₃), (M-451, H, H,F, EtO, H), (M-452, H, H, F, EtO, Cl), (M-453, H, H, F, EtO, F), (M-454,H, H, F, EtO, CF₃), (M-455, H, H, F, EtO, Br), (M-456, H, H, F, EtO,CH₃), (M-457, H, H, F, n-PrO, H), (M-458, H, H, F, n-PrO, Cl), (M-459,H, H, F, n-PrO, F), (M-460, H, H, F, n-PrO, CF₃), (M-461, H, H, F,n-PrO, Br), (M-462, H, H, F, n-PrO, CH₃), (M-463, H, H, F, PhO, H),(M-464, H, H, F, PhO, Cl), (M-465, H, H, F, PhO, F), (M-466, H, H, F,PhO, CF₃), (M-467, H, H, F, PhO, Br), (M-468, H, H, F, PhO, CH₃),(M-469, H, H, F, BnO, H), (M-470, H, H, F, BnO, Cl), (M-471, H, H, F,BnO, F), (M-472, H, H, F, BnO, CF₃), (M-473, H, H, F, BnO, Br), (M-474,H, H, F, BnO, CH₃), (M-475, H, H, F, PhCH₂CH₂O, H), (M-476, H, H, F,PhCH₂CH₂O, Cl), (M-477, H, H, F, PhCH₂CH₂O, F), (M-478, H, H, F,PhCH₂CH₂O, CF₃), (M-479, H, H, F, PhCH₂CH₂O, Br), (M-480, H, H, F,PhCH₂CH₂O, CH₃), (M-481, H, H, F, CF₃O, H), (M-482, H, H, F, CF₃O, Cl),(M-483, H, H, F, CF₃O, F), (M-484, H, H, F, CF₃O, CF₃), (M-485, H, H, F,CF₃O, Br), (M-486, H, H, F, CF₃O, CH₃), (M-487, H, H, F, Ph, H), (M-488,H, H, F, Ph, Cl), (M-489, H, H, F, Ph, F), (M-490, H, H, F, Ph, CF₃),(M-491, H, H, F, Ph, Br), (M-492, H, H, F, Ph, CH₃), (M-493, H, H, F,4-F-Ph, H), (M-494, H, H, F, 4-F-Ph, Cl), (M-495, H, H, F, 4-F-Ph, F),(M-496, H, H, F, 4-F-Ph, CF₃), (M-497, H, H, F, 4-F-Ph, Br), (M-498, H,H, F, 4-F-Ph, CH₃), (M-499, H, H, F, 4-CF₃-Ph, H), (M-500, H, H, F,4-CF₃-Ph, Cl), (M-501, H, H, F, 4-CF₃-Ph, F), (M-502, H, H, F, 4-CF₃-Ph,CF₃), (M-503, H, H, F, 4-CF₃-Ph, Br), (M-504, H, H, F, 4-CF₃-Ph, CH₃),(M-505, H, H, F, 4-(Me)₂N-Ph, H), (M-506, H, H, F, 4-(Me)₂N-Ph, Cl),(M-507, H, H, F, 4-(Me)₂N-Ph, F), (M-508, H, H, F, 4-(Me)₂N-Ph, CF₃),(M-509, H, H, F, 4-(Me)₂N-Ph, Br), (M-510, H, H, F, 4-(Me)₂N-Ph, CH₃),(M-511, H, H, F, 4-OH-Ph, H), (M-512, H, H, F, 4-OH-Ph, Cl), (M-513, H,H, F, 4-OH-Ph, F), (M-514, H, H, F, 4-OH-Ph, CF₃), (M-515, H, H, F,4-OH-Ph, Br), (M-516, H, H, F, 4-OH-Ph, CH₃), (M-517, H, H, F,3,4-di-F-Ph, H), (M-518, H, H, F, 3,4-di-F-Ph, Cl), (M-519, H, H, F,3,4-di-F-Ph, F), (M-520, H, H, F, 3,4-di-F-Ph, CF₃), (M-521, H, H, F,3,4-di-F-Ph, Br), (M-522, H, H, F, 3,4-di-F-Ph, CH₃), (M-523, H, H, F,4-COOH-Ph, H), (M-524, H, H, F, 4-COOH-Ph, Cl), (M-525, H, H, F,4-COOH-Ph, F), (M-526, H, H, F, 4-COOH-Ph, CF₃), (M-527, H, H, F,4-COOH-Ph, Br), (M-528, H, H, F, 4-COOH-Ph, CH₃), (M-529, H, H, F, Bn,H), (M-530, H, H, F, Bn, Cl), (M-531, H, H, F, Bn, F), (M-532, H, H, F,Bn, CF₃), (M-533, H, H, F, Bn, Br), (M-534, H, H, F, Bn, CH₃), (M-535,H, H, F, 4-F-Bn, H), (M-536, H, H, F, 4-F-Bn, Cl), (M-537, H, H, F,4-F-Bn, F), (M-538, H, H, F, 4-F-Bn, CF₃), (M-539, H, H, F, 4-F-Bn, Br),(M-540, H, H, F, 4-F-Bn, CH₃), (M-541, H, H, F, 2-Py, H), (M-542, H, H,F, 2-Py, Cl), (M-543, H, H, F, 2-Py, F), (M-544, H, H, F, 2-Py, CF₃),(M-545, H, H, F, 2-Py, Br), (M-546, H, H, F, 2-Py, CH₃), (M-547, H, H,F, 3-Py, H), (M-548, H, H, F, 3-Py, Cl), (M-549, H, H, F, 3-Py, F),(M-550, H, H, F, 3-Py, CF₃), (M-551, H, H, F, 3-Py, Br), (M-552, H, H,F, 3-Py, CH₃), (M-553, H, H, F, 4-Py, H), (M-554, H, H, F, 4-Py, Cl),(M-555, H, H, F, 4-Py, F), (M-556, H, H, F, 4-Py, CF₃), (M-557, H, H, F,4-Py, Br), (M-558, H, H, F, 4-Py, CH₃), (M-559, H, H, F, 2-Th, H),(M-560, H, H, F, 2-Th, Cl), (M-561, H, H, F, 2-Th, F), (M-562, H, H, F,2-Th, CF₃), (M-563, H, H, F, 2-Th, Br), (M-564, H, H, F, 2-Th, CH₃),(M-565, H, H, F, 3-Th, H), (M-566, H, H, F, 3-Th, Cl), (M-567, H, H, F,3-Th, F), (M-568, H, H, F, 3-Th, CF₃), (M-569, H, H, F, 3-Th, Br),(M-570, H, H, F, 3-Th, CH₃), (M-571, H, H, F, pyrrazol-2-yl, H), (M-572,H, H, F, pyrrazol-2-yl, Cl), (M-573, H, H, F, pyrrazol-2-yl, F), (M-574,H, H, F, pyrrazol-2-yl, CF₃), (M-575, H, H, F, pyrrazol-2-yl, Br),(M-576, H, H, F, pyrrazol-2-yl, CH₃), (M-577, H, H, F, pyrrazol-3-yl,H), (M-578, H, H, F, pyrrazol-3-yl, Cl), (M-579, H, H, F, pyrrazol-3-yl,F), (M-580, H, H, F, pyrrazol-3-yl, CF₃), (M-581, H, H, F,pyrrazol-3-yl, Br), (M-582, H, H, F, pyrrazol-3-yl, CH₃), (M-583, H, H,F, pyrimidin-2-yl, H), (M-584, H, H, F, pyrimidin-2-yl, Cl), (M-585, H,H, F, pyrimidin-2-yl, F), (M-586, H, H, F, pyrimidin-2-yl, CF₃), (M-587,H, H, F, pyrimidin-2-yl, Br), (M-588, H, H, F, pyrimidin-2-yl, CH₃),(M-589, H, H, F, pyrimidin-4-yl, H), (M-590, H, H, F, pyrimidin-4-yl,Cl), (M-591, H, H, F, pyrimidin-4-yl, F), (M-592, H, H, F,pyrimidin-4-yl, CF₃), (M-593, H, H, F, pyrimidin-4-yl, Br), (M-594, H,H, F, pyrimidin-4-yl, CH₃), (M-595, H, H, F, pyrimidin-5-yl, H), (M-596,H, H, F, pyrimidin-5-yl, Cl), (M-597, H, H, F, pyrimidin-5-yl, F),(M-598, H, H, F, pyrimidin-5-yl, CF₃), (M-599, H, H, F, pyrimidin-5-yl,Br), (M-600, H, H, F, pyrimidin-5-yl, CH₃), (M-601, H, H, F,HOOCCH₂CH₂CH₂, H), (M-602, H, H, F, HOOCCH₂CH₂CH₂, Cl), (M-603, H, H, F,HOOCCH₂CH₂CH₂, F), (M-604, H, H, F, HOOCCH₂CH₂CH₂, CF₃), (M-605, H, H,F, HOOCCH₂CH₂CH₂, Br), (M-606, H, H, F, HOOCCH₂CH₂CH₂, CH₃), (M-607, H,H, F, HOOCCH₂CH₂CH₂CH₂, H), (M-608, H, H, F, HOOCCH₂CH₂CH₂CH₂, Cl),(M-609, H, H, F, HOOCCH₂CH₂CH₂CH₂, F), (M-610, H, H, F,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-611, H, H, F, HOOCCH₂CH₂CH₂CH₂, Br), (M-612,H, H, F, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-613, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂,H), (M-614, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-615, H, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-616, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃),(M-617, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-618, H, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-619, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,H), (M-620, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-621, H, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-622, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CF₃), (M-623, H, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-624, H, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-625, H, H, F, MeOCH₂, H), (M-626, H,H, F, MeOCH₂, Cl), (M-627, H, H, F, MeOCH₂, F), (M-628, H, H, F, MeOCH₂,CF₃), (M-629, H, H, F, MeOCH₂, Br), (M-630, H, H, F, MeOCH₂, CH₃),(M-631, H, H, F, EtOCH₂, H), (M-632, H, H, F, EtOCH₂, Cl), (M-633, H, H,F, EtOCH₂, F), (M-634, H, H, F, EtOCH₂, CF₃), (M-635, H, H, F, EtOCH₂,Br), (M-636, H, H, F, EtOCH₂, CH₃), (M-637, H, H, F, EtOCH₂CH₂, H),(M-638, H, H, F, EtOCH₂CH₂, Cl), (M-639, H, H, F, EtOCH₂CH₂, F), (M-640,H, H, F, EtOCH₂CH₂, CF₃), (M-641, H, H, F, EtOCH₂CH₂, Br), (M-642, H, H,F, EtOCH₂CH₂, CH₃), (M-643, H, H, F, MeOCH₂CH₂OCH₂CH₂, H), (M-644, H, H,F, MeOCH₂CH₂OCH₂CH₂, Cl), (M-645, H, H, F, MeOCH₂CH₂OCH₂CH₂, F), (M-646,H, H, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-647, H, H, F, MeOCH₂CH₂OCH₂CH₂, Br),(M-648, H, H, F, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-649, H, H, F, MeOCH₂CH₂, H),(M-650, H, H, F, MeOCH₂CH₂, Cl), (M-651, H, H, F, MeOCH₂CH₂, F), (M-652,H, H, F, MeOCH₂CH₂, CF₃), (M-653, H, H, F, MeOCH₂CH₂, Br), (M-654, H, H,F, MeOCH₂CH₂, CH₃), (M-655, H, H, F, HOCH₂, H), (M-656, H, H, F, HOCH₂,Cl), (M-657, H, H, F, HOCH₂, F), (M-658, H, H, F, HOCH₂, CF₃), (M-659,H, H, F, HOCH₂, Br), (M-660, H, H, F, HOCH₂, CH₃), (M-661, H, H, F,HOCH₂CH₂, H), (M-662, H, H, F, HOCH₂CH₂, Cl), (M-663, H, H, F, HOCH₂CH₂,F), (M-664, H, H, F, HOCH₂CH₂, CF₃), (M-665, H, H, F, HOCH₂CH₂, Br),(M-666, H, H, F, HOCH₂CH₂, CH₃), (M-667, H, H, F, HOCH₂CH₂CH₂, H),(M-668, H, H, F, HOCH₂CH₂CH₂, Cl), (M-669, H, H, F, HOCH₂CH₂CH₂, F),(M-670, H, H, F, HOCH₂CH₂CH₂, CF₃), (M-671, H, H, F, HOCH₂CH₂CH₂, Br),(M-672, H, H, F, HOCH₂CH₂CH₂, CH₃), (M-673, H, H, F, HOCH₂CH₂CH₂CH₂, H),(M-674, H, H, F, HOCH₂CH₂CH₂CH₂, Cl), (M-675, H, H, F, HOCH₂CH₂CH₂CH₂,F), (M-676, H, H, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-677, H, H, F,HOCH₂CH₂CH₂CH₂, Br), (M-678, H, H, F, HOCH₂CH₂CH₂CH₂, CH₃), (M-679, H,H, F, HOCH₂CH₂CH₂CH₂CH₂, H), (M-680, H, H, F, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-681, H, H, F, HOCH₂CH₂CH₂CH₂CH₂, F), (M-682, H, H, F,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-683, H, H, F, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-684, H, H, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-685, H, H, F,HOCH₂CH₂OCH₂CH₂, H), (M-686, H, H, F, HOCH₂CH₂OCH₂CH₂, Cl), (M-687, H,H, F, HOCH₂CH₂OCH₂CH₂, F), (M-688, H, H, F, HOCH₂CH₂OCH₂CH₂, CF₃),(M-689, H, H, F, HOCH₂CH₂OCH₂CH₂, Br), (M-690, H, H, F, HOCH₂CH₂OCH₂CH₂,CH₃), (M-691, H, H, F, (Me)₂N, H), (M-692, H, H, F, (Me)₂N, Cl), (M-693,H, H, F, (Me)₂N, F), (M-694, H, H, F, (Me)₂N, CF₃), (M-695, H, H, F,(Me)₂N, Br), (M-696, H, H, F, (Me)₂N, CH₃), (M-697, H, H, F,piperidin-4-yl-methyl, H), (M-698, H, H, F, piperidin-4-yl-methyl, Cl),(M-699, H, H, F, piperidin-4-yl-methyl, F), (M-700, H, H, F,piperidin-4-yl-methyl, CF₃), (M-701, H, H, F, piperidin-4-yl-methyl,Br), (M-702, H, H, F, piperidin-4-yl-methyl, CH₃), (M-703, H, H, F,cyclohexylmethyl, H), (M-704, H, H, F, cyclohexylmethyl, Cl), (M-705, H,H, F, cyclohexylmethyl, F), (M-706, H, H, F, cyclohexylmethyl, CF₃),(M-707, H, H, F, cyclohexylmethyl, Br), (M-708, H, H, F,cyclohexylmethyl, CH₃), (M-709, H, H, Cl, H, H), (M-710, H, H, Cl, H,Cl), (M-711, H, H, Cl, H, F), (M-712, H, H, Cl, H, CF₃), (M-713, H, H,Cl, H, Br), (M-714, H, H, Cl, H, CH₃), (M-715, H, H, Cl, F, H), (M-716,H, H, Cl, F, Cl), (M-717, H, H, Cl, F, F), (M-718, H, H, Cl, F, CF₃),(M-719, H, H, Cl, F, Br), (M-720, H, H, Cl, F, CH₃), (M-721, H, H, Cl,Cl, H), (M-722, H, H, Cl, Cl, Cl), (M-723, H, H, Cl, Cl, F), (M-724, H,H, Cl, Cl, CF₃), (M-725, H, H, Cl, Cl, Br), (M-726, H, H, Cl, Cl, CH₃),(M-727, H, H, Cl, CH₃, H), (M-728, H, H, Cl, CH₃, Cl), (M-729, H, H, Cl,CH₃, F), (M-730, H, H, Cl, CH₃, CF₃), (M-731, H, H, Cl, CH₃, Br),(M-732, H, H, Cl, CH₃, CH₃), (M-733, H, H, Cl, Et, H), (M-734, H, H, Cl,Et, Cl), (M-735, H, H, Cl, Et, F), (M-736, H, H, Cl, Et, CF₃), (M-737,H, H, Cl, Et, Br), (M-738, H, H, Cl, Et, CH₃), (M-739, H, H, Cl, n-Pr,H), (M-740, H, H, Cl, n-Pr, Cl), (M-741, H, H, Cl, n-Pr, F), (M-742, H,H, Cl, n-Pr, CF₃), (M-743, H, H, Cl, n-Pr, Br), (M-744, H, H, Cl, n-Pr,CH₃), (M-745, H, H, Cl, c-Pr, H), (M-746, H, H, Cl, c-Pr, Cl), (M-747,H, H, Cl, c-Pr, F), (M-748, H, H, Cl, c-Pr, CF₃), (M-749, H, H, Cl,c-Pr, Br), (M-750, H, H, Cl, c-Pr, CH₃), (M-751, H, H, Cl, i-Pr, H),(M-752, H, H, Cl, i-Pr, Cl), (M-753, H, H, Cl, i-Pr, F), (M-754, H, H,Cl, i-Pr, CF₃), (M-755, H, H, Cl, i-Pr, Br), (M-756, H, H, Cl, i-Pr,CH₃), (M-757, H, H, Cl, n-Bu, H), (M-758, H, H, Cl, n-Bu, Cl), (M-759,H, H, Cl, n-Bu, F), (M-760, H, H, Cl, n-Bu, CF₃), (M-761, H, H, Cl,n-Bu, Br), (M-762, H, H, Cl, n-Bu, CH₃), (M-763, H, H, Cl, i-Bu, H),(M-764, H, H, Cl, i-Bu, Cl), (M-765, H, H, Cl, i-Bu, F), (M-766, H, H,Cl, i-Bu, CF₃), (M-767, H, H, Cl, i-Bu, Br), (M-768, H, H, Cl, i-Bu,CH₃), (M-769, H, H, Cl, sec-Bu, H), (M-770, H, H, Cl, sec-Bu, Cl),(M-771, H, H, Cl, sec-Bu, F), (M-772, H, H, Cl, sec-Bu, CF₃), (M-773, H,H, Cl, sec-Bu, Br), (M-774, H, H, Cl, sec-Bu, CH₃), (M-775, H, H, Cl,n-Pen, H), (M-776, H, H, Cl, n-Pen, Cl), (M-777, H, H, Cl, n-Pen, F),(M-778, H, H, Cl, n-Pen, CF₃), (M-779, H, H, Cl, n-Pen, Br), (M-780, H,H, Cl, n-Pen, CH₃), (M-781, H, H, Cl, c-Pen, H), (M-782, H, H, Cl,c-Pen, Cl), (M-783, H, H, Cl, c-Pen, F), (M-784, H, H, Cl, c-Pen, CF₃),(M-785, H, H, Cl, c-Pen, Br), (M-786, H, H, Cl, c-Pen, CH₃), (M-787, H,H, Cl, n-Hex, H), (M-788, H, H, Cl, n-Hex, Cl), (M-789, H, H, Cl, n-Hex,F), (M-790, H, H, Cl, n-Hex, CF₃), (M-791, H, H, Cl, n-Hex, Br), (M-792,H, H, Cl, n-Hex, CH₃), (M-793, H, H, Cl, c-Hex, H), (M-794, H, H, Cl,c-Hex, Cl), (M-795, H, H, Cl, c-Hex, F), (M-796, H, H, Cl, c-Hex, CF₃),(M-797, H, H, Cl, c-Hex, Br), (M-798, H, H, Cl, c-Hex, CH₃), (M-799, H,H, Cl, OH, H), (M-800, H, H, Cl, OH, Cl), (M-801, H, H, Cl, OH, F),(M-802, H, H, Cl, OH, CF₃), (M-803, H, H, Cl, OH, Br), (M-804, H, H, Cl,OH, CH₃), (M-805, H, H, Cl, EtO, H), (M-806, H, H, Cl, EtO, Cl), (M-807,H, H, Cl, EtO, F), (M-808, H, H, Cl, EtO, CF₃), (M-809, H, H, Cl, EtO,Br), (M-810, H, H, Cl, EtO, CH₃), (M-811, H, H, Cl, n-PrO, H), (M-812,H, H, Cl, n-PrO, Cl), (M-813, H, H, Cl, n-PrO, F), (M-814, H, H, Cl,n-PrO, CF₃), (M-815, H, H, Cl, n-PrO, Br), (M-816, H, H, Cl, n-PrO,CH₃), (M-817, H, H, Cl, PhO, H), (M-818, H, H, Cl, PhO, Cl), (M-819, H,H, Cl, PhO, F), (M-820, H, H, Cl, PhO, CF₃), (M-821, H, H, Cl, PhO, Br),(M-822, H, H, Cl, PhO, CH₃), (M-823, H, H, Cl, BnO, H), (M-824, H, H,Cl, BnO, Cl), (M-825, H, H, Cl, BnO, F), (M-826, H, H, Cl, BnO, CF₃),(M-827, H, H, Cl, BnO, Br), (M-828, H, H, Cl, BnO, CH₃), (M-829, H, H,Cl PhCH₂CH₂O, H), (M-830, H, H, Cl, PhCH₂CH₂O, Cl), (M-831, H, H, Cl,PhCH₂CH₂O, F), (M-832, H, H, Cl, PhCH₂CH₂O, CF₃), (M-833, H, H, Cl,PhCH₂CH₂O, Br), (M-834, H, H, Cl, PhCH₂CH₂O, CH₃), (M-835, H, H, Cl,CF₃O, H), (M-836, H, H, Cl, CF₃O, Cl), (M-837, H, H, Cl, CF₃O, F),(M-838, H, H, Cl, CF₃O, CF₃), (M-839, H, H, Cl, CF₃O, Br), (M-840, H, H,Cl, CF₃O, CH₃), (M-841, H, H, Cl, Ph, H), (M-842, H, H, Cl, Ph, Cl),(M-843, H, H, Cl, Ph, F), (M-844, H, H, Cl, Ph, CF₃), (M-845, H, H, Cl,Ph, Br), (M-846, H, H, Cl, Ph, CH₃), (M-847, H, H, Cl, 4-F-Ph, H),(M-848, H, H, Cl, 4-F-Ph, Cl), (M-849, H, H, Cl, 4-F-Ph, F), (M-850, H,H, Cl, 4-F-Ph, CF₃), (M-851, H, H, Cl, 4-F-Ph, Br), (M-852, H, H, Cl,4-F-Ph, CH₃), (M-853, H, H, Cl, 4-CF₃-Ph, H), (M-854, H, H, Cl,4-CF₃-Ph, Cl), (M-855, H, H, Cl, 4-CF₃-Ph, F), (M-856, H, H, Cl,4-CF₃-Ph, CF₃), (M-857, H, H, Cl, 4-CF₃-Ph, Br), (M-858, H, H, Cl,4-CF₃-Ph, CH₃), (M-859, H, H, Cl, 4-(Me)₂N-Ph, H), (M-860, H, H, Cl,4-(Me)₂N-Ph, Cl), (M-861, H, H, Cl, 4-(Me)₂N-Ph, F), (M-862, H, H, Cl,4-(Me)₂N-Ph, CF₃), (M-863, H, H, Cl, 4-(Me)₂N-Ph, Br), (M-864, H, H, Cl,4-(Me)₂N-Ph, CH₃), (M-865, H, H, Cl, 4-OH-Ph, H), (M-866, H, H, Cl,4-OH-Ph, Cl), (M-867, H, H, Cl, 4-OH-Ph, F), (M-868, H, H, Cl, 4-OH-Ph,CF₃), (M-869, H, H, Cl, 4-OH-Ph, Br), (M-870, H, H, Cl, 4-OH-Ph, CH₃),(M-871, H, H, Cl, 3,4-di-F-Ph, H), (M-872, H, H, Cl, 3,4-di-F-Ph, Cl),(M-873, H, H, Cl, 3,4-di-F-Ph, F), (M-874, H, H, Cl, 3,4-di-F-Ph, CF₃),(M-875, H, H, Cl, 3,4-di-F-Ph, Br), (M-876, H, H, Cl, 3,4-di-F-Ph, CH₃),(M-877, H, H, Cl, 4-COOH-Ph, H), (M-878, H, H, Cl, 4-COOH-Ph, Cl),(M-879, H, H, Cl, 4-COOH-Ph, F), (M-880, H, H, Cl, 4-COOH-Ph, CF₃),(M-881, H, H, Cl, 4-COOH-Ph, Br), (M-882, H, H, Cl, 4-COOH-Ph, CH₃),(M-883, H, H, Cl, Bn, H), (M-884, H, H, Cl, Bn, Cl), (M-885, H, H, Cl,Bn, F), (M-886, H, H, Cl, Bn, CF₃), (M-887, H, H, Cl, Bn, Br), (M-888,H, H, Cl, Bn, CH₃), (M889, H, H, Cl, 4-F-Bn, H), (M-890, H, H, Cl,4-F-Bn, Cl), (M-891, H, H, Cl, 4-F-Bn, F), (M-892, H, H, Cl, 4-F-Bn,CF₃), (M-893, H, H, Cl, 4-F-Bn, Br), (M-894, H, H, Cl, 4-F-Bn, CH₃),(M-895, H, H, Cl, 2-Py, H), (M-896, H, H, Cl, 2-Py, Cl), (M-897, H, H,Cl, 2-Py, F), (M-898, H, H, Cl, 2-Py, CF₃), (M-899, H, H, Cl, 2-Py, Br),(M-900, H, H, Cl, 2-Py, CH₃), (M-901, H, H, Cl, 3-Py, H), (M-902, H, H,Cl, 3-Py, Cl), (M-903, H, H, Cl, 3-Py, F), (M-904, H, H, Cl, 3-Py, CF₃),(M-905, H, H, Cl, 3-Py, Br), (M-906, H, H, Cl, 3-Py, CH₃), (M-907, H, H,Cl, 4-Py, H), (M-908, H, H, Cl, 4-Py, Cl), (M-909, H, H, Cl, 4-Py, F),(M-910, H, H, Cl, 4-Py, CF₃), (M-911, H, H, Cl, 4-Py, Br), (M-912, H, H,Cl, 4-Py, CH₃), (M-913, H, H, Cl, 2-Th, H), (M-914, H, H, Cl, 2-Th, Cl),(M-915, H, H, Cl, 2-Th, F), (M-916, H, H, Cl, 2-Th, CF₃), (M-917, H, H,Cl, 2-Th, Br), (M-918, H, H, Cl, 2-Th, CH₃), (M-919, H, H, Cl, 3-Th, H),(M-920, H, H, Cl, 3-Th, Cl), (M-921, H, H, Cl, 3-Th, F), (M-922, H, H,Cl, 3-Th, CF₃), (M-923, H, H, Cl, 3-Th, Br), (M-924, H, H, Cl, 3-Th,CH₃), (M-925, H, H, Cl, pyrrazol-2-yl, H), (M-926, H, H, Cl,pyrrazol-2-yl, Cl), (M-927, H, H, Cl, pyrrazol-2-yl, F), (M-928, H, H,Cl, pyrrazol-2-yl, CF₃), (M-929, H, H, Cl, pyrrazol-2-yl, Br), (M-930,H, H, Cl, pyrrazol-2-yl, CH₃), (M-931, H, H, Cl, pyrrazol-3-yl, H),(M-932, H, H, Cl, pyrrazol-3-yl, Cl), (M-933, H, H, Cl, pyrrazol-3-yl,F), (M-934, H, H, Cl, pyrrazol-3-yl, CF₃), (M-935, H, H, Cl,pyrrazol-3-yl, Br), (M-936, H, H, Cl, pyrrazol-3-yl, CH₃), (M-937, H, H,Cl, pyrimidin-2-yl, H), (M-938, H, H, Cl, pyrimidin-2-yl, Cl), (M-939,H, H, Cl, pyrimidin-2-yl, F), (M-940, H, H, Cl, pyrimidin-2-yl, CF₃),(M-941, H, H, Cl, pyrimidin-2-yl, Br), (M-942, H, H, Cl, pyrimidin-2-yl,CH₃), (M-943, H, H, Cl, pyrimidin-4-yl, H), (M-944, H, H, Cl,pyrimidin-4-yl, Cl), (M-945, H, H, Cl, pyrimidin-4-yl, F), (M-946, H, H,Cl, pyrimidin-4-yl, CF₃), (M-947, H, H, Cl, pyrimidin-4-yl, Br), (M-948,H, H, Cl, pyrimidin-4-yl, CH₃), (M-949, H, H, Cl, pyrimidin-5-yl, H),(M-950, H, H, Cl, pyrimidin-5-yl, Cl), (M-951, H, H, Cl, pyrimidin-5-yl,F), (M-952, H, H, Cl, pyrimidin-5-yl, CF₃), (M-953, H, H, Cl,pyrimidin-5-yl, Br), (M-954, H, H, Cl, pyrimidin-5-yl, CH₃), (M-955, H,H, Cl, HOOCCH₂CH₂CH₂, H), (M-956, H, H, Cl, HOOCCH₂CH₂CH₂, Cl), (M-957,H, H, Cl, HOOCCH₂CH₂CH₂, F), (M-958, H, H, Cl, HOOCCH₂CH₂CH₂, CF₃),(M-959, H, H, Cl, HOOCCH₂CH₂CH₂, Br), (M-960, H, H, Cl, HOOCCH₂CH₂CH₂,CH₃), (M-961, H, H, Cl, HOOCCH₂CH₂CH₂CH₂, H), (M-962, H, H, Cl,HOOCCH₂CH₂CH₂CH₂, Cl), (M-963, H, H, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-964,H, H, Cl, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-965, H, H, Cl, HOOCCH₂CH₂CH₂CH₂,Br), (M-966, H, H, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-967, H, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-968, H, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-969, H, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-970, H, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-971, H, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Br),(M-972, H, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-973, H, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-974, H, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-975, H, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-976, H, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-977, H, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-978, H, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CH₃), (M-979, H, H, Cl, MeOCH₂, H), (M-980, H, H, Cl, MeOCH₂, Cl),(M-981, H, H, Cl, MeOCH₂, F), (M-982, H, H, Cl, MeOCH₂, CF₃), (M-983, H,H, Cl, MeOCH₂, Br), (M-984, H, H, Cl, MeOCH₂, CH₃), (M-985, H, H, Cl,EtOCH₂, H), (M-986, H, H, Cl, EtOCH₂, Cl), (M-987, H, H, Cl, EtOCH₂, F),(M-988, H, H, Cl, EtOCH₂, CF₃), (M-989, H, H, Cl, EtOCH₂, Br), (M-990,H, H, Cl, EtOCH₂, CH₃), (M-991, H, H, Cl, EtOCH₂CH₂, H), (M-992, H, H,Cl, EtOCH₂CH₂, Cl), (M-993, H, H, Cl, EtOCH₂CH₂, F), (M-994, H, H, Cl,EtOCH₂CH₂, CF₃), (M-995, H, H, Cl, EtOCH₂CH₂, Br), (M-996, H, H, Cl,EtOCH₂CH₂, CH₃), (M-997, H, H, Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-998, H, H,Cl, MeOCH₂CH₂OCH₂CH₂, Cl), (M-999, H, H, Cl, MeOCH₂CH₂OCH₂CH₂, F),(M-1000, H, H, Cl, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-1001, H, H, Cl,MeOCH₂CH₂OCH₂CH₂, Br), (M-1002, H, H, Cl, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-1003, H, H, Cl, MeOCH₂CH₂, H), (M-1004, H, H, Cl, MeOCH₂CH₂, Cl),(M-1005, H, H, Cl, MeOCH₂CH₂, F), (M-1006, H, H, Cl, MeOCH₂CH₂, CF₃),(M-1007, H, H, Cl, MeOCH₂CH₂, Br), (M-1008, H, H, Cl, MeOCH₂Cl₂, CH₃),(M-1009, H, H, Cl, HOCH₂, H), (M-1010, H, H, Cl, HOCH₂, Cl), (M-1011, H,H, Cl, HOCH₂, F), (M-1012, H, H, Cl, HOCH₂, CF₃), (M-1013, H, H, Cl,HOCH₂, Br), (M-1014, H, H, Cl, HOCH₂, CH₃), (M-1015, H, H, Cl, HOCH₂CH₂,H), (M-1016, H, H, Cl, HOCH₂CH₂, Cl), (M-1017, H, H, Cl, HOCH₂CH₂, F),(M-1018, H, H, Cl, HOCH₂CH₂, CF₃), (M-1019, H, H, Cl, HOCH₂CH₂, Br),(M-1020, H, H, Cl, HOCH₂CH₂, CH₃), (M-1021, H, H, Cl, HOCH₂CH₂CH₂, H),(M-1022, H, H, Cl, HOCH₂CH₂CH₂, Cl), (M-1023, H, H, Cl, HOCH₂CH₂CH₂, F),(M-1024, H, H, Cl, HOCH₂CH₂CH₂, CF₃), (M-1025, H, H, Cl, HOCH₂CH₂CH₂,Br), (M-1026, H, H, Cl, HOCH₂CH₂CH₂, CH₃), (M-1027, H, H, Cl,HOCH₂CH₂CH₂CH₂, H), (M-1028, H, H, Cl, HOCH₂CH₂CH₂CH₂, Cl), (M-1029, H,H, Cl, HOCH₂CH₂CH₂CH₂, F), (M-1030, H, H, Cl, HOCH₂CH₂CH₂CH₂, CF₃),(M-1031, H, H, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-1032, H, H, Cl,HOCH₂CH₂CH₂CH₂, CH₃), (M-1033, H, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, H), (M-1034,H, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-1035, H, H, Cl, HOCH₂CH₂CH₂CH₂CH₂,F), (M-1036, H, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-1037, H, H, Cl,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-1038, H, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-1039, H, H, Cl, HOCH₂CH₂OCH₂CH₂, H), (M-1040, H, H, Cl,HOCH₂CH₂OCH₂CH₂, Cl), (M-1041, H, H, Cl, HOCH₂CH₂OCH₂CH₂, F), (M-1042,H, H, Cl, HOCH₂CH₂OCH₂CH₂, CF₃), (M-1043, H, H, Cl, HOCH₂CH₂OCH₂CH₂,Br), (M-1044, H, H, Cl, HOCH₂CH₂OCH₂CH₂, CH₃), (M-1045, H, H, Cl,(Me)₂N, H), (M-1046, H, H, Cl, (Me)₂N, Cl), (M-1047, H, H, Cl, (Me)₂N,F), (M-1048, H, H, Cl, (Me)₂N, CF₃), (M-1049, H, H, Cl, (Me)₂N, Br),(M-1050, H, H, Cl, (Me)₂N, CH₃), (M-1051, H, H, Cl,piperidin-4-yl-methyl, H), (M-1052, H, H, Cl, piperidin-4-yl-methyl,Cl), (M-1053, H, H, Cl, piperidin-4-yl-methyl, F), (M-1054, H, H, Cl,piperidin-4-yl-methyl, CF₃), (M-1055, H, H, Cl, piperidin-4-yl-methyl,Br), (M-1056, H, H, Cl, piperidin-4-yl-methyl, CH₃), (M-1057, H, H, Cl,cyclohexylmethyl, H), (M-1058, H, H, Cl, cyclohexylmethyl, Cl), (M-1059,H, H, Cl, cyclohexylmethyl, F), (M-1060, H, H, Cl, cyclohexylmethyl,CF₃), (M-1061, H, H, Cl, cyclohexylmethyl, Br), (M-1062, H, H, Cl,cyclohexylmethyl, CH₃), (M-1063, H, F, H, H, H), (M-1064, H, F, H, H,Cl), (M-1065, H, F, H, H, F), (M-1066, H, F, H, H, CF₃), (M-1067, H, F,H, H, Br), (M-1068, H, F, H, H, CH₃), (M-1069, H, F, H, F, H), (M-1070,H, F, H, F, Cl), (M-1071, H, F, H, F, F), (M-1072, H, F, H, F, CF₃),(M-1073, H, F, H, F, Br), (M-1074, H, F, H, F, CH₃), (M-1075, H, F, H,Cl, H), (M-1076, H, F, H, Cl, Cl), (M-1077, H, F, H, Cl, F), (M-1078, H,F, H, Cl, CF₃), (M-1079, H, F, H, Cl, Br), (M-1080, H, F, H, Cl, CH₃),(M-1081, H, F, H, CH₃, H), (M-1082, H, F, H, CH₃, Cl), (M-1083, H, F, H,CH₃, F), (M-1084, H, F, H, CH₃, CF₃), (M-1085, H, F, H, CH₃, Br),(M-1086, H, F, H, CH₃, CH₃), (M-1087, H, F, H, Et, H), (M-1088, H, F, H,Et, Cl), (M-1089, H, F, H, Et, F), (M-1090, H, F, H, Et, CF₃), (M-1091,H, F, H, Et, Br), (M-1092, H, F, H, Et, CH₃), (M-1093, H, F, H, n-Pr,H), (M-1094, H, F, H, n-Pr, Cl), (M-1095, H, F, H, n-Pr, F), (M-1096, H,F, H, n-Pr, CF₃), (M-1097, H, F, H, n-Pr, Br), (M-1098, H, F, H, n-Pr,CH₃), (M-1099, H, F, H, c-Pr, H), (M-1100, H, F, H, c-Pr, Cl), (M-1101,H, F, H, c-Pr, F), (M-1102, H, F, H, c-Pr, CF₃), (M-1103, H, F, H, c-Pr,Br), (M-1104, H, F, H, c-Pr, CH₃), (M-1105, H, F, H, i-Pr, H), (M-1106,H, F, H, i-Pr, Cl), (M-1107, H, F, H, i-Pr, F), (M-1108, H, F, H, i-Pr,CF₃), (M-1109, H, F, H, i-Pr, Br), (M-1110, H, F, H, i-Pr, CH₃),(M-1111, H, F, H, n-Bu, H), (M-1112, H, F, H, n-Bu, Cl), (M-1113, H, F,H, n-Bu, F), (M-1114, H, F, H, n-Bu, CF₃), (M-1115, H, F, H, n-Bu, Br),(M-1116, H, F, H, n-Bu, CH₃), (M-1117, H, F, H, i-Bu, H), (M-1118, H, F,H, i-Bu, Cl), (M-1119, H, F, H, i-Bu, F), (M-1120, H, F, H, i-Bu, CF₃),(M-1121, H, F, H, i-Bu, Br), (M-1122, H, F, H, i-Bu, CH₃), (M-1123, H,F, H, sec-Bu, H), (M-1124, H, F, H, sec-Bu, Cl), (M-1125, H, F, H,sec-Bu, F), (M-1126, H, F, H, sec-Bu, CF₃), (M-1127, H, F, H, sec-Bu,Br), (M-1128, H, F, H, sec-Bu, CH₃), (M-1129, H, F, H, n-Pen, H),(M-1130, H, F, H, n-Pen, Cl), (M-1131, H, F, H, n-Pen, F), (M-1132, H,F, H, n-Pen, CF₃), (M-1133, H, F, H, n-Pen, Br), (M-1134, H, F, H,n-Pen, CH₃), (M-1135, H, F, H, c-Pen, H), (M-1136, H, F, H, c-Pen, Cl),(M-1137, H, F, H, c-Pen, F), (M-1138, H, F, H, c-Pen, CF₃), (M-1139, H,F, H, c-Pen, Br), (M-1140, H, F, H, c-Pen, CH₃), (M-1141, H, F, H,n-Hex, H), (M-1142, H, F, H, n-Hex, Cl), (M-1143, H, F, H, n-Hex, F),(M-1144, H, F, H, n-Hex, CF₃), (M-1145, H, F, H, n-Hex, Br), (M-1146, H,F, H, n-Hex, CH₃), (M-1147, H, F, H, c-Hex, H), (M-1148, H, F, H, c-Hex,Cl), (M-1149, H, F, H, c-Hex, F), (M-1150, H, F, H, c-Hex, CF₃),(M-1151, H, F, H, c-Hex, Br), (M-1152, H, F, H, c-Hex, CH₃), (M-1153, H,F, H, OH, H), (M-1154, H, F, H, OH, Cl), (M-1155, H, F, H, OH, F),(M-1156, H, F, H, OH, CF₃), (M-1157, H, F, H, OH, Br), (M-1158, H, F, H,OH, CH₃), (M-1159, H, F, H, EtO, H), (M-1160, H, F, H, EtO, Cl),(M-1161, H, F, H, EtO, F), (M-1162, H, F, H, EtO, CF₃), (M-1163, H, F,H, EtO, Br), (M-1164, H, F, H, EtO, CH₃), (M-1165, H, F, H, n-PrO, H),(M-1166, H, F, H, n-PrO, Cl), (M-1167, H, F, H, n-PrO, F), (M-1168, H,F, H, n-PrO, CF₃), (M-1169, H, F, H, n-PrO, Br), (M-1170, H, F, H,n-PrO, CH₃), (M-1171, H, F, H, PhO, H), (M-1172, H, F, H, PhO, Cl),(M-1173, H, F, H, PhO, F), (M-1174, H, F, H, PhO, CF₃), (M-1175, H, F,H, PhO, Br), (M-1176, H, F, H, PhO, CH₃), (M-1177, H, F, H, BnO, H),(M-1178, H, F, H, BnO, Cl), (M-1179, H, F, H, BnO, F), (M-1180, H, F, H,BnO, CF₃), (M-1181, H, F, H, BnO, Br), (M-1182, H, F, H, BnO, CH₃),(M-1183, H, F, H, PhCH₂CH₂O, H), (M-1184, H, F, H, PhCH₂CH₂O, Cl),(M-1185, H, F, H, PhCH₂CH₂O, F), (M-1186, H, F, H, PhCH₂CH₂O, CF₃),(M-1187, H, F, H, PhCH₂CH₂O, Br), (M-1188, H, F, H, PhCH₂CH₂O, CH₃),(M-1189, H, F, H, CF₃O, H), (M-1190, H, F, H, CF₃O, Cl), (M-1191, H, F,H, CF₃O, F), (M-1192, H, F, H, CF₃O, CF₃), (M-1193, H, F, H, CF₃O, Br),(M-1194, H, F, H, CF₃O, CH₃), (M-1195, H, F, H, Ph, H), (M-1196, H, F,H, Ph, Cl), (M-1197, H, F, H, Ph, F), (M-1198, H, F, H, Ph, CF₃),(M-1199, H, F, H, Ph, Br), (M-1200, H, F, H, Ph, CH₃), (M-1201, H, F, H,4-F-Ph, H), (M-1202, H, F, H, 4-F-Ph, Cl), (M-1203, H, F, H, 4-F-Ph, F),(M-1204, H, F, H, 4-F-Ph, CF₃), (M-1205, H, F, H, 4-F-Ph, Br), (M-1206,H, F, H, 4-F-Ph, CH₃), (M-1207, H, F, H, 4-CF₃-Ph, H), (M-1208, H, F, H,4-CF₃-Ph, Cl), (M-1209, H, F, H, 4-CF₃-Ph, F), (M-1210, H, F, H,4-CF₃-Ph, CF₃), (M-1211, H, F, H, 4-CF₃-Ph, Br), (M-1212, H, F, H,4-CF₃-Ph, CH₃), (M-1213, H, F, H, 4-(Me)₂N-Ph, H), (M-1214, H, F, H,4-(Me)₂N-Ph, Cl), (M-1215, H, F, H, 4-(Me)₂N-Ph, F), (M-1216, H, F, H,4-(Me)₂N-Ph, CF₃), (M-1217, H, F, H, 4-(Me)₂N-Ph, Br), (M-1218, H, F, H,4-(Me)₂N-Ph, CH₃), (M-1219, H, F, H, 4-OH-Ph, H), (M-1220, H, F, H,4-OH-Ph, Cl), (M-1221, H, F, H, 4-OH-Ph, F), (M-1222, H, F, H, 4-OH-Ph,CF₃), (M-1223, H, F, H, 4-OH-Ph, Br), (M-1224, H, F, H, 4-OH-Ph, CH₃),(M-1225, H, F, H, 3,4-di-F-Ph, H), (M-1226, H, F, H, 3,4-di-F-Ph, Cl),(M-1227, H, F, H, 3,4-di-F-Ph, F), (M-1228, H, F, H, 3,4-di-F-Ph, CF₃),(M-1229, H, F, H, 3,4-di-F-Ph, Br), (M-1230, H, F, H, 3,4-di-F-Ph, CH₃),(M-1231, H, F, H, 4-COOH-Ph, H), (M-1232, H, F, H, 4-COOH-Ph, Cl),(M-1233, H, F, H, 4-COOH-Ph, F), (M-1234, H, F, H, 4-COOH-Ph, CF₃),(M-1235, H, F, H, 4-COOH-Ph, Br), (M-1236, H, F, H, 4-COOH-Ph, CH₃),(M-1237, H, F, H, Bn, H), (M-1238, H, F, H, Bn, Cl), (M-1239, H, F, H,Bn, F), (M-1240, H, F, H, Bn, CF₃), (M-1241, H, F, H, Bn, Br), (M-1242,H, F, H, Bn, CH₃), (M-1243, H, F, H, 4-F-Bn, H), (M-1244, H, F, H,4-F-Bn, Cl), (M-1245, H, F, H, 4-F-Bn, F), (M-1246, H, F, H, 4-F-Bn,CF₃), (M-1247, H, F, H, 4-F-Bn, Br), (M-1248, H, F, H, 4-F-Bn, CH₃),(M-1249, H, F, H, 2-Py, H), (M-1250, H, F, H, 2-Py, Cl), (M-1251, H, F,H, 2-Py, F), (M-1252, H, F, H, 2-Py, CF₃), (M-1253, H, F, H, 2-Py, Br),(M-1254, H, F, H, 2-Py, CH₃), (M-1255, H, F, H, 3-Py, H), (M-1256, H, F,H, 3-Py, Cl), (M-1257, H, F, H, 3-Py, F), (M-1258, H, F, H, 3-Py, CF₃),(M-1259, H, F, H, 3-Py, Br), (M-1260, H, F, H, 3-Py, CH₃), (M-1261, H,F, H, 4-Py, H), (M-1262, H, F, H, 4-Py, Cl), (M-1263, H, F, H, 4-Py, F),(M-1264, H, F, H, 4-Py, CF₃), (M-1265, H, F, H, 4-Py, Br), (M-1266, H,F, H, 4-Py, CH₃), (M-1267, H, F, H, 2-Th, H), (M-1268, H, F, H, 2-Th,Cl), (M-1269, H, F, H, 2-Th, F), (M-1270, H, F, H, 2-Th, CF₃), (M-1271,H, F, H, 2-Th, Br), (M-1272, H, F, H, 2-Th, CH₃), (M-1273, H, F, H,3-Th, H), (M-1274, H, F, H, 3-Th, Cl), (M-1275, H, F, H, 3-Th, F),(M-1276, H, F, H, 3-Th, CF₃), (M-1277, H, F, H, 3-Th, Br), (M-1278, H,F, H, 3-Th, CH₃), (M-1279, H, F, H, pyrrazol-2-yl, H), (M-1280, H, F, H,pyrrazol-2-yl, Cl), (M-1281, H, F, H, pyrrazol-2-yl, F), (M-1282, H, F,H, pyrrazol-2-yl, CF₃), (M-1283, H, F, H, pyrrazol-2-yl, Br), (M-1284,H, F, H, pyrrazol-2-yl, CH₃), (M-1285, H, F, H, pyrrazol-3-yl, H),(M-1286, H, F, H, pyrrazol-3-yl, Cl), (M-1287, H, F, H, pyrrazol-3-yl,F), (M-1288, H, F, H, pyrrazol-3-yl, CF₃), (M-1289, H, F, H,pyrrazol-3-yl, Br), (M-1290, H, F, H, pyrrazol-3-yl, CH₃), (M-1291, H,F, H, pyrimidin-2-yl, H), (M-1292, H, F, H, pyrimidin-2-yl, Cl),(M-1293, H, F, H, pyrimidin-2-yl, F), (M-1294, H, F, H, pyrimidin-2-yl,CF₃), (M-1295, H, F, H, pyrimidin-2-yl, Br), (M-1296, H, F, H,pyrimidin-2-yl, CH₃), (M-1297, H, F, H, pyrimidin-4-yl, H), (M-1298, H,F, H, pyrimidin-4-yl, Cl), (M-1299, H, F, H, pyrimidin-4-yl, F),(M-1300, H, F, H, pyrimidin-4-yl, CF₃), (M-1301, H, F, H,pyrimidin-4-yl, Br), (M-1302, H, F, H, pyrimidin-4-yl, CH₃), (M-1303, H,F, H, pyrimidin-5-yl, H), (M-1304, H, F, H, pyrimidin-5-yl, Cl),(M-1305, H, F, H, pyrimidin-5-yl, F), (M-1306, H, F, H, pyrimidin-5-yl,CF₃), (M-1307, H, F, H, pyrimidin-5-yl, Br), (M-1308, H, F, H,pyrimidin-5-yl, CH₃), (M-1309, H, F, H, HOOCCH₂CH₂CH₂, H), (M-1310, H,F, H, HOOCCH₂CH₂CH₂, Cl), (M-1311, H, F, H, HOOCCH₂CH₂CH₂, F), (M-1312,H, F, H, HOOCCH₂CH₂CH₂, CF₃), (M-1313, H, F, H, HOOCCH₂CH₂CH₂, Br),(M-1314, H, F, H, HOOCCH₂CH₂CH₂, CH₃), (M-1315, H, F, H,HOOCCH₂CH₂CH₂CH₂, H), (M-1316, H, F, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-1317,H, F, H, HOOCCH₂CH₂CH₂CH₂, F), (M-1318, H, F, H, HOOCCH₂CH₂CH₂CH₂, CF₃),(M-1319, H, F, H, HOOCCH₂CH₂CH₂CH₂, Br), (M-1320, H, F, H,HOOCCH₂CH₂CH₂CH₂, CH₃), (M-1321, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H),(M-1322, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-1323, H, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-1324, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃),(M-1325, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-1326, H, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-1327, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,H), (M-1328, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-1329, H, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-1330, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CF₃), (M-1331, H, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-1332, H, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-1333, H, F, H, MeOCH₂, H), (M-1334, H,F, H, MeOCH₂, Cl), (M-1335, H, F, H, MeOCH₂, F), (M-1336, H, F, H,MeOCH₂, CF₃), (M-1337, H, F, H, MeOCH₂, Br), (M-1338, H, F, H, MeOCH₂,CH₃), (M-1339, H, F, H, EtOCH₂, H), (M-1340, H, F, H, EtOCH₂, Cl),(M-1341, H, F, H, EtOCH₂, F), (M-1342, H, F, H, EtOCH₂, CF₃), (M-1343,H, F, H, EtOCH₂, Br), (M-1344, H, F, H, EtOCH₂, CH₃), (M-1345, H, F, H,EtOCH₂CH₂, H), (M-1346, H, F, H, EtOCH₂CH₂, Cl), (M-1347, H, F, H,EtOCH₂CH₂, F), (M-1348, H, F, H, EtOCH₂CH₂, CF₃), (M-1349, H, F, H,EtOCH₂CH₂, Br), (M-1350, H, F, H, EtOCH₂CH₂, CH₃), (M-1351, H, F, H,MeOCH₂CH₂OCH₂CH₂, H), (M-1352, H, F, H, MeOCH₂CH₂OCH₂CH₂, Cl), (M-1353,H, F, H, MeOCH₂CH₂OCH₂CH₂, F), (M-1354, H, F, H, MeOCH₂CH₂OCH₂CH₂, CF₃),(M-1355, H, F, H, MeOCH₂CH₂OCH₂CH₂, Br), (M-1356, H, F, H,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-1357, H, F, H, MeOCH₂CH₂, H), (M-1358, H, F,H, MeOCH₂CH₂, Cl), (M-1359, H, F, H, MeOCH₂CH₂, F), (M-1360, H, F, H,MeOCH₂CH₂, CF₃), (M-1361, H, F, H, MeOCH₂CH₂, Br), (M-1362, H, F, H,MeOCH₂CH₂, CH₃), (M-1363, H, F, H, HOCH₂, H), (M-1364, H, F, H, HOCH₂,Cl), (M-1365, H, F, H, HOCH₂, F), (M-1366, H, F, H, HOCH₂, CF₃),(M-1367, H, F, H, HOCH₂, Br), (M-1368, H, F, H, HOCH₂, CH₃), (M-1369, H,F, H, HOCH₂CH₂, H), (M-1370, H, F, H, HOCH₂CH₂, Cl), (M-1371, H, F, H,HOCH₂CH₂, F), (M-1372, H, F, H, HOCH₂CH₂, CF₃), (M-1373, H, F, H,HOCH₂CH₂, Br), (M-1374, H, F, H, HOCH₂CH₂, C₃), (M-1375, H, F, H,HOCH₂CH₂CH₂, H), (M-1376, H, F, H, HOCH₂CH₂CH₂, Cl), (M-1377, H, F, H,HOCH₂CH₂CH₂, F), (M-1378, H, F, H, HOCH₂CH₂CH₂, CF₃), (M-1379, H, F, H,HOCH₂CH₂CH₂, Br), (M-1380, H, F, H, HOCH₂CH₂CH₂, CH₃), (M-1381, H, F, H,HOCH₂CH₂CH₂CH₂, H), (M-1382, H, F, H, HOCH₂CH₂CH₂CH₂, Cl), (M-1383, H,F, H, HOCH₂CH₂CH₂CH₂, F), (M-1384, H, F, H, HOCH₂CH₂CH₂CH₂, CF₃),(M-1385, H, F, H, HOCH₂CH₂CH₂CH₂, Br), (M-1386, H, F, H, HOCH₂CH₂CH₂CH₂,CH₃), (M-1387, H, F, H, HOCH₂CH₂CH₂CH₂CH₂, H), (M-1388, H, F, H,HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-1389, H, F, H, HOCH₂CH₂CH₂CH₂CH₂, F),(M-1390, H, F, H, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-1391, H, F, H,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-1392, H, F, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-1393, H, F, H, HOCH₂CH₂OCH₂CH₂, H), (M-1394, H, F, H,HOCH₂CH₂OCH₂CH₂, Cl), (M-1395, H, F, H, HOCH₂CH₂OCH₂CH₂, F), (M-1396, H,F, H, HOCH₂CH₂OCH₂CH₂, CF₃), (M-1397, H, F, H, HOCH₂CH₂OCH₂CH₂, Br),(M-1398, H, F, H, HOCH₂CH₂OCH₂CH₂, CH₃), (M-1399, H, F, H, (Me)₂N, H),(M-1400, H, F, H, (Me)₂N, Cl), (M-1401, H, F, H, (Me)₂N, F), (M-1402, H,F, H, (Me)₂N, CF₃), (M-1403, H, F, H, (Me)₂N, Br), (M-1404, H, F, H,(Me)₂N, CH₃), (M-1405, H, F, H, piperidin-4-yl-methyl, H), (M-1406, H,F, H, piperidin-4-yl-methyl, Cl), (M-1407, H, F, H,piperidin-4-yl-methyl, F), (M-1408, H, F, H, piperidin-4-yl-methyl,CF₃), (M-1409, H, F, H, piperidin-4-yl-methyl, Br), (M-1410, H, F, H,piperidin-4-yl-methyl, CH₃), (M-1411, H, F, H, cyclohexylmethyl, H),(M-1412, H, F, H, cyclohexylmethyl, Cl), (M-1413, H, F, H,cyclohexylmethyl, F), (M-1414, H, F, H, cyclohexylmethyl, CF₃), (M-1415,H, F, H, cyclohexylmethyl, Br), (M-1416, H, F, H, cyclohexylmethyl,CH₃), (M-1417, H, F, F, H, H), (M-1418, H, F, F, H, Cl), (M-1419, H, F,F, H, F), (M-1420, H, F, F, H, CF₃), (M-1421, H, F, F, H, Br), (M-1422,H, F, F, H, CH₃), (M-1423, H, F, F, F, H), (M-1424, H, F, F, F, Cl),(M-1425, H, F, F, F, F), (M-1426, H, F, F, F, CF₃), (M-1427, H, F, F, F,Br), (M-1428, H, F, F, F, CH₃), (M-1429, H, F, F, Cl, H), (M-1430, H, F,F, Cl, Cl), (M-1431, H, F, F, Cl, F), (M-1432, H, F, F, Cl, CF₃),(M-1433, H, F, F, Cl, Br), (M-1434, H, F, F, Cl, CH₃), (M-1435, H, F, F,CH₃, H), (M-1436, H, F, F, CH₃, Cl), (M-1437, H, F, F, CH₃, F), (M-1438,H, F, F, CH₃, CF₃), (M-1439, H, F, F, CH₃, Br), (M-1440, H, F, F, CH₃,CH₃), (M-1441, H, F, F, Et, H), (M-1442, H, F, F, Et, Cl), (M-1443, H,F, F, Et, F), (M-1444, H, F, F, Et, CF₃), (M-1445, H, F, F, Et, Br),(M-1446, H, F, F, Et, CH₃), (M-1447, H, F, F, n-Pr, H), (M-1448, H, F,F, n-Pr, Cl), (M-1449, H, F, F, n-Pr, F), (M-1450, H, F, F, n-Pr, CF₃),(M-1451, H, F, F, n-Pr, Br), (M-1452, H, F, F, n-Pr, CH₃), (M-1453, H,F, F, c-Pr, H), (M-1454, H, F, F, c-Pr, Cl), (M-1455, H, F, F, c-Pr, F),(M-1456, H, F, F, c-Pr, CF₃), (M-1457, H, F, F, c-Pr, Br), (M-1458, H,F, F, c-Pr, CH₃), (M-1459, H, F, F, i-Pr, H), (M-1460, H, F, F, i-Pr,Cl), (M-1461, H, F, F, i-Pr, F), (M-1462, H, F, F, i-Pr, CF₃), (M-1463,H, F, F, i-Pr, Br), (M-1464, H, F, F, i-Pr, CH₃), (M-1465, H, F, F,n-Bu, H), (M-1466, H, F, F, n-Bu, Cl), (M-1467, H, F, F, n-Bu, F),(M-1468, H, F, F, n-Bu, CF₃), (M-1469, H, F, F, n-Bu, Br), (M-1470, H,F, F, n-Bu, CH₃), (M-1471, H, F, F, i-Bu, H), (M-1472, H, F, F, i-Bu,Cl), (M-1473, H, F, F, i-Bu, F), (M-1474, H, F, F, i-Bu, CF₃), (M-1475,H, F, F, i-Bu, Br), (M-1476, H, F, F, i-Bu, CH₃), (M-1477, H, F, F,sec-Bu, H), (M-1478, H, F, F, sec-Bu, Cl), (M-1479, H, F, F, sec-Bu, F),(M-1480, H, F, F, sec-Bu, CF₃), (M-1481, H, F, F, sec-Bu, Br), (M-1482,H, F, F, sec-Bu, CH₃), (M-1483, H, F, F, n-Pen, H), (M-1484, H, F, F,n-Pen, Cl), (M-1485, H, F, F, n-Pen, F), (M-1486, H, F, F, n-Pen, CF₃),(M-1487, H, F, F, n-Pen, Br), (M-1488, H, F, F, n-Pen, CH₃), (M-1489, H,F, F, c-Pen, H), (M-1490, H, F, F, c-Pen, Cl), (M-1491, H, F, F, c-Pen,F), (M-1492, H, F, F, c-Pen, CF₃), (M-1493, H, F, F, c-Pen, Br),(M-1494, H, F, F, c-Pen, CH₃), (M-1495, H, F, F, n-Hex, H), (M-1496, H,F, F, n-Hex, Cl), (M-1497, H, F, F, n-Hex, F), (M-1498, H, F, F, n-Hex,CF₃), (M-1499, H, F, F, n-Hex, Br), (M-1500, H, F, F, n-Hex, CH₃),(M-1501, H, F, F, c-Hex, H), (M-1502, H, F, F, c-Hex, Cl), (M-1503, H,F, F, c-Hex, F), (M-1504, H, F, F, c-Hex, CF₃), (M-1505, H, F, F, c-Hex,Br), (M-1506, H, F, F, c-Hex, CH₃), (M-1507, H, F, F, OH, H), (M-1508,H, F, F, OH, Cl), (M-1509, H, F, F, OH, F), (M-1510, H, F, F, OH, CF₃),(M-1511, H, F, F, OH, Br), (M-1512, H, F, F, OH, CH₃), (M-1513, H, F, F,EtO, H), (M-1514, H, F, F, EtO, Cl), (M-1515, H, F, F, EtO, F), (M-1516,H, F, F, EtO, CF₃), (M-1517, H, F, F, EtO, Br), (M-1518, H, F, F, EtO,CH₃), (M-1519, H, F, F, n-PrO, H), (M-1520, H, F, F, n-PrO, Cl),(M-1521, H, F, F, n-PrO, F), (M-1522, H, F, F, n-PrO, CF₃), (M-1523, H,F, F, n-PrO, Br), (M-1524, H, F, F, n-PrO, CH₃), (M-1525, H, F, F, PhO,H), (M-1526, H, F, F, PhO, Cl), (M-1527, H, F, F, PhO, F), (M-1528, H,F, F, PhO, CF₃), (M-1529, H, F, F, PhO, Br), (M-1530, H, F, F, PhO,CH₃), (M-1531, H, F, F, BnO, H), (M-1532, H, F, F, BnO, Cl), (M-1533, H,F, F, BnO, F), (M-1534, H, F, F, BnO, CF₃), (M-1535, H, F, F, BnO, Br),(M-1536, H, F, F, BnO, CH₃), (M-1537, H, F, F, PhCH₂CH₂O, H), (M-1538,H, F, F, PhCH₂CH₂O, Cl), (M-1539, H, F, F, PhCH₂CH₂O, F), (M-1540, H, F,F, PhCH₂CH₂O, CF₃), (M-1541, H, F, F, PhCH₂CH₂O, Br), (M-1542, H, F, F,PhCH₂CH₂O, CH₃), (M-1543, H, F, F, CF₃O, H), (M-1544, H, F, F, CF₃O,Cl), (M-1545, H, F, F, CF₃O, F), (M-1546, H, F, F, CF₃O, CF₃), (M-1547,H, F, F, CF₃O, Br), (M-1548, H, F, F, CF₃O, CH₃), (M-1549, H, F, F, Ph,H), (M-1550, H, F, F, Ph, Cl), (M-1551, H, F, F, Ph, F), (M-1552, H, F,F, Ph, CF₃), (M-1553, H, F, F, Ph, Br), (M-1554, H, F, F, Ph, CH₃),(M-1555, H, F, F, 4-F-Ph, H), (M-1556, H, F, F, 4-F-Ph, Cl), (M-1557, H,F, F, 4-F-Ph, F), (M-1558, H, F, F, 4-F-Ph, CF₃), (M-1559, H, F, F,4-F-Ph, Br), (M-1560, H, F, F, 4-F-Ph, CH₃), (M-1561, H, F, F, 4-CF₃-Ph,H), (M-1562, H, F, F, 4-CF₃-Ph, Cl), (M-1563, H, F, F, 4-CF₃-Ph, F),(M-1564, H, F, F, 4-CF₃-Ph, CF₃), (M-1565, H, F, F, 4-CF₃-Ph, Br),(M-1566, H, F, F, 4-CF₃-Ph, CH₃), (M-1567, H, F, F, 4-(Me)₂N-Ph, H),(M-1568, H, F, F, 4-(Me)₂N-Ph, Cl), (M-1569, H, F, F, 4-(Me)₂N-Ph, F),(M-1570, H, F, F, 4-(Me)₂N-Ph, CF₃), (M-1571, H, F, F, 4-(Me)₂N-Ph, Br),(M-1572, H, F, F, 4-(Me)₂N-Ph, CH₃), (M-1573, H, F, F, 4-OH-Ph, H),(M-1574, H, F, F, 4-OH-Ph, Cl), (M-1575, H, F, F, 4-OH-Ph, F), (M-1576,H, F, F, 4-OH-Ph, CF₃), (M-1577, H, F, F, 4-OH-Ph, Br), (M-1578, H, F,F, 4-OH-Ph, CH₃), (M-1579, H, F, F, 3,4-di-F-Ph, H), (M-1580, H, F, F,3,4-di-F-Ph, Cl), (M-1581, H, F, F, 3,4-di-F-Ph, F), (M-1582, H, F, F,3,4-di-F-Ph, CF₃), (M-1583, H, F, F, 3,4-di-F-Ph, Br), (M-1584, H, F, F,3,4-di-F-Ph, CH₃), (M-1585, H, F, F, 4-COOH-Ph, H), (M-1586, H, F, F,4-COOH-Ph, Cl), (M-1587, H, F, F, 4-COOH-Ph, F), (M-1588, H, F, F,4-COOH-Ph, CF₃), (M-1589, H, F, F, 4-COOH-Ph, Br), (M-1590, H, F, F,4-COOH-Ph, CH₃), (M-1591, H, F, F, Bn, H), (M-1592, H, F, F, Bn, Cl),(M-1593, H, F, F, Bn, F), (M-1594, H, F, F, Bn, CF₃), (M-1595, H, F, F,Bn, Br), (M-1596, H, F, F, Bn, CH₃), (M-1597, H, F, F, 4-F-Bn, H),(M-1598, H, F, F, 4-F-Bn, Cl), (M-1599, H, F, F, 4-F-Bn, F), (M-1600, H,F, F, 4-F-Bn, CF₃), (M-1601, H, F, F, 4-F-Bn, Br), (M-1602, H, F, F,4-F-Bn, CH₃), (M-1603, H, F, F, 2-Py, H), (M-1604, H, F, F, 2-Py, Cl),(M-1605, H, F, F, 2-Py, F), (M-1606, H, F, F, 2-Py, CF₃), (M-1607, H, F,F, 2-Py, Br), (M-1608, H, F, F, 2-Py, CH₃), (M-1609, H, F, F, 3-Py, H),(M-1610, H, F, F, 3-Py, Cl), (M-1611, H, F, F, 3-Py, F), (M-1612, H, F,F, 3-Py, CF₃), (M-1613, H, F, F, 3-Py, Br), (M-1614, H, F, F, 3-Py,CH₃), (M-1615, H, F, F, 4-Py, H), (M-1616, H, F, F, 4-Py, Cl), (M-1617,H, F, F, 4-Py, F), (M-1618, H, F, F, 4-Py, CF₃), (M-1619, H, F, F, 4-Py,Br), (M-1620, H, F, F, 4-Py, CH₃), (M-1621, H, F, F, 2-Th, H), (M-1622,H, F, F, 2-Th, Cl), (M-1623, H, F, F, 2-Th, F), (M-1624, H, F, F, 2-Th,CF₃), (M-1625, H, F, F, 2-Th, Br), (M-1626, H, F, F, 2-Th, CH₃),(M-1627, H, F, F, 3-Th, H), (M-1628, H, F, F, 3-Th, Cl), (M-1629, H, F,F, 3-Th, F), (M-1630, H, F, F, 3-Th, CF₃), (M-1631, H, F, F, 3-Th, Br),(M-1632, H, F, F, 3-Th, CH₃), (M-1633, H, F, F, pyrrazol-2-yl, H),(M-1634, H, F, F, pyrrazol-2-yl, Cl), (M-1635, H, F, F, pyrrazol-2-yl,F), (M-1636, H, F, F, pyrrazol-2-yl, CH₃), (M-1637, H, F, F,pyrrazol-2-yl, Br), (M-1638, H, F, F, pyrrazol-2-yl, CH₃), (M-1639, H,F, F, pyrrazol-3-yl, H), (M-1640, H, F, F, pyrrazol-3-yl, Cl), (M-1641,H, F, F, pyrrazol-3-yl, F), (M-1642, H, F, F, pyrrazol-3-yl, CF₃),(M-1643, H, F, F, pyrrazol-3-yl, Br), (M-1644, H, F, F, pyrrazol-3-yl,CH₃), (M-1645, H, F, F, pyrimidin-2-yl, H), (M-1646, H, F, F,pyrimidin-2-yl, Cl), (M-1647, H, F, F, pyrimidin-2-yl, F), (M-1648, H,F, F, pyrimidin-2-yl, CF₃), (M-1649, H, F, F, pyrimidin-2-yl, Br),(M-1650, H, F, F, pyrimidin-2-yl, C₃), (M-1651, H, F, F, pyrimidin-4-yl,H), (M-1652, H, F, F, pyrimidin-4-yl, Cl), (M-1653, H, F, F,pyrimidin-4-yl, F), (M-1654, H, F, F, pyrimidin-4-yl, CF₃), (M-1655, H,F, F, pyrimidin-4-yl, Br), (M-1656, H, F, F, pyrimidin-4-yl, CH₃),(M-1657, H, F, F, pyrimidin-5-yl, H), (M-1658, H, F, F, pyrimidin-5-yl,Cl), (M-1659, H, F, F, pyrimidin-5-yl, F), (M-1660, H, F, F,pyrimidin-5-yl, CF₃), (M-1661, H, F, F, pyrimidin-5-yl, Br), (M-1662, H,F, F, pyrimidin-5-yl, CH₃), (M-1663, H, F, F, HOOCCH₂CH₂CH₂, H),(M-1664, H, F, F, HOOCCH₂CH₂CH₂, Cl), (M-1665, H, F, F, HOOCCH₂CH₂CH₂,F), (M-1666, H, F, F, HOOCCH₂CH₂CH₂, CF₃), (M-1667, H, F, F,HOOCCH₂CH₂CH₂, Br), (M-1668, H, F, F, HOOCCH₂CH₂CH₂, CH₃), (M-1669, H,F, F, HOOCCH₂CH₂CH₂CH₂, H), (M-1670, H, F, F, HOOCCH₂CH₂CH₂CH₂, Cl),(M-1671, H, F, F, HOOCCH₂CH₂CH₂CH₂, F), (M-1672, H, F, F,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-1673, H, F, F, HOOCCH₂CH₂CH₂CH₂, Br),(M-1674, H, F, F, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-1675, H, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-1676, H, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-1677, H, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-1678, H, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-1679, H, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Br),(M-1680, H, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-1681, H, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-1682, H, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-1683, H, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-1684, H, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-1685, H, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-1686, H, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CH₃), (M-1687, H, F, F, MeOCH₂, H), (M-1688, H, F, F, MeOCH₂, Cl),(M-1689, H, F, F, MeOCH₂, F), (M-1690, H, F, F, MeOCH₂, CF₃), (M-1691,H, F, F, MeOCH₂, Br), (M-1692, H, F, F, MeOCH₂, CH₃), (M-1693, H, F, F,EtOCH₂, H), (M-1694, H, F, F, EtOCH₂, Cl), (M-1695, H, F, F, EtOCH₂, F),(M-1696, H, F, F, EtOCH₂, CF₃), (M-1697, H, F, F, EtOCH₂, Br), (M-1698,H, F, F, EtOCH₂, CH₃), (M-1699, H, F, F, EtOCH₂CH₂, H), (M-1700, H, F,F, EtOCH₂CH₂, Cl), (M-1701, H, F, F, EtOCH₂CH₂, F), (M-1702, H, F, F,EtOCH₂CH₂, CF₃), (M-1703, H, F, F, EtOCH₂CH₂, Br), (M-1704, H, F, F,EtOCH₂CH₂, CH₃), (M-1705, H, F, F, MeOCH₂CH₂OCH₂CH₂, H), (M-1706, H, F,F, MeOCH₂CH₂OCH₂CH₂, Cl), (M-1707, H, F, F, MeOCH₂CH₂OCH₂CH₂, F),(M-1708, H, F, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-1709, H, F, F,MeOCH₂CH₂OCH₂CH₂, Br), (M-1710, H, F, F, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-1711, H, F, F, MeOCH₂CH₂, H), (M-1712, H, F, F, MeOCH₂CH₂, Cl),(M-1713, H, F, F, MeOCH₂CH₂, F), (M-1714, H, F, F, MeOCH₂CH₂, CF₃),(M-1715, H, F, F, MeOCH₂CH₂, Br), (M-1716, H, F, F, MeOCH₂CH₂, CH₃),(M-1717, H, F, F, HOCH₂, H), (M-1718, H, F, F, HOCH₂, Cl), (M-1719, H,F, F, HOCH₂, F), (M-1720, H, F, F, HOCH₂, CF₃), (M-1721, H, F, F, HOCH₂,Br), (M-1722, H, F, F, HOCH₂, CH₃), (M-1723, H, F, F, HOCH₂CH₂, H),(M-1724, H, F, F, HOCH₂CH₂, Cl), (M-1725, H, F, F, HOCH₂CH₂, F),(M-1726, H, F, F, HOCH₂CH₂, CF₃), (M-1727, H, F, F, HOCH₂CH₂, Br),(M-1728, H, F, F, HOCH₂CH₂, CH₃), (M-1729, H, F, F, HOCH₂CH₂CH₂, H),(M-1730, H, F, F, HOCH₂CH₂CH₂, Cl), (M-1731, H, F, F, HOCH₂CH₂CH₂, F),(M-1732, H, F, F, HOCH₂CH₂CH₂, CF₃), (M-1733, H, F, F, HOCH₂CH₂CH₂, Br),(M-1734, H, F, F, HOCH₂CH₂CH₂, CH₃), (M-1735, H, F, F, HOCH₂CH₂CH₂CH₂,H), (M-1736, H, F, F, HOCH₂CH₂CH₂CH₂, Cl), (M-1737, H, F, F,HOCH₂CH₂CH₂CH₂, F), (M-1738, H, F, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-1739, H,F, F, HOCH₂CH₂CH₂CH₂, Br), (M-1740, H, F, F, HOCH₂CH₂CH₂CH₂, CH₃),(M-1741, H, F, F, HOCH₂CH₂CH₂CH₂CH₂, H), (M-1742, H, F, F,HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-1743, H, F, F, HOCH₂CH₂CH₂CH₂CH₂, F),(M-1744, H, F, F, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-1745, H, F, F,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-1746, H, F, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-1747, H, F, F, HOCH₂CH₂OCH₂CH₂, H), (M-1748, H, F, F,HOCH₂CH₂OCH₂CH₂, Cl), (M-1749, H, F, F, HOCH₂CH₂OCH₂CH₂, F), (M-1750, H,F, F, HOCH₂CH₂OCH₂CH₂, CF₃), (M-1751, H, F, F, HOCH₂CH₂OCH₂CH₂, Br),(M-1752, H, F, F, HOCH₂CH₂OCH₂CH₂, CH₃), (M-1753, H, F, F, (Me)₂N, H),(M-1754, H, F, F, (Me)₂N, Cl), (M-1755, H, F, F, (Me)₂N, F), (M-1756, H,F, F, (Me)₂N, CF₃), (M-1757, H, F, F, (Me)₂N, Br), (M-1758, H, F, F,(Me)₂N, CH₃), (M-1759, H, F, F, piperidin-4-yl-methyl, H), (M-1760, H,F, F, piperidin-4-yl-methyl, Cl), (M-1761, H, F, F,piperidin-4-yl-methyl, F), (M-1762, H, F, F, piperidin-4-yl-methyl,CF₃), (M-1763, H, F, F, piperidin-4-yl-methyl, Br), (M-1764, H, F, F,piperidin-4-yl-methyl, CH₃), (M-1765, H, F, F, cyclohexylmethyl, H),(M-1766, H, F, F, cyclohexylmethyl, Cl), (M-1767, H, F, F,cyclohexylmethyl, F), (M-1768, H, F, F, cyclohexylmethyl, CF₃), (M-1769,H, F, F, cyclohexylmethyl, Br), (M-1770, H, F, F, cyclohexylmethyl,CH₃), (M-1771, H, F, Cl, H, H), (M-1772, H, F, Cl, H, Cl), (M-1773, H,F, Cl, H, F), (M-1774, H, F, Cl, H, CF₃), (M-1775, H, F, Cl, H, Br),(M-1776, H, F, Cl, H, CH₃), (M-1777, H, F, Cl, F, H), (M-1778, H, F, Cl,F, Cl), (M-1779, H, F, Cl, F, F), (M-1780, H, F, Cl, F, CF₃), (M-1781,H, F, Cl, F, Br), (M-1782, H, F, Cl, F, CH₃), (M-1783, H, F, Cl, Cl, H),(M-1784, H, F, Cl, Cl, Cl), (M-1785, H, F, Cl, Cl, F), (M-1786, H, F,Cl, Cl, CF₃), (M-1787, H, F, Cl, Cl, Br), (M-1788, H, F, Cl, Cl, CH₃),(M-1789, H, F, Cl, CH₃, H), (M-1790, H, F, Cl, CH₃, Cl), (M-1791, H, F,Cl, CH₃, F), (M-1792, H, F, Cl, CH₃, CF₃), (M-1793, H, F, Cl, CH₃, Br),(M-1794, H, F, Cl, CH₃, CH₃), (M-1795, H, F, Cl, Et, H), (M-1796, H, F,Cl, Et, Cl), (M-1797, H, F, Cl, Et, F), (M-1798, H, F, Cl, Et, CF₃),(M-1799, H, F, Cl, Et, Br), (M-1800, H, F, Cl, Et, CH₃), (M-1801, H, F,Cl, n-Pr, H), (M-1802, H, F, Cl, n-Pr, Cl), (M-1803, H, F, Cl, n-Pr, F),(M-1804, H, F, Cl, n-Pr, CF₃), (M-1805, H, F, Cl, n-Pr, Br), (M-1806, H,F, Cl, n-Pr, CH₃), (M-1807, H, F, Cl, c-Pr, H), (M-1808, H, F, Cl, c-Pr,Cl), (M-1809, H, F, Cl, c-Pr, F), (M-1810, H, F, Cl, c-Pr, CF₃),(M-1811, H, F, Cl, c-Pr, Br), (M-1812, H, F, Cl, c-Pr, CH₃), (M-1813, H,F, Cl, i-Pr, H), (M-1814, H, F, Cl, i-Pr, Cl), (M-1815, H, F, Cl, i-Pr,F), (M-1816, H, F, Cl, i-Pr, CF₃), (M-1817, H, F, Cl, i-Pr, Br),(M-1818, H, F, Cl, i-Pr, CH₃), (M-1819, H, F, Cl, n-Bu, H), (M-1820, H,F, Cl, n-Bu, Cl), (M-1821, H, F, Cl, n-Bu, F), (M-1822, H, F, Cl, n-Bu,CF₃), (M-1823, H, F, Cl, n-Bu, Br), (M-1824, H, F, Cl, n-Bu, CH₃),(M-1825, H, F, Cl, i-Bu, H), (M-1826, H, F, Cl, i-Bu, Cl), (M-1827, H,F, Cl, i-Bu, F), (M-1828, H, F, Cl, i-Bu, CF₃), (M-1829, H, F, Cl, i-Bu,Br), (M-1830, H, F, Cl, i-Bu, CH₃), (M-1831, H, F, Cl, sec-Bu, H),(M-1832, H, F, Cl, sec-Bu, Cl), (M-1833, H, F, Cl, sec-Bu, F), (M-1834,H, F, Cl, sec-Bu, CF₃), (M-1835, H, F, Cl, sec-Bu, Br), (M-1836, H, F,Cl, sec-Bu, CH₃), (M-1837, H, F, Cl, n-Pen, H), (M-1838, H, F, Cl,n-Pen, Cl), (M-1839, H, F, Cl, n-Pen, F), (M-1840, H, F, Cl, n-Pen,CF₃), (M-1841, H, F, Cl, n-Pen, Br), (M-1842, H, F, Cl, n-Pen, CH₃),(M-1843, H, F, Cl, c-Pen, H), (M-1844, H, F, Cl, c-Pen, Cl), (M-1845, H,F, Cl, c-Pen, F), (M-1846, H, F, Cl, c-Pen, CF₃), (M-1847, H, F, Cl,c-Pen, Br), (M-1848, H, F, Cl, c-Pen, CH₃), (M-1849, H, F, Cl, n-Hex,H), (M-1850, H, F, Cl, n-Hex, Cl), (M-1851, H, F, Cl, n-Hex, F),(M-1852, H, F, Cl, n-Hex, CF₃), (M-1853, H, F, Cl, n-Hex, Br), (M-1854,H, F, Cl, n-Hex, CH₃), (M-1855, H, F, Cl, c-Hex, H), (M-1856, H, F, Cl,c-Hex, Cl), (M-1857, H, F, Cl, c-Hex, F), (M-1858, H, F, Cl, c-Hex,CF₃), (M-1859, H, F, Cl, c-Hex, Br), (M-1860, H, F, Cl, c-Hex, CH₃),(M-1861, H, F, Cl, OH, H), (M-1862, H, F, Cl, OH, Cl), (M-1863, H, F,Cl, OH, F), (M-1864, H, F, Cl, OH, CF₃), (M-1865, H, F, Cl, OH, Br),(M-1866, H, F, Cl, OH, CH₃), (M-1867, H, F, Cl, EtO, H), (M-1868, H, F,Cl, EtO, Cl), (M-1869, H, F, Cl, EtO, F), (M-1870, H, F, Cl, EtO, CF₃),(M-1871, H, F, Cl, EtO, Br), (M-1872, H, F, Cl, EtO, CH₃), (M-1873, H,F, Cl, n-PrO, H), (M-1874, H, F, Cl, n-PrO, Cl), (M-1875, H, F, Cl,n-PrO, F), (M-1876, H, F, Cl, n-PrO, CF₃), (M-1877, H, F, Cl, n-PrO,Br), (M-1878, H, F, Cl, n-PrO, CH₃), (M-1879, H, F, Cl, PhO, H),(M-1880, H, F, Cl, PhO, Cl), (M-1881, H, F, Cl, PhO, F), (M-1882, H, F,Cl, PhO, CF₃), (M-1883, H, F, Cl, PhO, Br), (M-1884, H, F, Cl, PhO,CH₃), (M-1885, H, F, Cl, BnO, H), (M-1886, H, F, Cl, BnO, Cl), (M-1887,H, F, Cl, BnO, F), (M-1888, H, F, Cl, BnO, CF₃), (M-1889, H, F, Cl, BnO,Br), (M-1890, H, F, Cl, BnO, CH₃), (M-1891, H, F, Cl, PhCH₂CH₂O, H),(M-1892, H, F, Cl, PhCH₂CH₂O, Cl), (M-1893, H, F, Cl, PhCH₂CH₂O, F),(M-1894, H, F, Cl, PhCH₂CH₂O, CF₃), (M-1895, H, F, Cl, PhCH₂CH₂O, Br),(M-1896, H, F, Cl, PhCH₂CH₂O, CH₃), (M-1897, H, F, Cl, CF₃O, H),(M-1898, H, F, Cl, CF₃O, Cl), (M-1899, H, F, Cl, CF₃O, F), (M-1900, H,F, Cl, CF₃O, CF₃), (M-1901, H, F, Cl, CF₃O, Br), (M-1902, H, F, Cl,CF₃O, CH₃), (M-1903, H, F, Cl, Ph, H), (M-1904, H, F, Cl, Ph, Cl),(M-1905, H, F, Cl, Ph, F), (M-1906, H, F, Cl, Ph, CF₃), (M-1907, H, F,Cl, Ph, Br), (M-1908, H, F, Cl, Ph, CH₃), (M-1909, H, F, Cl, 4-F-Ph, H),(M-1910, H, F, Cl, 4-F-Ph, Cl), (M-1911, H, F, Cl, 4-F-Ph, F), (M-1912,H, F, Cl, 4-F-Ph, CF₃), (M-1913, H, F, Cl, 4-F-Ph, Br), (M-1914, H, F,Cl, 4-F-Ph, CH₃), (M-1915, H, F, Cl, 4-CF₃-Ph, H), (M-1916, H, F, Cl,4-CF₃-Ph, Cl), (M-1917, H, F, Cl, 4-CF₃-Ph, F), (M-1918, H, F, Cl,4-CF₃-Ph, CF₃), (M-1919, H, F, Cl, 4-CF₃-Ph, Br), (M-1920, H, F, Cl,4-CF₃-Ph, CH₃), (M-1921, H, F, Cl, 4-(Me)₂N-Ph, H), (M-1922, H, F, Cl,4-(Me)₂N-Ph, Cl), (M-1923, H, F, Cl, 4-(Me)₂N-Ph, F), (M-1924, H, F, Cl,4-(Me)₂N-Ph, CF₃), (M-1925, H, F, Cl, 4-(Me)₂N-Ph, Br), (M-1926, H, F,Cl, 4-(Me)₂N-Ph, CH₃), (M-1927, H, F, Cl, 4-OH-Ph, H), (M-1928, H, F,Cl, 4-OH-Ph, Cl), (M-1929, H, F, Cl, 4-OH-Ph, F), (M-1930, H, F, Cl,4-OH-Ph, CF₃), (M-1931, H, F, Cl, 4-OH-Ph, Br), (M-1932, H, F, Cl,4-OH-Ph, CH₃), (M-1933, H, F, Cl, 3,4-di-F-Ph, H), (M-1934, H, F, Cl,3,4-di-F-Ph, Cl), (M-1935, H, F, Cl, 3,4-di-F-Ph, F), (M-1936, H, F, Cl,3,4-di-F-Ph, CF₃), (M-1937, H, F, Cl, 3,4-di-F-Ph, Br), (M-1938, H, F,Cl, 3,4-di-F-Ph, CH₃), (M-1939, H, F, Cl, 4-COOH-Ph, H), (M-1940, H, F,Cl, 4-COOH-Ph, Cl), (M-1941, H, F, Cl, 4-COOH-Ph, F), (M-1942, H, F, Cl,4-COOH-Ph, CF₃), (M-1943, H, F, Cl, 4-COOH-Ph, Br), (M-1944, H, F, Cl,4-COOH-Ph, CH₃), (M-1945, H, F, Cl, Bn, H), (M-1946, H, F, Cl, Bn, Cl),(M-1947, H, F, Cl, Bn, F), (M-1948, H, F, Cl, Bn, CF₃), (M-1949, H, F,Cl, Bn, Br), (M-1950, H, F, Cl, Bn, CH₃), (M-1951, H, F, Cl, 4-F-Bn, H),(M-1952, H, F, Cl, 4-F-Bn, Cl), (M-1953, H, F, Cl, 4-F-Bn, F), (M-1954,H, F, Cl, 4-F-Bn, CF₃), (M-1955, H, F, Cl, 4-F-Bn, Br), (M-1956, H, F,Cl, 4-F-Bn, CH₃), (M-1957, H, F, Cl, 2-Py, H), (M-1958, H, F, Cl, 2-Py,Cl), (M-1959, H, F, Cl, 2-Py, F), (M-1960, H, F, Cl, 2-Py, CF₃),(M-1961, H, F, Cl, 2-Py, Br), (M-1962, H, F, Cl, 2-Py, CH₃), (M-1963, H,F, Cl, 3-Py, H), (M-1964, H, F, Cl, 3-Py, Cl), (M-1965, H, F, Cl, 3-Py,F), (M-1966, H, F, Cl, 3-Py, CF₃), (M-1967, H, F, Cl, 3-Py, Br),(M-1968, H, F, Cl, 3-Py, CH₃), (M-1969, H, F, Cl, 4-Py, H), (M-1970, H,F, Cl, 4-Py, Cl), (M-1971, H, F, Cl, 4-Py, F), (M-1972, H, F, Cl, 4-Py,CF₃), (M-1973, H, F, Cl, 4-Py, Br), (M-1974, H, F, Cl, 4-Py, CH₃),(M-1975, H, F, Cl, 2-Th, H), (M-1976, H, F, Cl, 2-Th, Cl), (M-1977, H,F, Cl, 2-Th, F), (M-1978, H, F, Cl, 2-Th, CF₃), (M-1979, H, F, Cl, 2-Th,Br), (M-1980, H, F, Cl, 2-Th, CH₃), (M-1981, H, F, Cl, 3-Th, H),(M-1982, H, F, Cl, 3-Th, Cl), (M-1983, H, F, Cl, 3-Th, F), (M-1984, H,F, Cl, 3-Th, CF₃), (M-1985, H, F, Cl, 3-Th, Br), (M-1986, H, F, Cl,3-Th, CH₃), (M-1987, H, F, Cl, pyrrazol-2-yl, H), (M-1988, H, F, Cl,pyrrazol-2-yl, Cl), (M-1989, H, F, Cl, pyrrazol-2-yl, F), (M-1990, H, F,Cl, pyrrazol-2-yl, CF₃), (M-1991, H, F, Cl, pyrrazol-2-yl, Br), (M-1992,H, F, Cl, pyrrazol-2-yl, CH₃), (M-1993, H, F, Cl, pyrrazol-3-yl, H),(M-1994, H, F, Cl, pyrrazol-3-yl, Cl), (M-1995, H, F, Cl, pyrrazol-3-yl,F), (M-1996, H, F, Cl, pyrrazol-3-yl, CF₃), (M-1997, H, F, Cl,pyrrazol-3-yl, Br), (M-1998, H, F, Cl, pyrrazol-3-yl, CH₃), (M-1999, H,F, Cl, pyrimidin-2-yl, H), (M-2000, H, F, Cl, pyrimidin-2-yl, Cl),(M-2001, H, F, Cl, pyrimidin-2-yl, F), (M-2002, H, F, Cl, pyrimidin-2yl,CF₃), (M-2003, H, F, Cl, pyrimidin-2-yl, Br), (M-2004, H, F, Cl,pyrimidin-2-yl, CH₃), (M-2005, H, F, Cl, pyrimidin-4-yl, H), (M-2006, H,F, Cl, pyrimidin-4-yl, Cl), (M-2007, H, F, Cl, pyrimidin-4-yl, F),(M-2008, H, F, Cl, pyrimidin-4-yl, CF₃), (M-2009, H, F, Cl,pyrimidin-4-yl, Br), (M-2010, H, F, Cl, pyrimidin-4-yl, CH₃), (M-2011,H, F, Cl, pyrimidin-5-yl, H), (M-2012, H, F, Cl, pyrimidin-5-yl, Cl),(M-2013, H, F, Cl, pyrimidin-5-yl, F), (M-2014, H, F, Cl,pyrimidin-5-yl, CF₃), (M-2015, H, F, Cl, pyrimidin-5-yl, Br), (M-2016,H, F, Cl, pyrimidin-5-yl, CH₃), (M-2017, H, F, Cl, HOOCCH₂CH₂CH₂, H),(M-2018, H, F, Cl, HOOCCH₂CH₂CH₂, Cl), (M-2019, H, F, Cl, HOOCCH₂CH₂CH₂,F), (M-2020, H, F, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-2021, H, F, Cl,HOOCCH₂CH₂CH₂, Br), (M-2022, H, F, Cl, HOOCCH₂CH₂CH₂, CH₃), (M-2023, H,F, Cl, HOOCCH₂CH₂CH₂CH₂, H), (M-2024, H, F, Cl, HOOCCH₂CH₂CH₂CH₂, Cl),(M-2025, H, F, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-2026, H, F, Cl,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-2027, H, F, Cl, HOOCCH₂CH₂CH₂CH₂, Br),(M-2028, H, F, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-2029, H, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-2030, H, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-2031, H, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-2032, H, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-2033, H, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-2034, H, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-2035, H, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-2036, H, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-2037, H, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-2038, H, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-2039, H, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-2040, H, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-2041, H, F, Cl, MeOCH₂, H), (M-2042,H, F, Cl, MeOCH₂, Cl), (M-2043, H, F, Cl, MeOCH₂, F), (M-2044, H, F, Cl,MeOCH₂, CF₃), (M-2045, H, F, Cl, MeOCH₂, Br), (M-2046, H, F, Cl, MeOCH₂,CH₃), (M-2047, H, F, Cl, EtOCH₂, H), (M-2048, H, F, Cl, EtOCH₂, Cl),(M-2049, H, F, Cl, EtOCH₂, F), (M-2050, H, F, Cl, EtOCH₂, CF₃), (M-2051,H, F, Cl, EtOCH₂, Br), (M-2052, H, F, Cl, EtOCH₂, CH₃), (M-2053, H, F,Cl, EtOCH₂CH₂, H), (M-2054, H, F, Cl, EtOCH₂CH₂, Cl), (M-2055, H, F, Cl,EtOCH₂CH₂, F), (M-2056, H, F, Cl, EtOCH₂CH₂, CF₃), (M-2057, H, F, Cl,EtOCH₂CH₂, Br), (M-2058, H, F, Cl, EtOCH₂CH₂, CH₃), (M-2059, H, F, Cl,MeOCH₂CH₂OCH₂CH₂, H), (M-2060, H, F, Cl, MeOCH₂CH₂OCH₂CH₂, Cl), (M-2061,H, F, Cl, MeOCH₂CH₂OCH₂CH₂, F), (M-2062, H, F, Cl, MeOCH₂CH₂OCH₂CH₂,CF₃), (M-2063, H, F, Cl, MeOCH₂CH₂OCH₂CH₂, Br), (M-2064, H, F, Cl,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-2065, H, F, Cl, MeOCH₂CH₂, H), (M-2066, H, F,Cl, MeOCH₂CH₂, Cl), (M-2067, H, F, Cl, MeOCH₂CH₂, F), (M-2068, H, F, Cl,MeOCH₂CH₂, CF₃), (M-2069, H, F, Cl, MeOCH₂CH₂, Br), (M-2070, H, F, Cl,MeOCH₂CH₂, CH₃), (M-2071, H, F, Cl, HOCH₂, H), (M-2072, H, F, Cl, HOCH₂,Cl), (M-2073, H, F, Cl, HOCH₂, F), (M-2074, H, F, Cl, HOCH₂, CF₃),(M-2075, H, F, Cl, HOCH₂, Br), (M-2076, H, F, Cl, HOCH₂, CH₃), (M-2077,H, F, Cl, HOCH₂CH₂, H), (M-2078, H, F, Cl, HOCH₂CH₂, Cl), (M-2079, H, F,Cl, HOCH₂CH₂, F), (M-2080, H, F, Cl, HOCH₂CH₂, CF₃), (M-2081, H, F, Cl,HOCH₂CH₂, Br), (M-2082, H, F, Cl, HOCH₂CH₂, CH₃), (M-2083, H, F, Cl,HOCH₂CH₂CH₂, H), (M-2084, H, F, Cl, HOCH₂CH₂CH₂, Cl), (M-2085, H, F, Cl,HOCH₂CH₂CH₂, F), (M-2086, H, F, Cl, HOCH₂CH₂CH₂, CF₃), (M-2087, H, F,Cl, HOCH₂CH₂CH₂, Br), (M-2088, H, F, Cl, HOCH₂CH₂CH₂, CH₃), (M-2089, H,F, Cl, HOCH₂CH₂CH₂CH₂, H), (M-2090, H, F, Cl, HOOCH₂CH₂CH₂CH₂, Cl),(M-2091, H, F, Cl, HOCH₂CH₂CH₂CH₂, F), (M-2092, H, F, Cl,HOCH₂CH₂CH₂CH₂, CF₃), (M-2093, H, F, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-2094,H, F, Cl, HOCH₂CH₂CH₂CH₂, CH₃), (M-2095, H, F, Cl, HOCH₂CH₂CH₂CH₂CH₂,H), (M-2096, H, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-2097, H, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-2098, H, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-2099, H, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-2100, H, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃) (M-2101, H, F, Cl, HOCH₂CH₂OCH₂CH₂, H), (M-2102,H, F, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-2103, H, F, Cl, HOCH₂CH₂OCH₂CH₂, F),(M-2104, H, F, Cl, HOCH₂CH₂OCH₂CH₂, CF₃), (M-2105, H, F, Cl,HOCH₂CH₂OCH₂CH₂, Br), (M-2106, H, F, Cl, HOCH₂CH₂OCH₂CH₂, CH₃), (M-2107,H, F, Cl, (Me)₂N, H), (M-2108, H, F, Cl, (Me)₂N, Cl), (M-2109, H, F, Cl,(Me)₂N, F), (M-2110, H, F, Cl, (Me)₂N, CF₃), (M-2111, H, F, Cl, (Me)₂N,Br), (M-2112, H, F, Cl, (Me)₂N, CH₃), (M-2113, H, F, Cl,piperidin-4-yl-methyl, H), (M-2114, H, F, Cl, piperidin-4-yl-methyl,Cl), (M-2115, H, F, Cl, piperidin-4-yl-methyl, F), (M-2116, H, F, Cl,piperidin-4-yl-methyl, CF₃), (M-2117, H, F, Cl, piperidin-4-yl-methyl,Br), (M-2118, H, F, Cl, piperidin-4-yl-methyl, CH₃), (M-2119, H, F, Cl,cyclohexylmethyl, H), (M-2120, H, F, Cl, cyclohexylmethyl, Cl), (M-2121,H, F, Cl, cyclohexylmethyl, F), (M-2122, H, F, Cl, cyclohexylmethyl,CF₃), (M-2123, H, F, Cl, cyclohexylmethyl, Br), (M-2124, H, F, Cl,cyclohexylmethyl, CH₃), (M-2125, H, CH₃, H, H, H), (M-2126, H, CH₃, H,H, Cl), (M-2127, H, CH₃, H, H, F), (M-2128, H, CH₃, H, H, CF₃), (M-2129,H, CH₃, H, H, Br), (M-2130, H, CH₃, H, H, CH₃), (M-2131, H, CH₃, H, F,H), (M-2132, H, CH₃, H, F, Cl), (M-2133, H, CH₃, H, F, F), (M-2134, H,CH₃, H, F, CF₃), (M-2135, H, CH₃, H, F, Br), (M-2136, H, CH₃, H, F,CH₃), (M-2137, H, CH₃, H, Cl, H), (M-2138, H, CH₃, H, Cl, Cl), (M-2139,H, CH₃, H, Cl, F), (M-2140, H, CH₃, H, Cl, CF₃), (M-2141, H, CH₃, H, Cl,Br), (M-2142, H, CH₃, H, Cl, CH₃), (M-2143, H, CH₃, H, CH₃, H), (M-2144,H, CH₃, H, CH₃, Cl), (M-2145, H, CH₃, H, CH₃, F), (M-2146, H, CH₃, H,CH₃, CF₃), (M-2147, H, CH₃, H, CH₃, Br), (M-2148, H, CH₃, H, CH₃, CH₃),(M-2149, H, CH₃, H, Et, H), (M-2150, H, CH₃, H, Et, Cl), (M-2151, H,CH₃, H, Et, F), (M-2152, H, CH₃, H, Et, CF₃), (M-2153, H, CH₃, H, Et,Br), (M-2154, H, CH₃, H, Et, CH₃), (M-2155, H, CH₃, H, n-Pr, H),(M-2156, H, CH₃, H, n-Pr, Cl), (M-2157, H, CH₃, H, n-Pr, F), (M-2158, H,CH₃, H, n-Pr, CF₃), (M-2159, H, CH₃, H, n-Pr, Br), (M-2160, H, CH₃, H,n-Pr, CH₃), (M-2161, H, CH₃, H, c-Pr, H), (M-2162, H, CH₃, H, c-Pr, Cl),(M-2163, H, CH₃, H, c-Pr, F), (M-2164, H, CH₃, H, c-Pr, CF₃), (M-2165,H, CH₃, H, c-Pr, Br), (M-2166, H, CH₃, H, c-Pr, CH₃), (M-2167, H, CH₃,H, i-Pr, H), (M-2168, H, CH₃, H, i-Pr, Cl), (M-2169, H, CH₃, H, i-Pr,F), (M-2170, H, CH₃, H, i-Pr, CF₃), (M-2171, H, CH₃, H, i-Pr, Br),(M-2172, H, CH₃, H, i-Pr, CH₃), (M-2173, H, CH₃, H, n-Bu, H), (M-2174,H, CH₃, H, n-Bu, Cl), (M-2175, H, CH₃, H, n-Bu, F), (M-2176, H, CH₃, H,n-Bu, CF₃), (M-2177, H, CH₃, H, n-Bu, Br), (M-2178, H, CH₃, H, n-Bu,CH₃), (M-2179, H, CH₃, H, i-Bu, H), (M-2180, H, CH₃, H, i-Bu, Cl),(M-2181, H, CH₃, H, i-Bu, F), (M-2182, H, CH₃, H, i-Bu, CF₃), (M-2183,H, CH₃, H, i-Bu, Br), (M-2184, H, CH₃, H, i-Bu, CH₃), (M-2185, H, CH₃,H, sec-Bu, H), (M-2186, H, CH₃, H, sec-Bu, Cl), (M-2187, H, CH₃, H,sec-Bu, F), (M-2188, H, CH₃, H, sec-Bu, CF₃), (M-2189, H, CH₃, H,sec-Bu, Br), (M-2190, H, CH₃, H, sec-Bu, CH₃), (M-2191, H, CH₃, H,n-Pen, H), (M-2192, H, CH₃, H, n-Pen, Cl), (M-2193, H, CH₃, H, n-Pen,F), (M-2194, H, CH₃, H, n-Pen, CF₃), (M-2195, H, CH₃, H, n-Pen, Br),(M-2196, H, CH₃, H, n-Pen, CH₃), (M-2197, H, CH₃, H, c-Pen, H), (M-2198,H, CH₃, H, c-Pen, Cl), (M-2199, H, CH₃, H, c-Pen, F), (M-2200, H, CH₃,H, c-Pen, CF₃), (M-2201, H, CH₃, H, c-Pen, Br), (M-2202, H, CH₃, H,c-Pen, CH₃), (M-2203, H, CH₃, H, n-Hex, H), (M-2204, H, CH₃, H, n-Hex,Cl), (M-2205, H, CH₃, H, n-Hex, F), (M-2206, H, CH₃, H, n-Hex, CF₃),(M-2207, H, CH₃, H, n-Hex, Br), (M-2208, H, CH₃, H, n-Hex, CH₃),(M-2209, H, CH₃, H, c-Hex, H), (M-2210, H, CH₃, H, c-Hex, Cl), (M-2211,H, CH₃, H, c-Hex, F), (M-2212, H, CH₃, H, c-Hex, CF₃), (M-2213, H, CH₃,H, c-Hex, Br), (M-2214, H, CH₃, H, c-Hex, CH₃), (M-2215, H, CH₃, H, OH,H), (M-2216, H, CH₃, H, OH, Cl), (M-2217, H, CH₃, H, OH, F), (M-2218, H,CH₃, H, OH, CF₃), (M-2219, H, CH₃, H, OH, Br), (M-2220, H, CH₃, H, OH,CH₃), (M-2221, H, CH₃, H, EtO, H), (M-2222, H, CH₃, H, EtO, Cl),(M-2223, H, CH₃, H, EtO, F), (M-2224, H, CH₃, H, EtO, CF₃), (M-2225, H,CH₃, H, EtO, Br), (M-2226, H, CH₃, H, EtO, CH₃), (M-2227, H, CH₃, H,n-PrO, H), (M-2228, H, CH₃, H, n-PrO, Cl), (M-2229, H, CH₃, H, n-PrO,F), (M-2230, H, CH₃, H, n-PrO, CF₃), (M-2231, H, CH₃, H, n-PrO, Br),(M-2232, H, CH₃, H, n-PrO, CH₃), (M-2233, H, CH₃, H, PhO, H), (M-2234,H, CH₃, H, PhO, Cl), (M-2235, H, CH₃, H, PhO, F), (M-2236, H, CH₃, H,PhO, CF₃), (M-2237, H, CH₃, H, PhO, Br), (M-2238, H, CH₃, H, PhO, CH₃),(M-2239, H, CH₃, H, BnO, H), (M-2240, H, CH₃, H, BnO, Cl), (M-2241, H,CH₃, H, BnO, F), (M-2242, H, CH₃, H, BnO, CF₃), (M-2243, H, CH₃, H, BnO,Br), (M-2244, H, CH₃, H, BnO, CH₃), (M-2245, H, CH₃, H, PhCH₂CH₂O, H),(M-2246, H, CH₃, H, PhCH₂CH₂O, Cl), (M-2247, H, CH₃, H, PhCH₂CH₂O, F),(M-2248, H, CH₃, H, PhCH₂CH₂O, CF₃), (M-2249, H, CH₃, H, PhCH₂CH₂O, Br),(M-2250, H, CH₃, H, PhCH₂CH₂O, CH₃), (M-2251, H, CH₃, H, CF₃O, H),(M-2252, H, CH₃, H, CF₃O, Cl), (M-2253, H, CH₃, H, CF₃O, F), (M-2254, H,CH₃, H, CF₃O, CF₃), (M-2255, H, CH₃, H, CF₃O, Br), (M-2256, H, CH₃, H,CF₃O, CH₃), (M-2257, H, CH₃, H, Ph, H), (M-2258, H, CH₃, H, Ph, Cl),(M-2259, H, CH₃, H, Ph, F), (M-2260, H, CH₃, H, Ph, CF₃), (M-2261, H,CH₃, H, Ph, Br), (M-2262, H, CH₃, H, Ph, CH₃), (M-2263, H, CH₃, H,4-F-Ph, H), (M-2264, H, CH₃, H, 4-F-Ph, Cl), (M-2265, H, CH₃, H, 4-F-Ph,F), (M-2266, H, CH₃, H, 4-F-Ph, CF₃), (M-2267, H, CH₃, H, 4-F-Ph, Br),(M-2268, H, CH₃, H, 4-F-Ph, CH₃), (M-2269, H, CH₃, H, 4-CF₃-Ph, H),(M-2270, H, CH₃, H, 4-CF₃-Ph, Cl), (M-2271, H, CH₃, H, 4-CF₃-Ph, F),(M-2272, H, CH₃, H, 4-CF₃-Ph, CF₃), (M-2273, H, CH₃, H, 4-CF₃-Ph, Br),(M-2274, H, CH₃, H, 4-CF₃-Ph, CH₃), (M-2275, H, CH₃, H, 4-(Me)₂N-Ph, H),(M-2276, H, CH₃, H, 4-(Me)₂N-Ph, Cl), (M-2277, H, CH₃, H, 4-(Me)₂N-Ph,F), (M-2278, H, CH₃, H, 4-(Me)₂N-Ph, CF₃), (M-2279, H, CH₃, H,4-(Me)₂N-Ph, Br), (M-2280, H, CH₃, H, 4-(Me)₂N-Ph, CH₃), (M-2281, H,CH₃, H, 4-OH-Ph, H), (M-2282, H, CH₃, H, 4-OH-Ph, Cl), (M-2283, H, CH₃,H, 4-OH-Ph, F), (M-2284, H, CH₃, H, 4-OH-Ph, CF₃), (M-2285, H, CH₃, H,4-OH-Ph, Br), (M-2286, H, CH₃, H, 4-OH-Ph, CH₃), (M-2287, H, CH₃, H,3,4-di-F-Ph, H), (M-2288, H, CH₃, H, 3,4-di-F-Ph, Cl), (M-2289, H, CH₃,H, 3,4-di-F-Ph, F), (M-2290, H, CH₃, H, 3,4-di-F-Ph, CF₃), (M-2291, H,CH₃, H, 3,4-di-F-Ph, Br), (M-2292, H, CH₃, H, 3,4-di-F-Ph, CH₃),(M-2293, H, CH₃, H, 4-COOH-Ph, H), (M-2294, H, CH₃, H, 4-COOH-Ph, Cl),(M-2295, H, CH₃, H, 4-COOH-Ph, F), (M-2296, H, CH₃, H, 4-COOH-Ph, CF₃),(M-2297, H, CH₃, H, 4-COOH-Ph, Br), (M-2298, H, CH₃, H, 4-COOH-Ph, CH₃),(M-2299, H, CH₃, H, Bn, H), (M-2300, H, CH₃, H, Bn, Cl), (M-2301, H,CH₃, H, Bn, F), (M-2302, H, CH₃, H, Bn, CF₃), (M-2303, H, CH₃, H, Bn,Br), (M-2304, H, CH₃, H, Bn, CH₃), (M-2305, H, CH₃, H, 4-F-Bn, H),(M-2306, H, CH₃, H, 4-F-Bn, Cl), (M-2307, H, CH₃, H, 4-F-Bn, F),(M-2308, H, CH₃, H, 4-F-Bn, CF₃), (M-2309, H, CH₃, H, 4-F-Bn, Br),(M-2310, H, CH₃, H, 4-F-Bn, CH₃), (M-2311, H, CH₃, H, 2-Py, H), (M-2312,H, CH₃, H, 2-Py, Cl), (M-2313, H, CH₃, H, 2-Py, F), (M-2314, H, CH₃, H,2-Py, CF₃), (M-2315, H, CH₃, H, 2-Py, Br), (M-2316, H, CH₃, H, 2-Py,CH₃), (M-2317, H, CH₃, H, 3-Py, H), (M-2318, H, CH₃, H, 3-Py, Cl),(M-2319, H, CH₃, H, 3-Py, F), (M-2320, H, CH₃, H, 3-Py, CF₃), (M-2321,H, CH₃, H, 3-Py, Br), (M-2322, H, CH₃, H, 3-Py, CH₃), (M-2323, H, CH₃,H, 4-Py, H), (M-2324, H, CH₃, H, 4-Py, Cl), (M-2325, H, CH₃, H, 4-Py,F), (M-2326, H, CH₃, H, 4-Py, CF₃), (M-2327, H, CH₃, H, 4-Py, Br),(M-2328, H, CH₃, H, 4-Py, CH₃), (M-2329, H, CH₃, H, 2-Th, H), (M-2330,H, CH₃, H, 2-Th, Cl), (M-2331, H, CH₃, H, 2-Th, F), (M-2332, H, CH₃, H,2-Th, CF₃), (M-2333, H, CH₃, H, 2-Th, Br), (M-2334, H, CH₃, H, 2-Th,CH₃), (M-2335, H, CH₃, H, 3-Th, H), (M-2336, H, CH₃, H, 3-Th, Cl),(M-2337, H, CH₃, H, 3-Th, F), (M-2338, H, CH₃, H, 3-Th, CF₃), (M-2339,H, CH₃, H, 3-Th, Br), (M-2340, H, CH₃, H, 3-Th, CH₃), (M-2341, H, CH₃,H, pyrrazol-2-yl, H), (M-2342, H, CH₃, H, pyrrazol-2-yl, Cl), (M-2343,H, CH₃, H, pyrrazol-2-yl, F), (M-2344, H, CH₃, H, pyrrazol-2-yl, CF₃),(M-2345, H, CH₃, H, pyrrazol-2-yl, Br), (M-2346, H, CH₃, H,pyrrazol-2-yl, CH₃), (M-2347, H, CH₃, H, pyrrazol-3-yl, H), (M-2348, H,CH₃, H, pyrrazol-3-yl, Cl), (M-2349, H, CH₃, H, pyrrazol-3-yl, F),(M-2350, H, CH₃, H, pyrrazol-3-yl, CF₃), (M-2351, H, C₃, H,pyrrazol-3-yl, Br), (M-2352, H, CH₃, H, pyrrazol-3-yl, CH₃), (M-2353, H,CH₃, H, pyrimidin-2-yl, H), (M-2354, H, CH₃, H, pyrimidin-2-yl, Cl),(M-2355, H, CH₃, H, pyrimidin-2-yl, F), (M-2356, H, CH₃, H,pyrimidin-2-yl, CF₃), (M-2357, H, CH₃, H, pyrimidin-2-yl, Br), (M-2358,H, CH₃, H, pyrimidin-2-yl, CH₃), (M-2359, H, CH₃, H, pyrimidin-4-yl, H),(M-2360, H, CH₃, H, pyrimidin-4-yl, Cl), (M-2361, H, CH₃, H,pyrimidin-4-yl, F), (M-2362, H, CH₃, H, pyrimidin-4-yl, CF₃), (M-2363,H, CH₃, H, pyrimidin-4-yl, Br), (M-2364, H, CH₃, H, pyrimidin-4-yl,CH₃), (M-2365, H, CH, H, pyrimidin-5-yl, H), (M-2366, H, CH₃, H,pyrimidin-5-yl, Cl), (M-2367, H, CH₃, H, pyrimidin-5-yl, F), (M-2368, H,CH₃, H, pyrimidin-5-yl, CH₃), (M-2369, H, CH₃, H, pyrimidin-5-yl, Br),(M-2370, H, CH₃, H, pyrimidin-5-yl, CH₃), (M-2371, H, CH₃, H,HOOCCH₂CH₂CH₂, H), (M-2372, H, CH₃, H, HOOCCH₂CH₂CH₂, Cl), (M-2373, H,CH₃, H, HOOCCH₂CH₂CH₂, F), (M-2374, H, CH₃, H, HOOCCH₂CH₂CH₂, CF₃),(M-2375, H, CH₃, H, HOOCCH₂CH₂CH₂, Br), (M-2376, H, CH₃, H,HOOCCH₂CH₂CH₂, CH₃), (M-2377, H, CH₃, H, HOOCCH₂CH₂CH₂CH₂, H), (M-2378,H, CH₃, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-2379, H, CH₃, H, HOOCCH₂CH₂CH₂CH₂,F), (M-2380, H, CH₃, H, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-2381, H, CH₃, H,HOOCCH₂CH₂CH₂CH₂, Br), (M-2382, H, CH₃, H, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-2383, H, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-2384, H, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-2385, H, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-2386, H, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-2387, H, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-2388, H, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-2389, H, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-2390, H, CH₃,H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-2391, H, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-2392, H, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-2393, H, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-2394, H, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-2395, H, CH₃, H, MeOCH₂, H), (M-2396,H, CH₃, H, MeOCH₂, Cl), (M-2397, H, CH₃, H, MeOCH₂, F), (M-2398, H, CH₃,H, MeOCH₂, CF₃), (M-2399, H, CH₃, H, MeOCH₂, Br), (M-2400, H, CH₃, H,MeOCH₂, CH₃), (M-2401, H, CH₃, H, EtOCH₂, H), (M-2402, H, CH₃, H,EtOCH₂, Cl), (M-2403, H, CH₃, H, EtOCH₂, F), (M-2404, H, CH₃, H, EtOCH₂,CF₃), (M-2405, H, CH₃, H, EtOCH₂, Br), (M-2406, H, CH₃, H, EtOCH₂, CH₃),(M-2407, H, CH₃, H, EtOCH₂CH₂, H), (M-2408, H, CH₃, H, EtOCH₂CH₂, Cl),(M-2409, H, CH₃, H, EtOCH₂CH₂, F), (M-2410, H, CH₃, H, EtOCH₂CH₂, CF₃),(M-2411, H, CH₃, H, EtOCH₂CH₂, Br), (M-2412, H, CH₃, H, EtOCH₂CH₂, CH₃),(M-2413, H, CH₃, H, MeOCH₂CH₂OCH₂CH₂, H), (M-2414, H, CH₃, H,MeOCH₂CH₂OCH₂CH₂, Cl), (M-2415, H, CH₃, H, MeOCH₂CH₂OCH₂CH₂, F),(M-2416, H, CH₃, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-2417, H, CH₃, H,MeOCH₂CH₂OCH₂CH₂, Br), (M-2418, H, CH₃, H, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-2419, H, CH₃, H, MeOCH₂CH₂, H), (M-2420, H, CH₃, H, MeOCH₂CH₂, Cl),(M-2421, H, CH₃, H, MeOCH₂CH₂, F), (M2422, H, CH₃, H, MeOCH₂CH₂, CF₃),(M-2423, H, CH₃, H, MeOCH₂CH₂, Br), (M-2424, H, CH₃, H, MeOCH₂CH₂, CH₃),(M-2425, H, CH₃, H, HOCH₂, H), (M-2426, H, CH₃, H, HOCH₂, Cl), (M-2427,H, CH₃, H, HOCH₂, F), (M-2428, H, CH₃, H, HOCH₂, CF₃), (M-2429, H, CH₃,H, HOCH₂, Br), (M-2430, H, CH₃, H, HOCH₂, CH₃), (M-2431, H, CH₃, H,HOCH₂CH₂, H), (M-2432, H, CH₃, H, HOCH₂CH₂, Cl), (M-2433, H, CH₃, H,HOCH₂CH₂, F), (M-2434, H, CH₃, H, HOCH₂CH₂, CF₃), (M-2435, H, CH₃, H,HOCH₂CH₂, Br), (M-2436, H, CH₃, H, HOCH₂CH₂, CH₃), (M-2437, H, CH₃, H,HOCH₂CH₂CH₂, H), (M-2438, H, CH₃, H, HOCH₂CH₂CH₂, C), (M-2439, H, CH₃,H, HOCH₂CH₂CH₂, F), (M-2440, H, CH₃, H, HOCH₂CH₂CH₂, CF₃), (M-2441, H,CH₃, H, HOCH₂CH₂CH₂, Br), (M-2442, H, CH₃, H, HOCH₂CH₂CH₂, CH₃),(M-2443, H, CH₃, H, HOCH₂CH₂CH₂CH₂, H), (M-2444, H, CH₃, H,HOCH₂CH₂CH₂CH₂, C), (M-2445, H, CH₃, H, HOCH₂CH₂CH₂CH₂, F), (M-2446, H,CH₃, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-2447, H, CH₃, H, HOCH₂CH₂CH₂CH₂, Br),(M-2448, H, CH₃, H, HOCH₂CH₂CH₂CH₂, CH₃), (M-2449, H, CH₃, H,HOCH₂CH₂CH₂CH₂CH₂, H), (M-2450, H, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-2451, H, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, F), (M-2452, H, CH₃, H,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-2453, H, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-2454, H, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-2455, H, CH₃, H,HOCH₂CH₂OCH₂CH₂, H), (M-2456, H, CH₃, H, HOCH₂CH₂CH₂CH₂, Cl), (M-2457,H, CH₃, H, HOCH₂CH₂OCH₂CH₂, F), (M-2458, H, CH₃, H, HOCH₂CH₂CH₂CH₂,CF₃), (M-2459, H, CH₃, H, HOCH₂CH₂OCH₂CH₂, Br), (M-2460, H, CH₃, H,HOCH₂CH₂OCH₂CH₂, CH₃), (M-2461, H, CH₃, H, (Me)₂N, H), (M-2462, H, CH₃,H, (Me)₂N, Cl), (M-2463, H, CH₃, H, (Me)₂N, F), (M-2464, H, CH₃, H,(Me)₂N, CF₃), (M-2465, H, CH₃, H, (Me)₂N, Br), (M-2466, H, CH₃, H,(Me)₂N, CH₃), (M-2467, H, CH₃, H, piperidin-4-yl-methyl, H), (M-2468, H,CH₃, H, piperidin-4-yl-methyl, Cl), (M-2469, H, CH₃, H,piperidin-4-yl-methyl, F), (M-2470, H, CH₃, H, piperidin-4-yl-methyl,CF₃), (M-2471, H, CH₃, H, piperidin-4-yl-methyl, Br), (M-2472, H, CH₃,H, piperidin-4-yl-methyl, CH₃), (M-2473, H, CH₃, H, cyclohexylmethyl,H), (M-2474, H, CH₃, H, cyclohexylmethyl, Cl), (M-2475, H, CH₃, H,cyclohexylmethyl, F), (M-2476, H, CH₃, H, cyclohexylmethyl, CF₃),(M-2477, H, CH₃, H, cyclohexylmethyl, Br), (M-2478, H, CH₃, H,cyclohexylmethyl, CH₃), (M-2479, H, CH₃, F, H, H), (M-2480, H, CH₃, F,H, Cl), (M-2481, H, CH₃, F, H, F), (M-2482, H, CH₃, F, H, CF₃), (M-2483,H, CH₃, F, H, Br), (M-2484, H, CH₃, F, H, CH₃), (M-2485, H, CH₃, F, F,H), (M-2486, H, CH₃, F, F, Cl), (M-2487, H, CH₃, F, F, F), (M-2488, H,CH₃, F, F, CF₃), (M-2489, H, CH₃, F, F, Br), (M-2490, H, CH₃, F, F,CH₃), (M-2491, H, CH₃, F, Cl, H), (M-2492, H, CH₃, F, Cl, Cl), (M-2493,H, CH₃, F, Cl, F), (M-2494, H, CH₃, F, Cl, CF₃), (M-2495, H, CH₃, F, Cl,Br), (M-2496, H, CH₃, F, Cl, CH₃), (M-2497, H, CH₃, F, CH₃, H), (M-2498,H, CH₃, F, CH₃, Cl), (M-2499, H, CH₃, F, CH₃, F), (M-2500, H, CH₃, F,CH₃, CF₃), (M-2501, H, CH₃, F, CH₃, Br), (M-2502, H, CH₃, F, CH₃, CH₃),(M-2503, H, CH₃, F, Et, H), (M-2504, H, CH₃, F, Et, Cl), (M-2505, H,CH₃, F, Et, F), (M-2506, H, CH₃, F, Et, CF₃), (M-2507, H, CH₃, F, Et,Br), (M-2508, H, CH₃, F, Et, CH₃), (M-2509, H, CH₃, F, n-Pr, H),(M-2510, H, CH₃, F, n-Pr, Cl), (M-2511, H, CH₃, F, n-Pr, F), (M-2512, H,CH₃, F, n-Pr, CF₃), (M-2513, H, CH₃, F, n-Pr, Br), (M-2514, H, CH₃, F,n-Pr, CH₃), (M-2515, H, CH₃, F, c-Pr, H), (M-2516, H, CH₃, F, c-Pr, Cl),(M-2517, H, CH₃, F, c-Pr, F), (M-2518, H, CH₃, F, c-Pr, CF₃), (M-2519,H, CH₃, F, c-Pr, Br), (M-2520, H, CH₃, F, c-Pr, CH₃), (M-2521, H, CH₃,F, i-Pr, H), (M-2522, H, CH₃, F, i-Pr, Cl), (M-2523, H, CH₃, F, i-Pr,F), (M-2524, H, CH₃, F, i-Pr, CF₃), (M-2525, H, CH₃, F, i-Pr, Br),(M-2526, H, CH₃, F, i-Pr, CH₃), (M-2527, H, CH₃, F, n-Bu, H), (M-2528,H, CH₃, F, n-Bu, Cl), (M-2529, H, CH₃, F, n-Bu, F), (M-2530, H, CH₃, F,n-Bu, CF₃), (M-2531, H, CH₃, F, n-Bu, Br), (M-2532, H, CH₃, F, n-Bu,CH₃), (M-2533, H, CH₃, F, i-Bu, H), (M-2534, H, CH₃, F, i-Bu, Cl),(M-2535, H, CH₃, F, i-Bu, F), (M-2536, H, CH₃, F, i-Bu, CF₃), (M-2537,H, CH₃, F, i-Bu, Br), (M-2538, H, CH₃, F, i-Bu, CH₃), (M-2539, H, CH₃,F, sec-Bu, H), (M-2540, H, CH₃, F, sec-Bu, Cl), (M-2541, H, CH₃, F,sec-Bu, F), (M-2542, H, CH₃, F, sec-Bu, CF₃), (M-2543, H, CH₃, F,sec-Bu, Br), (M-2544, H, CH₃, F, sec-Bu, CH₃), (M-2545, H, CH₃, F,n-Pen, H), (M-2546, H, CH₃, F, n-Pen, Cl), (M-2547, H, CH₃, F, n-Pen,F), (M-2548, H, CH₃, F, n-Pen, CF₃), (M-2549, H, CH₃, F, n-Pen, Br),(M-2550, H, CH₃, F, n-Pen, CH₃), (M-2551, H, CH₃, F, c-Pen, H), (M-2552,H, CH₃, F, c-Pen, Cl), (M-2553, H, CH₃, F, c-Pen, F), (M-2554, H, CH₃,F, c-Pen, CF₃), (M-2555, H, CH₃, F, c-Pen, Br), (M-2556, H, CH₃, F,c-Pen, CH₃), (M-2557, H, CH₃, F, n-Hex, H), (M-2558, H, CH₃, F, n-Hex,Cl), (M-2559, H, CH₃, F, n-Hex, F), (M-2560, H, CH₃, F, n-Hex, CF₃),(M-2561, H, CH₃, F, n-Hex, Br), (M-2562, H, CH₃, F, n-Hex, CH₃),(M-2563, H, CH₃, F, c-Hex, H), (M-2564, H, CH₃, F, c-Hex, Cl), (M-2565,H, CH₃, F, c-Hex, F), (M-2566, H, CH₃, F, c-Hex, CF₃), (M-2567, H, CH₃,F, c-Hex, Br), (M-2568, H, CH₃, F, c-Hex, CH₃), (M-2569, H, CH₃, F, OH,H), (M-2570, H, CH₃, F, OH, Cl), (M-2571, H, CH₃, F, OH, F), (M-2572, H,CH₃, F, OH, CF₃), (M-2573, H, CH₃, F, OH, Br), (M-2574, H, CH₃, F, OH,CH₃), (M-2575, H, CH₃, F, EtO, H), (M-2576, H, CH₃, F, EtO, Cl),(M-2577, H, CH₃, F, EtO, F), (M-2578, H, CH₃, F, EtO, CF₃), (M-2579, H,CH₃, F, EtO, Br), (M-2580, H, CH₃, F, EtO, CH₃), (M-2581, H, CH₃, F,n-PrO, H), (M-2582, H, CH₃, F, n-PrO, Cl), (M-2583, H, CH₃, F, n-PrO,F), (M-2584, H, CH₃, F, n-PrO, CF₃), (M-2585, H, CH₃, F, n-PrO, Br),(M-2586, H, CH₃, F, n-PrO, CH₃), (M-2587, H, C₃, F, PhO, H), (M-2588, H,CH₃, F, PhO, Cl), (M-2589, H, CH₃, F, PhO, F), (M-2590, H, CH₃, F, PhO,CF₃), (M-2591, H, CH₃, F, PhO, Br), (M-2592, H, CH₃, F, PhO, CH₃),(M-2593, H, CH₃, F, BnO, H), (M-2594, H, CH₃, F, BnO, Cl), (M-2595, H,CH₃, F, BnO, F), (M-2596, H, CH₃, F, BnO, CF₃), (M-2597, H, CH₃, F, BnO,Br), (M-2598, H, CH₃, F, BnO, CH₃), (M-2599, H, CH₃, F, PhCH₂CH₂O, H),(M-2600, H, CH₃, F, PhCH₂CH₂O, Cl), (M-2601, H, CH₃, F, PhCH₂CH₂O, F),(M-2602, H, CH₃, F, PhCH₂CH₂O, CF₃), (M-2603, H, CH₃, F, PhCH₂CH₂O, Br),(M-2604, H, CH₃, F, PhCH₂CH₂O, CH₃), (M-2605, H, CH₃, F, CF₃O, H),(M-2606, H, CH₃, F, CF₃O, Cl), (M-2607, H, CH₃, F, CF₃O, F), (M-2608, H,CH₃, F, CF₃O, CF₃), (M-2609, H, CH₃, F, CF₃O, Br), (M-2610, H, CH₃, F,CF₃O, CH₃), (M-2611, H, CH₃, F, Ph, H), (M-2612, H, CH₃, F, Ph, Cl),(M-2613, H, CH₃, F, Ph, F), (M-2614, H, CH₃, F, Ph, CF₃), (M-2615, H,CH₃, F, Ph, Br), (M-2616, H, CH₃, F, Ph, CH₃), (M-2617, H, CH₃, F,4-F-Ph, H), (M-2618, H, CH₃, F, 4-F-Ph, Cl), (M-2619, H, CH₃, F, 4-F-Ph,F), (M-2620, H, CH₃, F, 4-F-Ph, CF₃), (M-2621, H, CH₃, F, 4-F-Ph, Br),(M-2622, H, CH₃, F, 4-F-Ph, CH₃), (M-2623, H, CH₃, F, 4-CF₃-Ph, H),(M-2624, H, CH₃, F, 4-CF₃-Ph, Cl), (M-2625, H, CH₃, F, 4-CF₃-Ph, F),(M-2626, H, CH₃, F, 4-CF₃-Ph, CF₃), (M-2627, H, CH₃, F, 4-CF₃-Ph, Br),(M-2628, H, CH₃, F, 4-CF₃-Ph, CH₃), (M-2629, H, CH₃, F, 4-(Me)₂N-Ph, H),(M-2630, H, CH₃, F, 4-(Me)₂N-Ph, Cl), (M-2631, H, CH₃, F, 4-(Me)₂N-Ph,F), (M-2632, H, CH₃, F, 4-(Me)₂N-Ph, CF₃), (M-2633, H, CH₃, F,4-(Me)₂N-Ph, Br), (M-2634, H, CH₃, F, 4-(Me)₂N-Ph, CH₃), (M-2635, H,CH₃, F, 4-OH-Ph, H), (M-2636, H, CH₃, F, 4-OH-Ph, Cl), (M-2637, H, CH₃,F, 4-OH-Ph, F), (M-2638, H, CH₃, F, 4-OH-Ph, CF₃), (M-2639, H, CH₃, F,4-OH-Ph, Br), (M-2640, H, CH₃, F, 4-OH-Ph, CH₃), (M-2641, H, CH₃, F,3,4-di-F-Ph, H), (M-2642, H, CH₃, F, 3,4-di-F-Ph, Cl), (M-2643, H, CH₃,F, 3,4-di-F-Ph, F), (M-2644, H, CH₃, F, 3,4-di-F-Ph, CF₃), (M-2645, H,CH₃, F, 3,4-di-F-Ph, Br), (M-2646, H, CH₃, F, 3,4-di-F-Ph, CH₃),(M-2647, H, CH₃, F, 4-COOH-Ph, H), (M-2648, H, CH₃, F, 4-COOH-Ph, Cl),(M-2649, H, CH₃, F, 4-COOH-Ph, F), (M-2650, H, CH₃, F, 4-COOH-Ph, CF₃),(M-2651, H, CH₃, F, 4-COOH-Ph, Br), (M-2652, H, CH₃, F, 4-COOH-Ph, CH₃),(M-2653, H, CH₃, F, Bn, H), (M-2654, H, CH₃, F, Bn, Cl), (M-2655, H,CH₃, F, Bn, F), (M-2656, H, CH₃, F, Bn, CF₃), (M-2657, H, CH₃, F, Bn,Br), (M-2658, H, CH₃, F, Bn, CH₃), (M-2659, H, CH₃, F, 4-F-Bn, H),(M-2660, H, CH₃, F, 4-F-Bn, Cl), (M-2661, H, CH₃, F, 4-F-Bn, F),(M-2662, H, CH₃, F, 4-F-Bn, CF₃), (M-2663, H, CH₃, F, 4-F-Bn, Br),(M-2664, H, CH₃, F, 4-F-Bn, CH₃), (M-2665, H, CH₃, F, 2-Py, H), (M-2666,H, CH₃, F, 2-Py, Cl), (M-2667, H, CH₃, F, 2-Py, F), (M-2668, H, CH₃, F,2-Py, CF₃), (M-2669, H, CH₃, F, 2-Py, Br), (M-2670, H, CH₃, F, 2-Py,CH₃), (M-2671, H, CH₃, F, 3-Py, H), (M-2672, H, CH₃, F, 3-Py, Cl),(M-2673, H, CH₃, F, 3-Py, F), (M-2674, H, CH₃, F, 3-Py, CF₃), (M-2675,H, CH₃, F, 3-Py, Br), (M-2676, H, CH₃, F, 3-Py, CH₃), (M-2677, H, CH₃,F, 4-Py, H), (M-2678, H, CH₃, F, 4-Py, Cl), (M-2679, H, CH₃, F, 4-Py,F), (M-2680, H, CH₃, F, 4-Py, CF₃), (M-2681, H, CH₃, F, 4-Py, Br),(M-2682, H, CH₃, F, 4-Py, CH₃), (M-2683, H, CH₃, F, 2-Th, H), (M-2684,H, CH₃, F, 2-Th, Cl), (M-2685, H, CH₃, F, 2-Th, F), (M-2686, H, CH₃, F,2-Th, CF₃), (M-2687, H, CH₃, F, 2-Th, Br), (M-2688, H, CH₃, F, 2-Th,CH₃), (M-2689, H, CH₃, F, 3-Th, H), (M-2690, H, CH₃, F, 3-Th, Cl),(M-2691, H, CH₃, F, 3-Th, F), (M-2692, H, CH₃, F, 3-Th, CF₃), (M-2693,H, CH₃, F, 3-Th, Br), (M-2694, H, CH₃, F, 3-Th, CH₃), (M-2695, H, CH₃,F, pyrrazol-2-yl, H), (M-2696, H, CH₃, F, pyrrazol-2-yl, Cl), (M-2697,H, CH₃, F, pyrrazol-2-yl, F), (M-2698, H, CH₃, F, pyrrazol-2-yl, CF₃),(M-2699, H, CH₃, F, pyrrazol-2-yl, Br), (M-2700, H, CH₃, F,pyrrazol-2-yl, CH₃), (M-2701, H, CH₃, F, pyrrazol-3-yl, H), (M-2702, H,CH₃, F, pyrrazol-3-yl, Cl), (M-2703, H, CH₃, F, pyrrazol-3-yl, F),(M-2704, H, CH₃, F, pyrrazol-3-yl, CF₃), (M-2705, H, CH₃, F,pyrrazol-3-yl, Br), (M-2706, H, CH₃, F, pyrrazol-3-yl, CH₃), (M-2707, H,CH₃, F, pyrimidin-2-yl, H), (M-2708, H, CH₃, F, pyrimidin-2-yl, Cl),(M-2709, H, CH₃, F, pyrimidin-2-yl, F), (M-2710, H, CH₃, F,pyrimidin-2-yl, CF₃), (M-2711, H, CH₃, F, pyrimidin-2-yl, Br), (M-2712,H, CH₃, F, pyrimidin-2-yl, CH₃), (M-2713, H, CH₃, F, pyrimidin-4-yl, H),(M-2714, H, CH₃, F, pyrimidin-4-yl, Cl), (M-2715, H, CH₃, F,pyrimidin-4-yl, F), (M-2716, H, CH₃, F, pyrimidin-4-yl, CF₃), (M-2717,H, CH₃, F, pyrimidin-4-yl, Br), (M-2718, H, CH₃, F, pyrimidin-4-yl,CH₃), (M-2719, H, CH₃, F, pyrimidin-5-yl, H), (M-2720, H, CH₃, F,pyrimidin-5-yl, Cl), (M-2721, H, CH₃, F, pyrimidin-5-yl, F), (M-2722, H,CH₃, F, pyrimidin-5-yl, CF₃), (M-2723, H, CH₃, F, pyrimidin-5-yl, Br),(M-2724, H, CH₃, F, pyrimidin-5-yl, CH₃), (M-2725, H, CH₃, F,HOOCCH₂CH₂CH₂, H), (M-2726, H, CH₃, F, HOOCCH₂CH₂CH₂, Cl), (M-2727, H,CH₃, F, HOOCCH₂CH₂CH₂, F), (M-2728, H, CH₃, F, HOOCCH₂CH₂CH₂, CF₃),(M-2729, H, CH₃, F, HOOCCH₂CH₂CH₂, Br), (M-2730, H, CH₃, F,HOOCCH₂CH₂CH₂, CH₃), (M-2731, H, CH₃, F, HOOCCH₂CH₂CH₂CH₂, H), (M-2732,H, CH₃, F, HOOCCH₂CH₂CH₂CH₂, Cl), (M-2733, H, CH₃, F, HOOCCH₂CH₂CH₂CH₂,F), (M-2734, H, CH₃, F, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-2735, H, CH₃, F,HOOCCH₂CH₂CH₂CH₂, Br), (M-2736, H, CH₃, F, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-2737, H, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-2738, H, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-2739, H, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-2740, H, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-2741, H, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-2742, H, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-2743, H, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-2744, H, CH₃,F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-2745, H, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-2746, H, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-2747, H, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-2748, H, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-2749, H, CH₃, F, MeOCH₂, H), (M-2750,H, CH₃, F, MeOCH₂, Cl), (M-2751, H, CH₃, F, MeOCH₂, F), (M-2752, H, CH₃,F, MeOCH₂, CF₃), (M-2753, H, CH₃, F, MeOCH₂, Br), (M-2754, H, CH₃, F,MeOCH₂, CH₃), (M-2755, H, CH₃, F, EtOCH₂, H), (M-2756, H, CH₃, F,EtOCH₂, Cl), (M-2757, H, CH₃, F, EtOCH₂, F), (M-2758, H, CH₃, F, EtOCH₂,CF₃), (M-2759, H, CH₃, F, EtOCH₂, Br), (M-2760, H, CH₃, F, EtOCH₂, CH₃),(M-2761, H, CH₃, F, EtOCH₂CH₂, H), (M-2762, H, CH₃, F, EtOCH₂CH₂, Cl),(M-2763, H, CH₃, F, EtOCH₂CH₂, F), (M-2764, H, CH₃, F, EtOCH₂CH₂, CF₃),(M-2765, H, CH₃, F, EtOCH₂CH₂, Br), (M-2766, H, CH₃, F, EtOCH₂CH₂, CH₃),(M-2767, H, CH₃, F, MeOCH₂CH₂OCH₂CH₂, H), (M-2768, H, CH₃, F,MeOCH₂CH₂OCH₂CH₂, Cl), (M-2769, H, CH₃, F, MeOCH₂CH₂OCH₂CH₂, F),(M-2770, H, CH₃, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-2771, H, CH₃, F,MeOCH₂CH₂OCH₂CH₂, Br), (M-2772, H, CH₃, F, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-2773, H, CH₃, F, MeOCH₂CH₂, H), (M-2774, H, CH₃, F, MeOCH₂CH₂, Cl),(M-2775, H, CH₃, F, MeOCH₂CH₂, F), (M-2776, H, CH₃, F, MeOCH₂CH₂, CF₃),(M-2777, H, CH₃, F, MeOCH₂CH₂, Br), (M-2778, H, CH₃, F, MeOCH₂CH₂, CH₃),(M-2779, H, CH₃, F, HOCH₂, H), (M-2780, H, CH₃, F, HOCH₂, Cl), (M-2781,H, CH₃, F, HOCH₂, F), (M-2782, H, CH₃, F, HOCH₂, CF₃), (M-2783, H, CH₃,F, HOCH₂, Br), (M-2784, H, CH₃, F, HOCH₂, CH₃), (M-2785, H, CH₃, F,HOCH₂CH₂, H), (M-2786, H, CH₃, F, HOCH₂CH₂, Cl), (M-2787, H, CH₃, F,HOCH₂CH₂, F), (M-2788, H, CH₃, F, HOCH₂CH₂, CF₃), (M-2789, H, CH₃, F,HOCH₂CH₂, Br), (M-2790, H, CH₃, F, HOCH₂CH₂, CH₃), (M-2791, H, CH₃, F,HOCH₂CH₂CH₂, H), (M-2792, H, CH₃, F, HOCH₂CH₂CH₂, Cl), (M-2793, H, CH₃,F, HOCH₂CH₂CH₂, F), (M-2794, H, CH₃, F, HOCH₂CH₂CH₂, CF₃), (M-2795, H,CH₃, F, HOCH₂CH₂CH₂, Br), (M-2796, H, CH₃, F, HOCH₂CH₂CH₂, CH₃),(M-2797, H, CH₃, F, HOCH₂CH₂CH₂CH₂, H), (M-2798, H, CH₃, F,HOCH₂CH₂CH₂CH₂, Cl), (M-2799, H, CH₃, F, HOCH₂CH₂CH₂CH₂, F), (M-2800, H,CH₃, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-2801, H, CH₃, F, HOCH₂CH₂CH₂CH₂, Br),(M-2802, H, CH₃, F, HOCH₂CH₂CH₂CH₂, CH₃), (M-2803, H, CH₃, F,HOCH₂CH₂CH₂CH₂CH₂, H), (M-2804, H, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-2805, H, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, F), (M-2806, H, CH₃, F,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-2807, H, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-2808, H, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-2809, H, CH₃, F,HOCH₂CH₂OCH₂CH₂, H), (M-2810, H, CH₃, F, HOCH₂CH₂OCH₂CH₂, Cl), (M-2811,H, CH₃, F, HOCH₂CH₂OCH₂CH₂, F), (M-2812, H, CH₃, F, HOCH₂CH₂OCH₂CH₂,CF₃), (M-2813, H, CH₃, F, HOCH₂CH₂OCH₂CH₂, Br), (M-2814, H, CH₃, F,HOCH₂CH₂OCH₂CH₂, CH₃), (M-2815, H, CH₃, F, (Me)₂N, H), (M-2816, H, CH₃,F, (Me)₂N, Cl), (M-2817, H, CH₃, F, (Me)₂N, F), (M-2818, H, CH₃, F,(Me)₂N, CF₃), (M-2819, H, CH₃, F, (Me)₂N, Br), (M-2820, H, CH₃, F,(Me)₂N, CH₃), (M-2821, H, CH₃, F, piperidin-4-yl-methyl, H), (M-2822, H,CH₃, F, piperidin-4-yl-methyl, Cl), (M-2823, H, CH₃, F,piperidin-4-yl-methyl, F), (M-2824, H, CH₃, F, piperidin-4-yl-methyl,CF₃), (M-2825, H, CH₃, F, piperidin-4-yl-methyl, Br), (M-2826, H, CH₃,F, piperidin-4-yl-methyl, CH₃), (M-2827, H, CH₃, F, cyclohexylmethyl,H), (M-2828, H, CH₃, F, cyclohexylmethyl, Cl), (M-2829, H, CH₃, F,cyclohexylmethyl, F), (M-2830, H, CH₃, F, cyclohexylmethyl, CF₃),(M-2831, H, CH₃, F, cyclohexylmethyl, Br), (M-2832, H, CH₃, F,cyclohexylmethyl, CH₃), (M-2833, H, CH₃, Cl, H, H), (M-2834, H, CH₃, Cl,H, Cl), (M-2835, H, CH₃, Cl, H, F), (M-2836, H, CH₃, Cl, H, CF₃),(M-2837, H, CH₃, Cl, H, Br), (M-2838, H, CH₃, Cl, H, CH₃), (M-2839, H,CH₃, Cl, F, H), (M-2840, H, CH₃, Cl, F, Cl), (M-2841, H, CH₃, Cl, F, F),(M-2842, H, CH₃, Cl, F, CF₃), (M-2843, H, CH₃, Cl, F, Br), (M-2844, H,CH₃, Cl, F, CH₃), (M-2845, H, CH₃, Cl, Cl, H), (M-2846, H, CH₃, Cl, Cl,Cl), (M-2847, H, CH₃, Cl, Cl, F), (M-2848, H, CH₃, Cl, Cl, CF₃),(M-2849, H, CH₃, Cl, Cl, Br), (M-2850, H, CH₃, Cl, Cl, CH₃), (M-2851, H,CH₃, Cl, CH₃, H), (M-2852, H, CH₃, Cl, CH₃, Cl), (M-2853, H, CH₃, Cl,CH₃, F), (M-2854, H, CH₃, Cl, CH₃, CF₃), (M-2855, H, CH₃, Cl, CH₃, Br),(M-2856, H, CH₃, Cl, CH₃, CH₃), (M-2857, H, CH₃, Cl, Et, H), (M-2858, H,CH₃, Cl, Et, Cl), (M-2859, H, CH₃, Cl, Et, F), (M-2860, H, CH₃, Cl, Et,CF₃), (M-2861, H, CH₃, Cl, Et, Br), (M-2862, H, CH₃, Cl, Et, CH₃),(M-2863, H, CH₃, Cl, n-Pr, H), (M-2864, H, CH₃, Cl, n-Pr, Cl), (M-2865,H, CH₃, Cl, n-Pr, F), (M-2866, H, CH₃, Cl, n-Pr, CF₃), (M-2867, H, CH₃,Cl, n-Pr, Br), (M-2868, H, CH₃, Cl, n-Pr, CH₃), (M-2869, H, CH₃, Cl,c-Pr, H), (M-2870, H, CH₃, Cl, c-Pr, Cl), (M-2871, H, CH₃, Cl, c-Pr, F),(M-2872, H, CH₃, Cl, c-Pr, CF₃), (M-2873, H, CH₃, Cl, c-Pr, Br),(M-2874, H, CH₃, Cl, c-Pr, CH₃), (M-2875, H, CH₃, Cl, i-Pr, H), (M-2876,H, CH₃, Cl, i-Pr, Cl), (M-2877, H, CH₃, Cl, i-Pr, F), (M-2878, H, CH₃,Cl, i-Pr, CF₃), (M-2879, H, CH₃, Cl, i-Pr, Br), (M-2880, H, CH₃, Cl,i-Pr, CH₃), (M-2881, H, CH₃, Cl, n-Bu, H), (M-2882, H, CH₃, Cl, n-Bu,Cl), (M-2883, H, CH₃, Cl, n-Bu, F), (M-2884, H, CH₃, Cl, n-Bu, CF₃),(M-2885, H, CH₃, Cl, n-Bu, Br), (M-2886, H, CH₃, Cl, n-Bu, CH₃),(M-2887, H, CH₃, Cl, i-Bu, H), (M-2888, H, CH₃, Cl, i-Bu, Cl), (M-2889,H, CH₃, Cl, i-Bu, F), (M-2890, H, CH₃, Cl, i-Bu, CF₃), (M-2891, H, CH₃,Cl, i-Bu, Br), (M-2892, H, CH₃, Cl, i-Bu, CH₃), (M-2893, H, CH₃, Cl,sec-Bu, H), (M-2894, H, CH₃, Cl, sec-Bu, Cl), (M-2895, H, CH₃, Cl,sec-Bu, F), (M-2896, H, CH₃, Cl, sec-Bu, CF₃), (M-2897, H, CH₃, Cl,sec-Bu, Br), (M-2898, H, CH₃, Cl, sec-Bu, CH₃), (M-2899, H, CH₃, Cl,n-Pen, H), (M-2900, H, CH₃, Cl, n-Pen, Cl), (M-2901, H, CH₃, Cl, n-Pen,F), (M-2902, H, CH₃, Cl, n-Pen, CF₃), (M-2903, H, CH₃, Cl, n-Pen, Br),(M-2904, H, CH₃, Cl, n-Pen, CH₃), (M-2905, H, CH₃, Cl, c-Pen, H),(M-2906, H, CH₃, Cl, c-Pen, Cl), (M-2907, H, CH₃, Cl, c-Pen, F),(M-2908, H, CH₃, Cl, c-Pen, CF₃), (M-2909, H, CH₃, Cl, c-Pen, Br),(M-2910, H, CH₃, Cl, c-Pen, CH₃), (M-2911, H, CH₃, Cl, n-Hex, H),(M-2912, H, CH₃, Cl, n-Hex, Cl), (M-2913, H, CH₃, Cl, n-Hex, F),(M-2914, H, CH₃, Cl, n-Hex, CF₃), (M-2915, H, CH₃, Cl, n-Hex, Br),(M-2916, H, CH₃, Cl, n-Hex, CH₃), (M-2917, H, CH₃, Cl, c-Hex, H),(M-2918, H, CH₃, Cl, c-Hex, Cl), (M-2919, H, CH₃, Cl, c-Hex, F),(M-2920, H, CH₃, Cl, c-Hex, CF₃), (M-2921, H, CH₃, Cl, c-Hex, Br),(M-2922, H, CH₃, Cl, c-Hex, CH₃), (M-2923, H, CH₃, Cl, OH, H), (M-2924,H, CH₃, Cl, OH, Cl), (M-2925, H, CH₃, Cl, OH, F), (M-2926, H, CH₃, Cl,OH, CF₃), (M-2927, H, CH₃, Cl, OH, Br), (M-2928, H, CH₃, Cl, OH, CH₃),(M-2929, H, CH₃, Cl, EtO, H), (M-2930, H, CH₃, Cl, EtO, Cl), (M-2931, H,CH₃, Cl, EtO, F), (M-2932, H, CH₃, Cl, EtO, CF₃), (M-2933, H, CH₃, Cl,EtO, Br), (M-2934, H, CH₃, Cl, EtO, CH₃), (M-2935, H, CH₃, Cl, n-PrO,H), (M-2936, H, CH₃, Cl, n-PrO, Cl), (M-2937, H, CH₃, Cl, n-PrO, F),(M-2938, H, CH₃, Cl, n-PrO, CF₃), (M-2939, H, CH₃, Cl, n-PrO, Br),(M-2940, H, CH₃, Cl, n-PrO, CH₃), (M-2941, H, CH₃, Cl, PhO, H), (M-2942,H, CH₃, Cl, PhO, Cl), (M-2943, H, CH₃, Cl, PhO, F), (M-2944, H, CH₃, Cl,PhO, CF₃), (M-2945, H, CH₃, Cl, PhO, Br), (M-2946, H, CH₃, Cl, PhO,CH₃), (M-2947, H, CH₃, Cl, BnO, H), (M-2948, H, CH₃, Cl, BnO, Cl),(M-2949, H, CH₃, Cl, BnO, F), (M-2950, H, CH₃, Cl, BnO, CF₃), (M-2951,H, CH₃, Cl, BnO, Br), (M-2952, H, CH₃, Cl, BnO, CH₃), (M-2953, H, CH₃,Cl, PhCH₂CH₂O, H), (M-2954, H, CH₃, Cl, PhCH₂CH₂O, Cl), (M-2955, H, CH₃,Cl, PhCH₂CH₂O, F), (M-2956, H, CH₃, Cl, PhCH₂CH₂O, CF₃), (M-2957, H,CH₃, Cl, PhCH₂CH₂O, Br), (M-2958, H, CH₃, Cl, PhCH₂CH₂O, CH₃), (M-2959,H, CH₃, Cl, CF₃O, H), (M-2960, H, CH₃, Cl, CF₃O, Cl), (M-2961, H, CH₃,Cl, CF₃O, F), (M-2962, H, CH₃, Cl, CF₃O, CF₃), (M-2963, H, CH₃, Cl,CF₃O, Br), (M-2964, H, CH₃, Cl, CF₃O, CH₃), (M-2965, H, CH₃, Cl, Ph, H),(M-2966, H, CH₃, Cl, Ph, Cl), (M-2967, H, CH₃, Cl, Ph, F), (M-2968, H,CH₃, Cl, Ph, CF₃), (M-2969, H, CH₃, Cl, Ph, Br), (M-2970, H, CH₃, Cl,Ph, CH₃), (M-2971, H, CH₃, Cl, 4-F-Ph, H), (M-2972, H, CH₃, Cl, 4-F-Ph,Cl), (M-2973, H, CH₃, Cl, 4-F-Ph, F), (M-2974, H, CH₃, Cl, 4-F-Ph, CF₃),(M-2975, H, CH₃, Cl, 4-F-Ph, Br), (M-2976, H, CH₃, Cl, 4-F-Ph, CH₃),(M-2977, H, CH₃, Cl, 4-CF₃-Ph, H), (M-2978, H, CH₃, Cl, 4-CF₃-Ph, Cl),(M-2979, H, CH₃, Cl, 4-CF₃-Ph, F), (M-2980, H, CH₃, Cl, 4-CF₃-Ph, CF₃),(M-2981, H, CH₃, Cl, 4-CF₃-Ph, Br), (M-2982, H, CH₃, Cl, 4-CF₃-Ph, CH₃),(M-2983, H, CH₃, Cl, 4-(Me)₂N-Ph, H), (M-2984, H, CH₃, Cl, 4-(Me)₂N-Ph,Cl), (M-2985, H, CH₃, Cl, 4-(Me)₂N-Ph, F), (M-2986, H, CH₃, Cl,4-(Me)₂N-Ph, CF₃), (M-2987, H, CH₃, Cl, 4-(Me)₂N-Ph, Br), (M-2988, H,CH₃, Cl, 4-(Me)₂N-Ph, CH₃), (M-2989, H, CH₃, Cl, 4-OH-Ph, H), (M-2990,H, CH₃, Cl, 4-OH-Ph, Cl), (M-2991, H, CH₃, Cl, 4-OH-Ph, F), (M-2992, H,CH₃, Cl, 4-OH-Ph, CF₃), (M-2993, H, CH₃, Cl, 4-OH-Ph, Br), (M-2994, H,CH₃, Cl, 4-OH-Ph, CH₃), (M-2995, H, CH₃, Cl, 3,4-di-F-Ph, H), (M-2996,H, CH₃, Cl, 3,4-di-F-Ph, Cl), (M-2997, H, CH₃, Cl, 3,4-di-F-Ph, F),(M-2998, H, CH₃, Cl, 3,4-di-F-Ph, CF₃), (M-2999, H, CH₃, Cl,3,4-di-F-Ph, Br), (M-3000, H, CH₃, Cl, 3,4-di-F-Ph, CH₃), (M-3001, H,CH₃, Cl, 4-COOH-Ph, H), (M-3002, H, CH₃, Cl, 4-COOH-Ph, Cl), (M-3003, H,CH₃, Cl, 4-COOH-Ph, F), (M-3004, H, CH₃, Cl, 4-COOH-Ph, CF₃), (M-3005,H, CH₃, Cl, 4-COOH-Ph, Br), (M-3006, H, CH₃, Cl, 4-COOH-Ph, CH₃),(M-3007, H, CH₃, Cl, Bn, H), (M-3008, H, CH₃, Cl, Bn, Cl), (M-3009, H,CH₃, Cl, Bn, F), (M-3010, H, CH₃, Cl, Bn, CF₃), (M-3011, H, CH₃, Cl, Bn,Br), (M-3012, H, CH₃, Cl, Bn, CH₃), (M-3013, H, CH₃, Cl, 4-F-Bn, H),(M-3014, H, CH₃, Cl, 4-F-Bn, Cl), (M-3015, H, CH₃, Cl, 4-F-Bn, F),(M-3016, H, CH₃, Cl, 4-F-Bn, CF₃), (M-3017, H, CH₃, Cl, 4-F-Bn, Br),(M-3018, H, CH₃, Cl, 4-F-Bn, CH₃), (M-3019, H, CH₃, Cl, 2-Py, H),(M-3020, H, CH₃, Cl, 2-Py, Cl), (M-3021, H, CH₃, Cl, 2-Py, F), (M-3022,H, CH₃, Cl, 2-Py, CF₃), (M-3023, H, CH₃, Cl, 2-Py, Br), (M-3024, H, CH₃,Cl, 2-Py, CH₃), (M-3025, H, CH₃, Cl, 3-Py, H), (M-3026, H, CH₃, Cl,3-Py, Cl), (M-3027, H, CH₃, Cl, 3-Py, F), (M-3028, H, CH₃, Cl, 3-Py,CF₃), (M-3029, H, CH₃, Cl, 3-Py, Br), (M-3030, H, CH₃, Cl, 3-Py, CH₃),(M-3031, H, CH₃, Cl, 4-Py, H), (M-3032, H, CH₃, Cl, 4-Py, Cl), (M-3033,H, CH₃, Cl, 4-Py, F), (M-3034, H, CH₃, Cl, 4-Py, CF₃), (M-3035, H, CH₃,Cl, 4-Py, Br), (M-3036, H, CH₃, Cl, 4-Py, CH₃), (M-3037, H, CH₃, Cl,2-Th, H), (M-3038, H, CH₃, Cl, 2-Th, Cl), (M-3039, H, CH₃, Cl, 2-Th, F),(M-3040, H, CH₃, Cl, 2-Th, CF₃), (M-3041, H, CH₃, Cl, 2-Th, Br),(M-3042, H, CH₃, Cl, 2-Th, CH₃), (M-3043, H, CH₃, Cl, 3-Th, H), (M-3044,H, CH₃, Cl, 3-Th, Cl), (M-3045, H, CH₃, Cl, 3-Th, F), (M-3046, H, CH₃,Cl, 3-Th, CF₃), (M-3047, H, CH₃, Cl, 3-Th, Br), (M-3048, H, CH₃, Cl,3-Th, CH₃), (M-3049, H, CH₃, Cl, pyrrazol-2-yl, H), (M-3050, H, CH₃, Cl,pyrrazol-2-yl, Cl), (M-3051, H, CH₃, Cl, pyrrazol-2-yl, F), (M-3052, H,CH₃, Cl, pyrrazol-2-yl, CF₃), (M-3053, H, CH₃, Cl, pyrrazol-2-yl, Br),(M-3054, H, CH₃, Cl, pyrrazol-2-yl, CH₃), (M-3055, H, CH₃, Cl,pyrrazol-3-yl, H), (M-3056, H, CH₃, Cl, pyrrazol-3-yl, Cl), (M-3057, H,CH₃, Cl, pyrrazol-3-yl, F), (M-3058, H, CH₃, Cl, pyrrazol-3-yl, CF₃),(M-3059, H, CH₃, Cl, pyrrazol-3-yl, Br), (M-3060, H, CH₃, Cl,pyrrazol-3-yl, CH₃), (M-3061, H, CH₃, Cl, pyrimidin-2-yl, H), (M-3062,H, CH₃, Cl, pyrimidin-2-yl, Cl), (M-3063, H, CH₃, Cl, pyrimidin-2-yl,F), (M-3064, H, CH₃, Cl, pyrimidin-2-yl, CF₃), (M-3065, H, CH₃, Cl,pyrimidin-2-yl, Br), (M-3066, H, CH₃, Cl, pyrimidin-2-yl, CH₃), (M-3067,H, CH₃, Cl, pyrimidin-4-yl, H), (M-3068, H, CH₃, Cl, pyrimidin-4-yl,Cl), (M-3069, H, CH₃, Cl, pyrimidin-4-yl, F), (M-3070, H, CH₃, Cl,pyrimidin-4-yl, CF₃), (M-3071, H, CH₃, Cl, pyrimidin-4-yl, Br), (M-3072,H, CH₃, Cl, pyrimidin-4-yl, CH₃), (M-3073, H, CH₃, Cl, pyrimidin-5-yl,H), (M-3074, H, CH₃, Cl, pyrimidin-5-yl, Cl), (M-3075, H, CH₃, Cl,pyrimidin-5-yl, F), (M-3076, H, CH₃, Cl, pyrimidin-5-yl, CF₃), (M-3077,H, CH₃, Cl, pyrimidin-5-yl, Br), (M-3078, H, CH₃, Cl, pyrimidin-5-yl,CH₃), (M-3079, H, CH₃, Cl, HOOCCH₂CH₂CH₂, H), (M-3080, H, CH₃, Cl,HOOCCH₂CH₂CH₂, Cl), (M-3081, H, CH₃, Cl, HOOCCH₂CH₂CH₂, F), (M-3082, H,CH₃, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-3083, H, CH₃, Cl, HOOCCH₂CH₂CH₂, Br),(M-3084, H, CH₃, Cl, HOOCCH₂CH₂CH₂, CH₃), (M-3085, H, CH₃, Cl,HOOCCH₂CH₂CH₂CH₂, H), (M-3086, H, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Cl),(M-3087, H, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-3088, H, CH₃, Cl,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-3089, H, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Br),(M-3090, H, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-3091, H, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-3092, H, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Cl), (M-3093, H, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-3094, H, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-3095, H, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-3096, H, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-3097, H, CH₃,Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-3098, H, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-3099, H, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-3100, H, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-3101, H, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-3102, H, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-3103, H, CH₃, Cl, MeOCH₂, H), (M-3104,H, CH₃, Cl, MeOCH₂, Cl), (M-3105, H, CH₃, Cl, MeOCH₂, F), (M-3106, H,CH₃, Cl, MeOCH₂, CF₃), (M-3107, H, CH₃, Cl, MeOCH₂, Br), (M-3108, H,CH₃, Cl, MeOCH₂, CH₃), (M-3109, H, CH₃, Cl, EtOCH₂, H), (M-3110, H, CH₃,Cl, EtOCH₂, Cl), (M-3111, H, CH₃, Cl, EtOCH₂, F), (M-3112, H, CH₃, Cl,EtOCH₂, CF₃), (M-3113, H, CH₃, Cl, EtOCH₂, Br), (M-3114, H, CH₃, Cl,EtOCH₂, CH₃), (M-3115, H, CH₃, Cl, EtOCH₂CH₂, H), (M-3116, H, CH₃, Cl,EtOCH₂CH₂, Cl), (M-3117, H, CH₃, Cl, EtOCH₂CH₂, F), (M-3118, H, CH₃, Cl,EtOCH₂CH₂, CF₃), (M-3119, H, CH₃, Cl, EtOCH₂CH₂, Br), (M-3120, H, CH₃,Cl, EtOCH₂CH₂, CH₃), (M-3121, H, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-3122,H, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, Cl), (M-3123, H, CH₃, Cl,MeOCH₂CH₂OCH₂CH₂, F), (M-3124, H, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, CF₃),(M-3125, H, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, Br), (M-3126, H, CH₃, Cl,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-3127, H, CH₃, Cl, MeOCH₂CH₂, H), (M-3128, H,CH₃, Cl, MeOCH₂CH₂, Cl), (M-3129, H, CH₃, Cl, MeOCH₂CH₂, F), (M-3130, H,CH₃, Cl, MeOCH₂CH₂, CF₃), (M-3131, H, CH₃, Cl, MeOCH₂CH₂, Br), (M-3132,H, CH₃, Cl, MeOCH₂CH₂, CH₃), (M-3133, H, CH₃, Cl, HOCH₂, H), (M-3134, H,CH₃, Cl, HOCH₂, Cl), (M-3135, H, CH₃, Cl, HOCH₂, F), (M-3136, H, CH₃,Cl, HOCH₂, CF₃), (M-3137, H, CH₃, Cl, HOCH₂, Br), (M-3138, H, CH₃, Cl,HOCH₂, CH₃), (M-3139, H, CH₃, Cl, HOCH₂CH₂, H), (M-3140, H, CH₃, Cl,HOCH₂CH₂, Cl), (M-3141, H, CH₃, Cl, HOCH₂CH₂, F), (M-3142, H, CH₃, Cl,HOCH₂CH₂, CF₃), (M-3143, H, CH₃, Cl, HOCH₂CH₂, Br), (M-3144, H, CH₃, Cl,HOCH₂CH₂, CH₃), (M-3145, H, CH₃, Cl, HOCH₂CH₂CH₂, H), (M-3146, H, CH₃,Cl, HOCH₂CH₂CH₂, Cl), (M-3147, H, CH₃, Cl, HOCH₂CH₂CH₂, F), (M-3148, H,CH₃, Cl, HOCH₂CH₂CH₂, CF₃), (M-3149, H, CH₃, Cl, HOCH₂CH₂CH₂, Br),(M-3150, H, CH₃, Cl, HOCH₂CH₂CH₂, CH₃), (M-3151, H, CH₃, Cl,HOCH₂CH₂CH₂CH₂, H), (M-3152, H, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Cl), (M-3153,H, CH₃, Cl, HOCH₂CH₂CH₂CH₂, F), (M-3154, H, CH₃, Cl, HOCH₂CH₂CH₂CH₂,CF₃), (M-3155, H, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-3156, H, CH₃, Cl,HOCH₂CH₂CH₂CH₂, CH₃), (M-3157, H, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, H),(M-3158, H, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-3159, H, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-3160, H, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-3161, H, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-3162, H, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-3163, H, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, H),(M-3164, H, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-3165, H, CH₃, Cl,HOCH₂CH₂CH₂CH₂, F), (M-3166, H, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, CF₃), (M-3167,H, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, Br), (M-3168, H, CH₃, Cl, HOCH₂CH₂OCH₂CH₂,CH₃) (M-3169, H, CH₃, Cl, (Me)₂N, H), (M-3170, H, CH₃, Cl, (Me)₂N, Cl),(M-3171, H, CH₃, Cl, (Me)₂N, F), (M-3172, H, CH₃, Cl, (Me)₂N, CF₃),(M-3173, H, CH₃, Cl, (Me)₂N, Br), (M-3174, H, CH₃, Cl, (Me)₂N, CH₃),(M-3175, H, CH₃, Cl, piperidin-4-yl-methyl, H), (M-3176, H, CH₃, Cl,piperidin-4-yl-methyl, Cl), (M-3177, H, CH₃, Cl, piperidin-4-yl-methyl,F), (M-3178, H, CH₃, Cl, piperidin-4-yl-methyl, CF₃), (M-3179, H, CH₃,Cl, piperidin-4-yl-methyl, Br), (M-3180, H, CH₃, Cl,piperidin-4-yl-methyl, CH₃), (M-3181, H, CH₃, Cl, cyclohexylmethyl, H),(M-3182, H, CH₃, Cl, cyclohexylmethyl, Cl), (M-3183, H, CH₃, Cl,cyclohexylmethyl, F), (M-3184, H, CH₃, Cl, cyclohexylmethyl, CF₃),(M-3185, H, CH₃, Cl, cyclohexylmethyl, Br), (M-3186, H, CH₃, Cl,cyclohexylmethyl, CH₃), (M-3187, F, H, H, H, H), (M-3188, F, H, H, H,Cl), (M-3189, MeO, F, H, H, CF₃), (M-3190, MeO, F, F, H, CF₃), (M-3191,F, H, H, H, Br), (M-3192, F, H, H, H, CH₃), (M-3193, F, H, H, F, H),(M-3194, F, H, H, F, Cl), (M-3195, F, H, H, F, F), (M-3196, F, H, H, F,CF₃), (M-3197, F, H, H, F, Br), (M-3198, F, H, H, F, CH₃), (M-3199, F,H, H, Cl, H), (M-3200, MeO, F, H, H, n-Pr), (M-3201, F, H, H, Cl, F),(M-3202, F, H, H, Cl, CF₃), (M-3203, F, H, H, Cl, Br), (M-3204, F, H, H,Cl, CH₃), (M-3205, F, H, H, CH₃, H), (M-3206, F, H, H, CH₃, Cl),(M-3207, F, H, H, CH₃, F), (M-3208, F, H, H, CH₃, CF₃), (M-3209, F, H,H, CH₃, Br), (M-3210, F, H, H, CH₃, CH₃), (M-3211, F, H, H, Et, H),(M-3212, F, H, H, Et, Cl), (M-3213, F, H, H, Et, F), (M-3214, F, H, H,Et, CF₃), (M-3215, F, H, H, Et, Br), (M-3216, F, H, H, Et, CH₃),(M-3217, F, H, H, n-Pr, H), (M-3218, F, H, H, n-Pr, Cl), (M-3219, F, H,H, n-Pr, F), (M-3220, F, H, H, n-Pr, CF₃), (M-3221, F, H, H, n-Pr, Br),(M-3222, F, H, H, n-Pr, CH₃), (M-3223, F, H, H, c-Pr, H), (M-3224, F, H,H, c-Pr, Cl), (M-3225, F, H, H, c-Pr, F), (M-3226, F, H, H, c-Pr, CF₃),(M-3227, F, H, H, c-Pr, Br), (M-3228, F, H, H, c-Pr, CH₃), (M-3229, F,H, H, i-Pr, H), (M-3230, F, H, H, i-Pr, Cl), (M-3231, F, H, H, i-Pr, F),(M-3232, F, H, H, i-Pr, CF₃), (M-3233, F, H, H, i-Pr, Br), (M-3234, F,H, H, i-Pr, CH₃), (M-3235, F, H, H, n-Bu, H), (M-3236, F, H, H, n-Bu,Cl), (M-3237, F, H, H, n-Bu, F), (M-3238, F, H, H, n-Bu, CF₃), (M-3239,F, H, H, n-Bu, Br), (M-3240, F, H, H, n-Bu, CH₃), (M-3241, F, H, H,i-Bu, H), (M-3242, F, H, H, i-Bu, Cl), (M-3243, F, H, H, i-Bu, F),(M-3244, F, H, H, i-Bu, CF₃), (M-3245, F, H, H, i-Bu, Br), (M-3246, F,H, H, i-Bu, CH₃), (M-3247, F, H, H, sec-Bu, H), (M-3248, F, H, H,sec-Bu, Cl), (M-3249, F, H, H, sec-Bu, F), (M-3250, F, H, H, sec-Bu,CF₃), (M-3251, F, H, H, sec-Bu, Br), (M-3252, F, H, H, sec-Bu, CH₃),(M-3253, F, H, H, n-Pen, H), (M-3254, F, H, H, n-Pen, Cl), (M-3255, F,H, H, n-Pen, F), (M-3256, F, H, H, n-Pen, CF₃), (M-3257, F, H, H, n-Pen,Br), (M-3258, F, H, H, n-Pen, CH₃), (M-3259, F, H, H, c-Pen, H),(M-3260, F, H, H, c-Pen, Cl), (M-3261, F, H, H, c-Pen, F), (M-3262, F,H, H, c-Pen, CF₃), (M-3263, F, H, H, c-Pen, Br), (M-3264, F, H, H,c-Pen, CH₃), (M-3265, F, H, H, n-Hex, H), (M-3266, F, H, H, n-Hex, Cl),(M-3267, F, H, H, n-Hex, F), (M-3268, F, H, H, n-Hex, CF₃), (M-3269, F,H, H, n-Hex, Br), (M-3270, F, H, H, n-Hex, CH₃), (M-3271, F, H, H,c-Hex, H), (M-3272, F, H, H, c-Hex, Cl), (M-3273, F, H, H, c-Hex, F),(M-3274, F, H, H, c-Hex, CF₃), (M-3275, F, El, H, c-Hex, Br), (M-3276,F, H, H, c-Hex, CH₃), (M-3277, F, H, H, OH, H), (M-3278, F, H, H, OH,Cl), (M-3279, F, H, H, OH, F), (M-3280, F, H, H, OH, CF₃), (M-3281, F,H, H, OH, Br), (M-3282, F, H, H, OH, CH₃), (M-3283, F, H, H, EtO, H),(M-3284, F, H, H, EtO, Cl), (M-3285, F, H, H, EtO, F), (M-3286, F, H, H,EtO, CF₃), (M-3287, F, H, H, EtO, Br), (M-3288, F, H, H, EtO, CH₃),(M-3289, F, H, H, n-PrO, H), (M-3290, F, H, H, n-PrO, Cl), (M-3291, F,H, H, n-PrO, F), (M-3292, F, H, H, n-PrO, CF₃), (M-3293, F, H, H, n-PrO,Br), (M-3294, F, H, H, n-PrO, CH₃), (M-3295, F, H, H, PhO, H), (M-3296,F, H, H, PhO, Cl), (M-3297, F, H, H, PhO, F), (M-3298, F, H, H, PhO,CF₃), (M-3299, F, H, H, PhO, Br), (M-3300, F, H, H, PhO, CH₃), (M-3301,F, H, H, BnO, H), (M-3302, F, H, H, BnO, Cl), (M-3303, F, H, H, BnO, F),(M-3304, F, H, H, BnO, CF₃), (M-3305, F, H, H, BnO, Br), (M-3306, F, H,H, BnO, CH₃), (M-3307, F, H, H, PhCH₂CH₂O, H), (M-3308, F, H, H,PhCH₂CH₂O, Cl), (M-3309, F, H, H, PhCH₂CH₂O, F), (M-3310, F, H, H,PhCH₂CH₂O, CF₃), (M-3311, F, H, H, PhCH₂CH₂O, Br), (M-3312, F, H, H,PhCH₂CH₂O, CH₃), (M-3313, MeO, H, H, CF₃O, CH₃), (M-3314, F, H, H, CF₃O,Cl), (M-3315, F, H, H, CF₃O, F), (M-3316, F, H, H, CF₃O, CF₃), (M-3317,F, H, H, CF₃O, Br), (M-3318, F, H, H, CF₃O, CH₃), (M-3319, F, H, H, Ph,H), (M-3320, F, H, H, Ph, Cl), (M-3321, F, H, H, Ph, F), (M-3322, F, H,H, Ph, CF₃), (M-3323, F, H, H, Ph, Br), (M-3324, F, H, H, Ph, CH₃),(M-3325, F, H, H, 4-F-Ph, H), (M-3326, F, H, H, 4-F-Ph, Cl), (M-3327, F,H, H, 4-F-Ph, F), (M-3328, F, H, H, 4-F-Ph, CF₃), (M-3329, F, H, H,4-F-Ph, Br), (M-3330, F, H, H, 4-F-Ph, CH₃), (M-3331, F, H, H, 4-CF₃-Ph,H), (M-3332, F, H, H, 4-CF₃-Ph, Cl), (M-3333, F, H, H, 4-CF₃-Ph, F),(M-3334, F, H, H, 4-CF₃-Ph, CF₃), (M-3335, F, H, H, 4-CF₃-Ph, Br),(M-3336, F, H, H, 4-CF₃-Ph, CH₃), (M-3337, F, H, H, 4-(Me)₂N-Ph, H),(M-3338, F, H, H, 4-(Me)₂N-Ph, Cl), (M-3339, F, H, H, 4-(Me)₂N-Ph, F),(M-3340, F, H, H, 4-(Me)₂N-Ph, CF₃), (M-3341, F, H, H, 4-(Me)₂N-Ph, Br),(M-3342, F, H, H, 4-(Me)₂N-Ph, CH₃), (M-3343, F, H, H, 4-OH-Ph, H),(M-3344, F, H, H, 4-OH-Ph, Cl), (M-3345, F, H, H, 4-OH-Ph, F), (M-3346,F, H, H, 4-OH-Ph, CF₃), (M-3347, F, H, H, 4-OH-Ph, Br), (M-3348, F, H,H, 4-OH-Ph, CH₃), (M-3349, F, H, H, 3,4-di-F-Ph, H), (M-3350, F, H, H,3,4-di-F-Ph, Cl), (M-3351, F, H, H, 3,4-di-F-Ph, F), (M-3352, F, H, H,3,4-di-F-Ph, CF₃), (M-3353, F, H, H, 3,4-di-F-Ph, Br), (M-3354, F, H, H,3,4-di-F-Ph, CH₃), (M-3355, F, H, H, 4-COOH-Ph, H), (M-3356, F, H, H,4-COOH-Ph, Cl), (M-3357, F, H, H, 4-COOH-Ph, F), (M-3358, F, H, H,4-COOH-Ph, CF₃), (M-3359, F, H, H, 4-COOH-Ph, Br), (M-3360, F, H, H,4-COOH-Ph, CH₃), (M-3361, F, H, H, Bn, H), (M-3362, F, H, H, Bn, Cl),(M-3363, F, H, H, Bn, F), (M-3364, F, H, H, Bn, CF₃), (M-3365, F, H, H,Bn, Br), (M-3366, F, H, H, Bn, CH₃), (M-3367, F, H, H, 4-F-Bn, H),(M-3368, F, H, H, 4-F-Bn, Cl), (M-3369, F, H, H, 4-F-Bn, F), (M-3370, F,H, H, 4-F-Bn, CF₃), (M-3371, F, H, H, 4-F-Bn, Br), (M-3372, F, H, H,4-F-Bn, CH₃), (M-3373, F, H, H, 2-Py, H), (M-3374, F, H, H, 2-Py, Cl),(M-3375, F, H, H, 2-Py, F), (M-3376, F, H, H, 2-Py, CF₃), (M-3377, F, H,H, 2-Py, Br), (M-3378, F, H, H, 2-Py, CH₃), (M-3379, F, H, H, 3-Py, H),(M-3380, F, H, H, 3-Py, Cl), (M-3381, F, H, H, 3-Py, F), (M-3382, F, H,H, 3-Py, CF₃), (M-3383, F, H, H, 3-Py, Br), (M-3384, F, H, H, 3-Py,CH₃), (M-3385, F, H, H, 4-Py, H), (M-3386, F, H, H, 4-Py, Cl), (M-3387,F, H, H, 4-Py, F), (M-3388, F, H, H, 4-Py, CF₃), (M-3389, F, H, H, 4-Py,Br), (M-3390, F, H, H, 4-Py, CH₃), (M-3391, F, H, H, 2-Th, H), (M-3392,F, H, H, 2-Th, Cl), (M-3393, F, H, H, 2-Th, F), (M-3394, F, H, H, 2-Th,CF₃), (M-3395, F, H, H, 2-Th, Br), (M-3396, F, H, H, 2-Th, CH₃),(M-3397, F, H, H, 3-Th, H), (M-3398, F, H, H, 3-Th, Cl), (M-3399, F, H,H, 3-Th, F), (M-3400, F, H, H, 3-Th, CF₃), (M-3401, F, H, H, 3-Th, Br),(M-3402, F, H, H, 3-Th, CH₃), (M-3403, F, H, H, pyrrazol-2-yl, H),(M-3404, F, H, H, pyrrazol-2-yl, Cl), (M-3405, F, H, H, pyrrazol-2-yl,F), (M-3406, F, H, H, pyrrazol-2-yl, CF₃), (M-3407, F, H, H,pyrrazol-2-yl, Br), (M-3408, F, H, H, pyrrazol-2-yl, CH₃), (M-3409, F,H, H, pyrrazol-3-yl, H), (M-3410, F, H, H, pyrrazol-3-yl, Cl), (M-3411,F, H, H, pyrrazol-3-yl, F), (M-3412, F, H, H, pyrrazol-3-yl, CF₃),(M-3413, F, H, H, pyrrazol-3-yl, Br), (M-3414, F, H, H, pyrrazol-3-yl,CH₃), (M-3415, F, H, H, pyrimidin-2-yl, H), (M-3416, F, H, H,pyrimidin-2-yl, Cl), (M-3417, F, H, H, pyrimidin-2-yl, F), (M-3418, F,H, H, pyrimidin-2-yl, CF₃), (M-3419, F, H, H, pyrimidin-2-yl, Br),(M-3420, F, H, H, pyrimidin-2-yl, CH₃), (M-3421, F, H, H,pyrimidin-4-yl, H), (M-3422, F, H, H, pyrimidin-4-yl, Cl), (M-3423, F,H, H, pyrimidin-4-yl, F), (M-3424, F, H, H, pyrimidin-4-yl, CF₃),(M-3425, F, H, H, pyrimidin-4-yl, Br), (M-3426, F, H, H, pyrimidin-4-yl,CH₃), (M-3427, F, H, H, pyrimidin-5-yl, H), (M-3428, F, H, H,pyrimidin-5-yl, Cl), (M-3429, F, H, H, pyrimidin-5-yl, F), (M-3430, F,H, H, pyrimidin-5-yl, CF₃), (M-3431, F, H, H, pyrimidin-5-yl, Br),(M-3432, F, H, H, pyrimidin-5-yl, CH₃), (M-3433, F, H, H, HOOCCH₂CH₂CH₂,H), (M-3434, F, H, H, HOOCCH₂CH₂CH₂, Cl), (M-3435, F, H, H,HOOCCH₂CH₂CH₂, F), (M-3436, F, H, H, HOOCCH₂CH₂CH₂, CF₃), (M-3437, F, H,H, HOOCCH₂CH₂CH₂, Br), (M-3438, F, H, H, HOOCCH₂CH₂CH₂, CH₃), (M-3439,F, H, H, HOOCCH₂CH₂CH₂CH₂, H), (M-3440, F, H, H, HOOCCH₂CH₂CH₂CH₂, Cl),(M-3441, F, H, H, HOOCCH₂CH₂CH₂CH₂, F), (M-3442, F, H, H,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-3443, F, H, H, HOOCCH₂CH₂CH₂CH₂, Br),(M-3444, F, H, H, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-3445, F, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-3446, F, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-3447, F, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-3448, F, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-3449, F, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Br),(M-3450, F, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-3451, F, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-3452, F, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-3453, F, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-3454, F, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-3455, F, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-3456, F, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CH₃), (M-3457, F, H, H, MeOCH₂, H), (M-3458, F, H, H, MeOCH₂, Cl),(M-3459, F, H, H, MeOCH₂, F), (M-3460, F, H, H, MeOCH₂, CF₃), (M-3461,F, H, H, MeOCH₂, Br), (M-3462, F, H, H, MeOCH₂, CH₃), (M-3463, F, H, H,EtOCH₂, H), (M-3464, F, H, H, EtOCH₂, Cl), (M-3465, F, H, H, EtOCH₂, F),(M-3466, F, H, H, EtOCH₂, CF₃), (M-3467, F, H, H, EtOCH₂, Br), (M-3468,F, H, H, EtOCH₂, CH₃), (M-3469, F, H, H, EtOCH₂CH₂, H), (M-3470, F, H,H, EtOCH₂CH₂, Cl), (M-3471, F, H, H, EtOCH₂CH₂, F), (M-3472, F, H, H,EtOCH₂CH₂, CF₃), (M-3473, F, H, H, EtOCH₂CH₂, Br), (M-3474, F, H, H,EtOCH₂CH₂, CH₃), (M-3475, F, H, H, MeOCH₂CH₂OCH₂CH₂, H), (M-3476, F, H,H, MeOCH₂CH₂OCH₂CH₂, Cl), (M-3477, F, H, H, MeOCH₂CH₂OCH₂CH₂, F),(M-3478, F, H, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-3479, F, H, H,MeOCH₂CH₂OCH₂CH₂, Br), (M-3480, F, H, H, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-3481, F, H, H, MeOCH₂CH₂, H), (M-3482, F, H, H, MeOCH₂CH₂, Cl),(M-3483, F, H, H, MeOCH₂CH₂, F), (M-3484, F, H, H, MeOCH₂CH₂, CF₃),(M-3485, F, H, H, MeOCH₂CH₂, Br), (M-3486, F, H, H, MeOCH₂CH₂, CH₃),(M-3487, F, H, H, HOCH₂, H), (M-3488, F, H, H, HOCH₂, Cl), (M-3489, F,H, H, HOCH₂, F), (M-3490, F, H, H, HOCH₂, CF₃), (M-3491, F, H, H, HOCH₂,Br), (M-3492, F, H, H, HOCH₂, CH₃), (M-3493, F, H, H, HOCH₂CH₂, H),(M-3494, F, H, H, HOCH₂CH₂, Cl), (M-3495, F, H, H, HOCH₂CH₂, F),(M-3496, F, H, H, HOCH₂CH₂, CF₃), (M-3497, F, H, H, HOCH₂CH₂, Br),(M-3498, F, H, H, HOCH₂CH₂, CH₃), (M-3499, F, H, H, HOCH₂CH₂CH₂, H),(M-3500, F, H, H, HOCH₂CH₂CH₂, Cl), (M-3501, F, H, H, HOCH₂CH₂CH₂, F),(M-3502, F, H, H, HOCH₂CH₂CH₂, CF₃), (M-3503, F, H, H, HOCH₂CH₂CH₂, Br),(M-3504, F, H, H, HOCH₂CH₂CH₂, CH₃), (M-3505, F, H, H, HOCH₂CH₂CH₂CH₂,H), (M-3506, F, H, H, HOCH₂CH₂CH₂CH₂, Cl), (M-3507, F, H, H,HOCH₂CH₂CH₂CH₂, F), (M-3508, F, H, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-3509, F,H, H, HOCH₂CH₂CH₂CH₂, Br), (M-3510, F, H, H, HOCH₂CH₂CH₂CH₂, CH₃),(M-3511, F, H, H, HOCH₂CH₂CH₂CH₂CH₂, H), (M-3512, F, H, H,HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-3513, F, H, H, HOCH₂CH₂CH₂CH₂CH₂, F),(M-3514, F, H, H, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-3515, F, H, H,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-3516, F, H, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-3517, F, H, H, HOCH₂CH₂OCH₂CH₂, H), (M-3518, F, H, H,HOCH₂CH₂OCH₂CH₂, Cl), (M-3519, F, H, H, HOCH₂CH₂OCH₂CH₂, F), (M3520, F,H, H, HOCH₂CH₂OCH₂CH₂, CF₃), (M-3521, F, H, H, HOCH₂CH₂OCH₂CH₂, Br),(M-3522, F, H, H, HOCH₂CH₂OCH₂CH₂, CH₃), (M-3523, F, H, H, (Me)₂N, H),(M-3524, F, H, H, (Me)₂N, Cl), (M-3525, F, H, H, (Me)₂N, F), (M-3526, F,H, H, (Me)₂N, CF₃), (M-3527, F, H, H, (Me)₂N, Br), (M-3528, F, H, H,(Me)₂N, CH₃), (M-3529, F, H, H, piperidin-4-yl-methyl, H), (M-3530, F,H, H, piperidin-4-yl-methyl, Cl), (M-3531, F, H, H,piperidin-4-yl-methyl, F), (M-3532, F, H, H, piperidin-4-yl-methyl,CF₃), (M-3533, F, H, H, piperidin-4-yl-methyl, Br), (M-3534, F, H, H,piperidin-4-yl-methyl, CH₃), (M-3535, F, H, H, cyclohexylmethyl, H),(M-3536, F, H, H, cyclohexylmethyl, Cl), (M-3537, F, H, H,cyclohexylmethyl, F), (M-3538, F, H, H, cyclohexylmethyl, CF₃), (M-3539,F, H, H, cyclohexylmethyl, Br), (M-3540, F, H, H, cyclohexylmethyl,CH₃), (M-3541, F, H, F, H, H), (M-3542, F, H, F, H, Cl), (M-3543, F, H,F, H, F), (M-3544, F, H, F, H, CF₃), (M-3545, F, H, F, H, Br), (M-3546,F, H, F, H, CH₃), (M-3547, F, H, F, F, H), (M-3548, F, H, F, F, Cl),(M-3549, F, H, F, F, F), (M-3550, F, H, F, F, CF₃), (M-3551, F, H, F, F,Br), (M-3552, F, H, F, F, CH₃), (M-3553, F, H, F, Cl, H), (M-3554, F, H,F, Cl, Cl), (M-3555, F, H, F, Cl, F), (M-3556, F, H, F, Cl, CF₃),(M-3557, F, H, F, Cl, Br), (M-3558, F, H, F, Cl, CH₃), (M-3559, F, H, F,CH₃, H), (M-3560, F, H, F, CH₃, Cl), (M-3561, F, H, F, CH₃, F), (M-3562,F, H, F, CH₃, CF₃), (M-3563, F, H, F, CH₃, Br), (M-3564, F, H, F, CH₃,CH₃), (M-3565, F, H, F, Et, H), (M-3566, F, H, F, Et, Cl), (M-3567, F,H, F, Et, F), (M-3568, F, H, F, Et, CF₃), (M-3569, F, H, F, Et, Br),(M-3570, F, H, F, Et, CH₃), (M-3571, F, H, F, n-Pr, H), (M-3572, F, H,F, n-Pr, Cl), (M-3573, F, H, F, n-Pr, F), (M-3574, F, H, F, n-Pr, CF₃),(M-3575, F, H, F, n-Pr, Br), (M-3576, F, H, F, n-Pr, CH₃), (M-3577, F,H, F, c-Pr, H), (M-3578, F, H, F, c-Pr, Cl), (M-3579, F, H, F, c-Pr, F),(M-3580, F, H, F, c-Pr, CF₃), (M-3581, F, H, F, c-Pr, Br), (M-3582, F,H, F, c-Pr, CH₃), (M-3583, F, H, F, i-Pr, H), (M-3584, F, H, F, i-Pr,Cl), (M-3585, F, H, F, i-Pr, F), (M-3586, F, H, F, i-Pr, CF₃), (M-3587,F, H, F, i-Pr, Br), (M-3588, F, H, F, i-Pr, CH₃), (M-3589, F, H, F,n-Bu, H), (M-3590, F, H, F, n-Bu, Cl), (M-3591, F, H, F, n-Bu, F),(M-3592, F, H, F, n-Bu, CF₃), (M-3593, F, H, F, n-Bu, Br), (M-3594, F,H, F, n-Bu, CH₃), (M-3595, F, H, F, i-Bu, H), (M-3596, F, H, F, i-Bu,Cl), (M-3597, F, H, F, i-Bu, F), (M-3598, F, H, F, i-Bu, CF₃), (M-3599,F, H, F, i-Bu, Br), (M-3600, F, H, F, i-Bu, CH₃), (M-3601, F, H, F,sec-Bu, H), (M-3602, F, H, F, sec-Bu, Cl), (M-3603, F, H, F, sec-Bu, F),(M-3604, F, H, F, sec-Bu, CF₃), (M-3605, F, H, F, sec-Bu, Br), (M-3606,F, H, F, sec-Bu, CH₃), (M-3607, F, H, F, n-Pen, H), (M-3608, F, H, F,n-Pen, Cl), (M-3609, F, H, F, n-Pen, F), (M-3610, F, H, F, n-Pen, CF₃),(M-3611, F, H, F, n-Pen, Br), (M-3612, F, H, F, n-Pen, CH₃), (M-3613, F,H, F, c-Pen, H), (M-3614, F, H, F, c-Pen, Cl), (M-3615, F, H, F, c-Pen,F), (M-3616, F, H, F, c-Pen, CF₃), (M-3617, F, H, F, c-Pen, Br),(M-3618, F, H, F, c-Pen, CH₃), (M-3619, F, H, F, n-Hex, H), (M-3620, F,H, F, n-Hex, Cl), (M-3621, F, H, F, n-Hex, F), (M-3622, F, H, F, n-Hex,CF₃), (M-3623, F, H, F, n-Hex, Br), (M-3624, F, H, F, n-Hex, CH₃),(M-3625, F, H, F, c-Hex, H), (M-3626, F, H, F, c-Hex, Cl), (M-3627, F,H, F, c-Hex, F), (M-3628, F, H, F, c-Hex, CF₃), (M-3629, F, H, F, c-Hex,Br), (M-3630, F, H, F, c-Hex, CH₃), (M-3631, F, H, F, OH, H), (M-3632,F, H, F, OH, Cl), (M-3633, F, H, F, OH, F), (M-3634, F, H, F, OH, CF₃),(M-3635, F, H, F, OH, Br), (M-3636, F, H, F, OH, CH₃), (M-3637, F, H, F,EtO, H), (M-3638, F, H, F, EtO, Cl), (M-3639, F, H, F, EtO, F), (M-3640,F, H, F, EtO, CF₃), (M-3641, F, H, F, EtO, Br), (M-3642, F, H, F, EtO,CH₃), (M-3643, F, H, F, n-PrO, H), (M-3644, F, H, F, n-PrO, Cl),(M-3645, F, H, F, n-PrO, F), (M-3646, F, H, F, n-PrO, CF₃), (M-3647, F,H, F, n-PrO, Br), (M-3648, F, H, F, n-PrO, CH₃), (M-3649, F, H, F, PhO,H), (M-3650, F, H, F, PhO, Cl), (M-3651, F, H, F, PhO, F), (M-3652, F,H, F, PhO, CF₃), (M-3653, F, H, F, PhO, Br), (M-3654, F, H, F, PhO,CH₃), (M-3655, F, H, F, BnO, H), (M-3656, F, H, F, BnO, Cl), (M-3657, F,H, F, BnO, F), (M-3658, F, H, F, BnO, CF₃), (M-3659, F, H, F, BnO, Br),(M-3660, F, H, F, BnO, CH₃), (M-3661, F, H, F, PhCH₂CH₂O, H), (M-3662,F, H, F, PhCH₂CH₂O, Cl), (M-3663, F, H, F, PhCH₂CH₂O, F), (M-3664, F, H,F, PhCH₂CH₂O, CF₃), (M-3665, F, H, F, PhCH₂CH₂O, Br), (M-3666, F, H, F,PhCH₂CH₂O, CH₃), (M-3667, F, H, F, CF₃O, H), (M-3668, F, H, F, CF₃O,Cl), (M-3669, F, H, F, CF₃O, F), (M-3670, F, H, F, CF₃O, CF₃), (M-3671,F, H, F, CF₃O, Br), (M-3672, F, H, F, CF₃O, CH₃), (M-3673, F, H, F, Ph,H), (M-3674, F, H, F, Ph, Cl), (M-3675, F, H, F, Ph, F), (M-3676, F, H,F, Ph, CF₃), (M-3677, F, H, F, Ph, Br), (M-3678, F, H, F, Ph, CH₃),(M-3679, F, H, F, 4-F-Ph, H), (M-3680, F, H, F, 4-F-Ph, Cl), (M-3681, F,H, F, 4-F-Ph, F), (M-3682, F, H, F, 4-F-Ph, CF₃), (M-3683, F, H, F,4-F-Ph, Br), (M-3684, F, H, F, 4-F-Ph, CH₃), (M-3685, F, H, F, 4-CF₃-Ph,H), (M-3686, F, H, F, 4-CF₃-Ph, Cl), (M-3687, F, H, F, 4-CF₃-Ph, F),(M-3688, F, H, F, 4-CF₃-Ph, CF₃), (M-3689, F, H, F, 4-CF₃-Ph, Br),(M-3690, F, H, F, 4-CF₃-Ph, CH₃), (M-3691, F, H, F, 4-(Me)₂N-Ph, H),(M-3692, F, H, F, 4-(Me)₂N-Ph, Cl), (M-3693, F, H, F, 4-(Me)₂N-Ph, F),(M-3694, F, H, F, 4-(Me)₂N-Ph, CF₃), (M-3695, F, H, F, 4-(Me)₂N-Ph, Br),(M-3696, F, H, F, 4-(Me)₂N-Ph, CH₃), (M-3697, F, H, F, 4-OH-Ph, H),(M-3698, F, H, F, 4-OH-Ph, Cl), (M-3699, F, H, F, 4-OH-Ph, F), (M-3700,F, H, F, 4-OH-Ph, CF₃), (M-3701, F, H, F, 4-OH-Ph, Br), (M-3702, F, H,F, 4-OH-Ph, CH₃), (M-3703, F, H, F, 3,4-di-F-Ph, H), (M-3704, F, H, F,3,4-di-F-Ph, Cl), (M-3705, F, H, F, 3,4-di-F-Ph, F), (M-3706, F, H, F,3,4-di-F-Ph, CF₃), (M-3707, F, H, F, 3,4-di-F-Ph, Br), (M-3708, F, H, F,3,4-di-F-Ph, CH₃), (M-3709, F, H, F, 4-COOH-Ph, H), (M-3710, F, H, F,4-COOH-Ph, Cl), (M-3711, F, H, F, 4-COOH-Ph, F), (M-3712, F, H, F,4-COOH-Ph, CF₃), (M-3713, F, H, F, 4-COOH-Ph, Br), (M-3714, F, H, F,4-COOH-Ph, CH₃), (M-3715, F, H, F, Bn, H), (M-3716, F, H, F, Bn, Cl),(M-3717, F, H, F, Bn, F), (M-3718, F, H, F, Bn, CF₃), (M-3719, F, H, F,Bn, Br), (M-3720, F, H, F, Bn, CH₃), (M-3721, F, H, F, 4-F-Bn, H),(M-3722, F, H, F, 4-F-Bn, Cl), (M-3723, F, H, F, 4-F-Bn, F), (M-3724, F,H, F, 4-F-Bn, CF₃), (M-3725, F, H, F, 4-F-Bn, Br), (M-3726, F, H, F,4-F-Bn, CH₃), (M-3727, F, H, F, 2-Py, H), (M-3728, F, H, F, 2-Py, Cl),(M-3729, F, H, F, 2-Py, F), (M-3730, F, H, F, 2-Py, CF₃), (M-3731, F, H,F, 2-Py, Br), (M-3732, F, H, F, 2-Py, CH₃), (M-3733, F, H, F, 3-Py, H),(M-3734, F, H, F, 3-Py, Cl), (M-3735, F, H, F, 3-Py, F), (M-3736, F, H,F, 3-Py, CF₃), (M-3737, F, H, F, 3-Py, Br), (M-3738, F, H, F, 3-Py,CH₃), (M-3739, F, H, F, 4-Py, H), (M-3740, F, H, F, 4-Py, Cl), (M-3741,F, H, F, 4-Py, F), (M-3742, F, H, F, 4-Py, CF₃), (M-3743, F, H, F, 4-Py,Br), (M-3744, F, H, F, 4-Py, CH₃), (M-3745, F, H, F, 2-Th, H), (M-3746,F, H, F, 2-Th, Cl), (M-3747, F, H, F, 2-Th, F), (M-3748, F, H, F, 2-Th,CF₃), (M-3749, F, H, F, 2-Th, Br), (M-3750, F, H, F, 2-Th, CH₃),(M-3751, F, H, F, 3-Th, H), (M-3752, F, H, F, 3-Th, Cl), (M-3753, F, H,F, 3-Th, F), (M-3754, F, H, F, 3-Th, CF₃), (M-3755, F, H, F, 3-Th, Br),(M-3756, F, H, F, 3-Th, CH₃), (M-3757, F, H, F, pyrrazol-2-yl, H),(M-3758, F, H, F, pyrrazol-2-yl, Cl), (M-3759, F, H, F, pyrrazol-2-yl,F), (M-3760, F, H, F, pyrrazol-2-yl, CF₃), (M-3761, F, H, F,pyrrazol-2-yl, Br), (M-3762, F, H, F, pyrrazol-2-yl, CH₃), (M-3763, F,H, F, pyrrazol-3-yl, H), (M-3764, F, H, F, pyrrazol-3-yl, Cl), (M-3765,F, H, F, pyrrazol-3-yl, F), (M-3766, F, H, F, pyrrazol-3-yl, CF₃),(M-3767, F, H, F, pyrrazol-3-yl, Br), (M-3768, F, H, F, pyrrazol-3-yl,CH₃), (M-3769, F, H, F, pyrimidin-2-yl, H), (M-3770, F, H, F,pyrimidin-2-yl, Cl), (M-3771, F, H, F, pyrimidin-2-yl, F), (M-3772, F,H, F, pyrimidin-2-yl, CF₃), (M-3773, F, H, F, pyrimidin-2-yl, Br),(M-3774, F, H, F, pyrimidin-2-yl, CH₃), (M-3775, F, H, F,pyrimidin-4-yl, H), (M-3776, F, H, F, pyrimidin-4-yl, Cl), (M-3777, F,H, F, pyrimidin-4-yl, F), (M-3778, F, H, F, pyrimidin-4-yl, CF₃),(M-3779, F, H, F, pyrimidin-4-yl, Br), (M-3780, F, H, F, pyrimidin-4-yl,CH₃), (M-3781, F, H, F, pyrimidin-5-yl, H), (M-3782, F, H, F,pyrimidin-5-yl, Cl), (M-3783, F, H, F, pyrimidin-5-yl, F), (M-3784, F,H, F, pyrimidin-5-yl, CF₃), (M-3785, F, H, F, pyrimidin-5-yl, Br),(M-3786, F, H, F, pyrimidin-5-yl, CH₃), (M-3787, F, H, F, HOOCCH₂CH₂CH₂,H), (M-3788, F, H, F, HOOCCH₂CH₂CH₂, Cl), (M-3789, F, H, F,HOOCCH₂CH₂CH₂, F), (M-3790, F, H, F, HOOCCH₂CH₂CH₂, CF₃), (M-3791, F, H,F, HOOCCH₂CH₂CH₂, Br), (M-3792, F, H, F, HOOCCH₂CH₂CH₂, CH₃), (M-3793,F, H, F, HOOCCH₂CH₂CH₂CH₂, H), (M-3794, F, H, F, HOOCCH₂CH₂CH₂CH₂, Cl),(M-3795, F, H, F, HOOCCH₂CH₂CH₂CH₂, F), (M-3796, F, H, F,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-3797, F, H, F, HOOCCH₂CH₂CH₂CH₂, Br),(M-3798, F, H, F, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-3799, F, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-3800, F, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-3801, F, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-3802, F, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-3803, F, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Br),(M-3804, F, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-3805, F, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-3806, F, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-3807, F, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-3808, F, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-3809, F, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-3810, F, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CH₃), (M-3811, F, H, F, MeOCH₂, H), (M-3812, F, H, F, MeOCH₂, Cl),(M-3813, F, H, F, MeOCH₂, F), (M-3814, F, H, F, MeOCH₂, CF₃), (M-3815,F, H, F, MeOCH₂, Br), (M-3816, F, H, F, MeOCH₂, CH₃), (M-3817, F, H, F,EtOCH₂, H), (M-3818, F, H, F, EtOCH₂, Cl), (M-3819, F, H, F, EtOCH₂, F),(M-3820, F, H, F, EtOCH₂, CF₃), (M-3821, F, H, F, EtOCH₂, Br), (M-3822,F, H, F, EtOCH₂, CH₃), (M-3823, F, H, F, EtOCH₂CH₂, H), (M-3824, F, H,F, EtOCH₂CH₂, Cl), (M-3825, F, H, F, EtOCH₂CH₂, F), (M-3826, F, H, F,EtOCH₂CH₂, CF₃), (M-3827, F, H, F, EtOCH₂CH₂, Br), (M-3828, F, H, F,EtOCH₂CH₂, CH₃), (M-3829, F, H, F, MeOCH₂CH₂OCH₂CH₂, H), (M-3830, F, H,F, MeOCH₂CH₂OCH₂CH₂, Cl), (M-3831, F, H, F, MeOCH₂CH₂OCH₂CH₂, F),(M-3832, F, H, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-3833, F, H, F,MeOCH₂CH₂OCH₂CH₂, Br), (M-3834, F, H, F, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-3835, F, H, F, MeOCH₂CH₂, H), (M-3836, F, H, F, MeOCH₂CH₂, Cl),(M-3837, F, H, F, MeOCH₂CH₂, F), (M-3838, F, H, F, MeOCH₂CH₂, CF₃),(M-3839, F, H, F, MeOCH₂CH₂, Br), (M-3840, F, H, F, MeOCH₂CH₂, CH₃),(M-3841, F, H, F, HOCH₂, H), (M-3842, F, H, F, HOCH₂, Cl), (M-3843, F,H, F, HOCH₂, F), (M-3844, F, H, F, HOCH₂, CF₃), (M-3845, F, H, F, HOCH₂,Br), (M-3846, F, H, F, HOCH₂, CH₃), (M-3847, F, H, F, HOCH₂CH₂, H),(M-3848, F, H, F, HOCH₂CH₂, Cl), (M-3849, F, H, F, HOCH₂CH₂, F),(M-3850, F, H, F, HOCH₂CH₂, CF₃), (M-3851, F, H, F, HOCH₂CH₂, Br),(M-3852, F, H, F, HOCH₂CH₂, CH₃), (M-3853, F, H, F, HOCH₂CH₂CH₂, H),(M-3854, F, H, F, HOCH₂CH₂CH₂, Cl), (M-3855, F, H, F, HOCH₂CH₂CH₂, F),(M-3856, F, H, F, HOCH₂CH₂CH₂, CF₃), (M-3857, F, H, F, HOCH₂CH₂CH₂, Br),(M-3858, F, H, F, HOCH₂CH₂CH₂, CH₃), (M-3859, F, H, F, HOCH₂CH₂CH₂CH₂,H), (M-3860, F, H, F, HOCH₂CH₂CH₂CH₂, Cl), (M-3861, F, H, F,HOCH₂CH₂CH₂CH₂, F), (M-3862, F, H, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-3863, F,H, F, HOCH₂CH₂CH₂CH₂, Br), (M-3864, F, H, F, HOCH₂CH₂CH₂CH₂, CH₃),(M-3865, F, H, F, HOCH₂CH₂CH₂CH₂CH₂, H), (M-3866, F, H, F,HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-3867, F, H, F, HOCH₂CH₂CH₂CH₂CH₂, F),(M-3868, F, H, F, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-3869, F, H, F,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-3870, F, H, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-3871, F, H, F, HOCH₂CH₂OCH₂CH₂, H), (M-3872, F, H, F,HOCH₂CH₂OCH₂CH₂, Cl), (M-3873, F, H, F, HOCH₂CH₂OCH₂CH₂, F), (M-3874, F,H, F, HOCH₂CH₂OCH₂CH₂, CF₃), (M-3875, F, H, F, HOCH₂CH₂OCH₂CH₂, Br),(M-3876, F, H, F, HOCH₂CH₂OCH₂CH₂, CH₃), (M-3877, F, H, F, (Me)₂N, H),(M-3878, F, H, F, (Me)₂N, Cl), (M-3879, F, H, F, (Me)₂N, F), (M-3880, F,H, F, (Me)₂N, CF₃), (M-3881, F, H, F, (Me)₂N, Br), (M-3882, F, H, F,(Me)₂N, CH₃), (M-3883, F, H, F, piperidin-4-yl-methyl, H), (M-3884, F,H, F, piperidin-4-yl-methyl, Cl), (M-3885, F, H, F,piperidin-4-yl-methyl, F), (M-3886, F, H, F, piperidin-4-yl-methyl,CF₃), (M-3887, F, H, F, piperidin-4-yl-methyl, Br), (M-3888, F, H, F,piperidin-4-yl-methyl, CH₃), (M-3889, F, H, F, cyclohexylmethyl, H),(M-3890, F, H, F, cyclohexylmethyl, Cl), (M-3891, F, H, F,cyclohexylmethyl, F), (M-3892, F, H, F, cyclohexylmethyl, CF₃), (M-3893,F, H, F, cyclohexylmethyl, Br), (M-3894, F, H, F, cyclohexylmethyl,CH₃), (M-3895, F, H, Cl, H, H), (M-3896, F, H, Cl, H, Cl), (M-3897, F,H, Cl, H, F), (M-3898, F, H, Cl, H, CF₃), (M-3899, F, H, Cl, H, Br),(M-3900, F, H, Cl, H, CH₃), (M-3901, F, H, Cl, F, H), (M-3902, F, H, Cl,F, Cl), (M-3903, F, H, Cl, F, F), (M-3904, F, H, Cl, F, CF₃), (M-3905,F, H, Cl, F, Br), (M-3906, F, H, Cl, F, CH₃), (M-3907, F, H, Cl, Cl, H),(M-3908, F, H, Cl, Cl, Cl), (M-3909, F, H, Cl, Cl, F), (M-3910, F, H,Cl, Cl, CF₃), (M-3911, F, H, Cl, Cl, Br), (M-3912, F, H, Cl, Cl, CH₃),(M-3913, F, H, Cl, CH₃, H), (M-3914, F, H, Cl, CH₃, Cl), (M-3915, F, H,Cl, CH₃, F), (M-3916, F, H, Cl, CH₃, CF₃), (M-3917, F, H, Cl, CH₃, Br),(M-3918, F, H, Cl, CH₃, CH₃), (M-3919, F, H, Cl, Et, H), (M-3920, F, H,Cl, Et, Cl), (M-3921, F, H, Cl, Et, F), (M-3922, F, H, Cl, Et, CF₃),(M-3923, F, H, Cl, Et, Br), (M-3924, F, H, Cl, Et, CH₃), (M-3925, F, H,Cl, n-Pr, H), (M-3926, F, H, Cl, n-Pr, Cl), (M-3927, F, H, Cl, n-Pr, F),(M-3928, F, H, Cl, n-Pr, CF₃), (M-3929, F, H, Cl, n-Pr, Br), (M-3930, F,H, Cl, n-Pr, CH₃), (M-3931, F, H, Cl, c-Pr, H), (M-3932, F, H, Cl, c-Pr,Cl), (M-3933, F, H, Cl, c-Pr, F), (M-3934, F, H, Cl, c-Pr, CF₃),(M-3935, F, H, Cl, c-Pr, Br), (M-3936, F, H, Cl, c-Pr, CH₃), (M-3937, F,H, Cl, i-Pr, H), (M-3938, F, H, Cl, i-Pr, Cl), (M-3939, F, H, Cl, i-Pr,F), (M-3940, F, H, Cl, i-Pr, CF₃), (M-3941, F, H, Cl, i-Pr, Br),(M-3942, F, H, Cl, i-Pr, CH₃), (M-3943, F, H, Cl, n-Bu, H), (M-3944, F,H, Cl, n-Bu, Cl), (M-3945, F, H, Cl, n-Bu, F), (M-3946, F, H, Cl, n-Bu,CF₃), (M-3947, F, H, Cl, n-Bu, Br), (M-3948, F, H, Cl, n-Bu, CH₃),(M-3949, F, H, Cl, i-Bu, H), (M-3950, F, H, Cl, i-Bu, Cl), (M-3951, F,H, Cl, i-Bu, F), (M-3952, F, H, Cl, i-Bu, CF₃), (M-3953, F, H, Cl, i-Bu,Br), (M-3954, F, H, Cl, i-Bu, CH₃), (M-3955, F, H, Cl, sec-Bu, H),(M-3956, F, H, Cl, sec-Bu, Cl), (M-3957, F, H, Cl, sec-Bu, F), (M-3958,F, H, Cl, sec-Bu, CF₃), (M-3959, F, H, Cl, sec-Bu, Br), (M-3960, F, H,Cl, sec-Bu, CH₃), (M-3961, F, H, Cl, n-Pen, H), (M-3962, F, H, Cl,n-Pen, Cl), (M-3963, F, H, Cl, n-Pen, F), (M-3964, F, H, Cl, n-Pen,CF₃), (M-3965, F, H, Cl, n-Pen, Br), (M-3966, F, H, Cl, n-Pen, CH₃),(M-3967, F, H, Cl, c-Pen, H), (M-3968, F, H, Cl, c-Pen, Cl), (M-3969, F,H, Cl, c-Pen, F), (M-3970, F, H, Cl, c-Pen, CF₃), (M-3971, F, H, Cl,c-Pen, Br), (M-3972, F, H, Cl, c-Pen, CH₃), (M-3973, F, H, Cl, n-Hex,H), (M-3974, F, H, Cl, n-Hex, Cl), (M-3975, F, H, Cl, n-Hex, F),(M-3976, F, H, Cl, n-Hex, CF₃), (M-3977, F, H, Cl, n-Hex, Br), (M-3978,F, H, Cl, n-Hex, CH₃), (M-3979, F, H, Cl, c-Hex, H), (M-3980, F, H, Cl,c-Hex, Cl), (M-3981, F, H, Cl, c-Hex, F), (M-3982, F, H, Cl, c-Hex,CF₃), (M-3983, F, H, Cl, c-Hex, Br), (M-3984, F, H, Cl, c-Hex, CH₃),(M-3985, F, H, Cl, OH, H), (M-3986, F, H, Cl, OH, Cl), (M-3987, F, H,Cl, OH, F), (M-3988, F, H, Cl, OH, CF₃), (M-3989, F, H, Cl, OH, Br),(M-3990, F, H, Cl, OH, CH₃), (M-3991, F, H, Cl, EtO, H), (M-3992, F, H,Cl, EtO, Cl), (M-3993, F, H, Cl, EtO, F), (M-3994, F, H, Cl, EtO, CF₃),(M-3995, F, H, Cl, EtO, Br), (M-3996, F, H, Cl, EtO, CH₃), (M-3997, F,H, Cl, n-PrO, H), (M-3998, F, H, Cl, n-PrO, Cl), (M-3999, F, H, Cl,n-PrO, F), (M-4000, F, H, Cl, n-PrO, CF₃), (M-4001, F, H, Cl, n-PrO,Br), (M-4002, F, H, Cl, n-PrO, CH₃), (M-4003, F, H, Cl, PhO, H),(M-4004, F, H, Cl, PhO, Cl), (M-4005, F, H, Cl, PhO, F), (M-4006, F, H,Cl, PhO, CF₃), (M-4007, F, H, Cl, PhO, Br), (M-4008, F, H, Cl, PhO,CH₃), (M-4009, F, H, Cl, BnO, H), (M-4010, F, H, Cl, BnO, Cl), (M-4011,F, H, Cl, BnO, F), (M-4012, F, H, Cl, BnO, CF₃), (M-4013, F, H, Cl, BnO,Br), (M-4014, F, H, Cl, BnO, CH₃), (M-4015, F, H, Cl, PhCH₂CH₂O, H),(M-4016, F, H, Cl, PhCH₂CH₂O, Cl), (M-4017, F, H, Cl, PhCH₂CH₂O, F),(M-4018, F, H, Cl, PhCH₂CH₂O, CF₃), (M-4019, F, H, Cl, PhCH₂CH₂O, Br),(M-4020, F, H, Cl, PhCH₂CH₂O, CH₃), (M-4021, F, H, Cl, CF₃O, H),(M-4022, F, H, Cl, CF₃O, Cl), (M-4023, F, H, Cl, CF₃O, F), (M-4024, F,H, Cl, CF₃O, CF₃), (M-4025, F, H, Cl, CF₃O, Br), (M-4026, F, H, Cl,CF₃O, CH₃), (M-4027, F, H, Cl, Ph, H), (M-4028, F, H, Cl, Ph, Cl),(M-4029, F, H, Cl, Ph, F), (M-4030, F, H, Cl, Ph, CF₃), (M-4031, F, H,Cl, Ph, Br), (M-4032, F, H, Cl, Ph, CH₃), (M-4033, F, H, Cl, 4-F-Ph, H),(M-4034, F, H, Cl, 4-F-Ph, Cl), (M-4035, F, H, Cl, 4-F-Ph, F), (M-4036,F, H, Cl, 4-F-Ph, CF₃), (M-4037, F, H, Cl, 4-F-Ph, Br), (M-4038, F, H,Cl, 4-F-Ph, CH₃), (M-4039, F, H, Cl, 4-CF₃-Ph, H), (M-4040, F, H, Cl,4-CF₃-Ph, Cl), (M-4041, F, H, Cl, 4-CF₃-Ph, F), (M-4042, F, H, Cl,4-CF₃-Ph, CF₃), (M-4043, F, H, Cl, 4-CF₃-Ph, Br), (M-4044, F, H, Cl,4-CF₃-Ph, CH₃), (M-4045, F, H, Cl, 4-(Me)₂N-Ph, H), (M-4046, F, H, Cl,4-(Me)₂N-Ph, Cl), (M-4047, F, H, Cl, 4-(Me)₂N-Ph, F), (M-4048, F, H, Cl,4-(Me)₂N-Ph, CF₃), (M-4049, F, H, Cl, 4-(Me)₂N-Ph, Br), (M-4050, F, H,Cl, 4-(Me)₂N-Ph, CH₃), (M-4051, F, H, Cl, 4-OH-Ph, H), (M-4052, F, H,Cl, 4-OH-Ph, Cl), (M-4053, F, H, Cl, 4-OH-Ph, F), (M-4054, F, H, Cl,4-OH-Ph, CF₃), (M-4055, F, H, Cl, 4-OH-Ph, Br), (M-4056, F, H, Cl,4-OH-Ph, CH₃), (M-4057, F, H, Cl, 3,4-di-F-Ph, H), (M-4058, F, H, Cl,3,4-di-F-Ph, Cl), (M-4059, F, H, Cl, 3,4-di-F-Ph, F), (M-4060, F, H, Cl,3,4-di-F-Ph, CF₃), (M-4061, F, H, Cl, 3,4-di-F-Ph, Br), (M-4062, F, H,Cl, 3,4-di-F-Ph, CH₃), (M-4063, F, H, Cl, 4-COOH-Ph, H), (M-4064, F, H,Cl, 4-COOH-Ph, Cl), (M-4065, F, H, Cl, 4-COOH-Ph, F), (M-4066, F, H, Cl,4-COOH-Ph, CF₃), (M-4067, F, H, Cl, 4-COOH-Ph, Br), (M-4068, F, H, Cl,4-COOH-Ph, CH₃), (M-4069, F, H, Cl, Bn, H), (M-4070, F, H, Cl, Bn, Cl),(M-4071, F, H, Cl, Bn, F), (M-4072, F, H, Cl, Bn, CF₃), (M-4073, F, H,Cl, Bn, Br), (M-4074, F, H, Cl, Bn, CH₃), (M-4075, F, H, Cl, 4-F-Bn, H),(M-4076, F, H, Cl, 4-F-Bn, Cl), (M-4077, F, H, Cl, 4-F-Bn, F), (M-4078,F, H, Cl, 4-F-Bn, CF₃), (M-4079, F, H, Cl, 4-F-Bn, Br), (M-4080, F, H,Cl, 4-F-Bn, CH₃), (M-4081, F, H, Cl, 2-Py, H), (M-4082, F, H, Cl, 2-Py,Cl), (M-4083, F, H, Cl, 2-Py, F), (M-4084, F, H, Cl, 2-Py, CF₃),(M-4085, F, H, Cl, 2-Py, Br), (M-4086, F, H, Cl, 2-Py, CH₃), (M-4087, F,H, Cl, 3-Py, H), (M-4088, F, H, Cl, 3-Py, Cl), (M-4089, F, H, Cl, 3-Py,F), (M-4090, F, H, Cl, 3-Py, CF₃), (M-4091, F, H, Cl, 3-Py, Br),(M-4092, F, H, Cl, 3-Py, CH₃), (M-4093, F, H, Cl, 4-Py, H), (M-4094, F,H, Cl, 4-Py, Cl), (M-4095, F, H, Cl, 4-Py, F), (M-4096, F, H, Cl, 4-Py,CF₃), (M-4097, F, H, Cl, 4-Py, Br), (M-4098, F, H, Cl, 4-Py, CH₃),(M-4099, F, H, Cl, 2-Th, H), (M-4100, F, H, Cl, 2-Th, Cl), (M-4101, F,H, Cl, 2-Th, F), (M-4102, F, H, Cl, 2-Th, CF₃), (M-4103, F, H, Cl, 2-Th,Br), (M-4104, F, H, Cl, 2-Th, CH₃), (M-4105, F, H, Cl, 3-Th, H),(M-4106, F, H, Cl, 3-Th, Cl), (M-4107, F, H, Cl, 3-Th, F), (M-4108, F,H, Cl, 3-Th, CF₃), (M-4109, F, H, Cl, 3-Th, Br), (M-4110, F, H, Cl,3-Th, CH₃), (M-4111, F, H, Cl, pyrrazol-2-yl, H), (M-4112, F, H, Cl,pyrrazol-2-yl, Cl), (M-4113, F, H, Cl, pyrrazol-2-yl, F), (M-4114, F, H,Cl, pyrrazol-2-yl, CF₃), (M-4115, F, H, Cl, pyrrazol-2-yl, Br), (M-4116,F, H, Cl, pyrrazol-2-yl, CH₃), (M-4117, F, H, Cl, pyrrazol-3-yl, H),(M-4118, F, H, Cl, pyrrazol-3-yl, Cl), (M-4119, F, H, Cl, pyrrazol-3-yl,F), (M-4120, F, H, Cl, pyrrazol-3-yl, CF₃), (M-4121, F, H, Cl,pyrrazol-3-yl, Br), (M-4122, F, H, Cl, pyrrazol-3-yl, CH₃), (M-4123, F,H, Cl, pyrimidin-2-yl, H), (M-4124, F, H, Cl, pyrimidin-2-yl, Cl),(M-4125, F, H, Cl, pyrimidin-2-yl, F), (M-4126, F, H, Cl,pyrimidin-2-yl, CF₃), (M-4127, F, H, Cl, pyrimidin-2-yl, Br), (M-4128,F, H, Cl, pyrimidin-2-yl, CH₃), (M-4129, F, H, Cl, pyrimidin-4-yl, H),(M-4130, F, H, Cl, pyrimidin-4-yl, Cl), (M-4131, F, H, Cl,pyrimidin-4-yl, F), (M-4132, F, H, Cl, pyrimidin-4-yl, CF₃), (M-4133, F,H, Cl, pyrimidin-4-yl, Br), (M-4134, F, H, Cl, pyrimidin-4-yl, CH₃),(M-4135, F, H, Cl, pyrimidin-5-yl, H), (M-4136, F, H, Cl,pyrimidin-5-yl, Cl), (M-4137, F, H, Cl, pyrimidin-5-yl, F), (M-4138, F,H, Cl, pyrimidin-5-yl, CF₃), (M-4139, F, H, Cl, pyrimidin-5-yl, Br),(M-4140, F, H, Cl, pyrimidin-5-yl, CH₃), (M-4141, F, H, Cl,HOOCCH₂CH₂CH₂, H), (M-4142, F, H, Cl, HOOCCH₂CH₂CH₂, Cl), (M-4143, F, H,Cl, HOOCCH₂CH₂CH₂, F), (M-4144, F, H, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-4145,F, H, Cl, HOOCCH₂CH₂CH₂, Br), (M-4146, F, H, Cl, HOOCCH₂CH₂CH₂, CH₃),(M-4147, F, H, Cl, HOOCCH₂CH₂CH₂CH₂, H), (M-4148, F, H, Cl,HOOCCH₂CH₂CH₂CH₂, Cl), (M-4149, F, H, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-4150,F, H, Cl, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-4151, F, H, Cl, HOOCCH₂CH₂CH₂CH₂,Br), (M-4152, F, H, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-4153, F, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-4154, F, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-4155, F, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-4156, F, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-4157, F, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-4158, F, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-4159, F, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-4160, F, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-4161, F, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-4162, F, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-4163, F, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-4164, F, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-4165, F, H, Cl, MeOCH₂, H), (M-4166,F, H, Cl, MeOCH₂, Cl), (M-4167, F, H, Cl, MeOCH₂, F), (M-4168, F, H, Cl,MeOCH₂, CF₃), (M-4169, F, H, Cl, MeOCH₂, Br), (M-4170, F, H, Cl, MeOCH₂,CH₃), (M-4171, F, H, Cl, EtOCH₂, H), (M-4172, F, H, Cl, EtOCH₂, Cl),(M-4173, F, H, Cl, EtOCH₂, F), (M-4174, F, H, Cl, EtOCH₂, CF₃), (M-4175,F, H, Cl, EtOCH₂, Br), (M-4176, F, H, Cl, EtOCH₂, CH₃), (M-4177, F, H,Cl, EtOCH₂CH₂, H), (M-4178, F, H, Cl, EtOCH₂CH₂, Cl), (M-4179, F, H, Cl,EtOCH₂CH₂, F), (M-4180, F, H, Cl, EtOCH₂CH₂, CF₃), (M-4181, F, H, Cl,EtOCH₂CH₂, Br), (M-4182, F, H, Cl, EtOCH₂CH₂, CH₃), (M-4183, F, H, Cl,MeOCH₂CH₂OCH₂CH₂, H), (M-4184, F, H, Cl, MeOCH₂CH₂OCH₂CH₂, Cl), (M-4185,F, H, Cl, MeOCH₂CH₂OCH₂CH₂, F), (M-4186, F, H, Cl, MeOCH₂CH₂OCH₂CH₂,CF₃), (M-4187, F, H, Cl, MeOCH₂CH₂OCH₂CH₂, Br), (M-4188, F, H, Cl,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-4189, F, H, Cl, MeOCH₂CH₂, H), (M-4190, F, H,Cl, MeOCH₂CH₂, Cl), (M-4191, F, H, Cl, MeOCH₂CH₂, F), (M-4192, F, H, Cl,MeOCH₂CH₂, CF₃), (M-4193, F, H, Cl, MeOCH₂CH₂, Br), (M-4194, F, H, Cl,MeOCH₂CH₂, CH₃), (M-4195, F, H, Cl, HOCH₂, H), (M-4196, F, H, Cl, HOCH₂,Cl), (M-4197, F, H, Cl, HOCH₂, F), (M-4198, F, H, Cl, HOCH₂, CF₃),(M-4199, F, H, Cl, HOCH₂, Br), (M-4200, F, H, Cl, HOCH₂, CH₃), (M-4201,F, H, Cl, HOCH₂CH₂, H), (M-4202, F, H, Cl, HOCH₂CH₂, Cl), (M-4203, F, H,Cl, HOCH₂CH₂, F), (M-4204, F, H, Cl, HOCH₂CH₂, CF₃), (M-4205, F, H, Cl,HOCH₂CH₂, Br), (M-4206, F, H, Cl, HOCH₂CH₂, CH₃), (M-4207, F, H, Cl,HOCH₂CH₂CH₂, H), (M-4208, F, H, Cl, HOCH₂CH₂CH₂, Cl), (M-4209, F, H, Cl,HOCH₂CH₂CH₂, F), (M-4210, F, H, Cl, HOCH₂CH₂CH₂, CF₃), (M-4211, F, H,Cl, HOCH₂CH₂CH₂, Br), (M-4212, F, H, Cl, HOCH₂CH₂CH₂, CH₃), (M-4213, F,H, Cl, HOCH₂CH₂CH₂CH₂, H), (M-4214, F, H, Cl, HOCH₂CH₂CH₂CH₂, Cl),(M-4215, F, H, Cl, HOCH₂CH₂CH₂CH₂, F), (M-4216, F, H, Cl,HOCH₂CH₂CH₂CH₂, CF₃), (M-4217, F, H, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-4218,F, H, Cl, HOCH₂CH₂CH₂CH₂, CH₃), (M-4219, F, H, Cl, HOCH₂CH₂CH₂CH₂CH₂,H), (M-4220, F, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-4221, F, H, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-4222, F, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-4223, F, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-4224, F, H, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-4225, F, H, Cl, HOCH₂CH₂OCH₂CH₂, H),(M-4226, F, H, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-4227, F, H, Cl,HOCH₂CH₂OCH₂CH₂, F), (M-4228, F, H, Cl, HOCH₂CH₂OCH₂CH₂, CF₃), (M-4229,F, H, Cl, HOCH₂CH₂OCH₂CH₂, Br), (M-4230, F, H, Cl, HOCH₂CH₂OCH₂CH₂,CH₃), (M-4231, F, H, Cl, (Me)₂N, H), (M-4232, F, H, Cl, (Me)₂N, Cl),(M-4233, F, H, Cl, (Me)₂N, F), (M-4234, F, H, Cl, (Me)₂N, CF₃), (M-4235,F, H, Cl, (Me)₂N, Br), (M-4236, F, H, Cl, (Me)₂N, CH₃), (M-4237, F, H,Cl, piperidin-4-yl-methyl, H), (M-4238, F, H, Cl, piperidin-4-yl-methyl,Cl), (M-4239, F, H, Cl, piperidin-4-yl-methyl, F), (M-4240, F, H, Cl,piperidin-4-yl-methyl, CF₃), (M-4241, F, H, Cl, piperidin-4-yl-methyl,Br), (M-4242, F, H, Cl, piperidin-4-yl-methyl, CH₃), (M-4243, F, H, Cl,cyclohexylmethyl, H), (M-4244, F, H, Cl, cyclohexylmethyl, Cl), (M-4245,F, H, Cl, cyclohexylmethyl, F), (M-4246, F, H, Cl, cyclohexylmethyl,CF₃), (M-4247, F, H, Cl, cyclohexylmethyl, Br), (M-4248, F, H, Cl,cyclohexylmethyl, CH₃), (M-4249, F, F, H, H, H), (M-4250, F, F, H, H,Cl), (M-4251, F, F, H, H, F), (M-4252, F, F, H, H, CF₃), (M-4253, F, F,H, H, Br), (M-4254, F, F, H, H, CH₃), (M-4255, F, F, H, F, H), (M-4256,F, F, H, F, Cl), (M-4257, F, F, H, F, F), (M-4258, F, F, H, F, CF₃),(M-4259, F, F, H, F, Br), (M-4260, F, F, H, F, CH₃), (M-4261, F, F, H,Cl, H), (M-4262, F, F, H, Cl, Cl), (M-4263, F, F, H, Cl, F), (M-4264, F,F, H, Cl, CF₃), (M-4265, F, F, H, Cl, Br), (M-4266, F, F, H, Cl, CH₃),(M-4267, F, F, H, CH₃, H), (M-4268, F, F, H, CH₃, Cl), (M-4269, F, F, H,CH₃, F), (M-4270, F, F, H, CH₃, CF₃), (M-4271, F, F, H, CH₃, Br),(M-4272, F, F, H, CH₃, CH₃), (M-4273, F, F, H, Et, H), (M-4274, F, F, H,Et, Cl), (M-4275, F, F, H, Et, F), (M-4276, F, F, H, Et, CF₃), (M-4277,F, F, H, Et, Br), (M-4278, F, F, H, Et, CH₃), (M-4279, F, F, H, n-Pr,H), (M-4280, F, F, H, n-Pr, Cl), (M-4281, F, F, H, n-Pr, F), (M-4282, F,F, H, n-Pr, CF₃), (M-4283, F, F, H, n-Pr, Br), (M-4284, F, F, H, n-Pr,CH₃), (M-4285, F, F, H, c-Pr, H), (M-4286, F, F, H, c-Pr, Cl), (M-4287,F, F, H, c-Pr, F), (M-4288, F, F, H, c-Pr, CF₃), (M-4289, F, F, H, c-Pr,Br), (M-4290, F, F, H, c-Pr, CH₃), (M-4291, F, F, H, i-Pr, H), (M-4292,F, F, H, i-Pr, Cl), (M-4293, F, F, H, i-Pr, F), (M-4294, F, F, H, i-Pr,CF₃), (M-4295, F, F, H, i-Pr, Br), (M-4296, F, F, H, i-Pr, CH₃),(M-4297, F, F, H, n-Bu, H), (M-4298, F, F, H, n-Bu, Cl), (M-4299, F, F,H, n-Bu, F), (M-4300, F, F, H, n-Bu, CF₃), (M-4301, F, F, H, n-Bu, Br),(M-4302, F, F, H, n-Bu, CH₃), (M-4303, F, F, H, i-Bu, H), (M-4304, F, F,H, i-Bu, Cl), (M-4305, F, F, H, i-Bu, F), (M-4306, F, F, H, i-Bu, CF₃),(M-4307, F, F, H, i-Bu, Br), (M-4308, F, F, H, i-Bu, CH₃), (M-4309, F,F, H, sec-Bu, H), (M-4310, F, F, H, sec-Bu, Cl), (M-4311, F, F, H,sec-Bu, F), (M-4312, F, F, H, sec-Bu, CF₃), (M-4313, F, F, H, sec-Bu,Br), (M-4314, F, F, H, sec-Bu, CH₃), (M-4315, F, F, H, n-Pen, H),(M-4316, F, F, H, n-Pen, Cl), (M-4317, F, F, H, n-Pen, F), (M-4318, F,F, H, n-Pen, CF₃), (M-4319, F, F, H, n-Pen, Br), (M-4320, F, F, H,n-Pen, CH₃), (M-4321, F, F, H, c-Pen, H), (M-4322, F, F, H, c-Pen, Cl),(M-4323, F, F, H, c-Pen, F), (M-4324, F, F, H, c-Pen, CF₃), (M-4325, F,F, H, c-Pen, Br), (M-4326, F, F, H, c-Pen, CH₃), (M-4327, F, F, H,n-Hex, H), (M-4328, F, F, H, n-Hex, Cl), (M-4329, F, F, H, n-Hex, F),(M-4330, F, F, H, n-Hex, CF₃), (M-4331, F, F, H, n-Hex, Br), (M-4332, F,F, H, n-Hex, CH₃), (M-4333, F, F, H, c-Hex, H), (M-4334, F, F, H, c-Hex,Cl), (M-4335, F, F, H, c-Hex, F), (M-4336, F, F, H, c-Hex, CF₃),(M-4337, F, F, H, c-Hex, Br), (M-4338, F, F, H, c-Hex, CH₃), (M-4339, F,F, H, OH, H), (M-4340, F, F, H, OH, Cl), (M-4341, F, F, H, OH, F),(M-4342, F, F, H, OH, CF₃), (M-4343, F, F, H, OH, Br), (M-4344, F, F, H,OH, CH₃), (M-4345, F, F, H, EtO, H), (M-4346, F, F, H, EtO, Cl),(M-4347, F, F, H, EtO, F), (M-4348, F, F, H, EtO, CF₃), (M-4349, F, F,H, EtO, Br), (M-4350, F, F, H, EtO, CH₃), (M-4351, F, F, H, n-PrO, H),(M-4352, F, F, H, n-PrO, Cl), (M-4353, F, F, H, n-PrO, F), (M-4354, F,F, H, n-PrO, CF₃), (M-4355, F, F, H, n-PrO, Br), (M-4356, F, F, H,n-PrO, CH₃), (M-4357, F, F, H, PhO, H), (M-4358, F, F, H, PhO, Cl),(M-4359, F, F, H, PhO, F), (M-4360, F, F, H, PhO, CF₃), (M-4361, F, F,H, PhO, Br), (M-4362, F, F, H, PhO, CH₃), (M-4363, F, F, H, BnO, H),(M-4364, F, F, H, BnO, Cl), (M-4365, F, F, H, BnO, F), (M-4366, F, F, H,BnO, CF₃), (M-4367, F, F, H, BnO, Br), (M-4368, F, F, H, BnO, CH₃),(M-4369, F, F, H, PhCH₂CH₂O, H), (M-4370, F, F, H, PhCH₂CH₂O, Cl),(M-4371, F, F, H, PhCH₂CH₂O, F), (M-4372, F, F, H, PhCH₂CH₂O, CF₃),(M-4373, F, F, H, PhCH₂CH₂O, Br), (M-4374, F, F, H, PhCH₂CH₂O, CH₃),(M-4375, F, F, H, CF₃O, H), (M-4376, F, F, H, CF₃O, Cl), (M-4377, F, F,H, CF₃O, F), (M-4378, F, F, H, CF₃O, CF₃), (M-4379, F, F, H, CF₃O, Br),(M-4380, F, F, H, CF₃O, CH₃), (M-4381, F, F, H, Ph, H), (M-4382, F, F,H, Ph, Cl), (M-4383, F, F, H, Ph, F), (M-4384, F, F, H, Ph, CF₃),(M-4385, F, F, H, Ph, Br), (M-4386, F, F, H, Ph, CH₃), (M-4387, F, F, H,4-F-Ph, H), (M-4388, F, F, H, 4-F-Ph, Cl), (M-4389, F, F, H, 4-F-Ph, F),(M-4390, F, F, H, 4-F-Ph, CF₃), (M-4391, F, F, H, 4-F-Ph, Br), (M-4392,F, F, H, 4-F-Ph, CH₃), (M-4393, F, F, H, 4-CF₃-Ph, H), (M-4394, F, F, H,4-CF₃-Ph, Cl), (M-4395, F, F, H, 4-CF₃-Ph, F), (M-4396, F, F, H,4-CF₃-Ph, CF₃), (M-4397, F, F, H, 4-CF₃-Ph, Br), (M-4398, F, F, H,4-CF₃-Ph, CH₃), (M-4399, F, F, H, 4-(Me)₂N-Ph, H), (M-4400, F, F, H,4-(Me)₂N-Ph, Cl), (M-4401, F, F, H, 4-(Me)₂N-Ph, F), (M-4402, F, F, H,4-(Me)₂N-Ph, CF₃), (M-4403, F, F, H, 4-(Me)₂N-Ph, Br), (M-4404, F, F, H,4-(Me)₂N-Ph, CH₃), (M-4405, F, F, H, 4-OH-Ph, H), (M-4406, F, F, H,4-OH-Ph, Cl), (M-4407, F, F, H, 4-OH-Ph, F), (M-4408, F, F, H, 4-OH-Ph,CF₃), (M-4409, F, F, H, 4-OH-Ph, Br), (M-4410, F, F, H, 4-OH-Ph, CH₃),(M-4411, F, F, H, 3,4-di-F-Ph, H), (M-4412, F, F, H, 3,4-di-F-Ph, Cl),(M-4413, F, F, H, 3,4-di-F-Ph, F), (M-4414, F, F, H, 3,4-di-F-Ph, CF₃),(M-4415, F, F, H, 3,4-di-F-Ph, Br), (M-4416, F, F, H, 3,4-di-F-Ph, CH₃),(M-4417, F, F, H, 4-COOH-Ph, H), (M-4418, F, F, H, 4-COOH-Ph, Cl),(M-4419, F, F, H, 4-COOH-Ph, F), (M-4420, F, F, H, 4-COOH-Ph, CF₃),(M-4421, F, F, H, 4-COOH-Ph, Br), (M-4422, F, F, H, 4-COOH-Ph, CH₃),(M-4423, F, F, H, Bn, H), (M-4424, F, F, H, Bn, Cl), (M-4425, F, F, H,Bn, F), (M-4426, F, F, H, Bn, CF₃), (M-4427, F, F, H, Bn, Br), (M-4428,F, F, H, Bn, CH₃), (M-4429, F, F, H, 4-F-Bn, H), (M-4430, F, F, H,4-F-Bn, Cl), (M-4431, F, F, H, 4-F-Bn, F), (M-4432, F, F, H, 4-F-Bn,CF₃), (M-4433, F, F, H, 4-F-Bn, Br), (M-4434, F, F, H, 4-F-Bn, CH₃),(M-4435, F, F, H, 2-Py, H), (M-4436, F, F, H, 2-Py, Cl), (M-4437, F, F,H, 2-Py, F), (M-4438, F, F, H, 2-Py, CF₃), (M-4439, F, F, H, 2-Py, Br),(M-4440, F, F, H, 2-Py, CH₃), (M-4441, F, F, H, 3-Py, H), (M-4442, F, F,H, 3-Py, Cl), (M-4443, F, F, H, 3-Py, F), (M-4444, F, F, H, 3-Py, CF₃),(M-4445, F, F, H, 3-Py, Br), (M-4446, F, F, H, 3-Py, CH₃), (M-4447, F,F, H, 4-Py, H), (M-4448, F, F, H, 4-Py, Cl), (M-4449, F, F, H, 4-Py, F),(M-4450, F, F, H, 4-Py, CF₃), (M-4451, F, F, H, 4-Py, Br), (M-4452, F,F, H, 4-Py, CH₃), (M-4453, F, F, H, 2-Th, H), (M-4454, F, F, H, 2-Th,Cl), (M-4455, F, F, H, 2-Th, F), (M-4456, F, F, H, 2-Th, CF₃), (M-4457,F, F, H, 2-Th, Br), (M-4458, F, F, H, 2-Th, CH₃), (M-4459, F, F, H,3-Th, H), (M-4460, F, F, H, 3-Th, Cl), (M-4461, F, F, H, 3-Th, F),(M-4462, F, F, H, 3-Th, CF₃), (M-4463, F, F, H, 3-Th, Br), (M-4464, F,F, H, 3-Th, CH₃), (M-4465, F, F, H, pyrrazol-2-yl, H), (M-4466, F, F, H,pyrrazol-2-yl, Cl), (M-4467, F, F, H, pyrrazol-2-yl, F), (M-4468, F, F,H, pyrrazol-2-yl, CF₃), (M-4469, F, F, H, pyrrazol-2-yl, Br), (M-4470,F, F, H, pyrrazol-2-yl, CH₃), (M-4471, F, F, H, pyrrazol-3-yl, H),(M-4472, F, F, H, pyrrazol-3-yl, Cl), (M-4473, F, F, H, pyrrazol-3-yl,F), (M-4474, F, F, H, pyrrazol-3-yl, CF₃), (M-4475, F, F, H,pyrrazol-3-yl, Br), (M-4476, F, F, H, pyrrazol-3-yl, CH₃), (M-4477, F,F, H, pyrimidin-2-yl, H), (M-4478, F, F, H, pyrimidin-2-yl, Cl),(M-4479, F, F, H, pyrimidin-2-yl, F), (M-4480, F, F, H, pyrimidin-2-yl,CF₃), (M-4481, F, F, H, pyrimidin-2-yl, Br), (M-4482, F, F, H,pyrimidin-2-yl, CH₃), (M-4483, F, F, H, pyrimidin-4-yl, H), (M-4484, F,F, H, pyrimidin-4-yl, Cl), (M-4485, F, F, H, pyrimidin-4-yl, F),(M-4486, F, F, H, pyrimidin-4-yl, CF₃), (M-4487, F, F, H,pyrimidin-4-yl, Br), (M-4488, F, F, H, pyrimidin-4-yl, CH₃), (M-4489, F,F, H, pyrimidin-5-yl, H), (M-4490, F, F, H, pyrimidin-5-yl, Cl),(M-4491, F, F, H, pyrimidin-5-yl, F), (M-4492, F, F, H, pyrimidin-5-yl,CF₃), (M-4493, F, F, H, pyrimidin-5-yl, Br), (M-4494, F, F, H,pyrimidin-5-yl, CH₃), (M-4495, F, F, H, HOOCCH₂CH₂CH₂, H), (M-4496, F,F, H, HOOCCH₂CH₂CH₂, Cl), (M-4497, F, F, H, HOOCCH₂CH₂CH₂, F), (M-4498,F, F, H, HOOCCH₂CH₂CH₂, CF₃), (M-4499, F, F, H, HOOCCH₂CH₂CH₂, Br),(M-4500, F, F, H, HOOCCH₂CH₂CH₂, CH₃), (M-4501, F, F, H,HOOCCH₂CH₂CH₂CH₂, H), (M-4502, F, F, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-4503,F, F, H, HOOCCH₂CH₂CH₂CH₂, F), (M-4504, F, F, H, HOOCCH₂CH₂CH₂CH₂, CF₃),(M-4505, F, F, H, HOOCCH₂CH₂CH₂CH₂, Br), (M-4506, F, F, H,HOOCCH₂CH₂CH₂CH₂, CH₃), (M-4507, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H),(M-4508, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-4509, F, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-4510, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃),(M-4511, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂Br), (M-4512, F, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-4513, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,H), (M-4514, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-4515, F, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-4516, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CF₃), (M-4517, F, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-4518, F, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-4519, F, F, H, MeOCH₂, H), (M-4520, F,F, H, MeOCH₂, Cl), (M-4521, F, F, H, MeOCH₂, F), (M-4522, F, F, H,MeOCH₂, CF₃), (M-4523, F, F, H, MeOCH₂, Br), (M-4524, F, F, H, MeOCH₂,CH₃), (M-4525, F, F, H, EtOCH₂, H), (M-4526, F, F, H, EtOCH₂, Cl),(M-4527, F, F, H, EtOCH₂, F), (M-4528, F, F, H, EtOCH₂, CF₃), (M-4529,F, F, H, EtOCH₂, Br), (M-4530, F, F, H, EtOCH₂, CH₃), (M-4531, F, F, H,EtOCH₂CH₂, H), (M-4532, F, F, H, EtOCH₂CH₂, Cl), (M-4533, F, F, H,EtOCH₂CH₂, F), (M-4534, F, F, H, EtOCH₂CH₂, CF₃), (M-4535, F, F, H,EtOCH₂CH₂, Br), (M-4536, F, F, H, EtOCH₂CH₂, CH₃), (M-4537, F, F, H,MeOCH₂CH₂OCH₂CH₂, H), (M-4538, F, F, H, MeOCH₂CH₂OCH₂CH₂, Cl), (M-4539,F, F, H, MeOCH₂CH₂OCH₂CH₂, F), (M-4540, F, F, H, MeOCH₂CH₂OCH₂CH₂, CF₃),(M-4541, F, F, H, MeOCH₂CH₂OCH₂CH₂, Br), (M-4542, F, F, H,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-4543, F, F, H, MeOCH₂CH₂, H), (M-4544, F, F,H, MeOCH₂CH₂, Cl), (M-4545, F, F, H, MeOCH₂CH₂, F), (M-4546, F, F, H,MeOCH₂CH₂, CF₃), (M-4547, F, F, H, MeOCH₂CH₂, Br), (M-4548, F, F, H,MeOCH₂CH₂, CH₃), (M-4549, F, F, H, HOCH₂, H), (M-4550, F, F, H, HOCH₂,Cl), (M-4551, F, F, H, HOCH₂, F), (M-4552, F, F, H, HOCH₂, CF₃),(M-4553, F, F, H, HOCH₂, Br), (M-4554, F, F, H, HOCH₂, CH₃), (M-4555, F,F, H, HOCH₂CH₂, H), (M-4556, F, F, H, HOCH₂CH₂, Cl), (M-4557, F, F, H,HOCH₂CH₂, F), (M-4558, F, F, H, HOCH₂CH₂, CF₃), (M-4559, F, F, H,HOCH₂CH₂, Br), (M-4560, F, F, H, HOCH₂CH₂, CH₃), (M-4561, F, F, H,HOCH₂CH₂CH₂, H), (M-4562, F, F, H, HOCH₂CH₂CH₂, Cl), (M-4563, F, F, H,HOCH₂CH₂CH₂, F), (M-4564, F, F, H, HOCH₂CH₂CH₂, CF₃), (M-4565, F, F, H,HOCH₂CH₂CH₂, Br), (M-4566, F, F, H, HOCH₂CH₂CH₂, CH₃), (M-4567, F, F, H,HOCH₂CH₂CH₂CH₂, H), (M-4568, F, F, H, HOCH₂CH₂CH₂CH₂, Cl), (M-4569, F,F, H, HOCH₂CH₂CH₂CH₂, F), (M-4570, F, F, H, HOCH₂CH₂CH₂CH₂, CF₃),(M-4571, F, F, H, HOCH₂CH₂CH₂CH₂, Br), (M-4572, F, F, H, HOCH₂CH₂CH₂CH₂,CH₃), (M-4573, F, F, H, HOCH₂CH₂CH₂CH₂CH₂, H), (M-4574, F, F, H,HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-4575, F, F, H, HOCH₂CH₂CH₂CH₂CH₂, F),(M-4576, F, F, H, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-4577, F, F, H,HOCH₂CH₂CH₂CH₂CH₂, Br) (M-4578, F, F, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-4579, F, F, H, HOCH₂CH₂OCH₂CH₂, H), (M-4580, F, F, H,HOCH₂CH₂OCH₂CH₂, Cl), (M-4581, F, F, H, HOCH₂CH₂OCH₂CH₂, F), (M-4582, F,F, H, HOCH₂CH₂OCH₂CH₂, CF₃), (M-4583, F, F, H, HOCH₂CH₂OCH₂CH₂, Br),(M-4584, F, F, H, HOCH₂CH₂OCH₂CH₂, CH₃), (M-4585, F, F, H, (Me)₂N, H),(M-4586, F, F, H, (Me)₂N, Cl), (M-4587, F, F, H, (Me)₂N, F), (M-4588, F,F, H, (Me)₂N, CF₃), (M-4589, F, F, H, (Me)₂N, Br), (M-4590, F, F, H,(Me)₂N, CH₃), (M-4591, F, F, H, piperidin-4-yl-methyl, H), (M-4592, F,F, H, piperidin-4-yl-methyl, Cl), (M-4593, F, F, H,piperidin-4-yl-methyl, F), (M-4594, F, F, H, piperidin-4-yl-methyl,CF₃), (M-4595, F, F, H, piperidin-4-yl-methyl, Br), (M-4596, F, F, H,piperidin-4-yl-methyl, CH₃), (M-4597, F, F, H, cyclohexylmethyl, H),(M-4598, F, F, H, cyclohexylmethyl, Cl), (M-4599, F, F, H,cyclohexylmethyl, F), (M-4600, F, F, H, cyclohexylmethyl, CF₃), (M-4601,F, F, H, cyclohexylmethyl, Br), (M-4602, F, F, H, cyclohexylmethyl,CH₃), (M-4603, F, F, F, H, H), (M-4604, F, F, F, H, Cl), (M-4605, F, F,F, H, F), (M-4606, F, F, F, H, CF₃), (M-4607, F, F, F, H, Br), (M-4608,F, F, F, H, CH₃), (M-4609, F, F, F, F, H), (M-4610, F, F, F, F, Cl),(M-4611, F, F, F, F, F), (M-4612, F, F, F, F, CF₃), (M-4613, F, F, F, F,Br), (M-4614, F, F, F, F, CH₃), (M-4615, F, F, F, Cl, H), (M-4616, F, F,F, Cl, Cl), (M-4617, F, F, F, Cl, F), (M-4618, F, F, F, Cl, CF₃),(M-4619, F, F, F, Cl, Br), (M-4620, F, F, F, Cl, CH₃), (M-4621, F, F, F,CH₃, H), (M-4622, F, F, F, CH₃, Cl), (M-4623, F, F, F, CH₃, F), (M-4624,F, F, F, CH₃, CF₃), (M-4625, F, F, F, CH₃, Br), (M-4626, F, F, F, CH₃,CH₃), (M-4627, F, F, F, Et, H), (M-4628, F, F, F, Et, Cl), (M-4629, F,F, F, Et, F), (M-4630, F, F, F, Et, CF₃), (M-4631, F, F, F, Et, Br),(M-4632, F, F, F, Et, CH₃), (M-4633, F, F, F, n-Pr, H), (M-4634, F, F,F, n-Pr, Cl), (M-4635, F, F, F, n-Pr, F), (M-4636, F, F, F, n-Pr, CF₃),(M-4637, F, F, F, n-Pr, Br), (M-4638, F, F, F, n-Pr, CH₃), (M-4639, F,F, F, c-Pr, H), (M-4640, F, F, F, c-Pr, Cl), (M-4641, F, F, F, c-Pr, F),(M-4642, F, F, F, c-Pr, CF₃), (M-4643, F, F, F, c-Pr, Br), (M-4644, F,F, F, c-Pr, CH₃), (M-4645, F, F, F, i-Pr, H), (M-4646, F, F, F, i-Pr,Cl), (M-4647, F, F, F, i-Pr, F), (M-4648, F, F, F, i-Pr, CF₃), (M-4649,F, F, F, i-Pr, Br), (M-4650, F, F, F, i-Pr, CH₃), (M-4651, F, F, F,n-Bu, H), (M-4652, F, F, F, n-Bu, Cl), (M-4653, F, F, F, n-Bu, F),(M-4654, F, F, F, n-Bu, CF₃), (M-4655, F, F, F, n-Bu, Br), (M-4656, F,F, F, n-Bu, CH₃), (M-4657, F, F, F, i-Bu, H), (M-4658, F, F, F, i-Bu,Cl), (M-4659, F, F, F, i-Bu, F), (M-4660, F, F, F, i-Bu, CF₃), (M-4661,F, F, F, i-Bu, Br), (M-4662, F, F, F, i-Bu, CH₃), (M-4663, F, F, F,sec-Bu, H), (M-4664, F, F, F, sec-Bu, Cl), (M-4665, F, F, F, sec-Bu, F),(M-4666, F, F, F, sec-Bu, CF₃), (M-4667, F, F, F, sec-Bu, Br), (M-4668,F, F, F, sec-Bu, CH₃), (M-4669, F, F, F, n-Pen, H), (M-4670, F, F, F,n-Pen, Cl), (M-4671, F, F, F, n-Pen, F), (M-4672, F, F, F, n-Pen, CF₃),(M-4673, F, F, F, n-Pen, Br), (M-4674, F, F, F, n-Pen, CH₃), (M-4675, F,F, F, c-Pen, H), (M-4676, F, F, F, c-Pen, Cl), (M-4677, F, F, F, c-Pen,F), (M-4678, F, F, F, c-Pen, CF₃), (M-4679, F, F, F, c-Pen, Br),(M-4680, F, F, F, c-Pen, CH₃), (M-4681, F, F, F, n-Hex, H), (M-4682, F,F, F, n-Hex, Cl), (M-4683, F, F, F, n-Hex, F), (M-4684, F, F, F, n-Hex,CF₃), (M-4685, F, F, F, n-Hex, Br), (M-4686, F, F, F, n-Hex, CH₃),(M-4687, F, F, F, c-Hex, H), (M-4688, F, F, F, c-Hex, Cl), (M-4689, F,F, F, c-Hex, F), (M-4690, F, F, F, c-Hex, CF₃), (M-4691, F, F, F, c-Hex,Br), (M-4692, F, F, F, c-Hex, CH₃), (M-4693, F, F, F, OH, H), (M-4694,F, F, F, OH, Cl), (M-4695, F, F, F, OH, F), (M-4696, F, F, F, OH, CF₃),(M-4697, F, F, F, OH, Br), (M-4698, F, F, F, OH, CH₃), (M-4699, F, F, F,EtO, H), (M-4700, F, F, F, EtO, Cl), (M-4701, F, F, F, EtO, F), (M-4702,F, F, F, EtO, CF₃), (M-4703, F, F, F, EtO, Br), (M-4704, F, F, F, EtO,CH₃), (M-4705, F, F, F, n-PrO, H), (M-4706, F, F, F, n-PrO, Cl),(M-4707, F, F, F, n-PrO, F), (M-4708, F, F, F, n-PrO, CF₃), (M-4709, F,F, F, n-PrO, Br), (M-4710, F, F, F, n-PrO, CH₃), (M-4711, F, F, F, PhO,H), (M-4712, F, F, F, PhO, Cl), (M-4713, F, F, F, PhO, F), (M-4714, F,F, F, PhO, CF₃), (M-4715, F, F, F, PhO, Br), (M-4716, F, F, F, PhO,CH₃), (M-4717, F, F, F, BnO, H), (M-4718, F, F, F, BnO, Cl), (M-4719, F,F, F, BnO, F), (M-4720, F, F, F, BnO, CF₃), (M-4721, F, F, F, BnO, Br),(M-4722, F, F, F, BnO, CH₃), (M-4723, F, F, F, PhCH₂CH₂O, H), (M-4724,F, F, F, PhCH₂CH₂O, Cl), (M-4725, F, F, F, PhCH₂CH₂O, F), (M-4726, F, F,F, PhCH₂CH₂O, CF₃), (M-4727, F, F, F, PhCH₂CH₂O, Br), (M-4728, F, F, F,PhCH₂CH₂O, CH₃), (M-4729, F, F, F, CF₃O, H), (M-4730, F, F, F, CF₃O,Cl), (M-4731, F, F, F, CF₃O, F), (M-4732, F, F, F, CF₃O, CF₃), (M-4733,F, F, F, CF₃O, Br), (M-4734, F, F, F, CF₃O, CH₃), (M-4735, F, F, F, Ph,H), (M-4736, F, F, F, Ph, Cl), (M-4737, F, F, F, Ph, F), (M-4738, F, F,F, Ph, CF₃), (M-4739, F, F, F, Ph, Br), (M-4740, F, F, F, Ph, CH₃),(M-4741, F, F, F, 4-F-Ph, H), (M-4742, F, F, F, 4-F-Ph, Cl), (M-4743, F,F, F, 4-F-Ph, F), (M-4744, F, F, F, 4-F-Ph, CF₃), (M-4745, F, F, F,4-F-Ph, Br), (M-4746, F, F, F, 4-F-Ph, CH₃), (M-4747, F, F, F, 4-CF₃-Ph,H), (M-4748, F, F, F, 4-CF₃-Ph, Cl), (M-4749, F, F, F, 4-CF₃-Ph, F),(M-4750, F, F, F, 4-CF₃-Ph, CF₃), (M-4751, F, F, F, 4-CF₃-Ph, Br),(M-4752, F, F, F, 4-CF₃-Ph, CH₃), (M-4753, F, F, F, 4-(Me)₂N-Ph, H),(M-4754, F, F, F, 4-(Me)₂N-Ph, Cl), (M-4755, F, F, F, 4-(Me)₂N-Ph, F),(M-4756, F, F, F, 4-(Me)₂N-Ph, CF₃), (M-4757, F, F, F, 4-(Me)₂N-Ph, Br),(M-4758, F, F, F, 4-(Me)₂N-Ph, CH₃), (M-4759, F, F, F, 4-OH-Ph, H),(M-4760, F, F, F, 4-OH-Ph, Cl), (M-4761, F, F, F, 4-OH-Ph, F), (M-4762,F, F, F, 4-OH-Ph, CF₃), (M-4763, F, F, F, 4-OH-Ph, Br), (M-4764, F, F,F, 4-OH-Ph, CH₃), (M-4765, F, F, F, 3,4-di-F-Ph, H), (M-4766, F, F, F,3,4-di-F-Ph, Cl), (M-4767, F, F, F, 3,4-di-F-Ph, F), (M-4768, F, F, F,3,4-di-F-Ph, CF₃), (M-4769, F, F, F, 3,4-di-F-Ph, Br), (M-4770, F, F, F,3,4-di-F-Ph, CH₃), (M-4771, F, F, F, 4-COOH-Ph, H), (M-4772, F, F, F,4-COOH-Ph, Cl), (M-4773, F, F, F, 4-COOH-Ph, F), (M-4774, F, F, F,4-COOH-Ph, CF₃), (M-4775, F, F, F, 4-COOH-Ph, Br), (M-4776, F, F, F,4-COOH-Ph, CH₃), (M-4777, F, F, F, Bn, H), (M-4778, F, F, F, Bn, Cl),(M-4779, F, F, F, Bn, F), (M-4780, F, F, F, Bn, CF₃), (M-4781, F, F, F,Bn, Br), (M-4782, F, F, F, Bn, CH₃), (M-4783, F, F, F, 4-F-Bn, H),(M-4784, F, F, F, 4-F-Bn, Cl), (M-4785, F, F, F, 4-F-Bn, F), (M-4786, F,F, F, 4-F-Bn, CF₃), (M-4787, F, F, F, 4-F-Bn, Br), (M-4788, F, F, F,4-F-Bn, CH₃), (M-4789, F, F, F, 2-Py, H), (M-4790, F, F, F, 2-Py, Cl),(M-4791, F, F, F, 2-Py, F), (M-4792, F, F, F, 2-Py, CF₃), (M-4793, F, F,F, 2-Py, Br), (M-4794, F, F, F, 2-Py, CH₃), (M-4795, F, F, F, 3-Py, H),(M-4796, F, F, F, 3-Py, Cl), (M-4797, F, F, F, 3-Py, F), (M-4798, F, F,F, 3-Py, CF₃), (M-4799, F, F, F, 3-Py, Br), (M-4800, F, F, F, 3-Py,CH₃), (M-4801, F, F, F, 4-Py, H), (M-4802, F, F, F, 4-Py, Cl), (M-4803,F, F, F, 4-Py, F), (M-4804, F, F, F, 4-Py, CF₃), (M-4805, F, F, F, 4-Py,Br), (M-4806, F, F, F, 4-Py, CH₃), (M-4807, F, F, F, 2-Th, H), (M-4808,F, F, F, 2-Th, Cl), (M-4809, F, F, F, 2-Th, F), (M-4810, F, F, F, 2-Th,CF₃), (M-4811, F, F, F, 2-Th, Br), (M-4812, F, F, F, 2-Th, CH₃),(M-4813, F, F, F, 3-Th, H), (M-4814, F, F, F, 3-Th, Cl), (M-4815, F, F,F, 3-Th, F), (M-4816, F, F, F, 3-Th, CF₃), (M-4817, F, F, F, 3-Th, Br),(M-4818, F, F, F, 3-Th, CH₃), (M-4819, F, F, F, pyrrazol-2-yl, H),(M-4820, F, F, F, pyrrazol-2-yl, Cl), (M-4821, F, F, F, pyrrazol-2-yl,F), (M-4822, F, F, F, pyrrazol-2-yl, CF₃), (M-4823, F, F, F,pyrrazol-2-yl, Br), (M-4824, F, F, F, pyrrazol-2-yl, CH₃), (M-4825, F,F, F, pyrrazol-3-yl, H), (M-4826, F, F, F, pyrrazol-3-yl, Cl), (M-4827,F, F, F, pyrrazol-3-yl, F), (M-4828, F, F, F, pyrrazol-3-yl, CF₃),(M-4829, F, F, F, pyrrazol-3-yl, Br), (M-4830, F, F, F, pyrrazol-3-yl,CH₃), (M-4831, F, F, F, pyrimidin-2-yl, H), (M-4832, F, F, F,pyrimidin-2-yl, Cl), (M-4833, F, F, F, pyrimidin-2-yl, F), (M-4834, F,F, F, pyrimidin-2-yl, CF₃), (M-4835, F, F, F, pyrimidin-2-yl, Br),(M-4836, F, F, F, pyrimidin-2-yl, CH₃), (M-4837, F, F, F,pyrimidin-4-yl, H), (M-4838, F, F, F, pyrimidin-4-yl, Cl), (M-4839, F,F, F, pyrimidin-4-yl, F), (M-4840, F, F, F, pyrimidin-4-yl, CF₃),(M-4841, F, F, F, pyrimidin-4-yl, Br), (M-4842, F, F, F, pyrimidin-4-yl,CH₃), (M-4843, F, F, F, pyrimidin-5-yl, H), (M-4844, F, F, F,pyrimidin-5-yl, Cl), (M-4845, F, F, F, pyrimidin-5-yl, F), (M-4846, F,F, F, pyrimidin-5-yl, CF₃), (M-4847, F, F, F, pyrimidin-5-yl, Br),(M-4848, F, F, F, pyrimidin-5-yl, CH₃), (M-4849, F, F, F, HOOCCH₂CH₂CH₂,H), (M-4850, F, F, F, HOOCCH₂CH₂CH₂, Cl), (M-4851, F, F, F,HOOCCH₂CH₂CH₂, F), (M-4852, F, F, F, HOOCCH₂CH₂CH₂, CF₃), (M-4853, F, F,F, HOOCCH₂CH₂CH₂, Br), (M-4854, F, F, F, HOOCCH₂CH₂CH₂, CH₃), (M-4855,F, F, F, HOOCCH₂CH₂CH₂CH₂, H), (M-4856, F, F, F, HOOCCH₂CH₂CH₂CH₂, Cl),(M-4857, F, F, F, HOOCCH₂CH₂CH₂CH₂, F), (M-4858, F, F, F,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-4859, F, F, F, HOOCCH₂CH₂CH₂CH₂, Br),(M-4860, F, F, F, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-4861, F, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-4862, F, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-4863, F, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-4864, F, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-4865, F, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Br),(M-4866, F, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-4867, F, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-4868, F, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-4869, F, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-4870, F, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-4871, F, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-4872, F, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CH₃), (M-4873, F, F, F, MeOCH₂, H), (M-4874, F, F, F, MeOCH₂, Cl),(M-4875, F, F, F, MeOCH₂, F), (M-4876, F, F, F, MeOCH₂, CF₃), (M-4877,F, F, F, MeOCH₂, Br), (M-4878, F, F, F, MeOCH₂, CH₃), (M-4879, F, F, F,EtOCH₂, H), (M-4880, F, F, F, EtOCH₂, Cl), (M-4881, F, F, F, EtOCH₂, F),(M-4882, F, F, F, EtOCH₂, CF₃), (M-4883, F, F, F, EtOCH₂, Br), (M-4884,F, F, F, EtOCH₂, CH₃), (M-4885, F, F, F, EtOCH₂CH₂, H), (M-4886, F, F,F, EtOCH₂CH₂, Cl), (M-4887, F, F, F, EtOCH₂CH₂, F), (M-4888, F, F, F,EtOCH₂CH₂, CF₃), (M-4889, F, F, F, EtOCH₂CH₂, Br), (M-4890, F, F, F,EtOCH₂CH₂, CH₃), (M-4891, F, F, F, MeOCH₂CH₂OCH₂CH₂, H), (M-4892, F, F,F, MeOCH₂CH₂OCH₂CH₂, Cl), (M-4893, F, F, F, MeOCH₂CH₂OCH₂CH₂, F),(M-4894, F, F, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-4895, F, F, F,MeOCH₂CH₂OCH₂CH₂, Br), (M-4896, F, F, F, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-4897, F, F, F, MeOCH₂CH₂, H), (M-4898, F, F, F, MeOCH₂CH₂, Cl),(M-4899, F, F, F, MeOCH₂CH₂, F), (M-4900, F, F, F, MeOCH₂CH₂, CF₃),(M-4901, F, F, F, MeOCH₂CH₂, Br), (M-4902, F, F, F, MeOCH₂CH₂, CH₃),(M-4903, F, F, F, HOCH₂, H), (M-4904, F, F, F, HOCH₂, Cl), (M-4905, F,F, F, HOCH₂, F), (M-4906, F, F, F, HOCH₂, CF₃), (M-4907, F, F, F, HOCH₂,Br), (M-4908, F, F, F, HOCH₂, CH₃), (M-4909, F, F, F, HOCH₂CH₂, H),(M-4910, F, F, F, HOCH₂CH₂, Cl), (M-4911, F, F, F, HOCH₂CH₂, F),(M-4912, F, F, F, HOCH₂CH₂, CF₃), (M-4913, F, F, F, HOCH₂CH₂, Br),(M-4914, F, F, F, HOCH₂CH₂, CH₃), (M-4915, F, F, F, HOCH₂CH₂CH₂, H),(M-4916, F, F, F, HOCH₂CH₂CH₂, Cl), (M-4917, F, F, F, HOCH₂CH₂CH₂, F),(M-4918, F, F, F, HOCH₂CH₂CH₂, CF₃), (M-4919, F, F, F, HOCH₂CH₂CH₂, Br),(M-4920, F, F, F, HOCH₂CH₂CH₂, CH₃), (M-4921, F, F, F, HOCH₂CH₂CH₂CH₂,H), (M-4922, F, F, F, HOCH₂CH₂CH₂CH₂, Cl), (M-4923, F, F, F,HOCH₂CH₂CH₂CH₂, F), (M-4924, F, F, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-4925, F,F, F, HOCH₂CH₂CH₂CH₂, Br), (M-4926, F, F, F, HOCH₂CH₂CH₂CH₂, CH₃),(M-4927, F, F, F, HOCH₂CH₂CH₂CH₂CH₂, H), (M-4928, F, F, F,HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-4929, F, F, F, HOCH₂CH₂CH₂CH₂CH₂, F),(M-4930, F, F, F, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-4931, F, F, F,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-4932, F, F, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-4933, F, F, F, HOCH₂CH₂OCH₂CH₂, H), (M-4934, F, F, F,HOCH₂CH₂OCH₂CH₂, Cl), (M-4935, F, F, F, HOCH₂CH₂OCH₂CH₂, F), (M-4936, F,F, F, HOCH₂CH₂OCH₂CH₂, CF₃), (M-4937, F, F, F, HOCH₂CH₂OCH₂CH₂, Br),(M-4938, F, F, F, HOCH₂CH₂OCH₂CH₂, CH₃), (M-4939, F, F, F, (Me)₂N, H),(M-4940, F, F, F, (Me)₂N, Cl), (M-4941, F, F, F, (Me)₂N, F), (M-4942, F,F, F, (Me)₂N, CF₃), (M-4943, F, F, F, (Me)₂N, Br), (M-4944, F, F, F,(Me)₂N, CH₃), (M-4945, F, F, F, piperidin-4-yl-methyl, H), (M-4946, F,F, F, piperidin-4-yl-methyl, Cl), (M-4947, F, F, F,piperidin-4-yl-methyl, F), (M-4948, F, F, F, piperidin-4-yl-methyl,CF₃), (M-4949, F, F, F, piperidin-4-yl-methyl, Br), (M-4950, F, F, F,piperidin-4-yl-methyl, CH₃), (M-4951, F, F, F, cyclohexylmethyl, H),(M-4952, F, F, F, cyclohexylmethyl, Cl), (M-4953, F, F, F,cyclohexylmethyl, F), (M-4954, F, F, F, cyclohexylmethyl, CF₃), (M-4955,F, F, F, cyclohexylmethyl, Br), (M-4956, F, F, F, cyclohexylmethyl,CH₃), (M-4957, F, F, Cl, H, H), (M-4958, F, F, Cl, H, Cl), (M-4959, F,F, Cl, H, F), (M-4960, F, F, Cl, H, CF₃), (M-4961, F, F, Cl, H, Br),(M-4962, F, F, Cl, H, CH₃), (M-4963, F, F, Cl, F, H), (M-4964, F, F, Cl,F, Cl), (M-4965, F, F, Cl, F, F), (M-4966, F, F, Cl, F, CF₃), (M-4967,F, F, Cl, F, Br), (M-4968, F, F, Cl, F, CH₃), (M-4969, F, F, Cl, Cl, H),(M-4970, F, F, Cl, Cl, Cl), (M-4971, F, F, Cl, Cl, F), (M-4972, F, F,Cl, Cl, CF₃), (M-4973, F, F, Cl, Cl, Br), (M-4974, F, F, Cl, Cl, CH₃),(M-4975, F, F, Cl, CH₃, H), (M-4976, F, F, Cl, CH₃, Cl), (M-4977, F, F,Cl, CH₃, F), (M-4978, F, F, Cl, CH₃, CF₃), (M-4979, F, F, Cl, CH₃, Br),(M-4980, F, F, Cl, CH₃, CH₃), (M-4981, F, F, Cl, Et, H), (M-4982, F, F,Cl, Et, Cl), (M-4983, F, F, Cl, Et, F), (M-4984, F, F, Cl, Et, CF₃),(M-4985, F, F, Cl, Et, Br), (M-4986, F, F, Cl, Et, CH₃), (M-4987, F, F,Cl, n-Pr, H), (M-4988, F, F, Cl, n-Pr, Cl), (M-4989, F, F, Cl, n-Pr, F),(M-4990, F, F, Cl, n-Pr, CF₃), (M-4991, F, F, Cl, n-Pr, Br), (M-4992, F,F, Cl, n-Pr, CH₃), (M-4993, F, F, Cl, c-Pr, H), (M-4994, F, F, Cl, c-Pr,Cl), (M-4995, F, F, Cl, c-Pr, F), (M-4996, F, F, Cl, c-Pr, CF₃),(M-4997, F, F, Cl, c-Pr, Br), (M-4998, F, F, Cl, c-Pr, CH₃), (M-4999, F,F, Cl, i-Pr, H), (M-5000, F, F, Cl, i-Pr, Cl), (M-5001, F, F, Cl, i-Pr,F), (M-5002, F, F, Cl, i-Pr, CF₃), (M-5003, F, F, Cl, i-Pr, Br),(M-5004, F, F, Cl, i-Pr, CH₃), (M-5005, F, F, Cl, n-Bu, H), (M-5006, F,F, Cl, n-Bu, Cl), (M-5007, F, F, Cl, n-Bu, F), (M-5008, F, F, Cl, n-Bu,CF₃), (M-5009, F, F, Cl, n-Bu, Br), (M-5010, F, F, Cl, n-Bu, CH₃),(M-5011, F, F, Cl, i-Bu, H), (M-5012, F, F, Cl, i-Bu, Cl), (M-5013, F,F, Cl, i-Bu, F), (M-5014, F, F, Cl, i-Bu, CF₃), (M-5015, F, F, Cl, i-Bu,Br), (M-5016, F, F, Cl, i-Bu, CH₃), (M-5017, F, F, Cl, sec-Bu, H),(M-5018, F, F, Cl, sec-Bu, Cl), (M-5019, F, F, Cl, sec-Bu, F), (M-5020,F, F, Cl, sec-Bu, CF₃), (M-5021, F, F, Cl, sec-Bu, Br), (M-5022, F, F,Cl, sec-Bu, CH₃), (M-5023, F, F, Cl, n-Pen, H), (M-5024, F, F, Cl,n-Pen, Cl), (M-5025, F, F, Cl, n-Pen, F), (M-5026, F, F, Cl, n-Pen,CF₃), (M-5027, F, F, Cl, n-Pen, Br), (M-5028, F, F, Cl, n-Pen, CH₃),(M-5029, F, F, Cl, c-Pen, H), (M-5030, F, F, Cl, c-Pen, Cl), (M-5031, F,F, Cl, c-Pen, F), (M-5032, F, F, Cl, c-Pen, CF₃), (M-5033, F, F, Cl,c-Pen, Br), (M-5034, F, F, Cl, c-Pen, CH₃), (M-5035, F, F, Cl, n-Hex,H), (M-5036, F, F, Cl, n-Hex, Cl), (M-5037, F, F, Cl, n-Hex, F),(M-5038, F, F, Cl, n-Hex, CF₃), (M-5039, F, F, Cl, n-Hex, Br), (M-5040,F, F, Cl, n-Hex, CH₃), (M-5041, F, F, Cl, c-Hex, H), (M-5042, F, F, Cl,c-Hex, Cl), (M-5043, F, F, Cl, c-Hex, F), (M-5044, F, F, Cl, c-Hex,CF₃), (M-5045, F, F, Cl, c-Hex, Br), (M-5046, F, F, Cl, c-Hex, CH₃),(M-5047, F, F, Cl, OH, H), (M-5048, F, F, Cl, OH, Cl), (M-5049, F, F,Cl, OH, F), (M-5050, F, F, Cl, OH, CF₃), (M-5051, F, F, Cl, OH, Br),(M-5052, F, F, Cl, OH, CH₃), (M-5053, F, F, Cl, EtO, H), (M-5054, F, F,Cl, EtO, Cl), (M-5055, F, F, Cl, EtO, F), (M-5056, F, F, Cl, EtO, CF₃),(M-5057, F, F, Cl, EtO, Br), (M-5058, F, F, Cl, EtO, CH₃), (M-5059, F,F, Cl, n-PrO, H), (M-5060, F, F, Cl, n-PrO, Cl), (M-5061, F, F, Cl,n-PrO, F), (M-5062, F, F, Cl, n-PrO, CF₃), (M-5063, F, F, Cl, n-PrO,Br), (M-5064, F, F, Cl, n-PrO, CH₃), (M-5065, F, F, Cl, PhO, H),(M-5066, F, F, Cl, PhO, Cl), (M-5067, F, F, Cl, PhO, F), (M-5068, F, F,Cl, PhO, CF₃), (M-5069, F, F, Cl, PhO, Br), (M-5070, F, F, Cl, PhO,CH₃), (M-5071, F, F, Cl, BnO, H), (M-5072, F, F, Cl, BnO, Cl), (M-5073,F, F, Cl, BnO, F), (M-5074, F, F, Cl, BnO, CF₃), (M-5075, F, F, Cl, BnO,Br), (M-5076, F, F, Cl, BnO, CH₃), (M-5077, F, F, Cl, PhCH₂CH₂O, H),(M-5078, F, F, Cl, PhCH₂CH₂O, Cl), (M-5079, F, F, Cl, PhCH₂CH₂O, F),(M-5080, F, F, Cl, PhCH₂CH₂O, CF₃), (M-5081, F, F, Cl, PhCH₂CH₂O, Br),(M-5082, F, F, Cl, PhCH₂CH₂O, CH₃), (M-5083, F, F, Cl, CF₃O, H),(M-5084, F, F, Cl, CF₃O, Cl), (M-5085, F, F, Cl, CF₃O, F), (M-5086, F,F, Cl, CF₃O, CF₃), (M-5087, F, F, Cl, CF₃O, Br), (M-5088, F, F, Cl,CF₃O, CH₃), (M-5089, F, F, Cl, Ph, H), (M-5090, F, F, Cl, Ph, Cl),(M-5091, F, F, Cl, Ph, F), (M-5092, F, F, Cl, Ph, CF₃), (M-5093, F, F,Cl, Ph, Br), (M-5094, F, F, Cl, Ph, CH₃), (M-5095, F, F, Cl, 4-F-Ph, H),(M-5096, F, F, Cl, 4-F-Ph, Cl), (M-5097, F, F, Cl, 4-F-Ph, F), (M-5098,F, F, Cl, 4-F-Ph, CF₃), (M-5099, F, F, Cl, 4-F-Ph, Br), (M-5100, F, F,Cl, 4-F-Ph, CH₃), (M-5101, F, F, Cl, 4-CF₃-Ph, H), (M-5102, F, F, Cl,4-CF₃-Ph, Cl), (M-5103, F, F, Cl, 4-CF₃-Ph, F), (M-5104, F, F, Cl,4-CF₃-Ph, CF₃), (M-5105, F, F, Cl, 4-CF₃-Ph, Br), (M-5106, F, F, Cl,4-CF₃-Ph, CH₃), (M-5107, F, F, Cl, 4-(Me)₂N-Ph, H), (M-5108, F, F, Cl,4-(Me)₂N-Ph, Cl), (M-5109, F, F, Cl, 4-(Me)₂N-Ph, F), (M-5110, F, F, Cl,4-(Me)₂N-Ph, CF₃), (M-5111, F, F, Cl, 4-(Me)₂N-Ph, Br), (M-5112, F, F,Cl, 4-(Me)₂N-Ph, CH₃), (M-5113, F, F, Cl, 4-OH-Ph, H), (M-5114, F, F,Cl, 4-OH-Ph, Cl), (M-5115, F, F, Cl, 4-OH-Ph, F), (M-5116, F, F, Cl,4-OH-Ph, CF₃), (M-5117, F, F, Cl, 4-OH-Ph, Br), (M-5118, F, F, Cl,4-OH-Ph, CH₃), (M-5119, F, F, Cl, 3,4-di-F-Ph, H), (M-5120, F, F, Cl,3,4-di-F-Ph, Cl), (M-5121, F, F, Cl, 3,4-di-F-Ph, F), (M-5122, F, F, Cl,3,4-di-F-Ph, CF₃), (M-5123, F, F, Cl, 3,4-di-F-Ph, Br), (M-5124, F, F,Cl, 3,4-di-F-Ph, CH₃), (M-5125, F, F, Cl, 4-COOH-Ph, H), (M-5126, F, F,Cl, 4-COOH-Ph, Cl), (M-5127, F, F, Cl, 4-COOH-Ph, F), (M-5128, F, F, Cl,4-COOH-Ph, CF₃), (M-5129, F, F, Cl, 4-COOH-Ph, Br), (M-5130, F, F, Cl,4-COOH-Ph, CH₃), (M-5131, F, F, Cl, Bn, H), (M-5132, F, F, Cl, Bn, Cl),(M-5133, F, F, Cl, Bn, F), (M-5134, F, F, Cl, Bn, CF₃), (M-5135, F, F,Cl, Bn, Br), (M-5136, F, F, Cl, Bn, CH₃), (M-5137, F, F, Cl, 4-F-Bn, H),(M-5138, F, F, Cl, 4-F-Bn, Cl), (M-5139, F, F, Cl, 4-F-Bn, F), (M-5140,F, F, Cl, 4-F-Bn, CF₃), (M-5141, F, F, Cl, 4-F-Bn, Br), (M-5142, F, F,Cl, 4-F-Bn, CH₃), (M-5143, F, F, Cl, 2-Py, H), (M-5144, F, F, Cl, 2-Py,Cl), (M-5145, F, F, Cl, 2-Py, F), (M-5146, F, F, Cl, 2-Py, CF₃),(M-5147, F, F, Cl, 2-Py, Br), (M-5148, F, F, Cl, 2-Py, CH₃), (M-5149, F,F, Cl, 3-Py, H), (M-5150, F, F, Cl, 3-Py, Cl), (M-5151, F, F, Cl, 3-Py,F), (M-5152, F, F, Cl, 3-Py, CF₃), (M-5153, F, F, Cl, 3-Py, Br),(M-5154, F, F, Cl, 3-Py, CH₃), (M-5155, F, F, Cl, 4-Py, H), (M-5156, F,F, Cl, 4-Py, Cl), (M-5157, F, F, Cl, 4-Py, F), (M-5158, F, F, Cl, 4-Py,CF₃), (M-5159, F, F, Cl, 4-Py, Br), (M-5160, F, F, Cl, 4-Py, CH₃),(M-5161, F, F, Cl, 2-Th, H), (M-5162, F, F, Cl, 2-Th, Cl), (M-5163, F,F, Cl, 2-Th, F), (M-5164, F, F, Cl, 2-Th, CF₃), (M-5165, F, F, Cl, 2-Th,Br), (M-5166, F, F, Cl, 2-Th, CH₃), (M-5167, F, F, Cl, 3-Th, H),(M-5168, F, F, Cl, 3-Th, Cl), (M-5169, F, F, Cl, 3-Th, F), (M-5170, F,F, Cl, 3-Th, CF₃), (M-5171, F, F, Cl, 3-Th, Br), (M-5172, F, F, Cl,3-Th, CH₃), (M-5173, F, F, Cl, pyrrazol-2-yl, H), (M-5174, F, F, Cl,pyrrazol-2-yl, Cl), (M-5175, F, F, Cl, pyrrazol-2-yl, F), (M-5176, F, F,Cl, pyrrazol-2-yl, CF₃), (M-5177, F, F, Cl, pyrrazol-2-yl, Br), (M-5178,F, F, Cl, pyrrazol-2-yl, CH₃), (M-5179, F, F, Cl, pyrrazol-3-yl, H),(M-5180, F, F, Cl, pyrrazol-3-yl, Cl), (M-5181, F, F, Cl, pyrrazol-3-yl,F), (M-5182, F, F, Cl, pyrrazol-3-yl, CF₃), (M-5183, F, F, Cl,pyrrazol-3-yl, Br), (M-5184, F, F, Cl, pyrrazol-3-yl, CH₃), (M-5185, F,F, Cl, pyrimidin-2-yl, H), (M-5186, F, F, Cl, pyrimidin-2-yl, Cl),(M-5187, F, F, Cl, pyrimidin-2-yl, F), (M-5188, F, F, Cl,pyrimidin-2-yl, CF₃), (M-5189, F, F, Cl, pyrimidin-2-yl, Br), (M-5190,F, F, Cl, pyrimidin-2-yl, CH₃), (M-5191, F, F, Cl, pyrimidin-4-yl, H),(M-5192, F, F, Cl, pyrimidin-4-yl, Cl), (M-5193, F, F, Cl,pyrimidin-4-yl, F), (M-5194, F, F, Cl, pyrimidin-4-yl, CF₃), (M-5195, F,F, Cl, pyrimidin-4-yl, Br), (M-5196, F, F, Cl, pyrimidin-4-yl, CH₃),(M-5197, F, F, Cl, pyrimidin-5-yl, H), (M-5198, F, F, Cl,pyrimidin-5-yl, Cl), (M-5199, F, F, Cl, pyrimidin-5-yl, F), (M-5200, F,F, Cl, pyrimidin-5-yl, CF₃), (M-5201, F, F, Cl, pyrimidin-5-yl, Br),(M-5202, F, F, Cl, pyrimidin-5-yl, CH₃), (M-5203, F, F, Cl,HOOCCH₂CH₂CH₂, H), (M-5204, F, F, Cl, HOOCCH₂CH₂CH₂, Cl), (M-5205, F, F,Cl, HOOCCH₂CH₂CH₂, F), (M-5206, F, F, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-5207,F, F, Cl, HOOCCH₂CH₂CH₂, Br), (M-5208, F, F, Cl, HOOCCH₂CH₂CH₂, CH₃),(M-5209, F, F, Cl, HOOCCH₂CH₂CH₂CH₂, H), (M-5210, F, F, Cl,HOOCCH₂CH₂CH₂CH₂, Cl), (M-5211, F, F, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-5212,F, F, Cl, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-5213, F, F, Cl, HOOCCH₂CH₂CH₂CH₂,Br), (M-5214, F, F, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-5215, F, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-5216, F, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-5217, F, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-5218, F, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-5219, F, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-5220, F, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-5221, F, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-5222, F, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,Cl), (M-5223, F, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-5224, F, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-5225, F, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-5226, F, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-5227, F, F, Cl, MeOCH₂, H), (M-5228,F, F, Cl, MeOCH₂, Cl), (M-5229, F, F, Cl, MeOCH₂, F), (M-5230, F, F, Cl,MeOCH₂, CF₃), (M-5231, F, F, Cl, MeOCH₂, Br), (M-5232, F, F, Cl, MeOCH₂,CH₃), (M-5233, F, F, Cl, EtOCH₂, H), (M-5234, F, F, Cl, EtOCH₂, Cl),(M-5235, F, F, Cl, EtOCH₂, F), (M-5236, F, F, Cl, EtOCH₂, CF₃), (M-5237,F, F, Cl, EtOCH₂, Br), (M-5238, F, F, Cl, EtOCH₂, CH₃), (M-5239, F, F,Cl, EtOCH₂CH₂, H), (M-5240, F, F, Cl, EtOCH₂CH₂, Cl), (M-5241, F, F, Cl,EtOCH₂CH₂, F), (M-5242, F, F, Cl, EtOCH₂CH₂, CF₃), (M-5243, F, F, Cl,EtOCH₂CH₂, Br), (M-5244, F, F, Cl, EtOCH₂CH₂, CH₃), (M-5245, F, F, Cl,MeOCH₂CH₂OCH₂CH₂, H), (M-5246, F, F, Cl, MeOCH₂CH₂OCH₂CH₂, Cl), (M-5247,F, F, Cl, MeOCH₂CH₂OCH₂CH₂, F), (M-5248, F, F, Cl, MeOCH₂CH₂OCH₂CH₂,CF₃), (M-5249, F, F, Cl, MeOCH₂CH₂OCH₂CH₂, Br), (M-5250, F, F, Cl,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-5251, F, F, Cl, MeOCH₂CH₂, H), (M-5252, F, F,Cl, MeOCH₂CH₂, Cl), (M-5253, F, F, Cl, MeOCH₂CH₂, F), (M-5254, F, F, Cl,MeOCH₂CH₂, CF₃), (M-5255, F, F, Cl, MeOCH₂CH₂, Br), (M-5256, F, F, Cl,MeOCH₂CH₂, CH₃), (M-5257, F, F, Cl, HOCH₂, H), (M-5258, F, F, Cl, HOCH₂,Cl), (M-5259, F, F, Cl, HOCH₂, F), (M-5260, F, F, Cl, HOCH₂, CF₃),(M-5261, F, F, Cl, HOCH₂, Br), (M-5262, F, F, Cl, HOCH₂, CH₃), (M-5263,F, F, Cl, HOCH₂CH₂, H), (M-5264, F, F, Cl, HOCH₂CH₂, Cl), (M-5265, F, F,Cl, HOCH₂CH₂, F), (M-5266, F, F, Cl, HOCH₂CH₂, CF₃), (M-5267, F, F, Cl,HOCH₂CH₂, Br), (M-5268, F, F, Cl, HOCH₂CH₂, CH₃), (M-5269, F, F, Cl,HOCH₂CH₂CH₂, H), (M-5270, F, F, Cl, HOCH₂CH₂CH₂, Cl), (M-5271, F, F, Cl,HOCH₂CH₂CH₂, F), (M-5272, F, F, Cl, HOCH₂CH₂CH₂, CF₃), (M-5273, F, F,Cl, HOCH₂CH₂CH₂, Br), (M-5274, F, F, Cl, HOCH₂CH₂CU₂, CH₃), (M5275, F,F, Cl, HOCH₂CH₂CH₂CH₂, H), (M-5276, F, F, Cl, HOCH₂CH₂CH₂CH₂, Cl),(M-5277, F, F, Cl, HOCH₂CH₂CH₂CH₂, F), (M-5278, F, F, Cl,HOCH₂CH₂CH₂CH₂, CF₃), (M-5279, F, F, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-5280,F, F, Cl, HOCH₂CH₂CH₂CH₂, CH₃), (M-5281, F, F, Cl, HOCH₂CH₂CH₂CH₂CH₂,H), (M-5282, F, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-5283, F, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-5284, F, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-5285, F, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-5286, F, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-5287, F, F, Cl, HOCH₂CH₂O CH₂CH₂, H),(M-5288, F, F, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-5289, F, F, Cl,HOCH₂CH₂OCH₂CH₂, F), (M-5290, F, F, Cl, HOCH₂CH₂OCH₂CH₂, CF₃), (M-5291,F, F, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-5292, F, F, Cl, HOCH₂CH₂OCH₂CH₂, CH₃),(M-5293, F, F, Cl, (Me)₂N, H), (M-5294, F, F, Cl, (Me)₂N, Cl), (M-5295,F, F, Cl, (Me)₂N, F), (M-5296, F, F, Cl, (Me)₂N, CF₃), (M-5297, F, F,Cl, (Me)₂N, Br), (M-5298, F, F, Cl, (Me)₂N, CH₃), (M-5299, F, F, Cl,piperidin-4-yl-methyl, H), (M-5300, F, F, Cl, piperidin-4-yl-methyl,Cl), (M-5301, F, F, Cl, piperidin-4-yl-methyl, F), (M-5302, F, F, Cl,piperidin-4-yl-methyl, CF₃), (M-5303, F, F, Cl, piperidin-4-yl-methyl,Br), (M-5304, F, F, Cl, piperidin-4-yl-methyl, CH₃), (M-5305, F, F, Cl,cyclohexylmethyl, H), (M-5306, F, F, Cl, cyclohexylmethyl, Cl), (M-5307,F, F, Cl, cyclohexylmethyl, F), (M-5308, F, F, Cl, cyclohexylmethyl,CF₃), (M-5309, F, F, Cl, cyclohexylmethyl, Br), (M-5310, F, F, Cl,cyclohexylmethyl, CH₃), (M-5311, F, CH₃, H, H, H), (M-5312, F, CH₃, H,H, Cl), (M-5313, F, CH₃, H, H, F), (M-5314, F, CH₃, H, H, CF₃), (M-5315,F, CH₃, H, H, Br), (M-5316, F, CH₃, H, H, CH₃), (M-5317, F, CH₃, H, F,H), (M-5318, F, CH₃, H, F, Cl), (M-5319, F, CH₃, H, F, F), (M-5320, F,CH₃, H, F, CF₃), (M-5321, F, CH₃, H, F, Br), (M-5322, F, CH₃, H, F,CH₃), (M-5323, F, CH₃, H, Cl, H), (M-5324, F, CH₃, H, Cl, Cl), (M-5325,F, CH₃, H, Cl, F), (M-5326, F, CH₃, H, Cl, CF₃), (M-5327, F, CH₃, H, Cl,Br), (M-5328, F, CH₃, H, Cl, CH₃), (M-5329, F, CH₃, H, CH₃, H), (M-5330,F, CH₃, H, CH₃, Cl), (M-5331, F, CH₃, H, CH₃, F), (M-5332, F, CH₃, H,CH₃, CF₃), (M-5333, F, CH₃, H, CH₃, Br), (M-5334, F, CH₃, H, CH₃, CH₃),(M-5335, F, CH₃, H, Et, H), (M-5336, F, CH₃, H, Et, Cl), (M-5337, F,CH₃, H, Et, F), (M-5338, F, CH₃, H, Et, CF₃), (M-5339, F, CH₃, H, Et,Br), (M-5340, F, CH₃, H, Et, CH₃), (M-5341, F, CH₃, H, n-Pr, H),(M-5342, F, CH₃, H, n-Pr, Cl), (M-5343, F, CH₃, H, n-Pr, F), (M-5344, F,CH₃, H, n-Pr, CF₃), (M-5345, F, CH₃, H, n-Pr, Br), (M-5346, F, CH₃, H,n-Pr, CH₃), (M-5347, F, CH₃, H, c-Pr, H), (M-5348, F, CH₃, H, c-Pr, Cl),(M-5349, F, CH₃, H, c-Pr, F), (M-5350, F, CH₃, H, c-Pr, CF₃), (M-5351,F, CH₃, H, c-Pr, Br), (M-5352, F, CH₃, H, c-Pr, CH₃), (M-5353, F, CH₃,H, i-Pr, H), (M-5354, F, CH₃, H, i-Pr, Cl), (M-5355, F, CH₃, H, i-Pr,F), (M-5356, F, CH₃, H, i-Pr, CF₃), (M-5357, F, CH₃, H, i-Pr, Br),(M-5358, F, CH₃, H, i-Pr, CH₃), (M-5359, F, CH₃, H, n-Bu, H), (M-5360,F, CH₃, H, n-Bu, Cl), (M-5361, F, CH₃, H, n-Bu, F), (M-5362, F, CH₃, H,n-Bu, CF₃), (M-5363, F, CH₃, H, n-Bu, Br), (M-5364, F, CH₃, H, n-Bu,CH₃), (M-5365, F, CH₃, H, i-Bu, H), (M-5366, F, CH₃, H, i-Bu, Cl),(M-5367, F, CH₃, H, i-Bu, F), (M-5368, F, CH₃, H, i-Bu, CF₃), (M-5369,F, CH₃, H, i-Bu, Br), (M-5370, F, CH₃, H, i-Bu, CH₃), (M-5371, F, CH₃,H, sec-Bu, H), (M-5372, F, CH₃, H, sec-Bu, Cl), (M-5373, F, CH₃, H,sec-Bu, F), (M-5374, F, CH₃, H, sec-Bu, CF₃), (M-5375, F, CH₃, H,sec-Bu, Br), (M-5376, F, CH₃, H, sec-Bu, CH₃), (M-5377, F, CH₃, H,n-Pen, H), (M-5378, F, CH₃, H, n-Pen, Cl), (M-5379, F, CH₃, H, n-Pen,F), (M-5380, F, CH₃, H, n-Pen, CF₃), (M-5381, F, CH₃, H, n-Pen, Br),(M-5382, F, CH₃, H, n-Pen, CH₃), (M-5383, F, CH₃, H, c-Pen, H), (M-5384,F, CH₃, H, c-Pen, Cl), (M-5385, F, CH₃, H, c-Pen, F), (M-5386, F, CH₃,H, c-Pen, CF₃), (M-5387, F, CH₃, H, c-Pen, Br), (M-5388, F, CH₃, H,c-Pen, CH₃), (M-5389, F, CH₃, H, n-Hex, H), (M-5390, F, CH₃, H, n-Hex,Cl), (M-5391, F, CH₃, H, n-Hex, F), (M-5392, F, CH₃, H, n-Hex, CF₃),(M-5393, F, CH₃, H, n-Hex, Br), (M-5394, F, CH₃, H, n-Hex, CH₃),(M-5395, F, CH₃, H, c-Hex, H), (M-5396, F, CH₃, H, c-Hex, Cl), (M-5397,F, CH₃, H, c-Hex, F), (M-5398, F, CH₃, H, c-Hex, CF₃), (M-5399, F, CH₃,H, c-Hex, Br), (M-5400, F, CH₃, H, c-Hex, CH₃), (M-5401, F, CH₃, H, OH,H), (M-5402, F, CH₃, H, OH, Cl), (M-5403, F, CH₃, H, OH, F), (M-5404, F,CH₃, H, OH, CF₃), (M-5405, F, CH₃, H, OH, Br), (M-5406, F, CH₃, H, OH,CH₃), (M-5407, F, CH₃, H, EtO, H), (M-5408, F, CH₃, H, EtO, Cl),(M-5409, F, CH₃, H, EtO, F), (M-5410, F, CH₃, H, EtO, CF₃), (M-5411, F,CH₃, H, EtO, Br), (M-5412, F, CH₃, H, EtO, CH₃), (M-5413, F, CH₃, H,n-PrO, H), (M-5414, F, CH₃, H, n-PrO, Cl), (M-5415, F, CH₃, H, n-PrO,F), (M-5416, F, CH₃, H, n-PrO, CF₃), (M-5417, F, CH₃, H, n-PrO, Br),(M-5418, F, CH₃, H, n-PrO, CH₃), (M-5419, F, CH₃, H, PhO, H), (M-5420,F, CH₃, H, PhO, Cl), (M-5421, F, CH₃, H, PhO, F), (M-5422, F, CH₃, H,PhO, CF₃), (M-5423, F, CH₃, H, PhO, Br), (M-5424, F, CH₃, H, PhO, CH₃),(M-5425, F, CH₃, H, BnO, H), (M-5426, F, CH₃, H, BnO, Cl), (M-5427, F,CH₃, H, BnO, F), (M-5428, F, CH₃, H, BnO, CF₃), (M-5429, F, CH₃, H, BnO,Br), (M-5430, F, CH₃, H, BnO, CH₃), (M-5431, F, CH₃, H, PhCH₂CH₂O, H),(M-5432, F, CH₃, H, PhCH₂CH₂O, Cl), (M-5433, F, CH₃, H, PhCH₂CH₂O, F),(M-5434, F, CH₃, H, PhCH₂CH₂O, CF₃), (M-5435, F, CH₃, H, PhCH₂CH₂O, Br),(M-5436, F, CH₃, H, PhCH₂CH₂O, CH₃), (M-5437, F, CH₃, H, CF₃O, H),(M-5438, F, CH₃, H, CF₃O, Cl), (M-5439, F, CH₃, H, CF₃O, F), (M-5440, F,CH₃, H, CF₃O, CF₃), (M-5441, F, CH₃, H, CF₃O, Br), (M-5442, F, CH₃, H,CF₃O, CH₃), (M-5443, F, CH₃, H, Ph, H), (M-5444, F, CH₃, H, Ph, Cl),(M-5445, F, CH₃, H, Ph, F), (M-5446, F, CH₃, H, Ph, CF₃), (M-5447, F,CH₃, H, Ph, Br), (M-5448, F, CH₃, H, Ph, CH₃), (M-5449, F, CH₃, H,4-F-Ph, H), (M-5450, F, CH₃, H, 4-F-Ph, Cl), (M-5451, F, CH₃, H, 4-F-Ph,F), (M-5452, F, CH₃, H, 4-F-Ph, CF₃), (M-5453, F, CH₃, H, 4-F-Ph, Br),(M-5454, F, CH₃, H, 4-F-Ph, CH₃), (M-5455, F, CH₃, H, 4-CF₃-Ph, H),(M-5456, F, CH₃, H, 4-CF₃-Ph, Cl), (M-5457, F, CH₃, H, 4-CF₃-Ph, F),(M-5458, F, CH₃, H, 4-CF₃-Ph, CF₃), (M-5459, F, CH₃, H, 4-CF₃-Ph, Br),(M-5460, F, CH₃, H, 4-CF₃-Ph, CH₃), (M-5461, F, CH₃, H, 4-(Me)₂N-Ph, H),(M-5462, F, CH₃, H, 4-(Me)₂N-Ph, Cl), (M-5463, F, CH₃, H, 4-(Me)₂N-Ph,F), (M-5464, F, CH₃, H, 4-(Me)₂N-Ph, CF₃), (M-5465, F, CH₃, H,4-(Me)₂N-Ph, Br), (M-5466, F, CH₃, H, 4-(Me)₂N-Ph, CH₃), (M-5467, F,CH₃, H, 4-OH-Ph, H), (M-5468, F, CH₃, H, 4-OH-Ph, Cl), (M-5469, F, CH₃,H, 4-OH-Ph, F), (M-5470, F, CH₃, H, 4-OH-Ph, CF₃), (M-5471, F, CH₃, H,4-OH-Ph, Br), (M-5472, F, CH₃, H, 4-OH-Ph, CH₃), (M-5473, F, CH₃, H,3,4-di-F-Ph, H), (M-5474, F, CH₃, H, 3,4-di-F-Ph, Cl), (M-5475, F, CH₃,H, 3,4-di-F-Ph, F), (M-5476, F, CH₃, H, 3,4-di-F-Ph, CF₃), (M-5477, F,CH₃, H, 3,4-di-F-Ph, Br), (M-5478, F, CH₃, H, 3,4-di-F-Ph, CH₃),(M-5479, F, CH₃, H, 4-COOH-Ph, H), (M-5480, F, CH₃, H, 4-COOH-Ph, Cl),(M-5481, F, CH₃, H, 4-COOH-Ph, F), (M-5482, F, CH₃, H, 4-COOH-Ph, CF₃),(M-5483, F, CH₃, H, 4-COOH-Ph, Br), (M-5484, F, CH₃, H, 4-COOH-Ph, CH₃),(M-5485, F, CH₃, H, Bn, H), (M-5486, F, CH₃, H, Bn, Cl), (M-5487, F,CH₃, H, Bn, F), (M-5488, F, CH₃, H, Bn, CF₃), (M-5489, F, CH₃, H, Bn,Br), (M-5490, F, CH₃, H, Bn, CH₃), (M-5491, F, CH₃, H, 4-F-Bn, H),(M-5492, F, CH₃, H, 4-F-Bn, Cl), (M-5493, F, CH₃, H, 4-F-Bn, F),(M-5494, F, CH₃, H, 4-F-Bn, CF₃), (M-5495, F, CH₃, H, 4-F-Bn, Br),(M-5496, F, CH₃, H, 4-F-Bn, CH₃), (M-5497, F, CH₃, H, 2-Py, H), (M-5498,F, CH₃, H, 2-Py, Cl), (M-5499, F, CH₃, H, 2-Py, F), (M-5500, F, CH₃, H,2-Py, CF₃), (M-5501, F, CH₃, H, 2-Py, Br), (M-5502, F, CH₃, H, 2-Py,CH₃), (M-5503, F, CH₃, H, 3-Py, H), (M-5504, F, CH₃, H, 3-Py, Cl),(M-5505, F, CH₃, H, 3-Py, F), (M-5506, F, CH₃, H, 3-Py, CF₃), (M-5507,F, CH₃, H, 3-Py, Br), (M-5508, F, CH₃, H, 3-Py, CH₃), (M-5509, F, CH₃,H, 4-Py, H), (M-5510, F, CH₃, H, 4-Py, Cl), (M-5511, F, CH₃, H, 4-Py,F), (M-5512, F, CH₃, H, 4-Py, CF₃), (M-5513, F, CH₃, H, 4-Py, Br),(M-5514, F, CH₃, H, 4-Py, CH₃), (M-5515, F, CH₃, H, 2-Th, H), (M-5516,F, CH₃, H, 2-Th, Cl), (M-5517, F, CH₃, H, 2-Th, F), (M-5518, F, CH₃, H,2-Th, CF₃), (M-5519, F, CH₃, H, 2-Th, Br), (M-5520, F, CH₃, H, 2-Th,CH₃), (M-5521, F, CH₃, H, 3-Th, H), (M-5522, F, CH₃, H, 3-Th, Cl),(M-5523, F, CH₃, H, 3-Th, F), (M-5524, F, CH₃, H, 3-Th, CF₃), (M-5525,F, CH₃, H, 3-Th, Br), (M-5526, F, CH₃, H, 3-Th, CH₃), (M-5527, F, CH₃,H, pyrrazol-2-yl, H), (M-5528, F, CH₃, H, pyrrazol-2-yl, Cl), (M-5529,F, CH₃, H, pyrrazol-2-yl, F), (M-5530, F, CH₃, H, pyrrazol-2-yl, CF₃),(M-5531, F, CH₃, H, pyrrazol-2-yl, Br), (M-5532, F, CH₃, H,pyrrazol-2-yl, CH₃), (M-5533, F, CH₃, H, pyrrazol-3-yl, H), (M-5534, F,CH₃, H, pyrrazol-3-yl, Cl), (M-5535, F, CH₃, H, pyrrazol-3-yl, F),(M-5536, F, CH₃, H, pyrrazol-3-yl, CF₃), (M-5537, F, CH₃, H,pyrrazol-3-yl, Br), (M-5538, F, CH₃, H, pyrrazol-3-yl, CH₃), (M-5539, F,CH₃, H, pyrimidin-2-yl, H), (M-5540, F, CH₃, H, pyrimidin-2-yl, Cl),(M-5541, F, CH₃, H, pyrimidin-2-yl, F), (M-5542, F, CH₃, H,pyrimidin-2-yl, CF₃), (M-5543, F, CH₃, H, pyrimidin-2-yl, Br), (M-5544,F, CH₃, H, pyrimidin-2-yl, CH₃), (M-5545, F, CH₃, H, pyrimidin-4-yl, H),(M-5546, F, CH₃, H, pyrimidin-4-yl, Cl), (M-5547, F, CH₃, H,pyrimidin-4-yl, F), (M-5548, F, CH₃, H, pyrimidin-4-yl, CF₃), (M-5549,F, CH₃, H, pyrimidin-4-yl, Br), (M-5550, F, CH₃, H, pyrimidin-4-yl,CH₃), (M-5551, F, CH₃, H, pyrimidin-5-yl, H), (M-5552, F, CH₃, H,pyrimidin-5-yl, Cl), (M-5553, F, CH₃, H, pyrimidin-5-yl, F), (M-5554, F,CH₃, H, pyrimidin-5-yl, CF₃), (M-5555, F, CH₃, H, pyrimidin-5-yl, Br),(M-5556, F, CH₃, H, pyrimidin-5-yl, CH₃), (M-5557, F, CH₃, H,HOOCCH₂CH₂CH₂, H), (M-5558, F, CH₃, H, HOOCCH₂CH₂CH₂, Cl), (M-5559, F,CH₃, H, HOOCCH₂CH₂CH₂, F), (M-5560, F, CH₃, H, HOOCCH₂CH₂CH₂, CF₃),(M-5561, F, CH₃, H, HOOCCH₂CH₂CH₂, Br), (M-5562, F, CH₃, H,HOOCCH₂CH₂CH₂, CH₃), (M-5563, F, CH₃, H, HOOCCH₂CH₂CH₂CH₂, H), (M-5564,F, CH₃, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-5565, F, CH₃, H, HOOCCH₂CH₂CH₂CH₂,F), (M-5566, F, CH₃, H, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-5567, F, CH₃, H,HOOCCH₂CH₂CH₂CH₂, Br), (M-5568, F, CH₃, H, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-5569, F, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-5570, F, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-5571, F, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-5572, F, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂CF₃), (M-5573, F, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-5574, F, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-5575, F, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-5576, F, CH₃,H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-5577, F, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-5578, F, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-5579, F, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-5580, F, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-5581, F, CH₃, H, MeOCH₂, H), (M-5582,F, CH₃, H, MeOCH₂, Cl), (M-5583, F, CH₃, H, MeOCH₂, F), (M-5584, F, CH₃,H, MeOCH₂, CF₃), (M-5585, F, CH₃, H, MeOCH₂, Br), (M-5586, F, CH₃, H,MeOCH₂, CH₃), (M-5587, F, CH₃, H, EtOCH₂, H), (M-5588, F, CH₃, H,EtOCH₂, Cl), (M-5589, F, CH₃, H, EtOCH₂, F), (M-5590, F, CH₃, H, EtOCH₂,CF₃), (M-5591, F, CH₃, H, EtOCH₂, Br), (M-5592, F, CH₃, H, EtOCH₂, CH₃),(M-5593, F, CH₃, H, EtOCH₂CH₂, H), (M-5594, F, CH₃, H, EtOCH₂CH₂, Cl),(M-5595, F, CH₃, H, EtOCH₂CH₂, F), (M-5596, F, CH₃, H, EtOCH₂CH₂, CF₃),(M-5597, F, CH₃, H, EtOCH₂CH₂, Br), (M-5598, F, CH₃, H, EtOCH₂CH₂, CH₃),(M-5599, F, CH₃, H, MeOCH₂CH₂OCH₂CH₂, H), (M-5600, F, CH₃, H,MeOCH₂CH₂OCH₂CH₂, Cl), (M-5601, F, CH₃, H, MeOCH₂CH₂OCH₂CH₂, F),(M-5602, F, CH₃, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-5603, F, CH₃, H,MeOCH₂CH₂OCH₂CH₂, Br), (M-5604, F, CH₃, H, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-5605, F, CH₃, H, MeOCH₂CH₂, H), (M-5606, F, CH₃, H, MeOCH₂CH₂, Cl),(M-5607, F, CH₃, H, MeOCH₂CH₂, F), (M-5608, F, CH₃, H, MeOCH₂CH₂, CF₃),(M-5609, F, CH₃, H, MeOCH₂CH₂, Br), (M-5610, F, CH₃, H, MeOCH₂CH₂, CH₃),(M-5611, F, CH₃, H, HOCH₂, H), (M-5612, F, CH₃, H, HOCH₂, Cl), (M-5613,F, CH₃, H, HOCH₂, F), (M-5614, F, CH₃, H, HOCH₂, CF₃), (M-5615, F, CH₃,H, HOCH₂, Br), (M-5616, F, CH₃, H, HOCH₂, CH₃), (M-5617, F, CH₃, H,HOCH₂CH₂, H), (M-5618, F, CH₃, H, HOCH₂CH₂, Cl), (M-5619, F, CH₃, H,HOCH₂CH₂, F), (M-5620, F, CH₃, H, HOCH₂CH₂, CF₃), (M-5621, F, CH₃, H,HOCH₂CH₂, Br), (M-5622, F, CH₃, H, HOCH₂CH₂, CH₃), (M-5623, F, CH₃, H,HOCH₂CH₂CH₂, H), (M-5624, F, CH₃, H, HOCH₂CH₂CH₂, Cl), (M-5625, F, CH₃,H, HOCH₂CH₂CH₂, F), (M-5626, F, CH₃, H, HOCH₂CH₂CH₂, CF₃), (M-5627, F,CH₃, H, HOCH₂CH₂CH₂, Br), (M-5628, F, CH₃, H, HOCH₂CH₂CH₂, CH₃),(M-5629, F, CH₃, H, HOCH₂CH₂CH₂CH₂, H), (M-5630, F, CH₃, H,HOCH₂CH₂CH₂CH₂, Cl), (M-5631, F, CH₃, H, HOCH₂CH₂CH₂CH₂, F), (M-5632, F,CH₃, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-5633, F, CH₃, H, HOCH₂CH₂CH₂CH₂, Br),(M-5634, F, CH₃, H, HOCH₂CH₂CH₂CH₂, CH₃), (M-5635, F, CH₃, H,HOCH₂CH₂CH₂CH₂CH₂, H), (M-5636, F, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-5637, F, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, F), (M-5638, F, CH₃, H,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-5639, F, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-5640, F, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-5641, F, CH₃, H,HOCH₂CH₂OCH₂CH₂, H), (M-5642, F, CH₃, H, HOCH₂CH₂OCH₂CH₂, Cl), (M-5643,F, CH₃, H, HOCH₂CH₂OCH₂CH₂, F), (M-5644, F, CH₃, H, HOCH₂CH₂OCH₂CH₂,CF₃), (M-5645, F, CH₃, H, HOCH₂CH₂OCH₂CH₂, Br) (M-5646, F, CH₃, H,HOCH₂CH₂OCH₂CH₂, CH₃), (M-5647, F, CH₃, H, (Me)₂N, H), (M-5648, F, CH₃,H, (Me)₂N, Cl), (M-5649, F, CH₃, H, (Me)₂N, F), (M-5650, F, CH₃, H,(Me)₂N, CF₃), (M-5651, F, CH₃, H, (Me)₂N, Br), (M-5652, F, CH₃, H,(Me)₂N, CH₃), (M-5653, F, CH₃, H, piperidin-4-yl-methyl, H), (M-5654, F,CH₃, H, piperidin-4-yl-methyl, Cl), (M-5655, F, CH₃, H,piperidin-4-yl-methyl, F), (M-5656, F, CH₃, H, piperidin-4-yl-methyl,CF₃), (M-5657, F, CH₃, H, piperidin-4-yl-methyl, Br), (M-5658, F, CH₃,H, piperidin-4-yl-methyl, CH₃), (M-5659, F, CH₃, H, cyclohexylmethyl,H), (M-5660, F, CH₃, H, cyclohexylmethyl, Cl), (M-5661, F, CH₃, H,cyclohexylmethyl, F), (M-5662, F, CH₃, H, cyclohexylmethyl, CF₃),(M-5663, F, CH₃, H, cyclohexylmethyl, Br), (M-5664, F, CH₃, H,cyclohexylmethyl, CH₃), (M-5665, F, CH₃, F, H, H), (M-5666, F, CH₃, F,H, Cl), (M-5667, F, CH₃, F, H, F), (M-5668, F, CH₃, F, H, CF₃), (M-5669,F, CH₃, F, H, Br), (M-5670, F, CH₃, F, H, CH₃), (M-5671, F, CH₃, F, F,H), (M-5672, F, CH₃, F, F, Cl), (M-5673, F, CH₃, F, F, F), (M-5674, F,CH₃, F, F, CF₃), (M-5675, F, CH₃, F, F, Br), (M-5676, F, CH₃, F, F,CH₃), (M-5677, F, CH₃, F, Cl, H), (M-5678, F, CH₃, F, Cl, Cl), (M-5679,F, CH₃, F, Cl, F), (M-5680, F, CH₃, F, Cl, CF₃), (M-5681, F, CH₃, F, Cl,Br), (M-5682, F, CH₃, F, Cl, CH₃), (M-5683, F, CH₃, F, CH₃, H), (M-5684,F, CH₃, F, CH₃, Cl), (M-5685, F, CH₃, F, CH₃, F), (M-5686, F, CH₃, F,CH₃, CF₃), (M-5687, F, CH₃, F, CH₃, Br), (M-5688, F, CH₃, F, CH₃, CH₃),(M-5689, F, CH₃, F, Et, H), (M-5690, F, CH₃, F, Et, Cl), (M-5691, F,CH₃, F, Et, F), (M-5692, F, CH₃, F, Et, CF₃), (M-5693, F, CH₃, F, Et,Br), (M-5694, F, CH₃, F, Et, CH₃), (M-5695, F, CH₃, F, n-Pr, H),(M-5696, F, CH₃, F, n-Pr, Cl), (M-5697, F, CH₃, F, n-Pr, F), (M-5698, F,CH₃, F, n-Pr, CF₃), (M-5699, F, CH₃, F, n-Pr, Br), (M-5700, F, CH₃, F,n-Pr, CH₃), (M-5701, F, CH₃, F, c-Pr, H), (M-5702, F, CH₃, F, c-Pr, Cl),(M-5703, F, CH₃, F, c-Pr, F), (M-5704, F, CH₃, F, c-Pr, CF₃), (M-5705,F, CH₃, F, c-Pr, Br), (M-5706, F, CH₃, F, c-Pr, CH₃), (M-5707, F, CH₃,F, i-Pr, H), (M-5708, F, CH₃, F, i-Pr, Cl), (M-5709, F, CH₃, F, i-Pr,F), (M-5710, F, CH₃, F, i-Pr, CF₃), (M-5711, F, CH₃, F, i-Pr, Br),(M-5712, F, CH₃, F, i-Pr, CH₃), (M-5713, F, CH₃, F, n-Bu, H), (M-5714,F, CH₃, F, n-Bu, Cl), (M-5715, F, CH₃, F, n-Bu, F), (M-5716, F, CH₃, F,n-Bu, CF₃), (M-5717, F, CH₃, F, n-Bu, Br), (M-5718, F, CH₃, F, n-Bu,CH₃), (M-5719, F, CH₃, F, i-Bu, H), (M-5720, F, CH₃, F, i-Bu, Cl),(M-5721, F, CH₃, F, i-Bu, F), (M-5722, F, CH₃, F, i-Bu, CF₃), (M-5723,F, CH₃, F, i-Bu, Br), (M-5724, F, CH₃, F, i-Bu, CH₃), (M-5725, F, CH₃,F, sec-Bu, H), (M-5726, F, CH₃, F, sec-Bu, Cl), (M-5727, F, CH₃, F,sec-Bu, F), (M-5728, F, CH₃, F, sec-Bu, CF₃), (M-5729, F, CH₃, F,sec-Bu, Br), (M-5730, F, CH₃, F, sec-Bu, CH₃), (M-5731, F, CH₃, F,n-Pen, H), (M-5732, F, CH₃, F, n-Pen, Cl), (M-5733, F, CH₃, F, n-Pen,F), (M-5734, F, CH₃, F, n-Pen, CF₃), (M-5735, F, CH₃, F, n-Pen, Br),(M-5736, F, CH₃, F, n-Pen, CH₃), (M-5737, F, CH₃, F, c-Pen, H), (M-5738,F, CH₃, F, c-Pen, Cl), (M-5739, F, CH₃, F, c-Pen, F), (M-5740, F, CH₃,F, c-Pen, CF₃), (M-5741, F, CH₃, F, c-Pen, Br), (M-5742, F, CH₃, F,c-Pen, CH₃), (M-5743, F, CH₃, F, n-Hex, H), (M-5744, F, CH₃, F, n-Hex,Cl), (M-5745, F, CH₃, F, n-Hex, F), (M-5746, F, CH₃, F, n-Hex, CF₃),(M-5747, F, CH₃, F, n-Hex, Br), (M-5748, F, CH₃, F, n-Hex, CH₃),(M-5749, F, CH₃, F, c-Hex, H), (M-5750, F, CH₃, F, c-Hex, Cl), (M-5751,F, CH₃, F, c-Hex, F), (M-5752, F, CH₃, F, c-Hex, CF₃), (M-5753, F, CH₃,F, c-Hex, Br), (M-5754, F, CH₃, F, c-Hex, CH₃), (M-5755, F, CH₃, F, OH,H), (M-5756, F, CH₃, F, OH, Cl), (M-5757, F, CH₃, F, OH, F), (M-5758, F,CH₃, F, OH, CF₃), (M-5759, F, CH₃, F, OH, Br), (M-5760, F, CH₃, F, OH,CH₃), (M-5761, F, CH₃, F, EtO, H), (M-5762, F, CH₃, F, EtO, Cl),(M-5763, F, CH₃, F, EtO, F), (M-5764, F, CH₃, F, EtO, CF₃), (M-5765, F,CH₃, F, EtO, Br), (M-5766, F, CH₃, F, EtO, CH₃), (M-5767, F, CH₃, F,n-PrO, H), (M-5768, F, CH₃, F, n-PrO, Cl), (M-5769, F, CH₃, F, n-PrO,F), (M-5770, F, CH₃, F, n-PrO, CF₃), (M-5771, F, CH₃, F, n-PrO, Br),(M-5772, F, CH₃, F, n-PrO, CH₃), (M-5773, F, CH₃, F, PhO, H), (M-5774,F, CH₃, F, PhO, Cl), (M-5775, F, CH₃, F, PhO, F), (M-5776, F, CH₃, F,PhO, CF₃), (M-5777, F, CH₃, F, PhO, Br), (M-5778, F, CH₃, F, PhO, CH₃),(M-5779, F, CH₃, F, BnO, H), (M-5780, F, CH₃, F, BnO, Cl), (M-5781, F,CH₃, F, BnO, F), (M-5782, F, CH₃, F, BnO, CF₃), (M-5783, F, CH₃, F, BnO,Br), (M-5784, F, CH₃, F, BnO, CH₃), (M-5785, F, CH₃, F, PhCH₂CH₂O, H),(M-5786, F, CH₃, F, PhCH₂CH₂O, Cl), (M-5787, F, CH₃, F, PhCH₂CH₂O, F),(M-5788, F, CH₃, F, PhCH₂CH₂O, CF₃), (M-5789, F, CH₃, F, PhCH₂CH₂O, Br),(M-5790, F, CH₃, F, PhCH₂CH₂O, CH₃), (M-5791, F, CH₃, F, CF₃O, H),(M-5792, F, CH₃, F, CF₃O, Cl), (M-5793, F, CH₃, F, CF₃O, F), (M-5794, F,CH₃, F, CF₃O, CF₃), (M-5795, F, CH₃, F, CF₃O, Br), (M-5796, F, CH₃, F,CF₃O, CH₃), (M-5797, F, CH₃, F, Ph, H), (M-5798, F, CH₃, F, Ph, Cl),(M-5799, F, CH₃, F, Ph, F), (M-5800, F, CH₃, F, Ph, CF₃), (M-5801, F,CH₃, F, Ph, Br), (M-5802, F, CH₃, F, Ph, CH₃), (M-5803, F, CH₃, F,4-F-Ph, H), (M-5804, F, CH₃, F, 4-F-Ph, Cl), (M-5805, F, CH₃, F, 4-F-Ph,F), (M-5806, F, CH₃, F, 4-F-Ph, CF₃), (M-5807, F, CH₃, F, 4-F-Ph, Br),(M-5808, F, CH₃, F, 4-F-Ph, CH₃), (M-5809, F, CH₃, F, 4-CF₃-Ph, H),(M-5810, F, CH₃, F, 4-CF₃-Ph, Cl), (M-5811, F, CH₃, F, 4-CF₃-Ph, F),(M-5812, F, CH₃, F, 4-CF₃-Ph, CF₃), (M-5813, F, CH₃, F, 4-CF₃-Ph, Br),(M-5814, F, CH₃, F, 4-CF₃-Ph, CH₃), (M-5815, F, CH₃, F, 4-(Me)₂N-Ph, H),(M-5816, F, CH₃, F, 4-(Me)₂N-Ph, Cl), (M-5817, F, CH₃, F, 4-(Me)₂N-Ph,F), (M-5818, F, CH₃, F, 4-(Me)₂N-Ph, CF₃), (M-5819, F, CH₃, F,4-(Me)₂N-Ph, Br), (M-5820, F, CH₃, F, 4-(Me)₂N-Ph, CH₃), (M-5821, F,CH₃, F, 4-OH-Ph, H), (M-5822, F, CH₃, F, 4-OH-Ph, Cl), (M-5823, F, CH₃,F, 4-OH-Ph, F), (M-5824, F, CH₃, F, 4-OH-Ph, CF₃), (M-5825, F, CH₃, F,4-OH-Ph, Br), (M-5826, F, CH₃, F, 4-OH-Ph, CH₃), (M-5827, F, CH₃, F,3,4-di-F-Ph, H), (M-5828, F, CH₃, F, 3,4-di-F-Ph, Cl), (M-5829, F, CH₃,F, 3,4-di-F-Ph, F), (M-5830, F, CH₃, F, 3,4-di-F-Ph, CF₃), (M-5831, F,CH₃, F, 3,4-di-F-Ph, Br), (M-5832, F, CH₃, F, 3,4-di-F-Ph, CH₃),(M-5833, F, CH₃, F, 4-COOH-Ph, H), (M-5834, F, CH₃, F, 4-COOH-Ph, Cl),(M-5835, F, CH₃, F, 4-COOH-Ph, F), (M-5836, F, CH₃, F, 4-COOH-Ph, CF₃),(M-5837, F, CH₃, F, 4-COOH-Ph, Br), (M-5838, F, CH₃, F, 4-COOH-Ph, CH₃),(M-5839, F, CH₃, F, Bn, H), (M-5840, F, CH₃, F, Bn, Cl), (M-5841, F,CH₃, F, Bn, F), (M-5842, F, CH₃, F, Bn, CF₃), (M-5843, F, CH₃, F, Bn,Br), (M-5844, F, CH₃, F, Bn, CH₃), (M-5845, F, CH₃, F, 4-F-Bn, H),(M-5846, F, CH₃, F, 4-F-Bn, Cl), (M-5847, F, CH₃, F, 4-F-Bn, F),(M-5848, F, CH₃, F, 4-F-Bn, CF₃), (M-5849, F, CH₃, F, 4-F-Bn, Br),(M-5850, F, CH₃, F, 4-F-Bn, CH₃), (M-5851, F, CH₃, F, 2-Py, H), (M-5852,F, CH,3, F, 2-Py, Cl), (M-5853, F, CH₃, F, 2-Py, F), (M-5854, F, CH₃, F,2-Py, CF₃), (M-5855, F, CH₃, F, 2-Py, Br), (M-5856, F, CH₃, F, 2-Py,CH₃), (M-5857, F, CH₃, F, 3-Py, H), (M-5858, F, CH₃, F, 3-Py, Cl),(M-5859, F, CH₃, F, 3-Py, F), (M-5860, F, CH₃, F, 3-Py, CF₃), (M-5861,F, CH₃, F, 3-Py, Br), (M-5862, F, CH₃, F, 3-Py, CH₃), (M-5863, F, CH₃,F, 4-Py, H), (M-5864, F, CH₃, F, 4-Py, Cl), (M-5865, F, CH₃, F, 4-Py,F), (M-5866, F, CH₃, F, 4-Py, CF₃), (M-5867, F, CH₃, F, 4-Py, Br),(M-5868, F, CH₃, F, 4-Py, CH₃), (M-5869, F, CH₃, F, 2-Th, H), (M-5870,F, CH₃, F, 2-Th, Cl), (M-5871, F, CH₃, F, 2-Th, F), (M-5872, F, CH₃, F,2-Th, CF₃), (M-5873, F, CH₃, F, 2-Th, Br), (M-5874, F, CH₃, F, 2-Th,CH₃), (M-5875, F, CH₃, F, 3-Th, H), (M-5876, F, CH₃, F, 3-Th, Cl),(M-5877, F, CH₃, F, 3-Th, F), (M-5878, F, CH₃, F, 3-Th, CF₃), (M-5879,F, CH₃, F, 3-Th, Br), (M-5880, F, CH₃, F, 3-Th, CH₃), (M-5881, F, CH₃,F, pyrrazol-2-yl, H), (M-5882, F, CH₃, F, pyrrazol-2-yl, Cl), (M-5883,F, CH₃, F, pyrrazol-2-yl, F), (M-5884, F, CH₃, F, pyrrazol-2-yl, CF₃),(M-5885, F, CH₃, F, pyrrazol-2-yl, Br), (M-5886, F, CH₃, F,pyrrazol-2-yl, CH₃), (M-5887, F, CH₃, F, pyrrazol-3-yl, H), (M-5888, F,CH₃, F, pyrrazol-3-yl, Cl), (M-5889, F, CH₃, F, pyrrazol-3-yl, F),(M-5890, F, CH₃, F, pyrrazol-3-yl, CF₃), (M-5891, F, CH₃, F,pyrrazol-3-yl, Br), (M-5892, F, CH₃, F, pyrrazol-3-yl, CH₃), (M-5893, F,CH₃, F, pyrimidin-2-yl, H), (M-5894, F, CH₃, F, pyrimidin-2-yl, Cl),(M-5895, F, CH₃, F, pyrimidin-2-yl, F), (M-5896, F, CH₃, F,pyrimidin-2-yl, CF₃), (M-5897, F, CH₃, F, pyrimidin-2-yl, Br), (M-5898,F, CH₃, F, pyrimidin-2-yl, CH₃), (M-5899, F, CH₃, F, pyrimidin-4-yl, H),(M-5900, F, CH₃, F, pyrimidin-4-yl, Cl), (M-5901, F, CH₃, F,pyrimidin-4-yl, F), (M-5902, F, CH₃, F, pyrimidin-4-yl, CF₃), (M-5903,F, CU₃, F, pyrimidin-4-yl, Br), (M-5904, F, CH₃, F, pyrimidin-4-yl,CH₃), (M-5905, F, CH₃, F, pyrimidin-5-yl, H), (M-5906, F, CH₃, F,pyrimidin-5-yl, Cl), (M-5907, F, CH₃, F, pyrimidin-5-yl, F), (M-5908, F,CH₃, F, pyrimidin-5-yl, CF₃), (M-5909, F, CH₃, F, pyrimidin-5-yl, Br),(M-5910, F, CH₃, F, pyrimidin-5-yl, CH₃), (M-5911, F, CH₃, F,HOOCCH₂CH₂CH₂, H), (M-5912, F, CH₃, F, HOOCCH₂CH₂CH₂, Cl), (M-5913, F,CH₃, F, HOOCCH₂CH₂CH₂, F), (M-5914, F, CH₃, F, HOOCCH₂CH₂CH₂, CF₃),(M-5915, F, CH₃, F, HOOCCH₂CH₂CH₂, Br), (M-5916, F, CH₃, F,HOOCCH₂CH₂CH₂, CH₃), (M-5917, F, CH₃, F, HOOCCH₂CH₂CH₂CH₂, H), (M-5918,F, CH₃, F, HOOCCH₂CH₂CH₂CH₂, Cl), (M-5919, F, CH₃, F, HOOCCH₂CH₂CH₂CH₂,F), (M-5920, F, CH₃, F, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-5921, F, CH₃, F,HOOCCH₂CH₂CH₂CH₂, Br), (M-5922, F, CH₃, F, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-5923, F, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-5924, F, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-5925, F, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-5926, F, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-5927, F, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-5928, F, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-5929, F, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-5930, F, CH₃,F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-5931, F, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-5932, F, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-5933, F, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-5934, F, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-5935, F, CH₃, F, MeOCH₂, H), (M-5936,F, CH₃, F, MeOCH₂, Cl), (M-5937, F, CH₃, F, MeOCH₂, F), (M-5938, F, CH₃,F, MeOCH₂, CF₃), (M-5939, F, CH₃, F, MeOCH₂, Br), (M-5940, F, CH₃, F,MeOCH₂, CH₃), (M-5941, F, CH₃, F, EtOCH₂, H), (M-5942, F, CH₃, F,EtOCH₂, Cl), (M-5943, F, CH₃, F, EtOCH₂, F), (M-5944, F, CH_(3,)F,EtOCH₂, CF₃), (M-5945, F, CH₃, F, EtOCH₂, Br), (M-5946, F, CH₃, F,EtOCH₂, CH₃), (M-5947, F, CH₃, F, EtOCH₂CH₂, H), (M-5948, F, CH₃, F,EtOCH₂CH₂, Cl), (M-5949, F, CH₃, F, EtOCH₂CH₂, F), (M-5950, F, CH₃, F,EtOCH₂CH₂, CF₃), (M-5951, F, CH₃, F, EtOCH₂CH₂, Br), (M-5952, F, CH₃, F,EtOCH₂CH₂, CH₃), (M-5953, F, CH₃, F, MeOCH₂CH₂OCH₂CH₂, H), (M-5954, F,CH₃, F, MeOCH₂CH₂OCH₂CH₂, Cl), (M-5955, F, CH₃, F, MeOCH₂CH₂OCH₂CH₂, F),(M-5956, F, CH₃, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-5957, F, CH₃, F,MeOCH₂CH₂OCH₂CH₂, Br), (M-5958, F, CH₃, F, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-5959, F, CH₃, F, MeOCH₂CH₂, H), (M-5960, F, CH₃, F, MeOCH₂CH₂, C),(M-5961, F, CH₃, F, MeOCH₂CH₂, F), (M-5962, F, CH₃, F, MeOCH₂CH₂, CF₃),(M-5963, F, CH₃, F, MeOCH₂CH₂, Br), (M-5964, F, CH₃, F, MeOCH₂CH₂, CH₃),(M-5965, F, CH₃, F, HOCH₂, H), (M-5966, F, CH₃, F, HOCH₂, Cl), (M-5967,F, CH₃, F, HOCH₂, F), (M-5968, F, CH₃, F, HOCH₂, CF₃), (M-5969, F, CH₃,F, HOCH₂, Br), (M-5970, F, CH₃, F, HOCH₂, CH₃), (M-5971, F, CH₃, F,HOCH₂CH₂, H), (M-5972, F, CH₃, F, HOCH₂CH₂, Cl), (M-5973, F, CH₃, F,HOCH₂CH₂, F), (M-5974, F, CH₃, F, HOCH₂CH₂, CF₃), (M-5975, F, CH₃, F,HOCH₂CH₂, Br), (M-5976, F, CH₃, F, HOCH₂CH₂, CH₃), (M-5977, F, CH₃, F,HOCH₂CH₂CH₂, H), (M-5978, F, CH₃, F, HOCH₂CH₂CH₂, Cl), (M-5979, F, CH₃,F, HOCH₂CH₂CH₂, F), (M-5980, F, CH₃, F, HOCH₂CH₂CH₂, CF₃), (M-5981, F,CH₃, F, HOCH₂CH₂CH₂, Br), (M-5982, F, CH₃, F, HOCH₂CH₂CH₂, CH₃),(M-5983, F, CH₃, F, HOCH₂CH₂CH₂CH₂, H), (M-5984, F, CH₃, F,HOCH₂CH₂CH₂CH₂, Cl), (M-5985, F, CH₃, F, HOCH₂CH₂CH₂CH₂, F), (M-5986, F,CH₃, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-5987, F, CH₃, F, HOCH₂CH₂CH₂CH₂, Br),(M-5988, F, CH₃, F, HOCH₂CH₂CH₂CH₂, CH₃), (M-5989, F, CH₃, F,HOCH₂CH₂CH₂CH₂CH₂, H), (M-5990, F, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-5991, F, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, F), (M-5992, F, CH₃, F,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-5993, F, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-5994, F, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-5995, F, CH₃, F,HOCH₂CH₂OCH₂CH₂, (M-5996, F, CH₃, F, HOCH₂CH₂OCH₂CH₂, Cl), (M-5997, F,CH₃, F, HOCH₂CH₂OCH₂CH₂, F), (M-5998, F, CH₃, F, HOCH₂CH₂OCH₂CH₂, CF₃),(M-5999, F, CH₃, F, HOCH₂CH₂OCH₂CH₂, Br), (M-6000, F, CH₃, F,HOCH₂CH₂OCH₂CH₂, CH₃), (M-6001, F, CH₃, F, (Me)₂N, H), (M-6002, F, CH₃,F, (Me)₂N, Cl), (M-6003, F, CH₃, F, (Me)₂N, F), (M-6004, F, CH₃, F,(Me)₂N, CF₃), (M-6005, F, CH₃, F, (Me)₂N, Br), (M-6006, F, CH₃, F,(Me)₂N, CH₃), (M-6007, F, CH₃, F, piperidin-4-yl-methyl, H), (M-6008, F,CH₃, F, piperidin-4-yl-methyl, Cl), (M-6009, F, CH₃, F,piperidin-4-yl-methyl, F), (M-6010, F, CH₃, F, piperidin-4-yl-methyl,CF₃), (M-6011, F, CH₃, F, piperidin-4-yl-methyl, Br), (M-6012, F, CH₃,F, piperidin-4-yl-methyl, CH₃), (M-6013, F, CH₃, F, cyclohexylmethyl,H), (M-6014, F, CH₃, F, cyclohexylmethyl, Cl), (M-6015, F, CH₃, F,cyclohexylmethyl, F), (M-6016, F, CH₃, F, cyclohexylmethyl, CF₃),(M-6017, F, CH₃, F, cyclohexylmethyl, Br), (M-6018, F, CH₃, F,cyclohexylmethyl, CH₃), (M-6019, F, CH₃, Cl, H, H), (M-6020, F, CH₃, Cl,H, Cl), (M-6021, F, CH₃, Cl, H, F), (M-6022, F, CH₃, Cl, H, CF₃),(M-6023, F, CH₃, Cl, H, Br), (M-6024, F, CH₃, Cl, H, CH₃), (M-6025, F,CH₃, Cl, F, H), (M-6026, F, CH₃, Cl, F, Cl), (M-6027, F, CH₃, Cl, F, F),(M-6028, F, CH₃, Cl, F, CF₃), (M-6029, F, CH₃, Cl, F, Br), (M-6030, F,CH₃, Cl, F, CH₃), (M-6031, F, CH₃, Cl, Cl, H), (M-6032, F, CH₃, Cl, Cl,Cl), (M-6033, F, CH₃, Cl, Cl, F), (M-6034, F, CH₃, Cl, Cl, CF₃),(M-6035, F, CH₃, Cl, Cl, Br), (M-6036, F, CH₃, Cl, Cl, CH₃), (M-6037, F,CH₃, Cl, CH₃, H), (M-6038, F, CH₃, Cl, CH₃, Cl), (M-6039, F, CH₃, Cl,CH₃, F), (M-6040, F, CH₃, Cl, CH₃, CF₃), (M-6041, F, CH₃, Cl, CH₃, Br),(M-6042, F, CH₃, Cl, CH₃, CH₃), (M-6043, F, CH₃, Cl, Et, H), (M-6044, F,CH₃, Cl, Et, Cl), (M-6045, F, CH₃, Cl, Et, F), (M-6046, F, CH₃, Cl, Et,CF₃), (M-6047, F, CH₃, Cl, Et, Br), (M-6048, F, CH₃, Cl, Et, CH₃),(M-6049, F, CH₃, Cl, n-Pr, H), (M-6050, F, CH₃, Cl, n-Pr, Cl), (M-6051,F, CH₃, Cl, n-Pr, F), (M-6052, F, CH₃, Cl, n-Pr, CF₃), (M-6053, F, CH₃,Cl, n-Pr, Br), (M-6054, F, CH₃, Cl, n-Pr, CH₃), (M-6055, F, CH₃, Cl,c-Pr, H), (M-6056, F, CH₃, Cl, c-Pr, Cl), (M-6057, F, CH₃, Cl, c-Pr, F),(M-6058, F, CH₃, Cl, c-Pr, CF₃), (M-6059, F, CH₃, Cl, c-Pr, Br),(M-6060, F, CH₃, Cl, c-Pr, CH₃), (M-6061, F, CH₃, Cl, i-Pr, H), (M-6062,F, CH₃, Cl, i-Pr, Cl), (M-6063, F, CH₃, Cl, i-Pr, F), (M-6064, F, CH₃,Cl, i-Pr, CF₃), (M-6065, F, CH₃, Cl, i-Pr, Br), (M-6066, F, CH₃, Cl,i-Pr, CH₃), (M-6067, F, CH₃, Cl, n-Bu, H), (M-6068, F, CH₃, Cl, n-Bu,Cl), (M-6069, F, CH₃, Cl, n-Bu, F), (M-6070, F, CH₃, Cl, n-Bu, CF₃),(M-6071, F, CH₃, Cl, n-Bu, Br), (M-6072, F, CH₃, Cl, n-Bu, CH₃),(M-6073, F, CH₃, Cl, i-Bu, H), (M-6074, F, CH₃, Cl, i-Bu, Cl), (M-6075,F, CH₃, Cl, i-Bu, F), (M-6076, F, CH₃, Cl, i-Bu, CF₃), (M-6077, F, CH₃,Cl, i-Bu, Br), (M-6078, F, CH₃, Cl, i-Bu, CH₃), (M-6079, F, CH₃, Cl,Sec-Bu, H), (M-6080, F, CH₃, Cl, sec-Bu, Cl), (M-6081, F, CH₃, Cl,sec-Bu, F), (M-6082, F, CH₃, Cl, sec-Bu, CF₃), (M-6083, F, CH₃, Cl,sec-Bu, Br), (M-6084, F, CH₃, Cl, sec-Bu, CH₃), (M-6085, F, CH₃, Cl,n-Pen, H), (M-6086, F, CH₃, Cl, n-Pen, Cl), (M-6087, F, CH₃, Cl, n-Pen,F), (M-6088, F, CH₃, Cl, n-Pen, CF₃), (M-6089, F, CH₃, Cl, n-Pen, Br),(M-6090, F, CH₃, Cl, n-Pen, CH₃), (M-6091, F, CH₃, Cl, c-Pen, H),(M-6092, F, CH₃, Cl, c-Pen, Cl), (M-6093, F, CH₃, Cl, c-Pen, F),(M-6094, F, CH₃, Cl, c-Pen, CF₃), (M-6095, F, CH₃, Cl, c-Pen, Br),(M-6096, F, CH₃, Cl, c-Pen, CH₃), (M-6097, F, CH₃, Cl, n-Hex, H),(M-6098, F, CH₃, Cl, n-Hex, Cl), (M-6099, F, CH₃, Cl, n-Hex, F),(M-6100, F, CH₃, Cl, n-Hex, CF₃), (M-6101, F, CH₃, Cl, n-Hex, Br),(M-6102, F, CH₃, Cl, n-Hex, CH₃), (M-6103, F, CH₃, Cl, c-Hex, H),(M-6104, F, CH₃, Cl, c-Hex, Cl), (M-6105, F, CH₃, Cl, c-Hex, F),(M-6106, F, CH₃, Cl, c-Hex, CF₃), (M-6107, F, CH₃, Cl, c-Hex, Br),(M-6108, F, CH₃, Cl, c-Hex, CH₃), (M-6109, F, CH₃, Cl, OH, H), (M-6110,F, CH₃, Cl, OH, Cl), (M-6111, F, CH₃, Cl, OH, F), (M-6112, F, CH₃, Cl,OH, CF₃), (M-6113, F, CH₃, Cl, OH, Br), (M-6114, F, CH₃, Cl, OH, CH₃),(M-6115, F, CH₃, Cl, EtO, H), (M-6116, F, CH₃, Cl, EtO, Cl), (M-6117, F,CH₃, Cl, EtO, F), (M-6118, F, CH₃, Cl, EtO, CF₃), (M-6119, F, CH₃, Cl,EtO, Br), (M-6120, F, CH₃, Cl, EtO, CH₃), (M-6121, F, CH₃, Cl, n-PrO,H), (M-6122, F, CH₃, Cl, n-PrO, Cl), (M-6123, F, CH₃, Cl, n-PrO, F),(M-6124, F, CH₃, Cl, n-PrO, CF₃), (M-6125, F, CH₃, Cl, n-PrO, Br),(M-6126, F, CH₃, Cl, n-PrO, CH₃), (M-6127, F, CH₃, Cl, PhO, H), (M-6128,F, CH₃, Cl, PhO, Cl), (M-6129, F, CH₃, Cl, PhO, F), (M-6130, F, CH₃, Cl,PhO, CF₃), (M-6131, F, CH₃, Cl, PhO, Br), (M-6132, F, CH₃, Cl, PhO,CH₃), (M-6133, F, CH₃, Cl, BnO, H), (M-6134, F, CH₃, Cl, BnO, Cl),(M-6135, F, CH₃, Cl, BnO, F), (M-6136, F, CH₃, Cl, BnO, CF₃), (M-6137,F, CH₃, Cl, BnO, Br), (M-6138, F, CH₃, Cl, BnO, CH₃), (M-6139, F, CH₃,Cl, PhCH₂CH₂O, H), (M-6140, F, CH₃, Cl, PhCH₂CH₂O, Cl), (M-6141, F, CH₃,Cl, PhCH₂CH₂O, F), (M-6142, F, CH₃, Cl, PhCH₂CH₂O, CF₃), (M-6143, F,CH₃, Cl, PhCH₂CH₂O, Br), (M-6144, F, CH₃, Cl, PhCH₂CH₂O, CH₃), (M-6145,F, CH₃, Cl, CF₃O, H), (M-6146, F, CH₃, Cl, CF₃O, Cl), (M-6147, F, CH₃,Cl, CF₃O, F), (M-6148, F, CH₃, Cl, CF₃O, CF₃), (M-6149, F, CH₃, Cl,CF₃O, Br), (M-6150, F, CH₃, Cl, CF₃O, CH₃), (M-6151, F, CH₃, Cl, Ph, H),(M-6152, F, CH₃, Cl, Ph, Cl), (M-6153, F, CH₃, Cl, Ph, F), (M-6154, F,CH₃, Cl, Ph, CF₃), (M-6155, F, CH₃, Cl, Ph, Br), (M-6156, F, CH₃, Cl,Ph, CH₃), (M-6157, F, CH₃, Cl, 4-F-Ph, H), (M-6158, F, CH₃, Cl, 4-F-Ph,Cl), (M-6159, F, CH₃, Cl, 4-F-Ph, F), (M-6160, F, CH₃, Cl, 4-F-Ph, CF₃),(M-6161, F, CH₃, Cl, 4-F-Ph, Br), (M-6162, F, CH₃, Cl, 4-F-Ph, CH₃),(M-6163, F, CH₃, Cl, 4-CF₃-Ph, H), (M-6164, F, CH₃, Cl, 4-CF₃-Ph, Cl),(M-6165, F, CH₃, Cl, 4-CF₃-Ph, F), (M-6166, F, CH₃, Cl, 4-CF₃-Ph, CF₃),(M-6167, F, CH₃, Cl, 4-CF₃-Ph, Br), (M-6168, F, CH₃, Cl, 4-CF₃-Ph, CH₃),(M-6169, F, CH₃, Cl, 4-(Me)₂N-Ph, H), (M-6170, F, CH₃, Cl, 4-(Me)₂N-Ph,Cl), (M-6171, F, CH₃, Cl, 4-(Me)₂N-Ph, F), (M-6172, F, CH₃, Cl,4-(Me)₂N-Ph, CF₃), (M-6173, F, CH₃, Cl, 4-(Me)₂N-Ph, Br), (M-6174, F,CH₃, Cl, 4-(Me)₂N-Ph, CH₃), (M-6175, F, CH₃, Cl, 4-OH-Ph, H), (M-6176,F, CH₃, Cl, 4-OH-Ph, Cl), (M-6177, F, CH₃, Cl, 4-OH-Ph, F), (M-6178, F,CH₃, Cl, 4-OH-Ph, CF₃), (M-6179, F, CH₃, Cl, 4-OH-Ph, Br), (M-6180, F,CH₃, Cl, 4-OH-Ph, CH₃), (M-6181, F, CH₃, Cl, 3,4-di-F-Ph, H), (M-6182,F, CH₃, Cl, 3,4-di-F-Ph, Cl), (M-6183, F, CH₃, Cl, 3,4-di-F-Ph, F),(M-6184, F, CH₃, Cl, 3,4-di-F-Ph, CF₃), (M-6185, F, CH₃, Cl,3,4-di-F-Ph, Br), (M-6186, F, CH₃, Cl, 3,4-di-F-Ph, CH₃), (M-6187, F,CH₃, Cl, 4-COOH-Ph, H), (M-6188, F, CH₃, Cl, 4-COOH-Ph, Cl), (M-6189, F,CH₃, Cl, 4-COOH-Ph, F), (M-6190, F, CH₃, Cl, 4-COOH-Ph, CF₃), (M-6191,F, CH₃, Cl, 4-COOH-Ph, Br), (M-6192, F, CH₃, Cl, 4-COOH-Ph, CH₃),(M-6193, F, CH₃, Cl, Bn, H), (M-6194, F, CH₃, Cl, Bn, Cl), (M-6195, F,CH₃, Cl, Bn, F), (M-6196, F, CH₃, Cl, Bn, CF₃), (M-6197, F, CH₃, Cl, Bn,Br), (M-6198, F, CH₃, Cl, Bn, CH₃), (M-6199, F, CH₃, Cl, 4-F-Bn, H),(M-6200, F, CH₃, Cl, 4-F-Bn, Cl), (M-6201, F, CH₃, Cl, 4-F-Bn, F),(M-6202, F, CH₃, Cl, 4-F-Bn, CF₃), (M-6203, F, CH₃, Cl, 4-F-Bn, Br),(M-6204, F, CH₃, Cl, 4-F-Bn, CH₃), (M-6205, F, CH₃, Cl, 2-Py, H),(M-6206, F, CH₃, Cl, 2-Py, Cl), (M-6207, F, CH₃, Cl, 2-Py, F), (M-6208,F, CH₃, Cl, 2-Py, CF₃), (M-6209, F, CH₃, Cl, 2-Py, Br), (M-6210, F, CH₃,Cl, 2-Py, CH₃), (M-6211, F, CH₃, Cl, 3-Py, H), (M-6212, F, CH₃, Cl,3-Py, Cl), (M-6213, F, CH₃, Cl, 3-Py, F), (M-6214, F, CH₃, Cl, 3-Py,CF₃), (M-6215, F, CH₃, Cl, 3-Py, Br), (M-6216, F, CH₃, Cl, 3-Py, CH₃),(M-6217, F, CH₃, Cl, 4-Py, H), (M-6218, F, CH₃, Cl, 4-Py, Cl), (M-6219,F, CH₃, Cl, 4-Py, F), (M-6220, F, CH₃, Cl, 4-Py, CF₃), (M-6221, F, CH₃,Cl, 4-Py, Br), (M-6222, F, CH₃, Cl, 4-Py, CH₃), (M-6223, F, CH₃, Cl,2-Th, H), (M-6224, F, CH₃, Cl, 2-Th, Cl), (M-6225, F, CH₃, Cl, 2-Th, F),(M-6226, F, CH₃, Cl, 2-Th, CF₃), (M-6227, F, CH₃, Cl, 2-Th, Br),(M-6228, F, CH₃, Cl, 2-Th, CH₃), (M-6229, F, CH₃, Cl, 3-Th, H), (M-6230,F, CH₃, Cl, 3-Th, Cl), (M-6231, F, CH₃, Cl, 3-Th, F), (M-6232, F, CH₃,Cl, 3-Th, CF₃), (M-6233, F, CH₃, Cl, 3-Th, Br), (M-6234, F, CH₃, Cl,3-Th, CH₃), (M-6235, F, CH₃, Cl, pyrrazol-2-yl, H), (M-6236, F, CH₃, Cl,pyrrazol-2-yl, Cl), (M-6237, F, CH₃, Cl, pyrrazol-2-yl, F), (M-6238, F,CH₃, Cl, pyrrazol-2-yl, CF₃),-(M-6239, F, CH₃, Cl, pyrrazol-2-yl, Br),(M-6240, F, CH₃, Cl, pyrrazol-2-yl, CH₃), (M-6241, F, CH₃, Cl,pyrrazol-3-yl, H), (M-6242, F, CH₃, Cl, pyrrazol-3-yl, Cl), (M-6243, F,CH₃, Cl, pyrrazol-3-yl, F), (M-6244, F, CH₃, Cl, pyrrazol-3-yl, CF₃),(M-6245, F, CH₃, Cl, pyrrazol-3-yl, Br), (M-6246, F, CH₃, Cl,pyrrazol-3-yl, CH₃), (M-6247, F, CH₃, Cl, pyrimidin-2-yl, H), (M-6248,F, CH₃, Cl, pyrimidin-2-yl, Cl), (M-6249, F, CH₃, Cl, pyrimidin-2-yl,F), (M-6250, F, CH₃, Cl, pyrimidin-2-yl, CF₃), (M-6251, F, CH₃, Cl,pyrimidin-2-yl, Br), (M-6252, F, CH₃, Cl, pyrimidin-2-yl, CH₃), (M-6253,F, CH₃, Cl, pyrimidin-4-yl, H), (M-6254, F, CH₃, Cl, pyrimidin-4-yl,Cl), (M-6255, F, CH₃, Cl, pyrimidin-4-yl, F), (M-6256, F, CH₃, Cl,pyrimidin-4-yl, CF₃), (M-6257, F, CH₃, Cl, pyrimidin-4-yl, Br), (M-6258,F, CH₃, Cl, pyrimidin-4-yl, CH₃), (M-6259, F, CH₃, Cl, pyrimidin-5-yl,E), (M-6260, F, CH₃, Cl, pyrimidin-5-yl, Cl), (M-6261, F, CH₃, Cl,pyrimidin-5-yl, F), (M-6262, F, CH₃, Cl, pyrimidin-5-yl, CF₃), (M-6263,F, CH₃, Cl, pyrimidin-5-yl, Br), (M-6264, F, CH₃, Cl, pyrimidin-5-yl,CH₃), (M-6265, F, CH₃, Cl, HOOCCH₂CH₂CH₂, H), (M-6266, F, CH₃, Cl,HOOCCH₂CH₂CH₂, Cl), (M-6267, F, CH₃, Cl, HOOCCH₂CH₂CH₂, F), (M-6268, F,CH₃, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-6269, F, CH₃, Cl, HOOCCH₂CH₂CH₂, Br),(M-6270, F, CH₃, Cl, HOOCCH₂CH₂CH₂, CH₃), (M-6271, F, CH₃, Cl,HOOCCH₂CH₂CH₂CH₂, H), (M-6272, F, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Cl),(M-6273, F, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-6274, F, CH₃, Cl,HOOCCH₂CH₂CU₂CH₂, CF₃), (M-6275, F, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Br),(M-6276, F, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-6277, F, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂H), (M-6278, F, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-6279, F, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-6280, F, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-6281, F, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-6282, F, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-6283, F, CH₃,Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-6284, F, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-6285, F, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-6286, F, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-6287, F, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-6288, F, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-6289, F, CH₃, Cl, MeOCH₂, H), (M-6290,F, CH₃, Cl, MeOCH₂, Cl), (M-6291, F, CH₃, Cl, MeOCH₂, F), (M-6292, F,CH₃, Cl, MeOCH₂, CF₃), (M-6293, F, CH₃, Cl, MeOCH₂, Br), (M-6294, F,CH₃, Cl, MeOCH₂, CH₃), (M-6295, F, CH₃, Cl, EtOCH₂, H), (M-6296, F, CH₃,Cl, EtOCH₂, Cl), (M-6297, F, CH₃, Cl, EtOCH₂, F), (M-6298, F, CH₃, Cl,EtOCH₂, CF₃), (M-6299, F, CH₃, Cl, EtOCH₂, Br), (M-6300, F, CH₃, Cl,EtOCH₂, CH₃), (M-6301, F, CH₃, Cl, EtOCH₂CH₂, H), (M-6302, F, CH₃, Cl,EtOCH₂CH₂, Cl), (M-6303, F, CH₃, Cl, EtOCH₂CH₂, F), (M-6304, F, CH₃, Cl,EtOCH₂CH₂, CF₃), (M-6305, F, CH₃, Cl, EtOCH₂CH₂, Br), (M-6306, F, CH₃,Cl, EtOCH₂CH₂, CH₃), (M-6307, F, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-6308,F, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, Cl), (M-6309, F, CH₃, Cl,MeOCH₂CH₂OCH₂CH₂, F), (M-6310, F, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, CF₃),(M-6311, F, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, Br), (M-6312, F, CH₃, Cl,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-6313, F, CH₃, Cl, MeOCH₂CH₂, H), (M-6314, F,CH₃, Cl, MeOCH₂CH₂, Cl), (M-6315, F, CH₃, Cl, MeOCH₂CH₂, F), (M-6316, F,CH₃, Cl, MeOCH₂CH₂, CF₃), (M-6317, F, CH₃, Cl, MeOCH₂CH₂, Br), (M-6318,F, CH₃, Cl, MeOCH₂CH₂, CH₃), (M-6319, F, CH₃, Cl, HOCH₂, H), (M-6320, F,CH₃, Cl, HOCH₂, Cl), (M-6321, F, CH₃, Cl, HOCH₂, F), (M-6322, F, CH₃,Cl, HOCH₂, CF₃), (M-6323, F, CH₃, Cl, HOCH₂, Br), (M-6324, F, CH₃, Cl,HOCH₂, CH₃), (M-6325, F, CH₃, Cl, HOCH₂CH₂, H), (M-6326, F, CH₃, Cl,HOCH₂CH₂, Cl), (M-6327, F, CH₃, Cl, HOCH₂CH₂, F), (M-6328, F, CH₃, Cl,HOCH₂CH₂, CF₃), (M-6329, F, CH₃, Cl, HOCH₂CH₂, Br), (M-6330, F, CH₃, Cl,HOCH₂CH₂, CH₃), (M-6331, F, CH₃, Cl, HOCH₂CH₂CH₂, H), (M-6332, F, CH₃,Cl, HOCH₂CH₂CH₂, Cl), (M-6333, F, CH₃, Cl, HOCH₂CH₂CH₂, F), (M-6334, F,CH₃, Cl, HOCH₂CH₂CH₂, CF₃), (M-6335, F, CH₃, Cl, HOCH₂CH₂CH₂, Br),(M-6336, F, CH₃, Cl, HOCH₂CH₂CH₂, CH₃), (M-6337, F, CH₃, Cl,HOCH₂CH₂CH₂CH₂, H), (M-6338, F, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Cl), (M-6339,F, CH₃, Cl, HOCH₂CH₂CH₂CH₂, F), (M-6340, F, CH₃, Cl, HOCH₂CH₂CH₂CH₂,CF₃), (M-6341, F, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-6342, F, CH₃, Cl,HOCH₂CH₂CH₂CH₂, CH₃), (M-6343, F, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, H),(M-6344, F, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-6345, F, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-6346, F, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-6347, F, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-6348, F, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-6349, F, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, H),(M-6350, F, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-6351, F, CH₃, Cl,HOCH₂CH₂OCH₂CH₂, F), (M-6352, F, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, CF₃),(M-6353, F, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, Br), (M-6354, F, CH₃, Cl,HOCH₂CH₂OCH₂CH₂, CH₃), (M-6355, F, CH₃, Cl, (Me)₂N, H), (M-6356, F, CH₃,Cl, (Me)₂N, Cl), (M-6357, F, CH₃, Cl, (Me)₂N, F), (M-6358, F, CH₃, Cl,(Me)₂N, CF₃), (M-6359, F, CH₃, Cl, (Me)₂N, Br), (M-6360, F, CH₃, Cl,(Me)₂N, CH₃), (M-6361, F, CH₃, Cl, piperidin-4-yl-methyl, H), (M-6362,F, CH₃, Cl, piperidin-4-yl-methyl, Cl), (M-6363, F, CH₃, Cl,piperidin-4-yl-methyl, F), (M-6364, F, CH₃, Cl, piperidin-4-yl-methyl,CF₃), (M-6365, F, CH₃, Cl, piperidin-4-yl-methyl, Br), (M-6366, F, CH₃,Cl, piperidin-4-yl-methyl, CH₃), (M-6367, F, CH₃, Cl, cyclohexylmethyl,H), (M-6368, F, CH₃, Cl, cyclohexylmethyl, Cl), (M-6369, F, CH₃, Cl,cyclohexylmethyl, F), (M-6370, F, CH₃, Cl, cyclohexylmethyl, CF₃),(M-6371, F, CH₃, Cl, cyclohexylmethyl, Br), (M-6372, F, CH₃, Cl,cyclohexylmethyl, CH₃), (M-6373, Cl, H, H, H, H), (M-6374, Cl, H, H, H,Cl), (M-6375, MeO, F, H, H, F), (M-6376, MeO, F, H, H, c-Pr), (M-6377,Cl, H, H, H, Br), (M-6378, Cl, H, H, H, CH₃), (M-6379, MeO, H, H, F,c-Pr), (M-6380, Cl, H, H, F, Cl), (M-6381, MeO, H, H, F, F), (M-6382,Cl, H, H, F, CF₃), (M-6383, Cl, H, H, F, Br), (M-6384, Cl, H, H, F,CH₃), (M-6385, Cl, H, H, Cl, H), (M-6386, MeO, F, H, H, Et), (M-6387,MeO, H, H, Cl, F), (M-6388, Cl, H, H, Cl, CF₃), (M-6389, Cl, H, H, Cl,Br), (M-6390, Cl, H, H, Cl, CH₃), (M-6391, Cl, H, H, CH₃, H), (M-6392,Cl, H, H, CH₃, Cl), (M-6393, Cl, H, H, CH₃, F), (M-6394, Cl, H, H, CH₃,CF₃), (M-6395, Cl, H, H, CH₃, Br), (M-6396, Cl, H, H, CH₃, CH₃),(M-6397, Cl, H, H, Et, H), (M-6398, Cl, H, H, Et, Cl), (M-6399, Cl, H,H, Et, F), (M-6400, Cl, H, H, Et, CF₃), (M-6401, Cl, H, H, Et, Br),(M-6402, Cl, H, H, Et, CH₃), (M-6403, Cl, H, H, n-Pr, H), (M-6404, Cl,H, H, n-Pr, Cl), (M-6405, Cl, H, H, n-Pr, F), (M-6406, Cl, H, H, n-Pr,CF₃), (M-6407, Cl, H, H, n-Pr, Br), (M-6408, Cl, H, H, n-Pr, CH₃),(M-6409, Cl, H, H, c-Pr, H), (M-6410, Cl, H, H, c-Pr, Cl), (M-6411, Cl,H, H, c-Pr, F), (M-6412, Cl, H, H, c-Pr, CF₃), (M-6413, Cl, H, H, c-Pr,Br), (M-6414, Cl, H, H, c-Pr, CH₃), (M-6415, Cl, H, H, i-Pr, H),(M-6416, Cl, H, H, i-Pr, Cl), (M-6417, Cl, H, H, i-Pr, F), (M-6418, Cl,H, H, i-Pr, CF₃), (M-6419, Cl, H, H, i-Pr, Br), (M-6420, Cl, H, H, i-Pr,CH₃), (M-6421, MeO, H, H, n-Bu, H), (M-6422, Cl, H, H, n-Bu, Cl),(M-6423, Cl, H, H, n-Bu, F), (M-6424, Cl, H, H, n-Bu, CF₃), (M-6425, Cl,H, H, n-Bu, Br), (M-6426, Cl, H, H, n-Bu, CH₃), (M-6427, Cl, H, H, i-Bu,H), (M-6428, Cl, H, H, i-Bu, Cl), (M-6429, Cl, H, H, i-Bu, F), (M-6430,Cl, H, H, i-Bu, CF₃), (M-6431, Cl, H, H, i-Bu, Br), (M-6432, Cl, H, H,i-Bu, CH₃), (M-6433, Cl, H, H, sec-Bu, H), (M-6434, Cl, H, H, sec-Bu,Cl), (M-6435, Cl, H, H, sec-Bu, F), (M-6436, Cl, H, H, sec-Bu, CF₃),(M-6437, Cl, H, H, sec-Bu, Br), (M-6438, Cl, H, H, sec-Bu, CH₃),(M-6439, Cl, H, H, n-Pen, H), (M-6440, Cl, H, H, n-Pen, Cl), (M-6441,MeO, H, H, n-Pen, F), (M-6442, Cl, H, H, n-Pen, CF₃), (M-6443, Cl, H, H,n-Pen, Br), (M-6444, Cl, H, H, n-Pen, CH₃), (M-6445, Cl, H, H, c-Pen,H), (M-6446, Cl, H, H, c-Pen, Cl), (M-6447, Cl, H, H, c-Pen, F),(M-6448, Cl, H, H, c-Pen, CF₃), (M-6449, Cl, H, H, c-Pen, Br), (M-6450,Cl, H, H, c-Pen, CH₃), (M-6451, Cl, H, H, n-Hex, H), (M-6452, Cl, H, H,n-Hex, Cl), (M-6453, Cl, H, H, n-Hex, F), (M-6454, Cl, H, H, n-Hex,CF₃), (M-6455, Cl, H, H, n-Hex, Br), (M-6456, Cl, H, H, n-Hex, CH₃),(M-6457, Cl, H, H, c-Hex, H), (M-6458, Cl, H, H, c-Hex, Cl), (M-6459,Cl, H, H, c-Hex, F), (M-6460, Cl, H, H, c-Hex, CF₃), (M-6461, Cl, H, H,c-Hex, Br), (M-6462, Cl, H, H, c-Hex, CH₃), (M-6463, Cl, H, H, OH, H),(M-6464, Cl, H, H, OH, Cl), (M-6465, Cl, H, H, OH, F), (M-6466, Cl, H,H, OH, CF₃), (M-6467, Cl, H, H, OH, Br), (M-6468, Cl, H, H, OH, CH₃),(M-6469, Cl, H, H, EtO, H), (M-6470, Cl, H, H, EtO, Cl), (M-6471, Cl, H,H, EtO, F), (M-6472, Cl, H, H, EtO, CF₃), (M-6473, Cl, H, H, EtO, Br),(M-6474, Cl, H, H, EtO, CH₃), (M-6475, Cl, H, H, n-PrO, H), (M-6476, Cl,H, H, n-PrO, Cl), (M-6477, Cl, H, H, n-PrO, F), (M-6478, Cl, H, H,n-PrO, CF₃), (M-6479, Cl, H, H, n-PrO, Br), (M-6480, Cl, H, H, n-PrO,CH₃), (M-6481, Cl, H, H, PhO, H), (M-6482, Cl, H, H, PhO, Cl), (M-6483,Cl, H, H, PhO, F), (M-6484, Cl, H, H, PhO, CF₃), (M-6485, Cl, H, H, PhO,Br), (M-6486, Cl, H, H, PhO, CH₃), (M-6487, Cl, H, H, BnO, H), (M-6488,Cl, H, H, BnO, Cl), (M-6489, Cl, H, H, BnO, F), (M-6490, Cl, H, H, BnO,CF₃), (M-6491, Cl, H, H, BnO, Br), (M-6492, Cl, H, H, BnO, CH₃),(M-6493, Cl, H, H, PhCH₂CH₂O, H), (M-6494, Cl, H, H, PhCH₂CH₂O, Cl),(M-6495, Cl, H, H, PhCH₂CH₂O, F), (M-6496, Cl, H, H, PhCH₂CH₂O, CF₃),(M-6497, Cl, H, H, PhCH₂CH₂O, Br), (M-6498, Cl, H, H, PhCH₂CH₂O, CH₃),(M-6499, MeO, H, H, CF₃O, CF₃), (M-6500, Cl, H, H, CF₃O, Cl), (M-6501,Cl, H, H, CF₃O, F), (M-6502, Cl, H, H, CF₃O, CF₃), (M-6503, Cl, H, H,CF₃O, Br), (M-6504, Cl, H, H, CF₃O, CH₃), (M-6505, MeO, H, H, Ph, H),(M-6506, Cl, H, H, Ph, Cl), (M-6507, Cl, H, H, Ph, F), (M-6508, Cl, H,H, Ph, CF₃), (M-6509, Cl, H, H, Ph, Br), (M-6510, Cl, H, H, Ph, CH₃),(M-6511, Cl, H, H, 4-F-Ph, H), (M-6512, Cl, H, H, 4-F-Ph, Cl), (M-6513,Cl, H, H, 4-F-Ph, F), (M-6514, Cl, H, H, 4-F-Ph, CF₃), (M-6515, Cl, H,H, 4-F-Ph, Br), (M-6516, Cl, H, H, 4-F-Ph, CH₃), (M-6517, Cl, H, H,4-CF₃-Ph, H), (M-6518, Cl, H, H, 4-CF₃-Ph, Cl), (M-6519, Cl, H, H,4-CF₃-Ph, F), (M-6520, Cl, H, H, 4-CF₃-Ph, CF₃), (M-6521, Cl, H, H,4-CF₃-Ph, Br), (M-6522, Cl, H, H, 4-CF₃-Ph, CH₃), (M-6523, Cl, H, H,4-(Me)₂N-Ph, H), (M-6524, Cl, H, H, 4-(Me)₂N-Ph, Cl), (M-6525, Cl, H, H,4-(Me)₂N-Ph, F), (M-6526, Cl, H, H, 4-(Me)₂N-Ph, CF₃), (M-6527, Cl, H,H, 4-(Me)₂N-Ph, Br), (M-6528, Cl, H, H, 4-(Me)₂N-Ph, CH₃), (M-6529, Cl,H, H, 4-OH-Ph, H), (M-6530, Cl, H, H, 4-OH-Ph, Cl), (M-6531, Cl, H, H,4-OH-Ph, F), (M-6532, Cl, H, H, 4-OH-Ph, CF₃), (M-6533, Cl, H, H,4-OH-Ph, Br), (M-6534, Cl, H, H, 4-OH-Ph, CH₃), (M-6535, Cl, H, H,3,4-di-F-Ph, H), (M-6536, Cl, H, H, 3,4-di-F-Ph, Cl), (M-6537, Cl, H, H,3,4-di-F-Ph, F), (M-6538, Cl, H, H, 3,4-di-F-Ph, CF₃), (M-6539, Cl, H,H, 3,4-di-F-Ph, Br), (M-6540, Cl, H, H, 3,4-di-F-Ph, CH₃), (M-6541, Cl,H, H, 4-COOH-Ph, H), (M-6542, Cl, H, H, 4-COOH-Ph, Cl), (M-6543, Cl, H,H, 4-COOH-Ph, F), (M-6544, Cl, H, H, 4-COOH-Ph, CF₃), (M-6545, Cl, H, H,4-COOH-Ph, Br), (M-6546, Cl, H, H, 4-COOH-Ph, CH₃), (M-6547, Cl, H, H,Bn, H), (M-6548, Cl, H, H, Bn, Cl), (M-6549, Cl, H, H, Bn, F), (M-6550,Cl, H, H, Bn, CF₃), (M-6551, Cl, H, H, Bn, Br), (M-6552, Cl, H, H, Bn,CH₃), (M-6553, Cl, H, H, 4-F-Bn, H), (M-6554, Cl, H, H, 4-F-Bn, Cl),(M-6555, Cl, H, H, 4-F-Bn, F), (M-6556, Cl, H, H, 4-F-Bn, CF₃), (M-6557,Cl, H, H, 4-F-Bn, Br), (M-6558, Cl, H, H, 4-F-Bn, CH₃), (M-6559, Cl, H,H, 2-Py, H), (M-6560, Cl, H, H, 2-Py, Cl), (M-6561, Cl, H, H, 2-Py, F),(M-6562, Cl, H, H, 2-Py, CF₃), (M-6563, Cl, H, H, 2-Py, Br), (M-6564,Cl, H, H, 2-Py, CH₃), (M-6565, Cl, H, H, 3-Py, H), (M-6566, Cl, H, H,3-Py, Cl), (M-6567, Cl, H, H, 3-Py, F), (M-6568, Cl, H, H, 3-Py, CF₃),(M-6569, Cl, H, H, 3-Py, Br), (M-6570, Cl, H, H, 3-Py, CH₃), (M-6571,Cl, H, H, 4-Py, H), (M-6572, Cl, H, H, 4-Py, Cl), (M-6573, Cl, H, H,4-Py, F), (M-6574, Cl, H, H, 4-Py, CF₃), (M-6575, Cl, H, H, 4-Py, Br),(M-6576, Cl, H, H, 4-Py, CH₃), (M-6577, Cl, H, H, 2-Th, H), (M-6578, Cl,H, H, 2-Th, Cl), (M-6579, Cl, H, H, 2-Th, F), (M-6580, Cl, H, H, 2-Th,CF₃), (M-6581, Cl, H, H, 2-Th, Br), (M-6582, Cl, H, H, 2-Th, CH₃),(M-6583, Cl, H, H, 3-Th, H), (M-6584, Cl, H, H, 3-Th, Cl), (M-6585, Cl,H, H, 3-Th, F), (M-6586, Cl, H, H, 3-Th, CF₃), (M-6587, Cl, H, H, 3-Th,Br), (M-6588, Cl, H, H, 3-Th, CH₃), (M-6589, Cl, H, H, pyrrazol-2-yl,H), (M-6590, Cl, H, H, pyrrazol-2-yl, Cl), (M-6591, Cl, H, H,pyrrazol-2-yl, F), (M-6592, Cl, H, H, pyrrazol-2-yl, CF₃), (M-6593, Cl,H, H, pyrrazol-2-yl, Br), (M-6594, Cl, H, H, pyrrazol-2-yl, CH₃),(M-6595, Cl, H, H, pyrrazol-3-yl, H), (M-6596, Cl, H, H, pyrrazol-3-yl,Cl), (M-6597, Cl, H, H, pyrrazol-3-yl, F), (M-6598, Cl, H, H,pyrrazol-3-yl, CF₃), (M-6599, Cl, H, H, pyrrazol-3-yl, Br), (M-6600, Cl,H, H, pyrrazol-3-yl, CH₃), (M-6601, Cl, H, H, pyrimidin-2-yl, H),(M-6602, Cl, H, H, pyrimidin-2-yl, Cl), (M-6603, Cl, H, H,pyrimidin-2-yl, F), (M-6604, Cl, H, H, pyrimidin-2-yl, CF₃), (M-6605,Cl, H, H, pyrimidin-2-yl, Br), (M-6606, Cl, H, H, pyrimidin-2-yl, CH₃),(M-6607, Cl, H, H, pyrimidin-4-yl, H), (M-6608, Cl, H, H,pyrimidin-4-yl, Cl), (M-6609, Cl, H, H, pyrimidin-4-yl, F), (M-6610, Cl,H, H, pyrimidin-4-yl, CF₃), (M-6611, Cl, H, H, pyrimidin-4-yl, Br),(M-6612, Cl, H, H, pyrimidin-4-yl, CH₃), (M-6613, Cl, H, H,pyrimidin-5-yl, H), (M-6614, Cl, H, H, pyrimidin-5-yl, Cl), (M-6615, Cl,H, H, pyrimidin-5-yl, F), (M-6616, Cl, H, H, pyrimidin-5-yl, CF₃),(M-6617, Cl, H, H, pyrimidin-5-yl, Br), (M-6618, Cl, H, H,pyrimidin-5-yl, CH₃), (M-6619, Cl, H, H, HOOCCH₂CH₂CH₂, H), (M-6620, Cl,H, H, HOOCCH₂CH₂CH₂, Cl), (M-6621, Cl, H, H, HOOCCH₂CH₂CH₂, F), (M-6622,Cl, H, H, HOOCCH₂CH₂CH₂, CF₃), (M-6623, Cl, H, H, HOOCCH₂CH₂CH₂, Br),(M-6624, Cl, H, H, HOOCCH₂CH₂CH₂, CH₃), (M-6625, Cl, H, H,HOOCCH₂CH₂CH₂CH₂, H), (M-6626, Cl, H, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-6627,Cl, H, H, HOOCCH₂CH₂CH₂CH₂, F), (M-6628, Cl, H, H, HOOCCH₂CH₂CH₂CH₂,CF₃), (M-6629, Cl, H, H, HOOCCH₂CH₂CH₂CH₂, Br), (M-6630, Cl, H, H,HOOCCH₂CH₂CH₂CH₂, CH₃), (M-6631, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H),(M-6632, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-6633, Cl, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-6634, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃),(M-6635, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-6636, Cl, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-6637, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,H), (M-6638, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-6639, Cl, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-6640, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CF₃), (M-6641, Cl, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-6642, Cl, H,H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-6643, Cl, H, H, MeOCH₂, H),(M-6644, Cl, H, H, MeOCH₂, Cl), (M-6645, Cl, H, H, MeOCH₂, F), (M-6646,Cl, H, H, MeOCH₂, CF₃), (M-6647, Cl, H, H, MeOCH₂, Br), (M-6648, Cl, H,H, MeOCH₂, CH₃), (M-6649, Cl, H, H, EtOCH₂, H), (M-6650, Cl, H, H,EtOCH₂, Cl), (M-6651, Cl, H, H, EtOCH₂, F), (M-6652, Cl, H, H, EtOCH₂,CF₃), (M-6653, Cl, H, H, EtOCH₂, Br), (M-6654, Cl, H, H, EtOCH₂, CH₃),(M-6655, Cl, H, H, EtOCH₂CH₂, H), (M-6656, Cl, H, H, EtOCH₂CH₂, Cl),(M-6657, Cl, H, H, EtOCH₂CH₂, F), (M-6658, Cl, H, H, EtOCH₂CH₂, CF₃),(M-6659, Cl, H, H, EtOCH₂CH₂, Br), (M-6660, Cl, H, H, EtOCH₂CH₂, CH₃),(M-6661, Cl, H, H, MeOCH₂CH₂OCH₂CH₂, H), (M-6662, Cl, H, H,MeOCH₂CH₂OCH₂CH₂, Cl), (M-6663, Cl, H, H, MeOCH₂CH₂OCH₂CH₂, F), (M-6664,Cl, H, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-6665, Cl, H, H, MeOCH₂CH₂OCH₂CH₂,Br), (M-6666, Cl, H, H, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-6667, Cl, H, H,MeOCH₂CH₂, H), (M-6668, Cl, H, H, MeOCH₂CH₂, Cl), (M-6669, Cl, H, H,MeOCH₂CH₂, F), (M-6670, Cl, H, H, MeOCH₂CH₂, CF₃), (M-6671, Cl, H, H,MeOCH₂CH₂, Br), (M-6672, Cl, H, H, MeOCH₂CH₂, CH₃), (M-6673, Cl, H, H,HOCH₂, H), (M-6674, Cl, H, H, HOCH₂, Cl), (M-6675, Cl, H, H, HOCH₂, F),(M-6676, Cl, H, H, HOCH₂, CF₃), (M-6677, Cl, H, H, HOCH₂, Br), (M-6678,Cl, H, H, HOCH₂, CH₃), (M-6679, Cl, H, H, HOCH₂CH₂, H), (M-6680, Cl, H,H, HOCH₂CH₂, Cl), (M-6681, Cl, H, H, HOCH₂CH₂, F), (M-6682, Cl, H, H,HOCH₂CH₂, CF₃), (M-6683, Cl, H, H, HOCH₂CH₂, Br), (M-6684, Cl, H, H,HOCH₂CH₂, CH₃), (M-6685, Cl, H, H, HOCH₂CH₂CH₂, H), (M-6686, Cl, H, H,HOCH₂CH₂CH₂, Cl), (M-6687, Cl, H, H, HOCH₂CH₂CH₂, F), (M-6688, Cl, H, H,HOCH₂CH₂CH₂, CF₃), (M-6689, Cl, H, H, HOCH₂CH₂CH₂, Br), (M-6690, Cl, H,H, HOCH₂CH₂CH₂, CH₃), (M-6691, Cl, H, H, HOCH₂CH₂CH₂CH₂, H), (M-6692,Cl, H, H, HOCH₂CH₂CH₂CH₂, Cl), (M-6693, Cl, H, H, HOCH₂CH₂CH₂CH₂, F),(M-6694, Cl, H, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-6695, Cl, H, H,HOCH₂CH₂CH₂CH₂, Br), (M-6696, Cl, H, H, HOCH₂CH₂CH₂CH₂, CH₃), (M-6697,Cl, H, H, HOCH₂CH₂CH₂CH₂CH₂, H), (M-6698, Cl, H, H, HOCH₂CH₂CH₂CH₂CH₂,Cl), (M-6699, Cl, H, H, HOCH₂CH₂CH₂CH₂CH₂, F), (M-6700, Cl, H, H,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-6701, Cl, H, H, HOCH₂CH₂CH₂CH₂CH₂Br),(M-6702, Cl, H, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-6703, Cl, H, H,HOCH₂CH₂OCH₂CH₂, H), (M-6704, Cl, H, H, HOCH₂CH₂OCH₂CH₂, Cl), (M-6705,Cl, H, H, HOCH₂CH₂OCH₂CH₂, F), (M-6706, Cl, H, H, HOCH₂CH₂OCH₂CH₂, CF₃),(M-6707, Cl, H, H, HOCH₂CH₂OCH₂CH₂, Br), (M-6708, Cl, H, H,HOCH₂CH₂OCH₂CH₂, CH₃), (M-6709, Cl, H, H, (Me)₂N, H), (M-6710, Cl, H, H,(Me)₂N, Cl), (M-6711, Cl, H, H, (Me)₂N, F), (M-6712, Cl, H, H, (Me)₂N,CF₃), (M-6713, Cl, H, H, (Me)₂N, Br), (M-6714, Cl, H, H, (Me)₂N, CH₃),(M-6715, Cl, H, H, piperidin-4-yl-methyl, H), (M-6716, Cl, H, H,piperidin-4-yl-methyl, Cl), (M-6717, Cl, H, H, piperidin-4-yl-methyl,F), (M-6718, Cl, H, H, piperidin-4-yl-methyl, CF₃), (M-6719, Cl, H, H,piperidin-4-yl-methyl, Br), (M-6720, Cl, H, H, piperidin-4-yl-methyl,CH₃), (M-6721, Cl, H, H, cyclohexylmethyl, H), (M-6722, Cl, H, H,cyclohexylmethyl, Cl), (M-6723, Cl, H, H, cyclohexylmethyl, F), (M-6724,Cl, H, H, cyclohexylmethyl, CF₃), (M-6725, Cl, H, H, cyclohexylmethyl,Br), (M-6726, Cl, H, H, cyclohexylmethyl, CH₃), (M-6727, MeO, H, F, H,H), (M-6728, Cl, H, F, H, Cl), (M-6729, MeO, H, F, H, F), (M-6730, MeO,H, F, H, CF₃), (M-6731, MeO, H, F, H, Br), (M-6732, MeO, H, F, H, CH₃),(M-6733, MeO, H, F, F, H), (M-6734, Cl, H, F, F, Cl), (M-6735, Cl, H, F,F, F), (M-6736, Cl, H, F, F, CF₃), (M-6737, Cl, H, F, F, Br), (M-6738,Cl, H, F, F, CH₃), (M-6739, Cl, H, F, Cl, H), (M-6740, Cl, H, F, Cl,Cl), (M-6741, Cl, H, F, Cl, F), (M-6742, Cl, H, F, Cl, CF₃), (M-6743,Cl, H, F, Cl, Br), (M-6744, Cl, H, F, Cl, CH₃), (M-6745, MeO, H, F, CH₃,H), (M-6746, Cl, H, F, CH₃, Cl), (M-6747, Cl, H, F, CH₃, F), (M-6748,Cl, H, F, CH₃, CF₃), (M-6749, Cl, H, F, CH₃, Br), (M-6750, Cl, H, F,CH₃, CH₃), (M-6751, MeO, H, F, Et, H), (M-6752, Cl, H, F, Et, Cl),(M-6753, Cl, H, F, Et, F), (M-6754, Cl, H, F, Et, CF₃), (M-6755, Cl, H,F, Et, Br), (M-6756, Cl, H, F, Et, CH₃), (M-6757, MeO, H, F, n-Pr, H),(M-6758, Cl, H, F, n-Pr, Cl), (M-6759, Cl, H, F, n-Pr, F), (M-6760, Cl,H, F, n-Pr, CF₃), (M-6761, MeO, H, F, n-Pr, Br), (M-6762, Cl, H, F,n-Pr, CH₃), (M-6763, Cl, H, F, c-Pr, H), (M-6764, Cl, H, F, c-Pr, Cl),(M-6765, Cl, H, F, c-Pr, F), (M-6766, Cl, H, F, c-Pr, CF₃), (M-6767, Cl,H, F, c-Pr, Br), (M-6768, Cl, H, F, c-Pr, CH₃), (M-6769, Cl, H, F, i-Pr,H), (M-6770, Cl, H, F, i-Pr, Cl), (M-6771, Cl, H, F, i-Pr, F), (M-6772,Cl, H, F, i-Pr, CF₃), (M-6773, Cl, H, F, i-Pr, Br), (M-6774, Cl, H, F,i-Pr, CH₃), (M-6775, MeO, H, F, n-Bu, H), (M-6776, Cl, H, F, n-Bu, Cl),(M-6777, Cl, H, F, n-Bu, F), (M-6778, Cl, H, F, n-Bu, CF₃), (M-6779, Cl,H, F, n-Bu, Br), (M-6780, Cl, H, F, n-Bu, CH₃), (M-6781, Cl, H, F, i-Bu,H), (M-6782, Cl, H, F, i-Bu, Cl), (M-6783, Cl, H, F, i-Bu, F), (M-6784,Cl, H, F, i-Bu, CF₃), (M-6785, Cl, H, F, i-Bu, Br), (M-6786, Cl, H, F,i-Bu, CH₃), (M-6787, Cl, H, F, sec-Bu, H), (M-6788, Cl, H, F, sec-Bu,Cl), (M-6789, Cl, H, F, sec-Bu, F), (M-6790, Cl, H, F, sec-Bu, CF₃),(M-6791, Cl, H, F, sec-Bu, Br), (M-6792, Cl, H, F, sec-Bu, CH₃),(M-6793, MeO, H, F, n-Pen, H), (M-6794, Cl, H, F, n-Pen, Cl), (M-6795,MeO, H, F, n-Pen, F), (M-6796, Cl, H, F, n-Pen, CF₃), (M-6797, Cl, H, F,n-Pen, Br), (M-6798, Cl, H, F, n-Pen, CH₃), (M-6799, Cl, H, F, c-Pen,H), (M-6800, Cl, H, F, c-Pen, Cl), (M-6801, Cl, H, F, c-Pen, F),(M-6802, Cl, H, F, c-Pen, CF₃), (M-6803, Cl, H, F, c-Pen, Br), (M-6804,Cl, H, F, c-Pen, CH₃), (M-6805, MeO, H, F, n-Hex, H), (M-6806, Cl, H, F,n-Hex, Cl), (M-6807, Cl, H, F, n-Hex, F), (M-6808, Cl, H, F, n-Hex,CF₃), (M-6809, Cl, H, F, n-Hex, Br), (M-6810, Cl, H, F, n-Hex, CH₃),(M-6811, MeO, H, F, c-Hex, H), (M-6812, Cl, H, F, c-Hex, Cl), (M-6813,Cl, H, F, c-Hex, F), (M-6814, Cl, H, F, c-Hex, CF₃), (M-6815, Cl, H, F,c-Hex, Br), (M-6816, Cl, H, F, c-Hex, CH₃), (M-6817, Cl, H, F, OH, H),(M-6818, Cl, H, F, OH, Cl), (M-6819, Cl, H, F, OH, F), (M-6820, Cl, H,F, OH, CF₃), (M-6821, Cl, H, F, OH, Br), (M-6822, Cl, H, F, OH, CH₃),(M-6823, MeO, H, F, EtO, H), (M-6824, Cl, H, F, EtO, Cl), (M-6825, Cl,H, F, EtO, F), (M-6826, Cl, H, F, EtO, CF₃), (M-6827, Cl, H, F, EtO,Br), (M-6828, Cl, H, F, EtO, CH₃), (M-6829, Cl, H, F, n-PrO, H),(M-6830, Cl, H, F, n-PrO, Cl), (M-6831, Cl, H, F, n-PrO, F), (M-6832,Cl, H, F, n-PrO, CF₃), (M-6833, Cl, H, F, n-PrO, Br), (M-6834, Cl, H, F,n-PrO, CH₃), (M-6835, Cl, H, F, PhO, H), (M-6836, Cl, H, F, PhO, Cl),(M-6837, Cl, H, F, PhO, F), (M-6838, Cl, H, F, PhO, CF₃), (M-6839, Cl,H, F, PhO, Br), (M-6840, Cl, H, F, PhO, CH₃), (M-6841, Cl, H, F, BnO,H), (M-6842, Cl, H, F, BnO, Cl), (M-6843, Cl, H, F, BnO, F), (M-6844,Cl, H, F, BnO, CF₃), (M-6845, Cl, H, F, BnO, Br), (M-6846, Cl, H, F,BnO, CH₃), (M-6847, Cl, H, F, PhCH₂CH₂O, H), (M-6848, Cl, H, F,PhCH₂CH₂O, Cl), (M-6849, Cl, H, F, PhCH₂CH₂O, F), (M-6850, Cl, H, F,PhCH₂CH₂O, CF₃), (M-6851, Cl, H, F, PhCH₂CH₂O, Br), (M-6852, Cl, H, F,PhCH₂CH₂O, CH₃), (M-6853, Cl, H, F, CF₃O, H), (M-6854, Cl, H, F, CF₃O,Cl), (M-6855, Cl, H, F, CF₃O, F), (M-6856, Cl, H, F, CF₃O, CF₃),(M-6857, Cl, H, F, CF₃O, Br), (M-6858, Cl, H, F, CF₃O, CH₃), (M-6859,MeO, H, F, Ph, H), (M-6860, Cl, H, F, Ph, Cl), (M-6861, MeO, H, F, Ph,F), (M-6862, Cl, H, F, Ph, CF₃), (M-6863, Cl, H, F, Ph, Br), (M-6864,Cl, H, F, Ph, CH₃), (M-6865, MeO, H, F, 4-F-Ph, H), (M-6866, Cl, H, F,4-F-Ph, Cl), (M-6867, Cl, H, F, 4-F-Ph, F), (M-6868, Cl, H, F, 4-F-Ph,CF₃), (M-6869, Cl, H, F, 4-F-Ph, Br), (M-6870, Cl, H, F, 4-F-Ph, CH₃),(M-6871, Cl, H, F, 4-CF₃-Ph, H), (M-6872, Cl, H, F, 4-CF₃-Ph, Cl),(M-6873, Cl, H, F, 4-CF₃-Ph, F), (M-6874, Cl, H, F, 4-CF₃-Ph, CF₃),(M-6875, Cl, H, F, 4-CF₃-Ph, Br), (M-6876, Cl, H, F, 4-CF₃-Ph, CH₃),(M-6877, Cl, H, F, 4-(Me)₂N-Ph, H), (M-6878, Cl, H, F, 4-(Me)₂N-Ph, Cl),(M-6879, Cl, H, F, 4-(Me)₂N-Ph, F), (M-6880, Cl, H, F, 4-(Me)₂N-Ph,CF₃), (M-6881, Cl, H, F, 4-(Me)₂N-Ph, Br), (M-6882, Cl, H, F,4-(Me)₂N-Ph, CH₃), (M-6883, Cl, H, F, 4-OH-Ph, H), (M-6884, Cl, H, F,4-OH-Ph, Cl), (M-6885, Cl, H, F, 4-OH-Ph, F), (M-6886, Cl, H, F,4-OH-Ph, CF₃), (M-6887, Cl, H, F, 4-OH-Ph, Br), (M-6888, Cl, H, F,4-OH-Ph, CH₃), (M-6889, Cl, H, F, 3,4-di-F-Ph, H), (M-6890, Cl, H, F,3,4-di-F-Ph, Cl), (M-6891, Cl, H, F, 3,4-di-F-Ph, F), (M-6892, Cl, H, F,3,4-di-F-Ph, CF₃), (M-6893, Cl, H, F, 3,4-di-F-Ph, Br), (M-6894, Cl, H,F, 3,4-di-F-Ph, CH₃), (M-6895, Cl, H, F, 4-COOH-Ph, H), (M-6896, Cl, H,F, 4-COOH-Ph, Cl), (M-6897, Cl, H, F, 4-COOH-Ph, F), (M-6898, Cl, H, F,4-COOH-Ph, CF₃), (M-6899, Cl, H, F, 4-COOH-Ph, Br), (M-6900, Cl, H, F,4-COOH-Ph, CH₃), (M-6901, MeO, H, F, Bn, H), (M-6902, Cl, H, F, Bn, Cl),(M-6903, Cl, H, F, Bn, F), (M-6904, Cl, H, F, Bn, CF₃), (M-6905, Cl, H,F, Bn, Br), (M-6906, Cl, H, F, Bn, CH₃), (M-6907, Cl, H, F, 4-F-Bn, H),(M-6908, Cl, H, F, 4-F-Bn, Cl), (M-6909, Cl, H, F, 4-F-Bn, F), (M-6910,Cl, H, F, 4-F-Bn, CF₃), (M-6911, Cl, H, F, 4-F-Bn, Br), (M-6912, Cl, H,F, 4-F-Bn, CH₃), (M-6913, Cl, H, F, 2-Py, H), (M-6914, Cl, H, F, 2-Py,Cl), (M-6915, Cl, H, F, 2-Py, F), (M-6916, Cl, H, F, 2-Py, CF₃),(M-6917, Cl, H, F, 2-Py, Br), (M-6918, Cl, H, F, 2-Py, CH₃), (M-6919,MeO, H, F, 3-Py, H), (M-6920, Cl, H, F, 3-Py, Cl), (M-6921, Cl, H, F,3-Py, F), (M-6922, Cl, H, F, 3-Py, CF₃), (M-6923, Cl, H, F, 3-Py, Br),(M-6924, Cl, H, F, 3-Py, CH₃), (M-6925, Cl, H, F, 4-Py, H), (M-6926, Cl,H, F, 4-Py, Cl), (M-6927, Cl, H, F, 4-Py, F), (M-6928, Cl, H, F, 4-Py,CF₃), (M-6929, Cl, H, F, 4-Py, Br), (M-6930, Cl, H, F, 4-Py, CH₃),(M-6931, Cl, H, F, 2-Th, H), (M-6932, Cl, H, F, 2-Th, Cl), (M-6933, Cl,H, F, 2-Th, F), (M-6934, Cl, H, F, 2-Th, CF₃), (M-6935, Cl, H, F, 2-Th,Br), (M-6936, Cl, H, F, 2-Th, CH₃), (M-6937, Cl, H, F, 3-Th, H),(M-6938, Cl, H, F, 3-Th, Cl), (M-6939, Cl, H, F, 3-Th, F), (M-6940, Cl,H, F, 3-Th, CF₃), (M-6941, Cl, H, F, 3-Th, Br), (M-6942, Cl, H, F, 3-Th,CH₃), (M-6943, Cl, H, F, pyrrazol-2-yl, H), (M-6944, Cl, H, F,pyrrazol-2-yl, Cl), (M-6945, Cl, H, F, pyrrazol-2-yl, F), (M-6946, Cl,H, F, pyrrazol-2-yl, CF₃), (M-6947, Cl, H, F, pyrrazol-2-yl, Br),(M-6948, Cl, H, F, pyrrazol-2-yl, CH₃), (M-6949, Cl, H, F,pyrrazol-3-yl, H), (M-6950, Cl, H, F, pyrrazol-3-yl, Cl), (M-6951, Cl,H, F, pyrrazol-3-yl, F), (M-6952, Cl, H, F, pyrrazol-3-yl, CF₃),(M-6953, Cl, H, F, pyrrazol-3-yl, Br), (M-6954, Cl, H, F, pyrrazol-3-yl,CH₃), (M-6955, Cl, H, F, pyrimidin-2-yl, H), (M-6956, Cl, H, F,pyrimidin-2-yl, Cl), (M-6957, Cl, H, F, pyrimidin-2-yl, F), (M-6958, Cl,H, F, pyrimidin-2-yl, CF₃), (M-6959, Cl, H, F, pyrimidin-2-yl, Br),(M-6960, Cl, H, F, pyrimidin-2-yl, CH₃), (M-6961, Cl, H, F,pyrimidin-4-yl, H), (M-6962, Cl, H, F, pyrimidin-4-yl, Cl), (M-6963, Cl,H, F, pyrimidin-4-yl, F), (M-6964, Cl, H, F, pyrimidin-4-yl, CF₃),(M-6965, Cl, H, F, pyrimidin-4-yl, Br), (M-6966, Cl, H, F,pyrimidin-4yl, CH₃), (M-6967, Cl, H, F, pyrimidin-5-yl, H), (M-6968, Cl,H, F, pyrimidin-5-yl, Cl), (M-6969, Cl, H, F, pyrimidin-5-yl, F),(M-6970, Cl, H, F, pyrimidin-5-yl, CF₃), (M-6971, Cl, H, F,pyrimidin-5-yl, Br), (M-6972, Cl, H, F, pyrimidin-5-yl, CH₃), (M-6973,Cl, H, F, HOOCCH₂CH₂CH₂, H), (M-6974, Cl, H, F, HOOCCH₂CH₂CH₂, Cl),(M-6975, Cl, H, F, HOOCCH₂CH₂CH₂, F), (M-6976, Cl, H, F, HOOCCH₂CH₂CH₂,CF₃), (M-6977, Cl, H, F, HOOCCH₂CH₂CH₂, Br), (M-6978, Cl, H, F,HOOCCH₂CH₂CH₂, CH₃), (M-6979, Cl, H, F, HOOCCH₂CH₂CH₂CH₂, H), (M-6980,Cl, H, F, HOOCCH₂CH₂CH₂CH₂, Cl), (M-6981, Cl, H, F, HOOCCH₂CH₂CH₂CH₂,F), (M-6982, Cl, H, F, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-6983, Cl, H, F,HOOCCH₂CH₂CH₂CH₂, Br), (M-6984, Cl, H, F, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-6985, Cl, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-6986, Cl, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-6987, Cl, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-6988, Cl, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-6989, Cl, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-6990, Cl, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-6991, Cl, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-6992, Cl, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-6993, Cl, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-6994, Cl, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CF₃), (M-6995, Cl, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-6996, Cl, H,F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-6997, Cl, H, F, MeOCH₂, H),(M-6998, Cl, H, F, MeOCH₂, Cl), (M-6999, Cl, H, F, MeOCH₂, F), (M-7000,Cl, H, F, MeOCH₂, CF₃), (M-7001, Cl, H, F, MeOCH₂, Br), (M-7002, Cl, H,F, MeOCH₂, CH₃), (M-7003, Cl, H, F, EtOCH₂, H), (M-7004, Cl, H, F,EtOCH₂, Cl), (M-7005, Cl, H, F, EtOCH₂, F), (M-7006, Cl, H, F, EtOCH₂,CF₃), (M-7007, Cl, H, F, EtOCH₂, Br), (M-7008, Cl, H, F, EtOCH₂, CH₃),(M-7009, MeO, H, F, EtOCH₂CH₂, H), (M-7010, Cl, H, F, EtOCH₂CH₂, Cl),(M-7011, Cl, H, F, EtOCH₂CH₂, F), (M-7012, Cl, H, F, EtOCH₂CH₂, CF₃),(M-7013, Cl, H, F, EtOCH₂CH₂, Br), (M-7014, Cl, H, F, EtOCH₂CH₂, CH₃),(M-7015, Cl, H, F, MeOCH₂CH₂OCH₂CH₂, H), (M-7016, Cl, H, F,MeOCH₂CH₂OCH₂CH₂, Cl), (M-7017, Cl, H, F, MeOCH₂CH₂OCH₂CH₂, F), (M-7018,Cl, H, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-7019, Cl, H, F, MeOCH₂CH₂OCH₂CH₂,Br), (M-7020, Cl, H, F, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-7021, Cl, H, F,MeOCH₂CH₂, H), (M-7022, Cl, H, F, MeOCH₂CH₂, Cl), (M-7023, Cl, H, F,MeOCH₂CH₂, F), (M-7024, Cl, H, F, MeOCH₂CH₂, CF₃), (M-7025, Cl, H, F,MeOCH₂CH₂, Br), (M-7026, Cl, H, F, MeOCH₂CH₂, CH₃), (M-7027, Cl, H, F,HOCH₂, H), (M-7028, Cl, H, F, HOCH₂, Cl), (M-7029, Cl, H, F, HOCH₂, F),(M-7030, Cl, H, F, HOCH₂, CF₃), (M-7031, Cl, H, F, HOCH₂, Br), (M-7032,Cl, H, F, HOCH₂, CH₃), (M-7033, Cl, H, F, HOCH₂CH₂, H), (M-7034, Cl, H,F, HOCH₂CH₂, Cl), (M-7035, Cl, H, F, HOCH₂CH₂, F), (M-7036, Cl, H, F,HOCH₂CH₂, CF₃), (M-7037, Cl, H, F, HOCH₂CH₂, Br), (M-7038, Cl, H, F,HOCH₂CH₂, CH₃), (M-7039, Cl, H, F, HOCH₂CH₂CH₂, H), (M-7040, Cl, H, F,HOCH₂CH₂CH₂, Cl), (M-7041, Cl, H, F, HOCH₂CH₂CH₂, F), (M-7042, Cl, H, F,HOCH₂CH₂CH₂, CF₃), (M-7043, Cl, H, F, HOCH₂CH₂CH₂, Br), (M-7044, Cl, H,F, HOCH₂CH₂CH₂, CH₃), (M-7045, Cl, H, F, HOCH₂CH₂CH₂CH₂, H), (M-7046,Cl, H, F, HOCH₂CH₂CH₂CH₂, Cl), (M-7047, Cl, H, F, HOCH₂CH₂CH₂CH₂, F),(M-7048, Cl, H, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-7049, Cl, H, F,HOCH₂CH₂CH₂CH₂, Br), (M-7050, Cl, H, F, HOCH₂CH₂CH₂CH₂, CH₃), (M-7051,Cl, H, F, HOCH₂CH₂CH₂CH₂CH₂, H), (M-7052, Cl, H, F, HOCH₂CH₂CH₂CH₂CH₂,Cl), (M-7053, Cl, H, F, HOCH₂CH₂CH₂CH₂CH₂, F), (M-7054, Cl, H, F,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-7055, Cl, H, F, HOCH₂CH₂CH₂CH₂CH₂Br),(M-7056, Cl, H, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-7057, Cl, H, F,HOCH₂CH₂OCH₂CH₂, H), (M-7058, Cl, H, F, HOCH₂CH₂OCH₂CH₂, Cl), (M-7059,Cl, H, F, HOCH₂CH₂OCH₂CH₂, F), (M-7060, Cl, H, F, HOCH₂CH₂OCH₂CH₂, CF₃),(M-7061, Cl, H, F, HOCH₂CH₂OCH₂CH₂, Br), (M-7062, Cl, H, F,HOCH₂CH₂OCH₂CH₂, CH₃), (M-7063, Cl, H, F, (Me)₂N, H), (M-7064, Cl, H, F,(Me)₂N, Cl), (M-7065, Cl, H, F, (Me)₂N, F), (M-7066, Cl, H, F, (Me)₂N,CF₃), (M-7067, Cl, H, F, (Me)₂N, Br), (M-7068, Cl, H, F, (Me)₂N, CH₃),(M-7069, Cl, H, F, piperidin-4-yl-methyl, H), (M-7070, Cl, H, F,piperidin-4-yl-methyl, Cl), (M-7071, Cl, H, F, piperidin-4-yl-methyl,F), (M-7072, Cl, H, F, piperidin-4-yl-methyl, CF₃), (M-7073, Cl, H, F,piperidin-4-yl-methyl, Br), (M-7074, Cl, H, F, piperidin-4-yl-methyl,CH₃), (M-7075, Cl, H, F, cyclohexylmethyl, H), (M-7076, Cl, H, F,cyclohexylmethyl, Cl), (M-7077, Cl, H, F, cyclohexylmethyl, F), (M-7078,Cl, H, F, cyclohexylmethyl, CF₃), (M-7079, Cl, H, F, cyclohexylmethyl,Br), (M-7080, Cl, H, F, cyclohexylmethyl, CH₃), (M-7081, Cl, H, Cl, H,H), (M-7082, Cl, H, Cl, H, Cl), (M-7083, Cl, H, Cl, H, F), (M-7084, Cl,H, Cl, H, CF₃), (M-7085, Cl, H, Cl, H, Br), (M-7086, Cl, H, Cl, H, CH₃),(M-7087, Cl, H, Cl, F, H), (M-7088, Cl, H, Cl, F, Cl), (M-7089, Cl, H,Cl, F, F), (M-7090, Cl, H, Cl, F, CF₃), (M-7091, Cl, H, Cl, F, Br),(M-7092, Cl, H, Cl, F, CH₃), (M-7093, MeO, H, Cl, Cl, H), (M-7094, Cl,H, Cl, Cl, Cl), (M-7095, Cl, H, Cl, Cl, F), (M-7096, Cl, H, Cl, Cl,CF₃), (M-7097, Cl, H, Cl, Cl, Br), (M-7098, Cl, H, Cl, Cl, CH₃),(M-7099, Cl, H, Cl, CH₃, H), (M-7100, Cl, H, Cl, CH₃, Cl), (M-7101, Cl,H, Cl, CH₃, F), (M-7102, Cl, H, Cl, CH₃, CF₃), (M-7103, Cl, H, Cl, CH₃,Br), (M-7104, Cl, H, Cl, CH₃, CH₃), (M-7105, Cl, H, Cl, Et, H), (M-7106,Cl, H, Cl, Et, Cl), (M-7107, Cl, H, Cl, Et, F), (M-7108, Cl, H, Cl, Et,CF₃), (M-7109, Cl, H, Cl, Et, Br), (M-7110, Cl, H, Cl, Et, CH₃),(M-7111, Cl, H, Cl, n-Pr, H), (M-7112, Cl, H, Cl, n-Pr, Cl), (M-7113,Cl, H, Cl, n-Pr, F), (M-7114, Cl, H, Cl, n-Pr, CF₃), (M-7115, Cl, H, Cl,n-Pr, Br), (M-7116, Cl, H, Cl, n-Pr, CH₃), (M-7117, Cl, H, Cl, c-Pr, H),(M-7118, Cl, H, Cl, c-Pr, Cl), (M-7119, Cl, H, Cl, c-Pr, F), (M-7120,Cl, H, Cl, c-Pr, CF₃), (M-7121, Cl, H, Cl, c-Pr, Br), (M-7122, Cl, H,Cl, c-Pr, CH₃), (M-7123, Cl, H, Cl, i-Pr, H), (M-7124, Cl, H, Cl, i-Pr,Cl), (M-7125, Cl, H, Cl, i-Pr, F), (M-7126, Cl, H, Cl, i-Pr, CF₃),(M-7127, Cl, H, Cl, i-Pr, Br), (M-7128, Cl, H, Cl, i-Pr, CH₃), (M-7129,Cl, H, Cl, n-Bu, H), (M-7130, Cl, H, Cl, n-Bu, Cl), (M-7131, Cl, H, Cl,n-Bu, F), (M-7132, Cl, H, Cl, n-Bu, CF₃), (M-7133, Cl, H, Cl, n-Bu, Br),(M-7134, Cl, H, Cl, n-Bu, CH₃), (M-7135, Cl, H, Cl, i-Bu, H), (M-7136,Cl, H, Cl, i-Bu, Cl), (M-7137, Cl, H, Cl, i-Bu, F), (M-7138, Cl, H, Cl,i-Bu, CF₃), (M-7139, Cl, H, Cl, i-Bu, Br), (M-7140, Cl, H, Cl, i-Bu,CH₃), (M-7141, Cl, H, Cl, sec-Bu, H), (M-7142, Cl, H, Cl, sec-Bu, Cl),(M-7143, Cl, H, Cl, sec-Bu, F), (M-7144, Cl, H, Cl, sec-Bu, CF₃),(M-7145, Cl, H, Cl, sec-Bu, Br), (M-7146, Cl, H, Cl, sec-Bu, CH₃),(M-7147, Cl, H, Cl, n-Pen, H), (M-7148, Cl, H, Cl, n-Pen, Cl), (M-7149,Cl, H, Cl, n-Pen, F), (M-7150, Cl, H, Cl, n-Pen, CF₃), (M-7151, Cl, H,Cl, n-Pen, Br), (M-7152, Cl, H, Cl, n-Pen, CH₃), (M-7153, Cl, H, Cl,c-Pen, H), (M-7154, Cl, H, Cl, c-Pen, Cl), (M-7155, Cl, H, Cl, c-Pen,F), (M-7156, Cl, H, Cl, c-Pen, CF₃), (M-7157, Cl, H, Cl, c-Pen, Br),(M-7158, Cl, H, Cl, c-Pen, CH₃), (M-7159, Cl, H, Cl, n-Hex, H), (M-7160,Cl, H, Cl, n-Hex, Cl), (M-7161, Cl, H, Cl, n-Hex, F), (M-7162, Cl, H,Cl, n-Hex, CF₃), (M-7163, Cl, H, Cl, n-Hex, Br), (M-7164, Cl, H, Cl,n-Hex, CH₃), (M-7165, Cl, H, Cl, c-Hex, H), (M-7166, Cl, H, Cl, c-Hex,Cl), (M-7167, Cl, H, Cl, c-Hex, F), (M-7168, Cl, H, Cl, c-Hex, CF₃),(M-7169, Cl, H, Cl, c-Hex, Br), (M-7170, Cl, H, Cl, c-Hex, CH₃),(M-7171, Cl, H, Cl, OH, H), (M-7172, Cl, H, Cl, OH, Cl), (M-7173, Cl, H,Cl, OH, F), (M-7174, Cl, H, Cl, OH, CF₃), (M-7175, Cl, H, Cl, OH, Br),(M-7176, Cl, H, Cl, OH, CH₃), (M-7177, Cl, H, Cl, EtO, H), (M-7178, Cl,H, Cl, EtO, Cl), (M-7179, Cl, H, Cl, EtO, F), (M-7180, Cl, H, Cl, EtO,CF₃), (M-7181, Cl, H, Cl, EtO, Br), (M-7182, Cl, H, Cl, EtO, CH₃),(M-7183, Cl, H, Cl, n-PrO, H), (M-7184, Cl, H, Cl, n-PrO, Cl), (M-7185,Cl, H, Cl, n-PrO, F), (M-7186, Cl, H, Cl, n-PrO, CF₃), (M-7187, Cl, H,Cl, n-PrO, Br), (M-7188, Cl, H, Cl, n-PrO, CH₃), (M-7189, Cl, H, Cl,PhO, H), (M-7190, Cl, H, Cl, PhO, Cl), (M-7191, Cl, H, Cl, PhO, F),(M-7192, Cl, H, Cl, PhO, CF₃), (M-7193, Cl, H, Cl, PhO, Br), (M-7194,Cl, H, Cl, PhO, CH₃), (M-7195, Cl, H, Cl, BnO, H), (M-7196, Cl, H, Cl,BnO, Cl), (M-7197, Cl, H, Cl, BnO, F), (M-7198, Cl, H, Cl, BnO, CF₃),(M-7199, Cl, H, Cl, BnO, Br), (M-7200, Cl, H, Cl, BnO, CH₃), (M-7201,Cl, H, Cl, PhCH₂CH₂O, H), (M-7202, Cl, H, Cl, PhCH₂CH₂O, Cl), (M-7203,Cl, H, Cl, PhCH₂CH₂O, F), (M-7204, Cl, H, Cl, PhCH₂CH₂O, CF₃), (M-7205,Cl, H, Cl, PhCH₂CH₂O, Br), (M-7206, Cl, H, Cl, PhCH₂CH₂O, CH₃), (M-7207,Cl, H, Cl, CF₃O, H), (M-7208, Cl, H, Cl, CF₃O, Cl), (M-7209, Cl, H, Cl,CF₃O, F), (M-7210, Cl, H, Cl, CF₃O, CF₃), (M-7211, Cl, H, Cl, CF₃O, Br),(M-7212, Cl, H, Cl, CF₃O, CH₃), (M-7213, Cl, H, Cl, Ph, H), (M-7214, Cl,H, Cl, Ph, Cl), (M-7215, Cl, H, Cl, Ph, F), (M-7216, Cl, H, Cl, Ph,CF₃), (M-7217, Cl, H, Cl, Ph, Br), (M-7218, Cl, H, Cl, Ph, CH₃),(M-7219, Cl, H, Cl, 4-F-Ph, H), (M-7220, Cl, H, Cl, 4-F-Ph, Cl),(M-7221, Cl, H, Cl, 4-F-Ph, F), (M-7222, Cl, H, Cl, 4-F-Ph, CF₃),(M-7223, Cl, H, Cl, 4-F-Ph, Br), (M-7224, Cl, H, Cl, 4-F-Ph, CH₃),(M-7225, Cl, H, Cl, 4-CF₃-Ph, H), (M-7226, Cl, H, Cl, 4-CF₃-Ph, Cl),(M-7227, Cl, H, Cl, 4-CF₃-Ph, F), (M-7228, Cl, H, Cl, 4-CF₃-Ph, CF₃),(M-7229, Cl, H, Cl, 4-CF₃-Ph, Br), (M-7230, Cl, H, Cl, 4-CF₃-Ph, CH₃),(M-7231, Cl, H, Cl, 4-(Me)₂N-Ph, H), (M-7232, Cl, H, Cl, 4-(Me)₂N-Ph,Cl), (M-7233, Cl, H, Cl, 4-(Me)₂N-Ph, F), (M-7234, Cl, H, Cl,4-(Me)₂N-Ph, CF₃), (M-7235, Cl, H, Cl, 4-(Me)₂N-Ph, Br), (M-7236, Cl, H,Cl, 4-(Me)₂N-Ph, CH₃), (M-7237, Cl, H, Cl, 4-OH-Ph, H), (M-7238, Cl, H,Cl, 4-OH-Ph, Cl), (M-7239, Cl, H, Cl, 4-OH-Ph, F), (M-7240, Cl, H, Cl,4-OH-Ph, CF₃), (M-7241, Cl, H, Cl, 4-OH-Ph, Br), (M-7242, Cl, H, Cl,4-OH-Ph, CH₃), (M-7243, Cl, H, Cl, 3,4-di-F-Ph, H), (M-7244, Cl, H, Cl,3,4-di-F-Ph, Cl), (M-7245, Cl, H, Cl, 3,4-di-F-Ph, F), (M-7246, Cl, H,Cl, 3,4-di-F-Ph, CF₃), (M-7247, Cl, H, Cl, 3,4-di-F-Ph, Br), (M-7248,Cl, H, Cl, 3,4-di-F-Ph, CH₃), (M-7249, Cl, H, Cl, 4-COOH-Ph, H),(M-7250, Cl, H, Cl, 4-COOH-Ph, Cl), (M-7251, Cl, H, Cl, 4-COOH-Ph, F),(M-7252, Cl, H, Cl, 4-COOH-Ph, CF₃), (M-7253, Cl, H, Cl, 4-COOH-Ph, Br),(M-7254, Cl, H, Cl, 4-COOH-Ph, CH₃), (M-7255, Cl, H, Cl, Bn, H),(M-7256, Cl, H, Cl, Bn, Cl), (M-7257, Cl, H, Cl, Bn, F), (M-7258, Cl, H,Cl, Bn, CF₃), (M-7259, Cl, H, Cl, Bn, Br), (M-7260, Cl, H, Cl, Bn, CH₃),(M-7261, Cl, H, Cl, 4-F-Bn, H), (M-7262, Cl, H, Cl, 4-F-Bn, Cl),(M-7263, Cl, H, Cl, 4-F-Bn, F), (M-7264, Cl, H, Cl, 4-F-Bn, CF₃),(M-7265, Cl, H, Cl, 4-F-Bn, Br), (M-7266, Cl, H, Cl, 4-F-Bn, CH₃),(M-7267, Cl, H, Cl, 2-Py, H), (M-7268, Cl, H, Cl, 2-Py, Cl), (M-7269,Cl, H, Cl, 2-Py, F), (M-7270, Cl, H, Cl, 2-Py, CF₃), (M-7271, Cl, H, Cl,2-Py, Br), (M-7272, Cl, H, Cl, 2-Py, CH₃), (M-7273, Cl, H, Cl, 3-Py, H),(M-7274, Cl, H, Cl, 3-Py, Cl), (M-7275, Cl, H, Cl, 3-Py, F), (M-7276,Cl, H, Cl, 3-Py, CF₃), (M-7277, Cl, H, Cl, 3-Py, Br), (M-7278, Cl, H,Cl, 3-Py, CH₃), (M-7279, Cl, H, Cl, 4-Py, H), (M-7280, Cl, H, Cl, 4-Py,Cl), (M-7281, Cl, H, Cl, 4-Py, F), (M-7282, Cl, H, Cl, 4-Py, CF₃),(M-7283, Cl, H, Cl, 4-Py, Br), (M-7284, Cl, H, Cl, 4-Py, CH₃), (M-7285,Cl, H, Cl, 2-Th, H), (M-7286, Cl, H, Cl, 2-Th, Cl), (M-7287, Cl, H, Cl,2-Th, F), (M-7288, Cl, H, Cl, 2-Th, CF₃), (M-7289, Cl, H, Cl, 2-Th, Br),(M-7290, Cl, H, Cl, 2-Th, CH₃), (M-7291, Cl, H, Cl, 3-Th, H), (M-7292,Cl, H, Cl, 3-Th, Cl), (M-7293, Cl, H, Cl, 3-Th, F), (M-7294, Cl, H, Cl,3-Th, CF₃), (M-7295, Cl, H, Cl, 3-Th, Br), (M-7296, Cl, H, Cl, 3-Th,CH₃), (M-7297, Cl, H, Cl, pyrrazol-2-yl, H), (M-7298, Cl, H, Cl,pyrrazol-2-yl, Cl), (M-7299, Cl, H, Cl, pyrrazol-2-yl, F), (M-7300, Cl,H, Cl, pyrrazol-2-yl, CF₃), (M-7301, Cl, H, Cl, pyrrazol-2-yl, Br),(M-7302, Cl, H, Cl, pyrrazol-2-yl, CH₃), (M-7303, Cl, H, Cl,pyrrazol-3-yl, H), (M-7304, Cl, H, Cl, pyrrazol-3-yl, Cl), (M-7305, Cl,H, Cl, pyrrazol-3-yl, F), (M-7306, Cl, H, Cl, pyrrazol-3-yl, CF₃),(M-7307, Cl, H, Cl, pyrrazol-3-yl, Br), (M-7308, Cl, H, Cl,pyrrazol-3-yl, CH₃), (M-7309, Cl, H, Cl, pyrimidin-2-yl, H), (M-7310,Cl, H, Cl, pyrimidin-2-yl, Cl), (M-7311, Cl, H, Cl, pyrimidin-2-yl, F),(M-7312, Cl, H, Cl, pyrimidin-2-yl, CF₃), (M-7313, Cl, H, Cl,pyrimidin-2-yl, Br), (M-7314, Cl, H, Cl, pyrimidin-2-yl, CH₃), (M-7315,Cl, H, Cl, pyrimidin-4-yl, H), (M-7316, Cl, H, Cl, pyrimidin-4-yl, Cl),(M-7317, Cl, H, Cl, pyrimidin-4-yl, F), (M-7318, Cl, H, Cl,pyrimidin-4-yl, CF₃), (M-7319, Cl, H, Cl, pyrimidin-4-yl, Br), (M-7320,Cl, H, Cl, pyrimidin-4-yl, CH₃), (M-7321, Cl, H, Cl, pyrimidin-5-yl, H),(M-7322, Cl, H, Cl, pyrimidin-5-yl, Cl), (M-7323, Cl, H, Cl,pyrimidin-5-yl, F), (M-7324, Cl, H, Cl, pyrimidin-5-yl, CF₃), (M-7325,Cl, H, Cl, pyrimidin-5-yl, Br), (M-7326, Cl, H, Cl, pyrimidin-5-yl,CH₃), (M-7327, Cl, H, Cl, HOOCCH₂CH₂CH₂, H), (M-7328, Cl, H, Cl,HOOCCH₂CH₂CH₂, Cl), (M-7329, Cl, H, Cl, HOOCCH₂CH₂CH₂, F), (M-7330, Cl,H, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-7331, Cl, H, Cl, HOOCCH₂CH₂CH₂, Br),(M-7332, Cl, H, Cl, HOOCCH₂CH₂CH₂, CH₃), (M-7333, Cl, H, Cl,HOOCCH₂CH₂CH₂CH₂, H), (M-7334, Cl, H, Cl, HOOCCH₂CH₂CH₂CH₂, Cl),(M-7335, Cl, H, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-7336, Cl, H, Cl,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-7337, Cl, H, Cl, HOOCCH₂CH₂CH₂CH₂, Br),(M-7338, Cl, H, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-7339, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-7340, Cl, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-7341, Cl, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-7342, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-7343, Cl, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-7344, Cl, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-7345, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-7346, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-7347, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-7348, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-7349, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-7350, Cl, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-7351, Cl, H, Cl, MeOCH₂, H), (M-7352,Cl, H, Cl, MeOCH₂, Cl), (M-7353, Cl, H, Cl, MeOCH₂, F), (M-7354, Cl, H,Cl, MeO CH₂, CF₃), (M-7355, Cl, H, Cl, MeO CH₂, Br ), (M-7356, Cl, H,Cl, MeOCH₂, CH₃), (M-7357, Cl, H, Cl, EtOCH₂, H), (M-7358, Cl, H ,EtOCH₂, Cl), (M-7359, Cl, H, Cl, EtOCH₂, F), (M-7360, Cl, H, Cl, EtOCH₂,CF₃), (M-7361, Cl, H, Cl, EtOCH₂, Br ), (M-7362, Cl, H, Cl, EtOCH₂,CH₃), (M-7363, Cl, H, Cl, EtOCH₂ CH₂, H), (M-7364, Cl, H, Cl, EtOCH₂CH₂,Cl), (M-7365, Cl, H, Cl, EtOCH₂CH₂, F), (M-7366, Cl, H, Cl, EtOCH₂CH₂,CF₃), (M-7367, Cl, H, Cl, EtOCH₂CH₂, Br), (M-7368, Cl, H, Cl, EtOCH₂CH₂,CH₃), (M-7369, Cl, H, Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-7370, Cl, H, Cl,MeOCH₂CH₂OCH₂CH₂, Cl), (M-7371, Cl, H, Cl, MeOCH₂CH₂OCH₂CH₂, F),(M-7372, Cl, H, Cl, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-7373, Cl, H, Cl,MeOCH₂CH₂OCH₂CH₂, Br), (M-7374, Cl, H, Cl, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-7375, Cl, H, Cl, MeOCH₂CH₂, H), (M-7376, Cl, H, Cl, MeOCH₂CH₂, Cl),(M-7377, Cl, H, Cl, MeOCH₂CH₂, F), (M-7378, Cl, H, Cl, MeOCH₂CH₂, CF₃),(M-7379, Cl, H, Cl, MeOCH₂CH₂, Br), (M-7380, Cl, H, Cl, MeOCH₂CH₂, CH₃),(M-7381, Cl, H, Cl, HOCH₂, H), (M-7382, Cl, H, Cl, HOCH₂, Cl), (M-7383,Cl, H, Cl, HOCH₂, F), (M-7384, Cl, H, Cl, HOCH₂, CF₃), (M-7385, Cl, H,Cl, HOCH₂, Br), (M-7386, Cl, H, Cl, HOCH₂, CH₃), (M-7387, Cl, H, Cl,HOCH₂CH₂, H), (M-7388, Cl, H, Cl, HOCH₂CH₂, Cl), (M-7389, Cl, H, Cl,HOCH₂CH₂, F), (M-7390, Cl, H, Cl, HOCH₂CH₂, CF₃), (M-7391, Cl, H, Cl,HOCH₂CH₂, Br), (M-7392, Cl, H, Cl, HOCH₂CH₂, CH₃), (M-7393, Cl, H, Cl,HOCH₂CH₂CH₂, H), (M-7394, Cl, H, Cl, HOCH₂CH₂CH₂, Cl), (M-7395, Cl, H,Cl, HOCH₂CH₂CH₂, F), (M-7396, Cl, H, Cl, HOCH₂CH₂CH₂, CF₃), (M-7397, Cl,H, Cl, HOCH₂CH₂CH₂, Br), (M-7398, Cl, H, Cl, HOCH₂CH₂CH₂, CH₃), (M-7399,Cl, H, Cl, HOCH₂CH₂CH₂CH₂, H), (M-7400, Cl, H, Cl, HOCH₂CH₂CH₂CH₂, Cl),(M-7401, Cl, H, Cl, HOCH₂CH₂CH₂CH₂, F), (M-7402, Cl, H, Cl,HOCH₂CH₂CH₂CH₂CF₃), (M-7403, Cl, H, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-7404,Cl, H, Cl, HOCH₂CH₂CH₂CH₂, CH₃), (M-7405, Cl, H, Cl, HOCH₂CH₂CH₂CH₂CH₂,H), (M-7406, Cl, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-7407, Cl, H, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-7408, Cl, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-7409, Cl, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-7410, Cl, H, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-7411, Cl, H, Cl, HOCH₂CH₂OCH₂CH₂, H),(M-7412, Cl, H, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-7413, Cl, H, Cl,HOCH₂CH₂OCH₂CH₂, F), (M-7414, Cl, H, Cl, HOCH₂CH₂OCH₂CH₂, CF₃), (M-7415,Cl, H, Cl, HOCH₂CH₂OCH₂CH₂, Br), (M-7416, Cl, H, Cl, HOCH₂CH₂OCH₂CH₂,CH₃), (M-7417, Cl, H, Cl, (Me)₂N, H), (M-7418, Cl, H, Cl, (Me)₂N, Cl),(M-7419, Cl, H, Cl, (Me)₂N, F), (M-7420, Cl, H, Cl, (Me)₂N, CF₃),(M-7421, Cl, H, Cl, (Me)₂N, Br), (M-7422, Cl, H, Cl, (Me)₂N, CH₃),(M-7423, Cl, H, Cl, piperidin-4-yl-methyl, H), (M-7424, Cl, H, Cl,piperidin-4-yl-methyl, Cl), (M-7425, Cl, H, Cl, piperidin-4-yl-methyl,F), (M-7426, Cl, H, Cl, piperidin-4-yl-methyl, CF₃), (M-7427, Cl, H, Cl,piperidin-4-yl-methyl, Br), (M-7428, Cl, H, Cl, piperidin-4-yl-methyl,CH₃), (M-7429, Cl, H, Cl, cyclohexylmethyl, H), (M-7430, Cl, H, Cl,cyclohexylmethyl, Cl), (M-7431, Cl, H, Cl, cyclohexylmethyl, F),(M-7432, Cl, H, Cl, cyclohexylmethyl, CF₃), (M-7433, Cl, H, Cl,cyclohexylmethyl, Br), (M-7434, Cl, H, Cl, cyclohexylmethyl, CH₃),(M-7435, Cl, F, H, H, H), (M-7436, Cl, F, H, H, Cl), (M-7437, Cl, F, H,H, F), (M-7438, Cl, F, H, H, CF₃), (M-7439, Cl, F, H, H, Br), (M-7440,Cl, F, H, H, CH₃), (M-7441, Cl, F, H, F, H), (M-7442, Cl, F, H, F, Cl),(M-7443, Cl, F, H, F, F), (M-7444, Cl, F, H, F, CF₃), (M-7445, Cl, F, H,F, Br), (M-7446, Cl, F, H, F, CH₃), (M-7447, Cl, F, H, Cl, H), (M-7448,Cl, F, H, Cl, Cl), (M-7449, Cl, F, H, Cl, F), (M-7450, Cl, F, H, Cl,CF₃), (M-7451, Cl, F, H, Cl, Br), (M-7452, Cl, F, H, Cl, CH₃), (M-7453,Cl, F, H, CH₃, H), (M-7454, Cl, F, H, CH₃, Cl), (M-7455, Cl, F, H, CH₃,F), (M-7456, Cl, F, H, CH₃, CF₃), (M-7457, Cl, F, H, CH₃, Br), (M-7458,Cl, F, H, CH₃, CH₃), (M-7459, Cl, F, H, Et, H), (M-7460, Cl, F, H, Et,Cl), (M-7461, Cl, F, H, Et, F), (M-7462, Cl, F, H, Et, CF₃), (M-7463,Cl, F, H, Et, Br), (M-7464, Cl, F, H, Et, CH₃), (M-7465, Cl, F, H, n-Pr,H), (M-7466, Cl, F, H, n-Pr, Cl), (M-7467, Cl, F, H, n-Pr, F), (M-7468,Cl, F, H, n-Pr, CF₃), (M-7469, Cl, F, H, n-Pr, Br), (M-7470, Cl, F, H,n-Pr, CH₃), (M-7471, Cl, F, H, c-Pr, H), (M-7472, Cl, F, H, c-Pr, Cl),(M-7473, Cl, F, H, c-Pr, F), (M-7474, Cl, F, H, c-Pr, CF₃), (M-7475, Cl,F, H, c-Pr, Br), (M-7476, Cl, F, H, c-Pr, CH₃), (M-7477, Cl, F, H, i-Pr,H), (M-7478, Cl, F, H, i-Pr, Cl), (M-7479, Cl, F, H, i-Pr, F), (M-7480,Cl, F, H, i-Pr, CF₃), (M-7481, Cl, F, H, i-Pr, Br), (M-7482, Cl, F, H,i-Pr, CH₃), (M-7483, MeO, F, H, n-Bu, H), (M-7484, Cl, F, H, n-Bu, Cl),(M-7485, Cl, F, H, n-Bu, F), (M-7486, Cl, F, H, n-Bu, CF₃), (M-7487, Cl,F, H, n-Bu, Br), (M-7488, Cl, F, H, n-Bu, CH₃), (M-7489, Cl, F, H, i-Bu,H), (M-7490, Cl, F, H, i-Bu, Cl), (M-7491, Cl, F, H, i-Bu, F), (M-7492,Cl, F, H, i-Bu, CF₃), (M-7493, Cl, F, H, i-Bu, Br), (M-7494, Cl, F, H,i-Bu, CH₃), (M-7495, Cl, F, H, sec-Bu, H), (M-7496, Cl, F, H, sec-Bu,Cl), (M-7497, Cl, F, H, sec-Bu, F), (M-7498, Cl, F, H, sec-Bu, CF₃),(M-7499, Cl, F, H, sec-Bu, Br), (M-7500, Cl, F, H, sec-Bu, CH₃),(M-7501, Cl, F, H, n-Pen, H), (M-7502, Cl, F, H, n-Pen, Cl), (M-7503,Cl, F, H, n-Pen, F), (M-7504, Cl, F, H, n-Pen, CF₃), (M-7505, Cl, F, H,n-Pen, Br), (M-7506, Cl, F, H, n-Pen, CH₃), (M-7507, Cl, F, H, c-Pen,H), (M-7508, Cl, F, H, c-Pen, Cl), (M-7509, Cl, F, H, c-Pen, F),(M-7510, Cl, F, H, c-Pen, CF₃), (M-7511, Cl, F, H, c-Pen, Br), (M-7512,Cl, F, H, c-Pen, CH₃), (M-7513, Cl, F, H, n-Hex, H), (M-7514, Cl, F, H,n-Hex, Cl), (M-7515, Cl, F, H, n-Hex, F), (M-7516, Cl, F, H, n-Hex,CF₃), (M-7517, Cl, F, H, n-Hex, Br), (M-7518, Cl, F, H, n-Hex, CH₃),(M-7519, Cl, F, H, c-Hex, H), (M-7520, Cl, F, H, c-Hex, Cl), (M-7521,Cl, F, H, c-Hex, F), (M-7522, Cl, F, H, c-Hex, CF₃), (M-7523, Cl, F, H,c-Hex, Br), (M-7524, Cl, F, H, c-Hex, CH₃), (M-7525, Cl, F, H, OH, H),(M-7526, Cl, F, H, OH, Cl), (M-7527, Cl, F, H, OH, F), (M-7528, Cl, F,H, OH, CF₃), (M-7529, Cl, F, H, OH, Br), (M-7530, Cl, F, H, OH, CH₃),(M-7531, Cl, F, H, EtO, H), (M-7532, Cl, F, H, EtO, Cl), (M-7533, Cl, F,H, EtO, F), (M-7534, Cl, F, H, EtO, CF₃), (M-7535, Cl, F, H, EtO, Br),(M-7536, Cl, F, H, EtO, CH₃), (M-7537, Cl, F, H, n-PrO, H), (M-7538, Cl,F, H, n-PrO, Cl), (M-7539, Cl, F, H, n-PrO, F), (M-7540, Cl, F, H,n-PrO, CF₃), (M-7541, Cl, F, H, n-PrO, Br), (M-7542, Cl, F, H, n-PrO,CH₃), (M-7543, Cl, F, H, PhO, H), (M-7544, Cl, F, H, PhO, Cl), (M-7545,Cl, F, H, PhO, F), (M-7546, Cl, F, H, PhO, CF₃), (M-7547, Cl, F, H, PhO,Br), (M-7548, Cl, F, H, PhO, CH₃), (M-7549, Cl, F, H, BnO, H), (M-7550,Cl, F, H, BnO, Cl), (M-7551, Cl, F, H, BnO, F), (M-7552, Cl, F, H, BnO,CF₃), (M-7553, Cl, F, H, BnO, Br), (M-7554, Cl, F, H, BnO, CH₃),(M-7555, Cl, F, H, PhCH₂CH₂O, H), (M-7556, Cl, F, H, PhCH₂CH₂O, Cl),(M-7557, Cl, F, H, PhCH₂CH₂O, F), (M-7558, Cl, F, H, PhCH₂CH₂O, CF₃),(M-7559, Cl, F, H, PhCH₂CH₂O, Br), (M-7560, Cl, F, H, PhCH₂CH₂O, CH₃),(M-7561, Cl, F, H, CF₃O, H), (M-7562, Cl, F, H, CF₃O, Cl), (M-7563, Cl,F, H, CF₃O, F), (M-7564, Cl, F, H, CF₃O, CF₃), (M-7565, Cl, F, H, CF₃O,Br), (M-7566, Cl, F, H, CF₃O, CH₃), (M-7567, Cl, F, H, Ph, H), (M-7568,Cl, F, H, Ph, Cl), (M-7569, Cl, F, H, Ph, F), (M-7570, Cl, F, H, Ph,CF₃), (M-7571, Cl, F, H, Ph, Br), (M-7572, Cl, F, H, Ph, CH₃), (M-7573,Cl, F, H, 4-F-Ph, H), (M-7574, Cl, F, H, 4-F-Ph, Cl), (M-7575, Cl, F, H,4-F-Ph, F), (M-7576, Cl, F, H, 4-F-Ph, CF₃), (M-7577, Cl, F, H, 4-F-Ph,Br), (M-7578, Cl, F, H, 4-F-Ph, CH₃), (M-7579, Cl, F, H, 4-CF₃-Ph, H),(M-7580, Cl, F, H, 4-CF₃-Ph, Cl), (M-7581, Cl, F, H, 4-CF₃-Ph, F),(M-7582, Cl, F, H, 4-CF₃-Ph, CF₃), (M-7583, Cl, F, H, 4-CF₃-Ph, Br),(M-7584, Cl, F, H, 4-CF₃-Ph, CH₃), (M-7585, Cl, F, H, 4-(Me)₂N-Ph, H),(M-7586, Cl, F, H, 4-(Me)₂N-Ph, Cl), (M-7587, Cl, F, H, 4-(Me)₂N-Ph, F),(M-7588, Cl, F, H, 4-(Me)₂N-Ph, CF₃), (M-7589, Cl, F, H, 4-(Me)₂N-Ph,Br), (M-7590, Cl, F, H, 4-(Me)₂N-Ph, CH₃), (M-7591, Cl, F, H, 4-OH-Ph,H), (M-7592, Cl, F, H, 4-OH-Ph, Cl), (M-7593, Cl, F, H, 4-OH-Ph, F),(M-7594, Cl, F, H, 4-OH-Ph, CF₃), (M-7595, Cl, F, H, 4-OH-Ph, Br),(M-7596, Cl, F, H, 4-OH-Ph, CH₃), (M-7597, Cl, F, H, 3,4-di-F-Ph, H),(M-7598, Cl, F, H, 3,4-di-F-Ph, Cl), (M-7599, Cl, F, H, 3,4-di-F-Ph, F),(M-7600, Cl, F, H, 3,4-di-F-Ph, CF₃), (M-7601, Cl, F, H, 3,4-di-F-Ph,Br), (M-7602, Cl, F, H, 3,4-di-F-Ph, CH₃), (M-7603, Cl, F, H, 4-COOH-Ph,H), (M-7604, Cl, F, H, 4-COOH-Ph, Cl), (M-7605, Cl, F, H, 4-COOH-Ph, F),(M-7606, Cl, F, H, 4-COOH-Ph, CF₃), (M-7607, Cl, F, H, 4-COOH-Ph, Br),(M-7608, Cl, F, H, 4-COOH-Ph, CH₃), (M-7609, Cl, F, H, Bn, H), (M-7610,Cl, F, H, Bn, Cl), (M-7611, Cl, F, H, Bn, F), (M-7612, Cl, F, H, Bn,CF₃), (M-7613, Cl, F, H, Bn, Br), (M-7614, Cl, F, H, Bn, CH₃), (M-7615,Cl, F, H, 4-F-Bn, H), (M-7616, Cl, F, H, 4-F-Bn, Cl), (M-7617, Cl, F, H,4-F-Bn, F), (M-7618, Cl, F, H, 4-F-Bn, CF₃), (M-7619, Cl, F, H, 4-F-Bn,Br), (M-7620, Cl, F, H, 4-F-Bn, CH₃), (M-7621, Cl, F, H, 2-Py, H),(M-7622, Cl, F, H, 2-Py, Cl), (M-7623, Cl, F, H, 2-Py, F), (M-7624, Cl,F, H, 2-Py, CF₃), (M-7625, Cl, F, H, 2-Py, Br), (M-7626, Cl, F, H, 2-Py,CH₃), (M-7627, Cl, F, H, 3-Py, H), (M-7628, Cl, F, H, 3-Py, Cl),(M-7629, Cl, F, H, 3-Py, F), (M-7630, Cl, F, H, 3-Py, CF₃), (M-7631, Cl,F, H, 3-Py, Br), (M-7632, Cl, F, H, 3-Py, CH₃), (M-7633, Cl, F, H, 4-Py,H), (M-7634, Cl, F, H, 4-Py, Cl), (M-7635, Cl, F, H, 4-Py, F), (M-7636,Cl, F, H, 4-Py, CF₃), (M-7637, Cl, F, H, 4-Py, Br), (M-7638, Cl, F, H,4-Py, CH₃), (M-7639, Cl, F, H, 2-Th, H), (M-7640, Cl, F, H, 2-Th, Cl),(M-7641, Cl, F, H, 2-Th, F), (M-7642, Cl, F, H, 2-Th, CF₃), (M-7643, Cl,F, H, 2-Th, Br), (M-7644, Cl, F, H, 2-Th, CH₃), (M-7645, Cl, F, H, 3-Th,H), (M-7646, Cl, F, H, 3-Th, Cl), (M-7647, Cl, F, H, 3-Th, F), (M-7648,Cl, F, H, 3-Th, CF₃), (M-7649, Cl, F, H, 3-Th, Br), (M-7650, Cl, F, H,3-Th, CH₃), (M-7651, Cl, F, H, pyrrazol-2-yl, H), (M-7652, Cl, F, H,pyrrazol-2-yl, Cl), (M-7653, Cl, F, H, pyrrazol-2-yl, F), (M-7654, Cl,F, H, pyrrazol-2-yl, CF₃), (M-7655, Cl, F, H, pyrrazol-2-yl, Br),(M-7656, Cl, F, H, pyrrazol-2-yl, CH₃), (M-7657, Cl, F, H,pyrrazol-3-yl, H), (M-7658, Cl, F, H, pyrrazol-3-yl, Cl), (M-7659, Cl,F, H, pyrrazol-3-yl, F), (M-7660, Cl, F, H, pyrrazol-3-yl, CF₃),(M-7661, Cl, F, H, pyrrazol-3-yl, Br), (M-7662, Cl, F, H, pyrrazol-3-yl,CH₃), (M-7663, Cl, F, H, pyrimidin-2-yl, H), (M-7664, Cl, F, H,pyrimidin-2-yl, Cl), (M-7665, Cl, F, H, pyrimidin-2-yl, F), (M-7666, Cl,F, H, pyrimidin-2-yl, CF₃), (M-7667, Cl, F, H, pyrimidin-2-yl, Br),(M-7668, Cl, F, H, pyrimidin-2-yl, CH₃), (M-7669, Cl, F, H,pyrimidin-4-yl, H), (M-7670, Cl, F, H, pyrimidin-4-yl, Cl), (M-7671, Cl,F, H, pyrimidin-4-yl, F), (M-7672, Cl, F, H, pyrimidin-4-yl, CF₃),(M-7673, Cl, F, H, pyrimidin-4-yl, Br), (M-7674, Cl, F, H,pyrimidin-4-yl, CH₃), (M-7675, Cl, F, H, pyrimidin-5-yl, H), (M-7676,Cl, F, H, pyrimidin-5-yl, Cl), (M-7677, Cl, F, H, pyrimidin-5-yl, F),(M-7678, Cl, F, H, pyrimidin-5-yl, CF₃), (M-7679, Cl, F, H,pyrimidin-5-yl, Br), (M-7680, Cl, F, H, pyrimidin-5-yl, CH₃), (M-7681,Cl, F, H, HOOCCH₂CH₂CH₂, H), (M-7682, Cl, F, H, HOOCCH₂CH₂CH₂, Cl),(M-7683, Cl, F, H, HOOCCH₂CH₂CH₂, F), (M-7684, Cl, F, H, HOOCCH₂CH₂CH₂,CF₃), (M-7685, Cl, F, H, HOOCCH₂CH₂CH₂, Br), (M-7686, Cl, F, H,HOOCCH₂CH₂CH₂, CH₃), (M-7687, Cl, F, H, HOOCCH₂CH₂CH₂CH₂, H), (M-7688,Cl, F, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-7689, Cl, F, H, HOOCCH₂CH₂CH₂CH₂,F), (M-7690, Cl, F, H, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-7691, Cl, F, H,HOOCCH₂CH₂CH₂CH₂, Br), (M-7692, Cl, F, H, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-7693, Cl, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-7694, Cl, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-7695, Cl, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-7696, Cl, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-7697, Cl, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-7698, Cl, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-7699, Cl, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-7700, Cl, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-7701, Cl, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-7702, Cl, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CF₃), (M-7703, Cl, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-7704, Cl, F,H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-7705, Cl, F, H, MeOCH₂, H),(M-7706, Cl, F, H, MeOCH₂, Cl), (M-7707, Cl, F, H, MeOCH₂, F), (M-7708,Cl, F, H, MeOCH₂, CF₃), (M-7709, Cl, F, H, MeOCH₂, Br), (M-7710, Cl, F,H, MeOCH₂, CH₃), (M-7711, Cl, F, H, EtOCH₂, H), (M-7712, Cl, F, H,EtOCH₂, Cl), (M-7713, Cl, F, H, EtOCH₂, F), (M-7714, Cl, F, H, EtOCH₂,CF₃), (M-7716, Cl, F, H, EtOCH₂, Br), (M-7716, Cl, F, H, EtOCH₂, CH₃),(M-7717, Cl, F, H, EtOCH₂CH₂, H), (M-7718, Cl, F, H, EtOCH₂CH₂, Cl),(M-7719, Cl, F, H, EtOCH₂CH₂, F), (M-7720, Cl, F, H, EtOCH₂CH₂, CF₃),(M-7721, Cl, F, H, EtOCH₂CH₂, Br), (M-7722, Cl, F, H, EtOCH₂CH₂, CH₃),(M-7723, Cl, F, H, MeOCH₂CH₂OCH₂CH₂, H), (M-7724, Cl, F, H,MeOCH₂CH₂OCH₂CH₂, Cl), (M-7725, Cl, F, H, MeOCH₂CH₂OCH₂CH₂, F), (M-7726,Cl, F, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-7727, Cl, F, H, MeOCH₂CH₂OCH₂CH₂,Br), (M-7728, Cl, F, H, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-7729, Cl, F, H,MeOCH₂CH₂, H), (M-7730, Cl, F, H, MeOCH₂CH₂, Cl), (M-7731, Cl, F, H,MeOCH₂CH₂, F), (M-7732, Cl, F, H, MeOCH₂CH₂, CF₃), (M-7733, Cl, F, H,MeOCH₂CH₂, Br), (M-7734, Cl, F, H, MeOCH₂CH₂, CH₃), (M-7735, Cl, F, H,HOCH₂, H), (M-7736, Cl, F, H, HOCH₂, Cl), (M-7737, Cl, F, H, HOCH₂, F),(M-7738, Cl, F, H, HOCH₂, CF₃), (M-7739, Cl, F, H, HOCH₂, Br), (M-7740,Cl, F, H, HOCH₂, CH₃), (M-7741, Cl, F, H, HOCH₂CH₂, H), (M-7742, Cl, F,H, HOCH₂CH₂, Cl), (M-7743, Cl, F, H, HOCH₂CH₂, F), (M-7744, Cl, F, H,HOCH₂CH₂, CF₃), (M-7745, Cl, F, H, HOCH₂CH₂, Br), (M-7746, Cl, F, H,HOCH₂CH₂, CH₃), (M-7747, Cl, F, H, HOCH₂CH₂CH₂, H), (M-7748, Cl, F, H,HOCH₂CH₂CH₂, Cl), (M-7749, Cl, F, H, HOCH₂CH₂CH₂, F), (M-7750, Cl, F, H,HOCH₂CH₂CH₂, CF₃), (M-7751, Cl, F, H, HOCH₂CH₂CH₂, Br), (M-7752, Cl, F,H, HOCH₂CH₂CH₂, CH₃), (M-7753, Cl, F, H, HOCH₂CH₂CH₂CH₂, H), (M-7754,Cl, F, H, HOCH₂CH₂CH₂CH₂, Cl), (M-7755, Cl, F, H, HOCH₂CH₂CH₂CH₂, F),(M-7756, Cl, F, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-7757, Cl, F, H,HOCH₂CH₂CH₂CH₂, Br), (M-7758, Cl, F, H, HOCH₂CH₂CH₂CH₂, CH₃), (M-7759,Cl, F, H, HOCH₂CH₂CH₂CH₂CH₂, H), (M-7760, Cl, F, H, HOCH₂CH₂CH₂CH₂CH₂,Cl), (M-7761, Cl, F, H, HOCH₂CH₂CH₂CH₂CH₂, F), (M-7762, Cl, F, H,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-7763, Cl, F, H, HOCH₂CH₂CH₂CH₂CH₂Br),(M-7764, Cl, F, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-7765, Cl, F, H,HOCH₂CH₂OCH₂CH₂, H), (M-7766, Cl, F, H, HOCH₂CH₂OCH₂CH₂, Cl), (M-7767,Cl, F, H, HOCH₂CH₂OCH₂CH₂, F), (M-7768, Cl, F, H, HOCH₂CH₂OCH₂CH₂, CF₃),(M-7769, Cl, F, H, HOCH₂CH₂OCH₂CH₂, Br), (M-7770, Cl, F, H,HOCH₂CH₂OCH₂CH₂, CH₃), (M-7771, Cl, F, H, (Me)₂N, H), (M-7772, Cl, F, H,(Me)₂N, Cl), (M-7773, Cl, F, H, (Me)₂N, F), (M-7774, Cl, F, H, (Me)₂N,CF₃), (M-7775, Cl, F, H, (Me)₂N, Br), (M-7776, Cl, F, H, (Me)₂N, CH₃),(M-7777, Cl, F, H, piperidin-4-yl-methyl, H), (M-7778, Cl, F, H,piperidin-4-yl-methyl, Cl), (M-7779, Cl, F, H, piperidin-4-yl-methyl,F), (M-7780, Cl, F, H, piperidin-4-yl-methyl, CF₃), (M-7781, Cl, F, H,piperidin-4-yl-methyl, Br), (M-7782, Cl, F, H, piperidin-4-yl-methyl,CH₃), (M-7783, Cl, F, H, cyclohexylmethyl, H), (M-7784, Cl, F, H,cyclohexylmethyl, Cl), (M-7785, Cl, F, H, cyclohexylmethyl, F), (M-7786,Cl, F, H, cyclohexylmethyl, CF₃), (M-7787, Cl, F, H, cyclohexylmethyl,Br), (M-7788, Cl, F, H, cyclohexylmethyl, CH₃), (M-7789, Cl, F, F, H,H), (M-7790, Cl, F, F, H, Cl), (M-7791, Cl, F, F, H, F), (M-7792, Cl, F,F, H, CF₃), (M-7793, Cl, F, F, H, Br), (M-7794, Cl, F, F, H, CH₃),(M-7795, Cl, F, F, F, H), (M-7796, Cl, F, F, F, Cl), (M-7797, Cl, F, F,F, F), (M-7798, Cl, F, F, F, CF₃), (M-7799, Cl, F, F, F, Br), (M-7800,Cl, F, F, F, CH₃), (M-7801, Cl, F, F, Cl, H), (M-7802, Cl, F, F, Cl,Cl), (M-7803, Cl, F, F, Cl, F), (M-7804, Cl, F, F, Cl, CF₃), (M-7805,Cl, F, F, Cl, Br), (M-7806, Cl, F, F, Cl, CH₃), (M-7807, Cl, F, F, CH₃,H), (M-7808, Cl, F, F, CH₃, Cl), (M-7809, Cl, F, F, CH₃, F), (M-7810,Cl, F, F, CH₃, CF₃), (M-7811, Cl, F, F, CH₃, Br), (M-7812, Cl, F, F,CH₃, CH₃), (M-7813, Cl, F, F, Et, H), (M-7814, Cl, F, F, Et, Cl),(M-7815, Cl, F, F, Et, F), (M-7816, Cl, F, F, Et, CF₃), (M-7817, Cl, F,F, Et, Br), (M-7818, Cl, F, F, Et, CH₃), (M-7819, Cl, F, F, n-Pr, H),(M-7820, Cl, F, F, n-Py, Cl), (M-7821, Cl, F, F, n-Pr, F), (M-7822, Cl,F, F, n-Pr, CF₃), (M-7823, Cl, F, F, n-Pr, Br), (M-7824, Cl, F, F, n-Pr,CH₃), (M-7825, Cl, F, F, c-Pr, H), (M-7826, Cl, F, F, c-Pr, Cl),(M-7827, Cl, F, F, c-Pr, F), (M-7828, Cl, F, F, c-Pr, CF₃), (M-7829, Cl,F, F, c-Pr, Br), (M-7830, Cl, F, F, c-Pr, CH₃), (M-7831, Cl, F, F, i-Pr,H), (M-7832, Cl, F, F, i-Pr, Cl), (M-7833, Cl, F, F, i-Pr, F), (M-7834,Cl, F, F, i-Pr, CF₃), (M-7835, Cl, F, F, i-Pr, Br), (M-7836, Cl, F, F,iPr, CH,3), (M-7837, Cl, F, F, n-Bu, H), (M-7838, Cl, F, F, n-Bu, Cl),(M-7839, Cl, F, F, n-Bu, F), (M-7840, Cl, F, F, n-Bu, CF₃), (M-7841, Cl,F, F, n-Bu, Br), (M-7842, Cl, F, F, n-Bu, CH₃), (M-7843, Cl, F, F, i-Bu,H), (M-7844, Cl, F, F, i-Bu, Cl), (M-7845, Cl, F, F, i-Bu, F), (M-7846,Cl, F, F, i-Bu, CF₃), (M-7847, Cl, F, F, i-Bu, Br), (M-7848, Cl, F, F,i-Bu, CH₃), (M-7849, Cl, F, F, sec-Bu, H), (M-7850, Cl, F, F, sec-Bu,Cl), (M-7851, Cl, F, F, sec-Bu, F), (M-7852, Cl, F, F, sec-Bu, CF₃),(M-7853, Cl, F, F, sec-Bu, Br), (M-7854, Cl, F, F, sec-Bn, CH₃),(M-7855, Cl, F, F, n-Pen, H), (M-7856, Cl, F, F, n-Pen, Cl), (M-7857,Cl, F, F, n-Pen, F), (M-7858, Cl, F, F, n-Pen, CF₃), (M-7859, Cl, F, F,n-Pen, Br), (M-7860, Cl, F, F, n-Pen, CH₃), (M-7861, Cl, F, F, c-Pen,HI), (M-7862, Cl, F, F, c-Pen, Cl), (M-7863, Cl, F, F, c-Pen, F),(M-7864, Cl, F, F, c-Pen, CF₃), (M-7865, Cl, F, F, c-Pen, Br), (M-7866,Cl, F, F, c-Pen, CH₃), (M-7867, Cl, F, F, n-Hex, H), (M-7868, Cl, F, F,n-Hex, Cl), (M-7869, Cl, F, F, n-Hex, F), (M-7870, Cl, F, F, n-Hex,CF₃), (M-7871, Cl, F, F, n-Hex, Br), (M-7872, Cl, F, F, n-Hex, CH₃),(M-7873, Cl, F, F, c-Hex, H), (M-7874, Cl, F, F, c-Hex, Cl), (M-7875,Cl, F, F, c-Hex, F), (M-7876, Cl, F, F, c-Hex, CF₃), (M-7877, Cl, F, F,c-Hex, Br), (M-7878, Cl, F, F, c-Hex, CH₃), (M-7879, Cl, F, F, OH, H),(M-7880, Cl, F, F, OH, Cl), (M-7881, Cl, F, F, OH, F), (M-7882, Cl, F,F, OH, CF₃), (M-7883, Cl, F, F, OH, Br), (M-7884, Cl, F, F, OH, CH₃),(M-7885, Cl, F, F, EtO, H), (M-7886, Cl, F, F, EtO, Cl), (M-7887, Cl, F,F, EtO, F), (M-7888, Cl, F, F, EtO, CF₃), (M-7889, Cl, F, F, EtO, Br),(M-7890, Cl, F, F, EtO, CH₃), (M-7891, Cl, F, F, n-PrO, H), (M-7892, Cl,F, F, n-PrO, Cl), (M-7893, Cl, F, F, n-PrO, F), (M-7894, Cl, F, F,n-PrO, CF₃), (M-7895, Cl, F, F, n-PrO, Br), (M-7896, Cl, F, F, n-PrO,CH₃), (M-7897, Cl, F, F, PhO, H), (M-7898, Cl, F, F, PhO, Cl), (M-7899,Cl, F, F, PhO, F), (M-7900, Cl, F, F, PhO, CF₃), (M-7901, Cl, F, F, PhO,Br), (M-7902, Cl, F, F, PhO, CH₃), (M-7903, Cl, F, F, BnO, H), (M-7904,Cl, F, F, BnO, Cl), (M-7905, Cl, F, F, BnO, F), (M-7906, Cl, F, F, BnO,CF₃), (M-7907, Cl, F, F, BnO, Br), (M-7908, Cl, F, F, BnO, CH₃),(M-7909, Cl, F, F, PhCH₂CH₂O, H), (M-7910, Cl, F, F, PhCH₂CH₂O, Cl),(M-7911, Cl, F, F, PhCH₂CH₂O, F), (M-7912, Cl, F, F, PhCH₂CH₂O, CF₃),(M-7913, Cl, F, F, PhCH₂CH₂O, Br), (M-7914, Cl, F, F, PhCH₂CH₂O, CH₃),(M-7915, Cl, F, F, CF₃O, H), (M-7916, Cl, F, F, CF₃O, Cl), (M-7917, Cl,F, F, CF₃O, F), (M-7918, Cl, F, F, CF₃O, CF₃), (M-7919, Cl, F, F, CF₃O,Br), (M-7920, Cl, F, F, CF₃O, CH₃), (M-7921, Cl, F, F, Ph, H), (M-7922,Cl, F, F, Ph, Cl), (M-7923, Cl, F, F, Ph, F), (M-7924, Cl, F, F, Ph,CF₃), (M-7925, Cl, F, F, Ph, Br), (M-7926, Cl, F, F, Ph, CH₃), (M-7927,Cl, F, F, 4-F-Ph, H), (M-7928, Cl, F, F, 4-F-Ph, Cl), (M-7929, Cl, F, F,4-F-Ph, F), (M-7930, Cl, F, F, 4-F-Ph, CF₃), (M-7931, Cl, F, F, 4-F-Ph,Br), (M-7932, Cl, F, F, 4-F-Ph, CH₃), (M-7933, Cl, F, F, 4-CF₃-Ph, H),(M-7934, Cl, F, F, 4-CF₃-Ph, Cl), (M-7935, Cl, F, F, 4-CF₃-Ph, F),(M-7936, Cl, F, F, 4-CF₃-Ph, CF₃), (M-7937, Cl, F, F, 4-CF₃-Ph, Br),(M-7938, Cl, F, F, 4-CF₃-Ph, CH₃), (M-7939, Cl, F, F, 4-(Me)₂N-Ph, H),(M-7940, Cl, F, F, 4-(Me)₂N-Ph, Cl), (M-7941, Cl, F, F, 4-(Me)₂N-Ph, F),(M-7942, Cl, F, F, 4-(Me)₂N-Ph, CF₃), (M-7943, Cl, F, F, 4-(Me)₂N-Ph,Br), (M-7944, Cl, F, F, 4-(Me)₂N-Ph, CH₃), (M-7945, Cl, F, F, 4-OH-Ph,H), (M-7946, Cl, F, F, 4-OH-Ph, Cl), (M-7947, Cl, F, F, 4-OH-Ph, F),(M-7948, Cl, F, F, 4-OH-Ph, CF₃), (M-7949, Cl, F, F, 4-OH-Ph, Br),(M-7950, Cl, F, F, 4-OH-Ph, CH₃), (M-7951, Cl, F, F, 3,4-di-F-Ph, H),(M-7952, Cl, F, F, 3,4-di-F-Ph, Cl), (M-7953, Cl, F, F, 3,4-di-F-Ph, F),(M-7954, Cl, F, F, 3,4-di-F-Ph, CF₃), (M-7955, Cl, F, F, 3,4-di-F-Ph,Br), (M-7956, Cl, F, F, 3,4-di-F-Ph, CH₃), (M-7957, Cl, F, F, 4-COOH-Ph,H), (M-7958, Cl, F, F, 4-COOH-Ph, Cl), (M-7959, Cl, F, F, 4-COOH-Ph, F),(M-7960, Cl, F, F, 4-COOH-Ph, CF₃), (M-7961, Cl, F, F, 4-COOH-Ph, Br),(M-7962, Cl, F, F, 4-COOH-Ph, CH₃), (M-7963, Cl, F, F, Bn, H), (M-7964,Cl, F, F, Bn, Cl), (M-7965, Cl, F, F, Bn, F), (M-7966, Cl, F, F, Bn,CF₃), (M-7967, Cl, F, F, Bn, Br), (M-7968, Cl, F, F, Bn, CH₃), (M-7969,Cl, F, F, 4-F-Bn, H), (M-7970, Cl, F, F, 4-F-Bn, Cl), (M-7971, Cl, F, F,4-F-Bn, F), (M-7972, Cl, F, F, 4-F-Bn, CF₃), (M-7973, Cl, F, F, 4-F-Bn,Br), (M-7974, Cl, F, F, 4-F-Bn, CH₃), (M-7975, Cl, F, F, 2-Py, H),(M-7976, Cl, F, F, 2-Py, Cl), (M-7977, Cl, F, F, 2-Py, F), (M-7978, Cl,F, F, 2-Py, CF₃), (M-7979, Cl, F, F, 2-Py, Br), (M-7980, Cl, F, F, 2-Py,CH₃), (M-7981, Cl, F, F, 3-Py, H), (M-7982, Cl, F, F, 3-Py, Cl),(M-7983, Cl, F, F, 3-Py, F), (M-7984, Cl, F, F, 3-Py, CF₃), (M-7985, Cl,F, F, 3-Py, Br), (M-7986, Cl, F, F, 3-Py, CH₃), (M-7987, Cl, F, F, 4-Py,H), (M-7988, Cl, F, F, 4-Py, Cl), (M-7989, Cl, F, F, 4-Py, F), (M-7990,Cl, F, F, 4-Py, CF₃), (M-7991, Cl, F, F, 4-Py, Br), (M-7992, Cl, F, F,4-Py, CH₃), (M-7993, Cl, F, F, 2-Th, H), (M-7994, Cl, F, F, 2-Th, Cl),(M-7995, Cl, F, F, 2-Th, F), (M-7996, Cl, F, F, 2-Th, CF₃), (M-7997, Cl,F, F, 2-Th, Br), (M-7998, Cl, F, F, 2-Th, CH₃), (M-7999, Cl, F, F, 3-Th,H), (M-8000, Cl, F, F, 3-Th, Cl), (M-8001, Cl, F, F, 3-Th, F), (M-8002,Cl, F, F, 3-Th, CF₃), (M-8003, Cl, F, F, 3-Th, Br), (M-8004, Cl, F, F,3-Th, CH₃), (M-8005, Cl, F, F, pyrrazol-2-yl, H), (M-8006, Cl, F, F,pyrrazol-2-yl, Cl), (M-8007, Cl, F, F, pyrrazol-2-yl, F), (M-8008, Cl,F, F, pyrrazol-2-yl, CF₃), (M-8009, Cl, F, F, pyrrazol-2-yl, Br),(M-8010, Cl, F, F, pyrrazol-2-yl, CH₃), (M-8011, Cl, F, F,pyrrazol-3-yl, H), (M-8012, Cl, F, F, pyrrazol-3-yl, Cl), (M-8013, Cl,F, F, pyrrazol-3-yl, F), (M-8014, Cl, F, F, pyrrazol-3-yl, CF₃),(M-8015, Cl, F, F, pyrrazol-3-yl, Br), (M-8016, Cl, F, F, pyrrazol-3-yl,CH₃), (M-8017, Cl, F, F, pyrimidin-2-yl, H), (M-8018, Cl, F, F,pyrimidin-2-yl, Cl), (M-8019, Cl, F, F, pyrimidin-2-yl, F), (M-8020, Cl,F, F, pyrimidin-2-yl, CF₃), (M-8021, Cl, F, F, pyrimidin-2-yl, Br),(M-8022, Cl, F, F, pyrimidin-2-yl, CH₃), (M-8023, Cl, F, F,pyrimidin-4-yl, H), (M-8024, Cl, F, F, pyrimidin-4-yl, Cl), (M-8025, Cl,F, F, pyrimidin-4-yl, F), (M-8026, Cl, F, F, pyrimidin-4-yl, CF₃),(M-8027, Cl, F, F, pyrimidin-4-yl, Br), (M-8028, Cl, F, F,pyrimidin-4-yl, CH₃), (M-8029, Cl, F, F, pyrimidin-5-yl, H), (M-8030,Cl, F, F, pyrimidin-5-yl, Cl), (M-8031, Cl, F, F, pyrimidin-5-yl, F),(M-8032, Cl, F, F, pyrimidin-5-yl, CF₃), (M-8033, Cl, F, F,pyrimidin-5-yl, Br), (M-8034, Cl, F, F, pyrimidin-5-yl, CH₃), (M-8035,Cl, F, F, HOOCCH₂CH₂CH₂, H), (M-8036, Cl, F, F, HOOCCH₂CH₂CH₂, Cl),(M-8037, Cl, F, F, HOOCCH₂CH₂CH₂, F), (M-8038, Cl, F, F, HOOCCH₂CH₂CH₂,CF₃), (M-8039, Cl, F, F, HOOCCH₂CH₂CH₂, Br), (M-8040, Cl, F, F,HOOCCH₂CH₂CH₂, CH₃), (M-8041, Cl, F, F, HOOCCH₂CH₂CH₂CH₂, H), (M-8042,Cl, F, F, HOOCCH₂CH₂CH₂CH₂, Cl), (M-8043, Cl, F, F, HOOCCH₂CH₂CH₂CH₂,F), (M-8044, Cl, F, F, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-8045, Cl, F, F,HOOCCH₂CH₂CH₂CH₂, Br), (M-8046, Cl, F, F, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-8047, Cl, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-8048, Cl, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-8049, Cl, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F),(M-8050, Cl, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CF₃), (M-8051, Cl, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-8052, Cl, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-8053, Cl, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-8054, Cl, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-8055, Cl, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-8056, Cl, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂,CF₃), (M-8057, Cl, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-8058, Cl, F,F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-8059, Cl, F, F, MeOCH₂, H),(M-8060, Cl, F, F, MeOCH₂, Cl), (M-8061, Cl, F, F, MeOCH₂, F), (M-8062,Cl, F, F, MeOCH₂, CF₃), (M-8063, Cl, F, F, MeOCH₂, Br), (M-8064, Cl, F,F, MeOCH₂, CH₃), (M-8065, Cl, F, F, EtOCH₂, H), (M-8066, Cl, F, F,EtOCH₂, Cl), (M-8067, Cl, F, F, EtOCH₂, F), (M-8068, Cl, F, F, EtOCH₂,CF₃), (M-8069, Cl, F, F, EtOCH₂, Br), (M-8070, Cl, F, F, EtOCH₂, CH₃),(M-8071, Cl, F, F, EtOCH₂CH₂, H), (M-8072, Cl, F, F, EtOCH₂CH₂, Cl),(M-8073, Cl, F, F, EtOCH₂CH₂, F), (M-8074, Cl, F, F, EtOCH₂CH₂, CF₃),(M-8075, Cl, F, F, EtOCH₂CH₂, Br), (M-8076, Cl, F, F, EtOCH₂CH₂, CH₃),(M-8077, Cl, F, F, MeOCH₂CH₂OCH₂CH₂, H), (M-8078, Cl, F, F,MeOCH₂CH₂OCH₂CH₂, Cl), (M-8079, Cl, F, F, MeOCH₂CH₂OCH₂CH₂, F), (M-8080,Cl, F, F, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-8081, Cl, F, F, MeOCH₂CH₂OCH₂CH₂,Br), (M-8082, Cl, F, F, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-8083, Cl, F, F,MeOCH₂CH₂, H), (M-8084, Cl, F, F, MeOCH₂CH₂, Cl), (M-8085, Cl, F, F,MeOCH₂CH₂, F), (M-8086, Cl, F, F, MeOCH₂CH₂, CF₃), (M-8087, Cl, F, F,MeOCH₂CH₂, Br), (M-8088, Cl, F, F, MeOCH₂CH₂, CH₃), (M-8089, Cl, F, F,HOCH₂, H), (M-8090, Cl, F, F, HOCH₂, Cl), (M-8091, Cl, F, F, HOCH₂, F),(M-8092, Cl, F, F, HOCH₂, CF₃), (M-8093, Cl, F, F, HOCH₂, Br), (M-8094,Cl, F, F, HOCH₂, CH₃), (M-8095, Cl, F, F, HOCH₂CH₂, H), (M-8096, Cl, F,F, HOCH₂CH₂, Cl), (M-8097, Cl, F, F, HOCH₂CH₂, F), (M-8098, Cl, F, F,HOCH₂CH₂, CF₃), (M-8099, Cl, F, F, HOCH₂CH₂, Br), (M-8100, Cl, F, F,HOCH₂CH₂, CH₃), (M-8101, Cl, F, F, HOCH₂CH₂CH₂, H), (M-8102, Cl, F, F,HOCH₂CH₂CH₂, Cl), (M-8103, Cl, F, F, HOCH₂CH₂CH₂, F), (M-8104, Cl, F, F,HOCH₂CH₂CH₂, CF₃), (M-8105, Cl, F, F, HOCH₂CH₂CH₂, Br), (M-8106, Cl, F,F, HOCH₂CH₂CH₂, CH₃), (M-8107, Cl, F, F, HOCH₂CH₂CH₂CH₂, H), (M-8108,Cl, F, F, HOCH₂CH₂CH₂CH₂, Cl), (M-8109, Cl, F, F, HOCH₂CH₂CH₂CH₂, F),(M-8110, Cl, F, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-8111, Cl, F, F,HOCH₂CH₂CH₂CH₂, Br), (M-8112, Cl, F, F, HOCH₂CH₂CH₂CH₂CH₃), (M-8113, Cl,F, F, HOCH₂CH₂CH₂CH₂CH₂, H), (M-8114, Cl, F, F, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-8115, Cl, F, F, HOCH₂CH₂CH₂CH₂CH₂, F), (M-8116, Cl, F, F,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-8117, Cl, F, F, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-8118, Cl, F, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-8119, Cl, F, F,HOCH₂CH₂OCH₂CH₂, H), (M-8120, Cl, F, F, HOCH₂CH₂OCH₂CH₂, Cl), (M-8121,Cl, F, F, HOCH₂CH₂OCH₂CH₂, F), (M-8122, Cl, F, F, HOCH₂CH₂OCH₂CH₂, CF₃),(M-8123, Cl, F, F, HOCH₂CH₂OCH₂CH₂, Br), (M-8124, Cl, F, F,HOCH₂CH₂OCH₂CH₂, CH₃), (M-8125, Cl, F, F, (Me)₂N, H), (M-8126, Cl, F, F,(Me)₂N, Cl), (M-8127, Cl, F, F, (Me)₂N, F), (M-8128, Cl, F, F, (Me)₂N,CF₃), (M-8129, Cl, F, F, (Me)₂N, Br), (M-8130, Cl, F, F, (Me)₂N, CH₃),(M-8131, Cl, F, F, piperidin-4-yl-methyl, H), (M-8132, Cl, F, F,piperidin-4-yl-methyl, Cl), (M-8133, Cl, F, F, piperidin-4-yl-methyl,F), (M-8134, Cl, F, F, piperidin-4-yl-methyl, CF₃), (M-8135, Cl, F, F,piperidin-4-yl-methyl, Br), (M-8136, Cl, F, F, piperidin-4-yl-methyl,CH₃), (M-8137, Cl, F, F, cyclohexylmethyl, H), (M-8138, Cl, F, F,cyclohexylmethyl, Cl), (M-8139, Cl, F, F, cyclohexylmethyl, F), (M-8140,Cl, F, F, cyclohexylmethyl, CF₃), (M-8141, Cl, F, F, cyclohexylmethyl,Br), (M-8142, Cl, F, F, cyclohexylmethyl, CH₃), (M-8143, Cl, F, Cl, H,H), (M-8144, Cl, F, Cl, H, Cl), (M-8145, Cl, F, Cl, H, F), (M-8146, Cl,F, Cl, H, CF₃), (M-8147, Cl, F, Cl, H, Br), (M-8148, Cl, F, Cl, H, CH₃),(M-8149, Cl, F, Cl, F, H), (M-8150, Cl, F, Cl, F, Cl), (M-8151, Cl, F,Cl, F, F), (M-8152, Cl, F, Cl, F, CF₃), (M-8153, Cl, F, Cl, F, Br),(M-8154, Cl, F, Cl, F, CH₃), (M-8155, Cl, F, Cl, Cl, H), (M-8156, Cl, F,Cl, Cl, Cl), (M-8157, Cl, F, Cl, Cl, F), (M-8158, Cl, F, Cl, Cl, CF₃),(M-8159, Cl, F, Cl, Cl, Br), (M-8160, Cl, F, Cl, Cl, CH₃), (M-8161, Cl,F, Cl, CH₃, H), (M-8162, Cl, F, Cl, CH₃, Cl), (M-8163, Cl, F, Cl, CH₃,F), (M-8164, Cl, F, Cl, CH₃, CF₃), (M-8165, Cl, F, Cl, CH₃, Br),(M-8166, Cl, F, Cl, CH₃, CH₃), (M-8167, Cl, F, Cl, Et, H), (M-8168, Cl,F, Cl, Et, Cl), (M-8169, Cl, F, Cl, Et, F), (M-8170, Cl, F, Cl, Et,CF₃), (M-8171, Cl, F, Cl, Et, Br), (M-8172, Cl, F, Cl, Et, CH₃),(M-8173, Cl, F, Cl, n-Pr, H), (M-8174, Cl, F, Cl, n-Pr, Cl), (M-8175,Cl, F, Cl, n-Pr, F), (M-8176, Cl, F, Cl, n-Pr, CF₃), (M-8177, Cl, F, Cl,n-Pr, Br), (M-8178, Cl, F, Cl, a-Pr, CH₃), (M-8179, Cl, F, Cl, c-Pr, H),(M-8180, Cl, F, Cl, c-Pr, Cl), (M-8181, Cl, F, Cl, c-Pr, F), (M-8182,Cl, F, Cl, c-Pr, CF₃), (M-8183, Cl, F, Cl, c-Pr, Br), (M-8184, Cl, F,Cl, c-Pr, CH₃), (M-8185, Cl, F, Cl, i-Pr, H), (M-8186, Cl, F, Cl, i-Pr,Cl), (M-8187, Cl, F, Cl, i-Pr, F), (M-8188, Cl, F, Cl, i-Pr, CF₃),(M-8189, Cl, F, Cl, i-Pr, Br), (M-8190, Cl, F, Cl, i-Pr, CH₃), (M-8191,Cl, F, Cl, n-Bu, H), (M-8192, Cl, F, Cl, n-Bu, Cl), (M-8193, Cl, F, Cl,n-Bu, F), (M-8194, Cl, F, Cl, n-Bu, CF₃), (M-8195, Cl, F, Cl, n-Bu, Br),(M-8196, Cl, F, Cl, n-Bu, CH₃), (M-8197, Cl, F, Cl, i-Bu, H), (M-8198,Cl, F, Cl, i-Bu, Cl), (M-8199, Cl, F, Cl, i-Bu, F), (M-8200, Cl, F, Cl,i-Bu, CF₃), (M-8201, Cl, F, Cl, i-Bu, Br), (M-8202, Cl, F, Cl, i-Bu,CH₃), (M-8203, Cl, F, Cl, sec-Bu, H), (M-8204, Cl, F, Cl, sec-Bu, Cl),(M-8205, Cl, F, Cl, sec-Bu, F), (M-8206, Cl, F, Cl, sec-Bu, CF₃),(M-8207, Cl, F, Cl, sec-Bu, Br), (M-8208, Cl, F, Cl, sec-Bu, CH₃),(M-8209, Cl, F, Cl, n-Pen, H), (M-8210, Cl, F, Cl, n-Pen, Cl), (M-8211,Cl, F, Cl, n-Pen, F), (M-8212, Cl, F, Cl, n-Pen, CF₃), (M-8213, Cl, F,Cl, n-Pen, Br), (M-8214, Cl, F, Cl, n-Pen, CH₃), (M-8215, Cl, F, Cl,c-Pen, H), (M-8216, Cl, F, Cl, c-Pen, Cl), (M-8217, Cl, F, Cl, c-Pen,F), (M-8218, Cl, F, Cl, c-Pen, CF₃), (M-8219, Cl, F, Cl, c-Pen, Br),(M-8220, Cl, F, Cl, c-Pen, CH₃), (M-8221, Cl, F, Cl, n-Hex, H), (M-8222,Cl, F, Cl, n-Hex, Cl), (M-8223, Cl, F, Cl, n-Hex, F), (M-8224, Cl, F,Cl, n-Hex, CF₃), (M-8225, Cl, F, Cl, n-Hex, Br), (M-8226, Cl, F, Cl,n-Hex, CH₃), (M-8227, Cl, F, Cl, c-Hex, H), (M-8228, Cl, F, Cl, c-Hex,Cl), (M-8229, Cl, F, Cl, c-Hex, F), (M-8230, Cl, F, Cl, c-Hex, CF₃),(M-8231, Cl, F, Cl, c-Hex, Br), (M-8232, Cl, F, Cl, c-Hex, CH₃),(M-8233, Cl, F, Cl, OH, H), (M-8234, Cl, F, Cl, OH, Cl), (M-8235, Cl, F,Cl, OH, F), (M-8236, Cl, F, Cl, OH, CF₃), (M-8237, Cl, F, Cl, OH, Br),(M-8238, Cl, F, Cl, OH, CH₃), (M-8239, Cl, F, Cl, EtO, H), (M-8240, Cl,F, Cl, EtO, Cl), (M-8241, Cl, F, Cl, EtO, F), (M-8242, Cl, F, Cl, EtO,CF₃), (M-8243, Cl, F, Cl, EtO, Br), (M-8244, Cl, F, Cl, EtO, CH₃),(M-8245, Cl, F, Cl, n-PrO, H), (M-8246, Cl, F, Cl, n-PrO, Cl), (M-8247,Cl, F, Cl, n-PrO, F), (M-8248, Cl, F, Cl, n-PrO, CF₃), (M-8249, Cl, F,Cl, n-PrO, Br), (M-8250, Cl, F, Cl, n-PrO, CH₃), (M-8251, Cl, F, Cl,PhO, H), (M-8252, Cl, F, Cl, PhO, Cl), (M-8253, Cl, F, Cl, PhO, F),(M-8254, Cl, F, Cl, PhO, CF₃), (M-8255, Cl, F, Cl, PhO, Br), (M-8256,Cl, F, Cl, PhO, CH₃), (M-8257, Cl, F, Cl, BnO, H), (M-8258, Cl, F, Cl,BnO, Cl), (M-8259, Cl, F, Cl, BnO, F), (M-8260, Cl, F, Cl, BnO, CF₃),(M-8261, Cl, F, Cl, BnO, Br), (M-8262, Cl, F, Cl, BnO, CH₃), (M-8263,Cl, F, Cl, PhCH₂CH₂O, H), (M-8264, Cl, F, Cl, PhCH₂CH₂O, Cl), (M-8265,Cl, F, Cl, PhCH₂CH₂O, F), (M-8266, Cl, F, Cl, PhCH₂CH₂O, CF₃), (M-8267,Cl, F, Cl, PhCH₂CH₂O, Br), (M-8268, Cl, F, Cl, PhCH₂CH₂O, CH₃), (M-8269,Cl, F, Cl, CF₃O, H), (M-8270, Cl, F, Cl, CF₃O, Cl), (M-8271, Cl, F, Cl,CF₃O, F), (M-8272, Cl, F, Cl, CF₃O, CF₃), (M-8273, Cl, F, Cl, CF₃O, Br),(M-8274, Cl, F, Cl, CF₃O, CH₃), (M-8275, Cl, F, Cl, Ph, H), (M-8276, Cl,F, Cl, Ph, Cl), (M-8277, Cl, F, Cl, Ph, F), (M-8278, Cl, F, Cl, Ph,CF₃), (M-8279, Cl, F, Cl, Ph, Br), (M-8280, Cl, F, Cl, Ph, CH₃),(M-8281, Cl, F, Cl, 4-F-Ph, H), (M-8282, Cl, F, Cl, 4-F-Ph, Cl),(M-8283, Cl, F, Cl, 4-F-Ph, F), (M-8284, Cl, F, Cl, 4-F-Ph, CF₃),(M-8285, Cl, F, Cl, 4-F-Ph, Br), (M-8286, Cl, F, Cl, 4-F-Ph, CH₃),(M-8287, Cl, F, Cl, 4-CF₃-Ph, H), (M-8288, Cl, F, Cl, 4-CF₃-Ph, Cl),(M-8289, Cl, F, Cl, 4-CF₃-Ph, F), (M-8290, Cl, F, Cl, 4-CF₃-Ph, CF₃),(M-8291, Cl, F, Cl, 4-CF₃-Ph, Br), (M-8292, Cl, F, Cl, 4-CF₃-Ph, CH₃),(M-8293, Cl, F, Cl, 4-(Me)₂N-Ph, H), (M-8294, Cl, F, Cl, 4-(Me)₂N-Ph,Cl), (M-8295, Cl, F, Cl, 4-(Me)₂N-Ph, F), (M-8296, Cl, F, Cl,4-(Me)₂N-Ph, CF₃), (M-8297, Cl, F, Cl, 4-(Me)₂N-Ph, Br), (M-8298, Cl, F,Cl, 4-(Me)₂N-Ph, CH₃), (M-8299, Cl, F, Cl, 4-OH-Ph, H), (M-8300, Cl, F,Cl, 4-OH-Ph, Cl), (M-8301, Cl, F, Cl, 4-OH-Ph, F), (M-8302, Cl, F, Cl,4-OH-Ph, CF₃), (M-8303, Cl, F, Cl, 4-OH-Ph, Br), (M-8304, Cl, F, Cl,4-OH-Ph, CH₃), (M-8305, Cl, F, Cl, 3,4-di-F-Ph, H), (M-8306, Cl, F, Cl,3,4-di-F-Ph, Cl), (M-8307, Cl, F, Cl, 3,4-di-F-Ph, F), (M-8308, Cl, F,Cl, 3,4-di-F-Ph, CF₃), (M-8309, Cl, F, Cl, 3,4-di-F-Ph, Br), (M-8310,Cl, F, Cl, 3,4-di-F-Ph, CH₃), (M-8311, Cl, F, Cl, 4-COOH-Ph, H),(M-8312, Cl, F, Cl, 4-COOH-Ph, Cl), (M-8313, Cl, F, Cl, 4-COOH-Ph, F),(M-8314, Cl, F, Cl, 4-COOH-Ph, CF₃), (M-8315, Cl, F, Cl, 4-COOH-Ph, Br),(M-8316, Cl, F, Cl, 4-COOH-Ph, CH₃), (M-8317, Cl, F, Cl, Bn, H),(M-8318, Cl, F, Cl, Bn, Cl), (M-8319, Cl, F, Cl, Bn, F), (M-8320, Cl, F,Cl, Bn, CF₃), (M-8321, Cl, F, Cl, Bn, Br), (M-8322, Cl, F, Cl, Bn, CH₃),(M-8323, Cl, F, Cl, 4-F-Bn, H), (M-8324, Cl, F, Cl, 4-F-Bn, Cl),(M-8325, Cl, F, Cl, 4-F-Bn, F), (M-8326, Cl, F, Cl, 4-F-Bn, CF₃),(M-8327, Cl, F, Cl, 4-F-Bn, Br), (M-8328, Cl, F, Cl, 4-F-Bn, CH₃),(M-8329, Cl, F, Cl, 2-Py, H), (M-8330, Cl, F, Cl, 2-Py, Cl), (M-8331,Cl, F, Cl, 2-Py, F), (M-8332, Cl, F, Cl, 2-Py, CF₃), (M-8333, Cl, F, Cl,2-Py, Br), (M-8334, Cl, F, Cl, 2-Py, CH₃), (M-8335, Cl, F, Cl, 3-Py, H),(M-8336, Cl, F, Cl, 3-Py, Cl), (M-8337, Cl, F, Cl, 3-Py, F), (M-8338,Cl, F, Cl, 3-Py, CF₃), (M-8339, Cl, F, Cl, 3-Py, Br), (M-8340, Cl, F,Cl, 3-Py, CH₃), (M-8341, Cl, F, Cl, 4-Py, H), (M-8342, Cl, F, Cl, 4-Py,Cl), (M-8343, Cl, F, Cl, 4-Py, F), (M-8344, Cl, F, Cl, 4-Py, CF₃),(M-8345, Cl, F, Cl, 4-Py, Br), (M-8346, Cl, F, Cl, 4-Py, CH₃), (M-8347,Cl, F, Cl, 2-Th, H), (M-8348, Cl, F, Cl, 2-Th, Cl), (M-8349, Cl, F, Cl,2-Th, F), (M-8350, Cl, F, Cl, 2-Th, CF₃), (M-8351, Cl, F, Cl, 2-Th, Br),(M-8352, Cl, F, Cl, 2-Th, CH₃), (M-8353, Cl, F, Cl, 3-Th, H), (M-8354,Cl, F, Cl, 3-Th, Cl), (M-8355, Cl, F, Cl, 3-Th, F), (M-8356, Cl, F, Cl,3-Th, CF₃), (M-8357, Cl, F, Cl, 3-Th, Br), (M-8358, Cl, F, Cl, 3-Th,CH₃), (M-8359, Cl, F, Cl, pyrrazol-2-yl, H), (M-8360, Cl, F, Cl,pyrrazol-2-yl, Cl), (M-8361, Cl, F, Cl, pyrrazol-2-yl, F), (M-8362, Cl,F, Cl, pyrrazol-2-yl, CF₃), (M-8363, Cl, F, Cl, pyrrazol-2-yl, Br),(M-8364, Cl, F, Cl, pyrrazol-2-yl, CH₃), (M-8365, Cl, F, Cl,pyrrazol-3-yl, H), (M-8366, Cl, F, Cl, pyrrazol-3-yl, Cl), (M-8367, Cl,F, Cl, pyrrazol-3-yl, F), (M-8368, Cl, F, Cl, pyrrazol-3-yl, CF₃),(M-8369, Cl, F, Cl, pyrrazol-3-yl, Br), (M-8370, Cl, F, Cl,pyrrazol-3-yl, CH₃), (M-8371, Cl, F, Cl, pyrimidin-2-yl, H), (M-8372,Cl, F, Cl, pyrimidin-2-yl, Cl), (M-8373, Cl, F, Cl, pyrimidin-2-yl, F),(M-8374, Cl, F, Cl, pyrimidin-2-yl, CF₃), (M-8375, Cl, F, Cl,pyrimidin-2-yl, Br), (M-8376, Cl, F, Cl, pyrimidin-2-yl, CH₃), (M-8377,Cl, F, Cl, pyrimidin-4-yl, H), (M-8378, Cl, F, Cl, pyrimidin-4-yl, Cl),(M-8379, Cl, F, Cl, pyrimidin-4-yl, F), (M-8380, Cl, F, Cl, pyrimidin-4-yl, CF₃), (M-8381, Cl, F, Cl, pyrimidin-4-yl, Br), (M-8382, Cl, F,Cl, pyrimidin-4-yl, CH₃), (M-8383, Cl, F, Cl, pyrimidin-5-yl, H),(M-8384, Cl, F, Cl, pyrimidin-5-yl, Cl), (M-8385, Cl, F, Cl,pyrimidin-5-yl, F), (M-8386, Cl, F, Cl, pyrimidin-5-yl, CF₃), (M-8387,Cl, F, Cl, pyrimidin-5-yl, Br), (M-8388, Cl, F, Cl, pyrimidin-5-yl,CH₃), (M-8389, Cl, F, Cl, HOOCCH₂CH₂CH₂, H), (M-8390, Cl, F, Cl,HOOCCH₂CH₂CH₂, Cl), (M-8391, Cl, F, Cl, HOOCCH₂CH₂CH₂, F), (M-8392, Cl,F, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-8393, Cl, F, Cl, HOOCCH₂CH₂CH₂, Br),(M-8394, Cl, F, Cl, HOOCCH₂CH₂CH₂, CH₃), (M-8395, Cl, F, Cl,HOOCCH₂CH₂CH₂CH₂, H), (M-8396, Cl, F, Cl, HOOCCH₂CH₂CH₂CH₂, Cl),(M-8397, Cl, F, Cl, HOOCCH₂CH₂CH₂CH₂, F), (M-8398, Cl, F, Cl,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-8399, Cl, F, Cl, HOOCCH₂CH₂CH₂CH₂, Br),(M-8400, Cl, F, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-8401, Cl, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-8402, Cl, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-8403, Cl, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-8404, Cl, F, Cl,(MO)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-8405, Cl, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-8406, Cl, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-8407, Cl, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-8408, Cl, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-8409, Cl, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-8410, Cl, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-8411, Cl, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-8412, Cl, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-8413, Cl, F, Cl, MeOCH₂, H), (M-8414,Cl, F, Cl, MeOCH₂, Cl), (M-8415, Cl, F, Cl, MeOCH₂, F), (M-8416, Cl, F,Cl, MeOCH₂, CF₃), (M-8417, Cl, F, Cl, MeOCH₂, Br), (M-8418, Cl, F, Cl,MeOCH₂, CH₃), (M-8419, Cl, F, Cl, EtOCH₂, H), (M-8420, Cl, F, Cl,EtOCH₂, Cl), (M-8421, Cl, F, Cl, EtOCH₂, F), (M-8422, Cl, F, Cl, EtOCH₂,CF₃), (M-8423, Cl, F, Cl, EtOCH₂, Br), (M-8424, Cl, F, Cl, EtOCH₂, CH₃),(M-8425, Cl, F, Cl, EtOCH₂CH₂, H), (M-8426, Cl, F, Cl, EtOCH₂CH₂, Cl),(M-8427, Cl, F, Cl, EtOCH₂CH₂, F), (M-8428, Cl, F, Cl, EtOCH₂CH₂, CF₃),(M-8429, Cl, F, Cl, EtOCH₂CH₂, Br), (M-8430, Cl, F, Cl, EtOCH₂CH₂, CH₃),(M-8431, Cl, F, Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-8432, Cl, F, Cl,MeOCH₂CH₂OCH₂CH₂, Cl), (M-8433, Cl, F, Cl, MeOCH₂CH₂OCH₂CH₂, F),(M-8434, Cl, F, Cl, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-8435, Cl, F, Cl,MeOCH₂CH₂OCH₂CH₂, Br), (M-8436, Cl, F, Cl, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-8437, Cl, F, Cl, MeOCH₂CH₂, H), (M-8438, Cl, F, Cl, MeOCH₂CH₂, Cl),(M-8439, Cl, F, Cl, MeOCH₂CH₂, F), (M-8440, Cl, F, Cl, MeOCH₂CH₂, CH₃),(M-8441, Cl, F, Cl, MeOCH₂CH₂, Br), (M-8442, Cl, F, Cl, MeOCH₂CH₂, CH₃),(M-8443, Cl, F, Cl, HOCH₂, H), (M-8444, Cl, F, Cl, HOCH₂, Cl), (M-8445,Cl, F, Cl, HOCH₂, F), (M-8446, Cl, F, Cl, HOCH₂, CF₃), (M-8447, Cl, F,Cl, HOCH₂, Br), (M-8448, Cl, F, Cl, HOCH₂, CH₃), (M-8449, Cl, F, Cl,HOCH₂CH₂, H), (M-8450, Cl, F, Cl, HOCH₂CH₂, Cl), (M-8451, Cl, F, Cl,HOCH₂CH₂, F), (M-8452, Cl, F, Cl, HOCH₂CH₂, CF₃), (M-8453, Cl, F, Cl,HOCH₂CH₂, Br), (M-8454, Cl, F, Cl, HOCH₂CH₂, CH₃), (M-8455, Cl, F, Cl,HOCH₂CH₂CH₂, H), (M-8456, Cl, F, Cl, HOCH₂CH₂CH₂, Cl), (M-8457, Cl, F,Cl, HOCH₂CH₂CH₂, F), (M-8458, Cl, F, Cl, HOCH₂CH₂CH₂, CF₃), (M-8459, Cl,F, Cl, HOCH₂CH₂CH₂, Br), (M-8460, Cl, F, Cl, HOCH₂CH₂CH₂, CH₃), (M-8461,Cl, F, Cl, HOCH₂CH₂CH₂CH₂, H), (M-8462, Cl, F, Cl, HOCH₂CH₂CH₂CH₂, Cl),(M-8463, Cl, F, Cl, HOCH₂CH₂CH₂CH₂, F), (M-8464, Cl, F, Cl,HOCH₂CH₂CH₂CH₂, CF₃), (M-8465, Cl, F, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-8466,Cl, F, Cl, HOCH₂CH₂CH₂CH₂, CH₃), (M-8467, Cl, F, Cl, HOCH₂CH₂CH₂CH₂CH₂,H), (M-8468, Cl, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-8469, Cl, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-8470, Cl, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-8471, Cl, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-8472, Cl, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-8473, Cl, F, Cl, HOCH₂CH₂OCH₂CH₂, H),(M-8474, Cl, F, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-8475, Cl, F, Cl,HOCH₂CH₂OCH₂CH₂, F), (M-8476, Cl, F, Cl, HOCH₂CH₂OCH₂CH₂, CF₃), (M-8477,Cl, F, Cl, HOCH₂CH₂OCH₂CH₂, Br), (M-8478, Cl, F, Cl, HOCH₂CH₂OCH₂CH₂,CH₃), (M-8479, Cl, F, Cl, (Me)₂N, H), (M-8480, Cl, F, Cl, (Me)₂N, Cl),(M-8481, Cl, F, Cl, (Me)₂N, F), (M-8482, Cl, F, Cl, (Me)₂N, CF₃),(M-8483, Cl, F, Cl, (Me)₂N, Br), (M-8484, Cl, F, Cl, (Me)₂N, CH₃),(M-8485, Cl, F, Cl, piperidin-4-yl-methyl, H), (M-8486, Cl, F, Cl,piperidin-4-yl-methyl, Cl), (M-8487, Cl, F, Cl, piperidin-4-yl-methyl,F), (M-8488, Cl, F, Cl, piperidin-4-yl-methyl, CF₃), (M-8489, Cl, F, Cl,piperidin-4-yl-methyl, Br), (M-8490, Cl, F, Cl, piperidin-4-yl-methyl,CH₃), (M-8491, Cl, F, Cl, cyclohexylmethyl, H), (M-8492, Cl, F, Cl,cyclohexylmethyl, Cl), (M-8493, Cl, F, Cl, cyclohexylmethyl, F),(M-8494, Cl, F, Cl, cyclohexylmethyl, CF₃), (M-8495, Cl, F, Cl,cyclohexylmethyl, Br), (M-8496, Cl, F, Cl, cyclohexylmethyl, CH₃),(M-8497, Cl, CH₃, H, H, H), (M-8498, Cl, CH₃, H, H, Cl), (M-8499, Cl,CH₃, H, H, F), (M-8500, Cl, CH₃, H, H, CF₃), (M-8501, Cl, CH₃, H, H,Br), (M-8502, Cl, CH₃, H, H, CH₃), (M-8503, Cl, CH₃, H, F, H), (M-8504,Cl, CH₃, H, F, Cl), (M-8505, Cl, CH₃, H, F, F), (M-8506, Cl, CH₃, H, F,CF₃), (M-8507, Cl, CH₃, H, F, Br), (M-8508, Cl, CH₃, H, F, CH₃),(M-8509, Cl, CH₃, H, Cl, H), (M-8510, Cl, CH₃, H, Cl, Cl), (M-8511, Cl,CH₃, H, Cl, F), (M-8512, Cl, CH₃, H, Cl, CF₃), (M-8513, Cl, CH₃, H, Cl,Br), (M-8514, Cl, CH₃, H, Cl, CH₃), (M-8515, Cl, CH₃, H, CH₃, H),(M-8516, Cl, CH₃, H, CH₃, Cl), (M-8517, Cl, CH₃, H, CH₃, F), (M-8518,Cl, CH₃, H, CH₃, CF₃), (M-8519, Cl, CH₃, H, CH₃, Br), (M-8520, Cl, CH₃,H, CH₃, CH₃), (M-8521, Cl, CH₃, H, Et, H), (M-8522, Cl, CH₃, H, Et, Cl),(M-8523, Cl, CH₃, H, Et, F), (M-8524, Cl, CH₃, H, Et, CF₃), (M-8525, Cl,CH₃, H, Et, Br), (M-8526, Cl, CH₃, H, Et, CH₃), (M-8527, Cl, CH₃, H,n-Pr, H), (M-8528, Cl, CH₃, H, n-Pr, Cl), (M-8529, Cl, CH₃, H, n-Pr, F),(M-8530, Cl, CH₃, H, n-Pr, CF₃), (M-8531, Cl, CH₃, H, n-Pr, Br),(M-8532, Cl, CH₃, H, n-Pr, CH₃), (M-8533, Cl, CH₃, H, c-Pr, H), (M-8534,Cl, CH₃, H, c-Pr, Cl), (M-8535, Cl, CH₃, H, c-Pr, F), (M-8536, Cl, CH₃,H, c-Pr, CF₃), (M-8537, Cl, CH₃, H, c-Pr, Br), (M-8538, Cl, CH₃, H,c-Pr, CH₃), (M-8539, Cl, CH₃, H, i-Pr, HI), (M-8540, Cl, CH₃, H, i-Pr,Cl), (M-8541, Cl, CH₃, H, i-Pr, F), (M-8542, Cl, CH₃, H, i-Pr, CF₃),(M-8543, Cl, CH₃, H, i-Pr, Br), (M-8544, Cl, CH₃, H, i-Pr, CH₃),(M-8545, Cl, CH₃, H, n-Bu, H), (M-8546, Cl, CH₃, H, n-Bu, Cl), (M-8547,Cl, CH₃, H, n-Bu, F), (M-8548, Cl, CH₃, H, n-Bu, CF₃), (M-8549, Cl, CH₃,H, n-Bu, Br), (M-8550, Cl, CH₃, H, n-Bu, CH₃), (M-8551, Cl, CH₃, H,i-Bu, H), (M-8552, Cl, CH₃, H, i-Bu, Cl), (M-8553, Cl, CH₃, H, i-Bu, F),(M-8554, Cl, CH₃, H, i-Bu, CF₃), (M-8555, Cl, CH₃, H, i-Bu, Br),(M-8556, Cl, CH₃, H, i-Bu, CH₃), (M-8557, Cl, CH₃, H, sec-Bu, H),(M-8558, Cl, CH₃, H, sec-Bu, Cl), (M-8559, Cl, CH₃, H, sec-Bu, F),(M-8560, Cl, CH₃, H, sec-Bu, CF₃), (M-8561, Cl, CH₃, H, sec-Bu, Br),(M-8562, Cl, CH₃, H, sec-Bu, CH₃), (M-8563, Cl, CH₃, H, n-Pen, H),(M-8564, Cl, CH₃, H, n-Pen, Cl), (M-8565, Cl, CH₃, H, n-Pen, F),(M-8566, Cl, CH₃, H, n-Pen, CF₃), (M-8567, Cl, CH₃, H, n-Pen, Br),(M-8568, Cl, CH₃, H, n-Pen, CH₃), (M-8569, Cl, CH₃, H, c-Pen, H),(M-8570, Cl, CH₃, H, c-Pen, Cl), (M-8571, Cl, CH₃, H, c-Pen, F),(M-8572, Cl, CH₃, H, c-Pen, CF₃), (M-8573, Cl, CH₃, H, c-Pen, Br),(M-8574, Cl, CH₃, H, c-Pen, CH₃), (M-8575, Cl, CH₃, H, n-Hex, H),(M-8576, Cl, CH₃, H, n-Hex, Cl), (M-8577, Cl, CH₃, H, n-Hex, F),(M-8578, Cl, CH₃, H, n-Hex, CF₃), (M-8579, Cl, CH₃, H, n-Hex, Br),(M-8580, Cl, CH₃, H, n-Hex, CH₃), (M-8581, Cl, CH₃, H, c-Hex, H),(M-8582, Cl, CH₃, H, c-Hex, Cl), (M-8583, Cl, CH₃, H, c-Hex, F),(M-8584, Cl, CH₃, H, c-Hex, CF₃), (M-8585, Cl, CH₃, H, c-Hex, Br),(M-8586, Cl, CH₃, H, c-Hex, CH₅), (M-8587, Cl, CH₃, H, OH, H), (M-8588,Cl, CH₃, H, OH, Cl), (M-8589, Cl, CH₃, H, OH, F), (M-8590, Cl, CH₃, H,OH, CF₃), (M-8591, Cl, CH₃, H, OH, Br), (M-8592, Cl, CH₅, H, OH, CH₃),(M-8593, Cl, CH₃, H, EtO, H), (M-8594, Cl, CH₃, H, EtO, Cl), (M-8595,Cl, CH₃, H, EtO, F), (M-8596, Cl, CH₃, H, EtO, CF₃), (M-8597, Cl, CH₃,H, EtO, Br), (M-8598, Cl, CH₃, H, EtO, CH₃), (M-8599, Cl, CH₃, H, n-PrO,H), (M-8600, Cl, CH₃, H, n-PrO, Cl), (M-8601, Cl, CH₃, H, n-PrO, F),(M-8602, Cl, CH₃, H, n-PrO, CF₃), (M-8603, Cl, CH₃, H, n-PrO, Br),(M-8604, Cl, CH₃, H, n-PrO, CH₃), (M-8605, Cl, CH₃, H, PhO, H), (M-8606,Cl, CH₃, H, PhO, Cl), (M-8607, Cl, CH₃, H, PhO, F), (M-8608, Cl, CH₃, H,PhO, CF₃), (M-8609, Cl, C₃, H, PhO, Br), (M-8610, Cl, CH₃, H, PhO, CH₃),(M-8611, Cl, CH₃, H, BnO, H), (M-8612, Cl, CH₃, H, BnO, Cl), (M-8613,Cl, CH₃, H, BnO, F), (M-8614, Cl, CH₃, H, BnO, CF₃), (M-8615, Cl, CH₃,H, BnO, Br), (M-8616, Cl, CH₃, H, BnO, CH₃), (M-8617, Cl, CH₃, H,PhCH₂CH₂O, H), (M-8618, Cl, CH₃, H, PhCH₂CH₂O, Cl), (M-8619, Cl, CH₃, H,PhCH₂CH₂O, F), (M-8620, Cl, CH₃, H, PhCH₂CH₂O, CF₃), (M-8621, Cl, CH₃,H, PhCH₂CH₂O, Br), (M-8622, Cl, CH₃, H, PhCH₂CH₂O, CH₃), (M-8623, Cl,CH₃, H, CF₃O, H), (M-8624, Cl, CH₃, H, CF₃O, Cl), (M-8625, Cl, CH₃, H,CF₃O, F), (M-8626, Cl, CH₃, H, CF₃O, CF₃), (M-8627, Cl, CH₃, H, CF₃O,Br), (M-8628, Cl, CH₃, H, CF₃O, CH₃), (M-8629, Cl, CH₃, H, Ph, H),(M-8630, Cl, CH₃, H, Ph, Cl), (M-8631, Cl, CH₃, H, Ph, F), (M-8632, Cl,CH₃, H, Ph, CF₃), (M-8633, Cl, CH₃, H, Ph, Br), (M-8634, Cl, CH₃, H, Ph,CH₃), (M-8635, Cl, CH₃, H, 4-F-Ph, H), (M-8636, Cl, CH₃, H, 4-F-Ph, Cl),(M-8637, Cl, CH₃, H, 4-F-Ph, F), (M-8638, Cl, CH₃, H, 4-F-Ph, CF₃),(M-8639, Cl, CH₃, H, 4-F-Ph, Br), (M-8640, Cl, CH₃, H, 4-F-Ph, CH₃),(M-8641, Cl, CH₃, H, 4-CF₃-Ph, H), (M-8642, Cl, CH₃, H, 4-CF₃-Ph, Cl),(M-8643, Cl, CH₃, H, 4-CF₃-Ph, F), (M-8644, Cl, CH₃, H, 4-CF₃-Ph, CF₃),(M-8645, Cl, CH₃, H, 4-CF₃-Ph, Br), (M-8646, Cl, CH₃, H, 4-CF₃-Ph, CH₃),(M-8647, Cl, CH₃, H, 4-(Me)₂N-Ph, H), (M-8648, Cl, CH₃, H, 4-(Me)₂N-Ph,Cl), (M-8649, Cl, CH₃, H, 4-(Me)₂N-Ph, F), (M-8650, Cl, CH₃, H,4-(Me)₂N-Ph, CF₃), (M-8651, Cl, CH₃, H, 4-(Me)₂N-Ph, Br), (M-8652, Cl,CH₃, H, 4-(Me)₂N-Ph, CH₃), (M-8653, Cl, CH₃, H, 4-OH-Ph, H), (M-8654,Cl, CH₃, H, 4-OH-Ph, Cl), (M-8655, Cl, CH₃, H, 4-OH-Ph, F), (M-8656, Cl,CH₃, H, 4-OH-Ph, CF₃), (M-8657, Cl, CH₃, H, 4-OH-Ph, Br), (M-8658, Cl,CH₃, H, 4-OH-Ph, CH₃), (M-8659, Cl, CH₃, H, 3,4-di-F-Ph, H), (M-8660,Cl, CH₃, H, 3,4-di-F-Ph, Cl), (M-8661, Cl, CH₃, H, 3,4-di-F-Ph, F),(M-8662, Cl, CH₃, H, 3,4-di-F-Ph, CF₃), (M-8663, Cl, CH₃, H,3,4-di-F-Ph, Br), (M-8664, Cl, CH₃, H, 3,4-di-F-Ph, CH₃), (M-8665, Cl,CH₃, H, 4-COOH-Ph, H), (M-8666, Cl, CH₃, H, 4-COOH-Ph, Cl), (M-8667, Cl,CH₃, H, 4-COOH-Ph, F), (M-8668, Cl, CH₃, H, 4-COOH-Ph, CF₃), (M-8669,Cl, CH₃, H, 4-COOH-Ph, Br), (M-8670, Cl, CH₃, H, 4-COOH-Ph, CH₃),(M-8671, Cl, CH₃, H, Bn, H), (M-8672, Cl, CH₃, H, Bn, Cl), (M-8673, Cl,CH₃, H, Bn, F), (M-8674, Cl, CH₃, H, Bn, CF₃), (M-8675, Cl, CH₃, H, Bn,Br), (M-8676, Cl, CH₃, H, Bn, CH₃), (M-8677, Cl, CH₃, H, 4-F-Bn, H),(M-8678, Cl, CH₃, H, 4-F-Bn, Cl), (M-8679, Cl, CH₃, H, 4-F-Bn, F),(M-8680, Cl, CH₃, H, 4-F-Bn, CF₃), (M-8681, Cl, CH₃, H, 4-F-Bn, Br),(M-8682, Cl, CH₃, H, 4-F-Bn, CH₃), (M-8683, Cl, CH₃, H, 2-Py, H),(M-8684, Cl, CH₃, H, 2-Py, Cl), (M-8685, Cl, CH₃, H, 2-Py, F), (M-8686,Cl, CH₃, H, 2-Py, CF₃), (M-8687, Cl, CH₃, H, 2-Py, Br), (M-8688, Cl,CH₃, H, 2-Py, CH₃), (M-8689, Cl, CH₃, H, 3-Py, H), (M-8690, Cl, CH₃, H,3-Py, Cl), (M-8691, Cl, CH₃, H, 3-Py, F), (M-8692, Cl, CH₃, H, 3-Py,CF₃), (M-8693, Cl, CH₃, H, 3-Py, Br), (M-8694, Cl, CH₃, H, 3-Py, CH₃),(M-8695, Cl, CH₃, H, 4-Py, H), (M-8696, Cl, CH₃, H, 4-Py, Cl), (M-8697,Cl, CH₃, H, 4-Py, F), (M-8698, Cl, CH₃, H, 4-Py, CF₃), (M-8699, Cl, CH₃,H, 4-Py, Br), (M-8700, Cl, CH₃, H, 4-Py, CH₃), (M-8701, Cl, CH₃, H,2-Th, H), (M-8702, Cl, CH₃, H, 2-Th, Cl), (M-8703, Cl, CH₃, H, 2-Th, F),(M-8704, Cl, CH₃, H, 2-Th, CF₃), (M-8705, Cl, CH₃, H, 2-Th, Br),(M-8706, Cl, CH₃, H, 2-Th, CH₃), (M-8707, Cl, CH₃, H, 3-Th, H), (M-8708,Cl, CH₃, H, 3-Th, Cl), (M-8709, Cl, CH₃, H, 3-Th, F), (M-8710, Cl, CH₃,H, 3-Th, CF₃), (M-8711, Cl, CH₃, H, 3-Th, Br), (M-8712, Cl, CH₃, H,3-Th, CH₃), (M-8713, Cl, CH₃, H, pyrrazol-2-yl, H), (M-8714, Cl, CH₃, H,pyrrazol-2-yl, Cl), (M-8715, Cl, CH₃, H, pyrrazol-2-yl, F), (M-8716, Cl,CH₃, H, pyrrazol-2-yl, CF₃), (M-8717, Cl, CH₃, H, pyrrazol-2-yl, Br),(M-8718, Cl, CH₃, H, pyrrazol-2-yl, CH₃), (M-8719, Cl, CH₃, H,pyrrazol-3-yl, H), (M-8720, Cl, CH₃, H, pyrrazol-3-yl, Cl), (M-8721, Cl,CH₃, H, pyrrazol-3-yl, F), (M-8722, Cl, CH₃, H, pyrrazol-3-yl, CF₃),(M-8723, Cl, CH₃, H, pyrrazol-3-yl, Br), (M-8724, Cl, CH₃, H,pyrrazol-3-yl, CH₃), (M-8725, Cl, CH₃, H, pyrimidin-2-yl, H), (M-8726,Cl, CH₃, H, pyrimidin-2-yl, Cl), (M-8727, Cl, CH₃, H, pyrimidin-2-yl,F), (M-8728, Cl, CH₃, H, pyrimidin-2-yl, CF₃), (M-8729, Cl, CH₃, H,pyrimidin-2-yl, Br), (M-8730, Cl, CH₃, H, pyrimidin-2-yl, CH₃), (M-8731,Cl, CH₃, H, pyrimidin-4-yl, H), (M-8732, Cl, CH₃, H, pyrimidin-4-yl,Cl), (M-8733, Cl, CH₃, H, pyrimidin-4-yl, F), (M-8734, Cl, CH₃, H,pyrimidin-4-yl, CF₃), (M-8735, Cl, CH₃, H, pyrimidin-4-yl, Br), (M-8736,Cl, CH₃, H, pyrimidin-4-yl, CH₃), (M-8737, Cl, CH₃, H, pyrimidin-5-yl,H), (M-8738, Cl, CH₃, H, pyrimidin-5-yl, Cl), (M-8739, Cl, CH₃, H,pyrimidin-5-yl, F), (M-8740, Cl, CH₃, H, pyrimidin-5-yl, CF₃), (M-8741,Cl, CH₃, H, pyrimidin-5-yl, Br), (M-8742, Cl, CH₃, H, pyrimidin-5-yl,CH₃), (M-8743, Cl, CH₃, H, HOOCCH₂CH₂CH₂, H), (M-8744, Cl, CH₃, H,HOOCCH₂CH₂CH₂, Cl), (M-8745, Cl, CH₃, H, HOOCCH₂CH₂CH₂, F), (M-8746, Cl,CH₃, H, HOOCCH₂CH₂CH₂, CF₃), (M-8747, Cl, CH₃, H, HOOCCH₂CH₂CH₂, Br),(M-8748, Cl, CH₃, H, HOOCCH₂CH₂CH₂, CH₃), (M-8749, Cl, CH₃, H,HOOCCH₂CH₂CH₂CH₂, H), (M-8750, Cl, CH₃, H, HOOCCH₂CH₂CH₂CH₂, Cl),(M-8751, Cl, CH₃, H, HOOCCH₂CH₂CH₂CH₂, F), (M-8752, Cl, CH₃, H,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-8753, Cl, CH₃, H, HOOCCH₂CH₂CH₂CH₂, Br),(M-8754, Cl, CH₃, H, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-8755, Cl, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-8756, Cl, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂,Cl), (M-8757, Cl, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-8758, Cl, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-8759, Cl, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-8760, Cl, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-8761, Cl, CH₃,H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-8762, Cl, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-8763, Cl, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-8764, Cl, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-8765, Cl, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-8766, Cl, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-8767, Cl, CH₃, H, MeOCH₂, H), (M-8768,Cl, CH₃, H, MeOCH₂, Cl), (M-8769, Cl, CH₃, H, MeOCH₂, F), (M-8770, Cl,CH₃, H, MeOCH₂, CF₃), (M-8771, Cl, CH₃, H, MeOCH₂, Br), (M-8772, Cl,CH₃, H, MeOCH₂, CH₃), (M-8773, Cl, CH₃, H, EtOCH₂, H), (M-8774, Cl, CH₃,H, EtOCH₂, Cl), (M-8775, Cl, CH₃, H, EtOCH₂, F), (M-8776, Cl, CH₃, H,EtOCH₂, CF₃), (M-8777, Cl, CH₃, H, EtOCH₂, Br), (M-8778, Cl, CH₃, H,EtOCH₂, CH₃), (M-8779, Cl, CH₃, H, EtOCH₂CH₂, H), (M-8780, Cl, CH₃, H,EtOCH₂CH₂, Cl), (M-8781, Cl, CH₃, H, EtOCH₂CH₂, F), (M-8782, Cl, CH₃, H,EtOCH₂CH₂, CF₃), (M-8783, Cl, CH₃, H, EtOCH₂CH₂, Br), (M-8784, Cl, CH₃,H, EtOCH₂CH₂, CH₃), (M-8785, Cl, CH₃, H, MeOCH₂CH₂OCH₂CH₂, H), (M-8786,Cl, CH₃, H, MeOCH₂CH₂OCH₂CH₂, Cl), (M-8787, Cl, CH₃, H,MeOCH₂CH₂OCH₂CH₂, F), (M-8788, Cl, CH₃, H, MeOCH₂CH₂OCH₂CH₂, CF₃),(M-8789, Cl, CH₃, H, MeOCH₂CH₂OCH₂CH₂, Br), (M-8790, Cl, CH₃, H,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-8791, Cl, CH₃, H, MeOCH₂CH₂, H), (M-8792, Cl,CH₃, H, MeOCH₂CH₂, Cl), (M-8793, Cl, CH₃, H, MeOCH₂CH₂, F), (M-8794, Cl,CH₃, H, MeOCH₂CH₂, CF₃), (M-8795, Cl, CH₃, H, MeOCH₂CH₂, Br), (M-8796,Cl, CH₃, H, MeOCH₂CH₂, CH₃), (M-8797, Cl, CH₃, H, HOCH₂, H), (M-8798,Cl, CH₃, H, HOCH₂, Cl), (M-8799, Cl, CH₃, H, HOCH₂, F), (M-8800, Cl,CH₃, H, HOCH₂, CF₃), (M-8801, Cl, CH₃, H, HOCH₂, Br), (M-8802, Cl, CH₃,H, HOCH₂, CH₃), (M-8803, Cl, CH₃, H, HOCH₂CH₂, H), (M-8804, Cl, CH₃, H,HOCH₂CH₂, Cl), (M-8805, Cl, CH₃, H, HOCH₂CH₂, F), (M-8806, Cl, CH₃, H,HOCH₂CH₂, CF₃), (M-8807, Cl, CH₃, H, HOCH₂CH₂, Br), (M-8808, Cl, CH₃, H,HOCH₂CH₂, CH₃), (M-8809, Cl, CH₃, H, HOCH₂CH₂CH₂, H), (M-8810, Cl, CH₃,H, HOCH₂CH₂CH₂, Cl), (M-8811, Cl, CH₃, H, HOCH₂CH₂CH₂, F), (M-8812, Cl,CH₃, H, HOCH₂CH₂CH₂, CF₃), (M-8813, Cl, CH₃, H, HOCH₂CH₂CH₂, Br),(M-8814, Cl, CH₃, H, HOCH₂CH₂CH₂, CH₃), (M-8815, Cl, CH₃, H,HOCH₂CH₂CH₂CH₂, H), (M-8816, Cl, CH₃, H, HOCH₂CH₂CH₂CH₂, Cl), (M-8817,Cl, CH₃, H, HOCH₂CH₂CH₂CH₂, F), (M-8818, Cl, CH₃, H, HOCH₂CH₂CH₂CH₂,CF₃), (M-8819, Cl, CH₃, H, HOCH₂CH₂CH₂CH₂, Br), (M-8820, Cl, CH₃, H,HOCH₂CH₂CH₂CH₂, CH₃), (M-8821, Cl, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, H),(M-8822, Cl, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂Cl), (M-8823, Cl, CH₃H,HOCH₂CH₂CH₂CH₂CH₂, F), (M-8824, Cl, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-8825, Cl, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-8826, Cl, CH₃, H,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-8827, Cl, CH₃, H, HOCH₂CH₂OCH₂CH₂, H),(M-8828, Cl, CH₃, H, HOCH₂CH₂OCH₂CH₂, Cl), (M-8829, Cl, CH₃, H,HOCH₂CH₂OCH₂CH₂, F), (M-8830, Cl, CH₃, H, HOCH₂CH₂OCH₂CH₂, CF₃),(M-8831, Cl, CH₃, H, HOCH₂CH₂OCH₂CH₂, Br), (M-8832, Cl, CH₃, H,HOCH₂CH₂OCH₂CH₂, CH₃), (M-8833, Cl, CH₃, H, (Me)₂N, H), (M-8834, Cl,CH₃, H, (Me)₂N, Cl), (M-8835, Cl, CH₃, H, (Me)₂N, F), (M-8836, Cl, CH₃,H, (Me)₂N, CF₃), (M-8837, Cl, CH₃, H, (Me)₂N, Br), (M-8838, Cl, CH₃, H,(Me)₂N, CH₃), (M-8839, Cl, CH₃, H, piperidin-4-yl-methyl, H), (M-8840,Cl, CH₃, H, piperidin-4-yl-methyl, Cl), (M-8841, Cl, CH₃, H,piperidin-4-yl-methyl, F), (M-8842, Cl, CH₃, H, piperidin-4-yl-methyl,CF₃), (M-8843, Cl, CH₃, H, piperidin-4-yl-methyl, Br), (M-8844, Cl, CH₃,H, piperidin-4-yl-methyl, CH₃), (M-8845, Cl, CH₃, H, cyclohexylmethyl,H), (M-8846, Cl, CH₃, H, cyclohexylmethyl, Cl), (M-8847, Cl, CH₃, H,cyclohexylmethyl, F), (M-8848, Cl, CH₃, H, cyclohexylmethyl, CF₃),(M-8849, Cl, CH₃, H, cyclohexylmethyl, Br), (M-8850, Cl, CH₃, H,cyclohexylmethyl, CH₃), (M-8851, Cl, CH₃, F, H, H), (M-8852, Cl, CH₃, F,H, Cl), (M-8853, MeO, CH₃, F, H, F), (M-8854, Cl, CH₃, F, H, CF₃),(M-8855, Cl, CH₃, F, H, Br), (M-8856, Cl, CH₃, F, H, CH₃), (M-8857, Cl,CH₃, F, F, H), (M-8858, Cl, CH₃, F, F, Cl), (M-8859, Cl, CH₃, F, F, F),(M-8860, Cl, CH₃, F, F, CF₃), (M-8861, Cl, CH₃, F, F, Br), (M-8862, Cl,CH₃, F, F, CH₃), (M-8863, Cl, CH₃, F, Cl, H), (M-8864, Cl, CH₃, F, Cl,Cl), (M-8865, Cl, CH₃, F, Cl, F), (M-8866, Cl, CH₃, F, Cl, CF₃),(M-8867, Cl, CH₃, F, Cl, Br), (M-8868, Cl, CH₃, F, Cl, CH₃), (M-8869,Cl, CH₃, F, CH₃, H), (M-8870, Cl, CH₃, F, CH₃, Cl), (M-8871, Cl, CH₃, F,CH₃, F), (M-8872, Cl, CH₃, F, CH₃, CF₃), (M-8873, Cl, CH₃, F, CH₃, Br),(M-8874, Cl, CH₃, F, CH₃, CH₃), (M-8875, Cl, CH₃, F, Et, H), (M-8876,Cl, CH₃, F, Et, Cl), (M-8877, Cl, CH₃, F, Et, F), (M-8878, Cl, CH₃, F,Et, CF₃), (M-8879, Cl, CH₃, F, Et, Br), (M-8880, Cl, CH₃, F, Et, CH₃),(M-8881, Cl, CH₃, F, n-Pr, H), (M-8882, Cl, CH₃, F, n-Pr, Cl), (M-8883,Cl, CH₃, F, n-Pr, F), (M-8884, Cl, CH₃, F, n-Pr, CF₃), (M-8885, Cl, CH₃,F, n-Pr, Br), (M-8886, Cl, CH₃, F, n-Pr, CH₃), (M-8887, Cl, CH₃, F,c-Pr, H), (M-8888, Cl, CH₃, F, c-Pr, Cl), (M-8889, Cl, CH₃, F, c-Pr, F),(M-8890, Cl, CH₃, F, c-Pr, CF₃), (M-8891, Cl, CH₃, F, c-Pr, Br),(M-8892, Cl, CH₃, F, c-Pr, CH₃), (M-8893, Cl, CH₃, F, i-Pr, H), (M-8894,Cl, C₃, F, i-Pr, Cl), (M-8895, Cl, CH₃, F, i-Pr, F), (M-8896, Cl, CH₃,F, i-Pr, CF₃), (M-8897, Cl, CH₃, F, i-Pr, Br), (M-8898, Cl, CH₃, F,i-Pr, CH₃), (M-8899, Cl, CH₃, F, n-Bu, H), (M-8900, Cl, CH₃, F, n-Bu,Cl), (M-8901, Cl, CH₃, F, n-Bu, F), (M-8902, Cl, CH₃, F, n-Bu, CF₃),(M-8903, Cl, CH₃, F, n-Bu, Br), (M-8904, Cl, CH₃, F, n-Bu, CH₃),(M-8905, Cl, CH₃, F, i-Bu, H), (M-8906, Cl, CH₃, F, i-Bu, Cl), (M-8907,Cl, CH₃, F, i-Bu, F), (M-8908, Cl, C₃, F, i-Bu, CF₃), (M-8909, Cl, CH₃,F, i-Bu, Br), (M-8910, Cl, CH₃, F, i-Bu, CH₃), (M-8911, Cl, CH₃, F,sec-Bu, H), (M-8912, Cl, CH₃, F, sec-Bu, Cl), (M-8913, Cl, CH₃, F,sec-Bu, F), (M-8914, Cl, CH₃, F, sec-Bu, CF₃), (M-8915, Cl, CH₃, F,sec-Bu, Br), (M-8916, Cl, CH₃, F, sec-Bu, CH₃), (M-8917, Cl, CH₃, F,n-Pen, H), (M-8918, Cl, CH₃, F, n-Pen, Cl), (M-8919, Cl, CH₃, F, n-Pen,F), (M-8920, Cl, CH₃, F, n-Pen, CF₃), (M-8921, Cl, CH₃, F, n-Pen, Br),(M-8922, Cl, CH₃, F, n-Pen, CH₃), (M-8923, Cl, CH₃, F, c-Pen, H),(M-8924, Cl, CH₃, F, c-Pen, Cl), (M-8925, Cl, CH₃, F, c-Pen, F),(M-8926, Cl, CH₃, F, c-Pen, CF₃), (M-8927, Cl, CH₃, F, c-Pen, Br),(M-8928, Cl, CH₃, F, c-Pen, CH₃), (M-8929, Cl, CH₃, F, n-Hex, H),(M-8930, Cl, CH₃, F, n-Hex, Cl), (M-8931, Cl, CH₃, F, n-Hex, F),(M-8932, Cl, CH₃, F, n-Hex, CF₃), (M-8933, Cl, CH₃, F, n-Hex, Br),(M-8934, Cl, CH₃, F, n-Hex, CH₃), (M-8935, Cl, CH₃, F, c-Hex, H),(M-893G, Cl, CH₃, F, c-Hex, Cl), (M-8937, Cl, CH₃, F, c-Hex, F),(M-8938, Cl, CH₃, F, c-Hex, CF₃), (M-8939, Cl, CH₃, F, c-Hex, Br),(M-8940, Cl, CH₃, F, c-Hex, CH₃), (M-8941, Cl, CH₃, F, OH, H), (M-8942,Cl, CH₃, F, OH, Cl), (M-8943, Cl, CH₃, F, OH, F), (M-8944, Cl, CH₃, F,OH, CF₃), (M-8945, Cl, CH₃, F, OH, Br), (M-8946, Cl, CH₃, F, OH, CH₃),(M-8947, Cl, CH₃, F, EtO, H), (M-8948, Cl, CH₃, F, EtO, Cl), (M-8949,Cl, CH₃, F, EtO, F), (M-8950, Cl, CH₃, F, EtO, CF₃), (M-8951, Cl, CH₃,F, EtO, Br), (M-8952, Cl, CH₃, F, EtO, CH₃), (M-8953, Cl, CH₃, F, n-PrO,H), (M-8954, Cl, CH₃, F, n-PrO, Cl), (M-8955, Cl, CH₃, F, n-PrO, F),(M-8956, Cl, CH₃, F, n-PrO, CF₃), (M-8957, Cl, CH₃, F, n-PrO, Br),(M-8958, Cl, CH₃, F, n-PrO, CH₃), (M-8959, Cl, CH₃, F, PhO, H), (M-8960,Cl, CH₃, F, PhO, Cl), (M-8961, Cl, CH₃, F, PhO, F), (M-8962, Cl, CH₃, F,PhO, CF₃), (M-8963, Cl, CH₃, F, PhO, Br), (M-8964, Cl, CH₃, F, PhO,CH₃), (M-8965, Cl, CH₃, F, BnO, H), (M-8966, Cl, CH₃, F, BnO, Cl),(M-8967, Cl, CH₃, F, BnO, F), (M-8968, Cl, CH₃, F, BnO, CF₃), (M-8969,Cl, CH₃, F, BnO, Br), (M-8970, Cl, CH₃, F, BnO, CH₃), (M-8971, Cl, CH₃,F, PhCH₂CH₂O, H), (M-8972, Cl, CH₃, F, PhCH₂CH₂O, Cl), (M-8973, Cl, CH₃,F, PhCH₂CH₂O, F) 8974, Cl, CH₃, F, PhCH₂CH₂O, CF₃), (M-8975, Cl, CH₃, F,PhCH₂CH₂O, Br), (M-8976, Cl, CH₃, F, PhCH₂CH₂O, CH₃), (M-8977, Cl, CH₃,F, CF₃O, H), (M-8978, Cl, CH₃, F, CF₃O, Cl), (M-8979, Cl, CH₃, F, CF₃O,F), (M-8980, Cl, CH₃, F, CF₃O, CF₃), (M-8981, Cl, CH₃, F, CF₃O, Br),(M-8982, Cl, CH₃, F, CF₃O, CH₃), (M-8983, Cl, CH₃, F, Ph, H), (M-8984,Cl, CH₃, F, Ph, Cl), (M-8985, Cl, CH₃, F, Ph, F), (M-8986, Cl, CH₃, F,Ph, CF₃), (M-8987, Cl, CH₃, F, Ph, Br), (M-8988, Cl, CH₃, F, Ph, CH₃),(M-8989, Cl, CH₃, F, 4-F-Ph, H), (M-8990, Cl, CH₃, F, 4-F-Ph, Cl),(M-8991, Cl, CH₃, F, 4-F-Ph, F), (M-8992, Cl, CH₃, F, 4-F-Ph, CF₃),(M-8993, Cl, CH₃, F, 4-F-Ph, Br), (M-8994, Cl, CH₃, F, 4-F-Ph, CH₃),(M-8995, Cl, CH₃, F, 4-CF₃-Ph, H), (M-8996, Cl, CH₃, F, 4-CF₃-Ph, Cl),(M-8997, Cl, CH₃, 4-CF₃-Ph, F), (M-8998, Cl, CH₃, F, 4-CF₃-Ph, CF₃),(M-8999, Cl, CH₃, F, 4-CF₃-Ph, Br), (M-9000, Cl, CH₃, F, 4-CF₃-Ph, CH₃),(M-9001, Cl, CH₃, F, 4-(Me)₂N-Ph, H), (M-9002, Cl, CH₃, F, 4-(Me)₂N-Ph,Cl), (M-9003, Cl, CH₃, F, 4-(Me)₂N-Ph, F), (M-9004, Cl, CH₃, F,4-(Me)₂N-Ph, CF₃), (M-9005, Cl, CH₃, F, 4-(Me)₂N-Ph, Br), (M-9006, Cl,CH₃, F, 4-(Me)₂N-Ph, CH₃), (M-9007, Cl, CH₃, F, 4-OH-Ph, H), (M-9008,Cl, CH₃, F, 4-OH-Ph, Cl), (M-9009, Cl, CH₃, F, 4-OH-Ph, F), (M-9010, Cl,CH₃, F, 4-OH-Ph, CF₃), (M-9011, Cl, CH₃, F, 4-OH-Ph, Br), (M-9012, Cl,CH₃, F, 4-OH-Ph, CH₃), (M-9013, Cl, CH₃, F, 3,4-di-F-Ph, H), (M-9014,Cl, CH₃, F, 3,4-di-F-Ph, Cl), (M-9015, Cl, CH₃, F, 3,4-di-F-Ph, F),(M-9016, Cl, CH₃, F, 3,4-di-F-Ph, CF₃), (M-9017, Cl, CH₃, F,3,4-di-F-Ph, Br), (M-9018, Cl, CH₃, F, 3,4-di-F-Ph, CH₃), (M-9019, Cl,CH₃, F, 4-COOH-Ph, H), (M-9020, Cl, CH₃, F, 4-COOH-Ph, Cl), (M-9021, Cl,CH₃, F, 4-COOH-Ph, F), (M-9022, Cl, CH₃, F, 4-COOH-Ph, CF₃), (M-9023,Cl, CH₃, F, 4-COOH-Ph, Br), (M-9024, Cl, CH₃, F, 4-COOH-Ph, CH₃),(M-9025, Cl, CH₃, F, Bn, H), (M-9026, Cl, CH₃, F, Bn, Cl), (M-9027, Cl,CH₃, F, Bn, F), (M-9028, Cl, CH₃, F, Bn, CF₃), (M-9029, Cl, CH₃, F, Bn,Br), (M-9030, Cl, CH₃, F, Bn, CH₃), (M-9031, Cl, CH₃, F, 4-F-Bn, H),(M-9032, Cl, CH₃, F, 4-F-Bn, Cl), (M-9033, Cl, CH₃, F, 4-F-Bn, F),(M-9034, Cl, CH₃, F, 4-F-Bn, CF₃), (M-9035, Cl, CH₃, F, 4-F-Bn, Br),(M-9036, Cl, CH₃, F, 4-F-Bn, CH₃), (M-9037, Cl, CH₃, F, 2-Py, H),(M-9038, Cl, CH₃, F, 2-Py, Cl), (M-9039, Cl, CH₃, F, 2-Py, F), (M-9040,Cl, CH₃, F, 2-Py, CF₃), (M-9041, Cl, CH₃, F, 2-Py, Br), (M-9042, Cl,CH₃, F, 2-Py, CH₃), (M-9043, Cl, CH₃, F, 3-Py, H), (M-9044, Cl, CH₃, F,3-Py, Cl), (M-9045, Cl, CH₃, F, 3-Py, F), (M-9046, Cl, CH₃, F, 3-Py,CF₃), (M-9047, Cl, CH₃, F, 3-Py, Br), (M-9048, Cl, CH₃, F, 3-Py, CH₃),(M-9049, Cl, CH₃, F, 4-Py, H), (M-9050, Cl, CH₃, F, 4-Py, Cl), (M-9051,Cl, CH₃, F, 4-Py, F), (M-9052, Cl, CH₃, F, 4-Py, CF₃), (M-9053, Cl, CH₃,F, 4-Py, Br), (M-9054, Cl, CH₃, F, 4-Py, CH₃), (M-9055, Cl, CH, F, 2-Th,H), (M-9056, Cl, CH₃, F, 2-Th, Cl), (M-9057, Cl, CH₃, F, 2-Th, F),(M-9058, Cl, CH₃, F, 2-Th, CF₃), (M-9059, Cl, CH₃, F, 2-Th, Br),(M-9060, Cl, CH₃, F, 2-Th, CH₃), (M-9061, Cl, CH₃, F, 3-Th, H), (M-9062,Cl, CH₃, F, 3-Th, Cl), (M-9063, Cl, CH₃, F, 3-Th, F), (M-9064, Cl, CH₃,F, 3-Th, CF₃), (M-9065, Cl, CH₃, F, 3-Th, Br), (M-9066, Cl, CH₃, F,3-Th, CH₃), (M-9067, Cl, CH₃, F, pyrrazol-2-yl, H), (M-9068, Cl, CH₃, F,pyrrazol-2-yl, Cl), (M-9069, Cl, CH₃, F, pyrrazol-2-yl, F), (M-9070, Cl,CH₃, F, pyrrazol-2-yl, CF₃), (M-9071, Cl, CH₃, F, pyrrazol-2-yl, Br),(M-9072, Cl, CH₃, F, pyrrazol-2-yl, CH₃), (M-9073, Cl, CH₃, F,pyrrazol-3-yl, H), (M-9074, Cl, CH₃, F, pyrrazol-3-yl, Cl), (M-9075, Cl,CH₃, F, pyrrazol-3-yl, F), (M-9076, Cl, CH₃, F, pyrrazol-3-yl, CF₃),(M-9077, Cl, CH₃, F, pyrrazol-3-yl, Br), (M-9078, Cl, CH₃, F,pyrrazol-3-yl, CH₃), (M-9079, Cl, CH₃, F, pyrimidin-2-yl, H), (M-9080,Cl, CH₃, F, pyrimidin-2-yl, Cl), (M-9081, Cl, CH₃, F, pyrimidin-2-yl,F), (M-9082, Cl, CH₃, F, pyrimidin-2-yl, CF₃), (M-9083, Cl, CH₃, F,pyrimidin-2-yl, Br), (M-9084, Cl, CH₃, F, pyrimidin-2-yl, CH₃), (M-9085,Cl, CH₃, F, pyrimidin-4-yl, H), (M-9086, Cl, CH₃, F, pyrimidin-4-yl,Cl), (M-9087, Cl, CH₃, F, pyrimidin-4-yl, F), (M-9088, Cl, CH₃, F,pyrimidin-4-yl, CF₃), (M-9089, Cl, CH₃, F, pyrimidin-4-yl, Br), (M-9090,Cl, CH₃, F, pyrimidin-4-yl, CH₃), (M-9091, Cl, CH₃, F, pyrimidin-5-yl,H), (M-9092, Cl, CH₃, F, pyrimidin-5-yl, Cl), (M-9093, Cl, CH₃, F,pyrimidin-5-yl, F), (M-9094, Cl, CH₃, F, pyrimidin-5-yl, CF₃), (M-9095,Cl, CH₃, F, pyrimidin-5-yl, Br), (M-9096, Cl, CH₃, F, pyrimidin-5-yl,CH₃), (M-9097, Cl, CH₃, F, HOOCCH₂CH₂CH₂, H), (M-9098, Cl, CH₃, F,HOOCCH₂CH₂CH₂, Cl), (M-9099, Cl, CH₃, F, HOOCCH₂CH₂CH₂, F), (M-9100, Cl,CH₃, F, HOOCCH₂CH₂CH₂, CF₃), (M-9101, Cl, CH₃, F, HOOCCH₂CH₂CH₂, Br),(M-9102, Cl, CH₃, F, HOOCCH₂CH₂CH₂, CH₃), (M-9103, Cl, CH₃, F,HOOCCH₂CH₂CH₂CH₂, H), (M-9104, Cl, CH₃, F, HOOCCH₂CH₂CH₂CH₂, Cl),(M-9105, Cl, CH₃, F, HOOCCH₂CH₂CH₂CH₂, F), (M-9106, Cl, CH₃, F,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-9107, Cl, CH₃, F, HOOCCH₂CH₂CH₂CH₂, Br),(M-9108, Cl, CH₃, F, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-9109, Cl, CH₃F,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-9110, Cl, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂,Cl), (M-9111, Cl, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-9112, Cl, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-9113, Cl, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-9114, Cl, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-9115, Cl, CH₃,F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-9116, Cl, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-9117, Cl, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-9118, Cl, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-9119, Cl, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-9120, Cl, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-9121, Cl, CH₃, F, MeOCH₂, U), (M-9122,Cl, CH₃, F, MeOCH₂, Cl), (M-9123, Cl, CH₃, F, MeOCH₂, F), (M-9124, Cl,CH₃, F, MeOCH₂, CF₃), (M-9125, Cl, CH₃, F, MeOCH₂, Br), (M-9126, Cl,CH₃, F, MeOCH₂, CH₃), (M-9127, Cl, CH₃, F, EtOCH₂, H), (M-9128, Cl, CH₃,F, EtOCH₂, Cl), (M-9129, Cl, CH₃, F, EtOCH₂, F), (M-9130, Cl, CH₃, F,EtOCH₂, CF₃), (M-9131, Cl, CH₃, F, EtOCH₂, Br), (M-9132, Cl, CH₃, F,EtOCH₂, CH₃), (M-9133, Cl, CH₃, F, EtOCH₂CH₂, H), (M-9134, Cl, CH₃, F,EtOCH₂CH₂, Cl), (M-9135, Cl, CH₃, F, EtOCH₂CH₂, F); (M-9136, Cl, CH₃, F,EtOCH₂CH₂, CF₃), (M-9137, Cl, CH₃, F, EtOCH₂CH₂, Br), (M-9138, Cl, CH₃,F, EtOCH₂CH₂, CH₃), (M-9139, Cl, CH₃, F, MeOCH₂CH₂OCH₂CH₂, H), (M-9140,Cl, CH₃, F, MeOCH₂CH₂OCH₂CH₂, Cl), (M-9141, Cl, CH₃, F,MeOCH₂CH₂OCH₂CH₂, F), (M-9142, Cl, CH₃, F, MeOCH₂CH₂OCH₂CH₂, CF₃),(M-9143, Cl, CH₃, F, MeOCH₂CH₂OCH₂CH₂, Br), (M-9144, Cl, CH₃, F,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-9145, Cl, CH₃, F, MeOCH₂CH₂, H), (M-9146, Cl,CH₃, F, MeOCH₂CH₂, Cl), (M-9147, Cl, CH₃, F, MeOCH₂CH₂, F), (M-9148, Cl,CH₃, F, MeOCH₂CH₂, CF₃), (M-9149, Cl, CH₃, F, MeOCH₂CH₂, Br), (M-9150,Cl, CH₃, F, MeOCH₂CH₂, CH₃), (M-9151, Cl, CH₃, F, HOCH₂, H), (M-9152,Cl, CH₃, F, HOCH₂, Cl), (M-9153, Cl, CH₃, F, HOCH₂, F), (M-9154, Cl,CH₃, F, HOCH₂, CF₃), (M-9155, Cl, CH₃, F, HOCH₂, Br), (M-9156, Cl, CH₃,F, HOCH₂, CH₃), (M-9157, Cl, CH₃, F, HOCH₂CH₂, H), (M-9158, Cl, CH₃, F,HOCH₂CH₂, Cl), (M-9159, Cl, CH₃, F, HOCH₂CH₂, F), (M-9160, Cl, CH₃, F,HOCH₂CH₂, CF₃), (M-9161, Cl, CH₃, F, HOCH₂CH₂, Br), (M-9162, Cl, CH₃, F,HOCH₂CH₂, CH₃), (M-9163, Cl, CH₃, F, HOCH₂CH₂CH₂, H), (M-9164, Cl, CH₃,F, HOCH₂CH₂CH₂, Cl), (M-9165, Cl, CH₃, F, HOCH₂CH₂CH₂, F), (M-9166, Cl,CH₃, F, HOCH₂CH₂CH₂, CF₃), (M-9167, Cl, CH₃, F, HOCH₂CH₂CH₂, Br),(M-9168, Cl, CH₃, F, HOCH₂CH₂CH₂, CH₃), (M-9169, Cl, CH₃, F,HOCH₂CH₂CH₂CH₂, H), (M-9170, Cl, CH₃, F, HOCH₂CH₂CH₂CH₂, Cl), (M-9171,Cl, CH₃, F, HOCH₂CH₂CH₂CH₂, F), (M-9172, Cl, CH₃F, HOCH₂CH₂CH₂CH₂CF₃),(M-9173, Cl, CH₃F, HOCH₂CH₂CH₂CH₂, Br), (M-9174, Cl, CH₃, F,HOCH₂CH₂CH₂CH₂, CH₃), (M-9175, Cl, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂H), (M-9176,Cl, CH₃F, HOCH₂CH₂CH₂CH₂CH₂, Cl) (M-9177, Cl, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂,F), (M-9178, Cl, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂CF₃), (M-9179, Cl, CH₃F,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-9180, Cl, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-9181, Cl, CH₃, F, HOCH₂CH₂OCH₂CH₂, H), (M-9182, Cl, CH₃, F,HOCH₂CH₂OCH₂CH₂Cl), (M-9183, Cl, CH₃, F, HOCH₂CH₂OCH₂CH₂, F), (M-9184,Cl, CH₃, F, HOCH₂CH₂OCH₂CH₂, CF₃), (M-9185, Cl, CH₃, F, HOCH₂CH₂OCH₂CH₂,Br), (M-9186, Cl, CH₃, F, HOCH₂CH₂OCH₂CH₂, CH₃), (M-9187, Cl, CH₃, F,(Me)₂N, H), (M-9188, Cl, CH₃, F, (Me)₂N, Cl), (M-9189, Cl, CH₃, F,(Me)₂N, F), (M-9190, Cl, CH₃, F, (Me)₂N, CF₃), (M-9191, Cl, CH₃, F,(Me)₂N, Br), (M-9192, Cl, CH₃, F, (Me)₂N, CH₃), (M-9193, Cl, CH₃, F,piperidin-4-yl-methyl, H), (M-9194, Cl, CH₃, F, piperidin-4-yl-methyl,Cl), (M-9195, Cl, CH₃, F, piperidin-4-yl-methyl, F), (M-9196, Cl, CH₃,F, piperidin-4-yl-methyl, CF₃), (M-9197, Cl, CH₃, F,piperidin-4-yl-methyl, Br), (M-9198, Cl, CH₃, F, piperidin-4-yl-methyl,CH₃), (M-9199, Cl, CH₃, F, cyclohexylmethyl, H), (M-9200, Cl, CH₃, F,cyclohexylmethyl, Cl), (M-9201, Cl, CH₃, F, cyclohexylmethyl, F),(M-9202, Cl, CH₃, F, cyclohexylmethyl, CF₃), (M-9203, Cl, CH₃, F,cyclohexylmethyl, Br), (M-9204, Cl, CH₃, F, cyclohexylmethyl, CH₃),(M-9205, Cl, CH₃, Cl, H, H), (M-9206, Cl, CH₃, Cl, H, Cl), (M-9207, Cl,CH₃, Cl, H, F), (M-9208, Cl, CH₃, Cl, H, CF₃), (M-9209, Cl, CH₃, Cl, H,Br), (M-9210, Cl, CH₃, Cl, H, CH₃), (M-9211, Cl, CH₃, Cl, F, H),(M-9212, Cl, CH₃, Cl, F, Cl), (M-9213, Cl, CH₃, Cl, F, F), (M-9214, Cl,CH₃, Cl, F, CF₃), (M-9215, Cl, CH₃, Cl, F, Br), (M-9216, Cl, CH₃, Cl, F,CH₃), (M-9217, Cl, CH₃, Cl, Cl, H), (M-9218, Cl, CH₃, Cl, Cl, Cl),(M-9219, Cl, CH₃, Cl, Cl, F), (M-9220, Cl, CH₃, Cl, Cl, CF₃), (M-9221,Cl, CH₃, Cl, Cl, Br), (M-9222, Cl, CH₃, Cl, Cl, CH₃), (M-9223, Cl, CH₃,Cl, CH₃, H), (M-9224, Cl, CH₃, Cl, CH₃, Cl), (M-9225, Cl, CH₃, Cl, CH₃,F), (M-9226, Cl, CH₃, Cl, CH₃, CF₃), (M-9227, Cl, CH₃, Cl, CH₃, Br),(M-9228, Cl, CH₃, Cl, CH₃, CH₃), (M-9229, Cl, CH₃, Cl, Et, H), (M-9230,Cl, CH₃, Cl, Et, Cl), (M-9231, Cl, CH₃, Cl, Et, F), (M-9232, Cl, CH₃,Cl, Et, CF₃), (M-9233, Cl, CH₃, Cl, Et, Br), (M-9234, Cl, CH₃, Cl, Et,CH₃), (M-9235, Cl, CH₃, Cl, n-Pr, H), (M-9236, Cl, CH₃, Cl, n-Pr, Cl),(M-9237, Cl, CH₃, Cl, n-Pr, F), (M-9238, Cl, CH₃, Cl, n-Pr, CF₃),(M-9239, Cl, CH₃, Cl, n-Pr, Br), (M-9240, Cl, CH₃, Cl, n-Pr, CH₃),(M-9241, Cl, CH₃, Cl, c-Pr, H), (M-9242, Cl, CH₃, Cl, c-Pr, Cl),(M-9243, Cl, CH₃, Cl, c-Pr, F), (M-9244, Cl, CH₃, Cl, c-Pr, CF₃),(M-9245, Cl, CH₃, Cl, c-Pr, Br), (M-9246, Cl, CH₃, Cl, c-Pr, CH₃),(M-9247, Cl, CH₃, Cl, i-Pr, H), (M-9248, Cl, CH₃, Cl, i-Pr, Cl),(M-9249, Cl, CH₃, Cl, i-Pr, F), (M-9250, Cl, CH₃, Cl, i-Pr, CF₃),(M-9251, Cl, CH₃, Cl, i-Pr, Br), (M-9252, Cl, CH₃, Cl, i-Pr, CH₃),(M-9253, Cl, CH₃, Cl, n-Bu, H), (M-9254, Cl, CH₃, Cl, n-Bu, Cl),(M-9255, Cl, CH₃, Cl, n-Bu, F), (M-9256, Cl, CH₃, Cl, n-Bu, CF₃),(M-9257, Cl, CH₃, Cl, n-Bu, Br), (M-9258, Cl, CH₃, Cl, n-Bu, CH₃),(M-9259, Cl, CH₃, Cl, i-Bu, H), (M-9260, Cl, CH₃, Cl, i-Bu, Cl),(M-9261, Cl, CH₃, Cl, i-Bu, F), (M-9262, Cl, CH₃, Cl, i-Bu, CF₃),(M-9263, Cl, CH₃, Cl, i-Bu, Br), (M-9264, Cl, CH₃, Cl, i-Bu, CH₃),(M-9265, Cl, CH₃, Cl, sec-Bu, H), (M-9266, Cl, CH₃, Cl, sec-Bu, Cl),(M-9267, Cl, CH₃, Cl, sec-Bu, F), (M-9268, Cl, CH₃, Cl, sec-Bu, CF₃),(M-9269, Cl, CH₃, Cl, sec-Bu, Br), (M-9270, Cl, CH₃, Cl, sec-Bu, CH₃),(M-9271, Cl, CH₃, Cl, n-Pen, H), (M-9272, Cl, CH₃, Cl, n-Pen, Cl),(M-9273, Cl, CH₃, Cl, n-Pen, F), (M-9274, Cl, CH₃, Cl, n-Pen, CF₃),(M-9275, Cl, CH₃, Cl, n-Pen, Br), (M-9276, Cl, CH₃, Cl, n-Pen, CH₃),(M-9277, Cl, CH₃, Cl, c-Pen, H), (M-9278, Cl, CH₃, Cl, c-Pen, Cl),(M-9279, Cl, CH₃, Cl, c-Pen, F), (M-9280, Cl, CH₃, Cl, c-Pen, CF₃),(M-9281, Cl, CH₃, Cl, c-Pen, Br), (M-9282, Cl, CH₃, Cl, c-Pen, CH₃),(M-9283, Cl, CH₃, Cl, n-Hex, H), (M-9284, Cl, CH₃, Cl, n-Hex, Cl),(M-9285, Cl, CH₃, Cl, n-Hex, F), (M-9286, Cl, CH₃, Cl, n-Hex, CF₃),(M-9287, Cl, CH₃, Cl, n-Hex, Br), (M-9288, Cl, CH₃, Cl, n-Hex, CH₃),(M-9289, Cl, CH₃, Cl, c-Hex, H), (M-9290, Cl, CH₃, Cl, c-Hex, Cl),(M-9291, Cl, CH₃, Cl, c-Hex, F), (M-9292, Cl, CH₃, Cl, c-Hex, CF₃),(M-9293, Cl, CH₃, Cl, c-Hex, Br), (M-9294, Cl, CH₃, Cl, c-Hex, CH₃),(M-9295, Cl, CH₃, Cl, OH, H), (M-9296, Cl, CH₃, Cl, OH, Cl), (M-9297,Cl, CH₃, Cl, OH, F), (M-9298, Cl, CH₃, Cl, OH, CF₃), (M-9299, Cl, CH₃,Cl, OH, Br), (M-9300, Cl, CH₃, Cl, OH, CH₃), (M-9301, Cl, CH₃, Cl, EtO,H), (M-9302, Cl, CH₃, Cl, EtO, Cl), (M-9303, Cl, CH₃, Cl, EtO, F),(M-9304, Cl, CH₃, Cl, EtO, CF₃), (M-9305, Cl, CH₃, Cl, EtO, Br),(M-9306, Cl, CH₃, Cl, EtO, CH₃), (M-9307, Cl, CH₃, Cl, n-PrO, H),(M-9308, Cl, CH₃, Cl, n-PrO, Cl), (M-9309, Cl, CH₃, Cl, n-PrO, F),(M-9310, Cl, CH₃, Cl, n-PrO, CF₃), (M-9311, Cl, CH₃, Cl, n-PrO, Br),(M-9312, Cl, CH₃, Cl, n-PrO, CH₃), (M-9313, Cl, CH₃, Cl, PhO, H),(M-9314, Cl, CH₃, Cl, PhO, Cl), (M-9315, Cl, CH₃, Cl, PhO, F), (M-9316,Cl, CH₃, Cl, PhO, CF₃), (M-9317, Cl, CH₃, Cl, PhO, Br), (M-9318, Cl,CH₃, Cl, PhO, CH₃), (M-9319, Cl, CH₃, Cl, BnO, H), (M-9320, Cl, CH₃, Cl,BnO, Cl), (M-9321, Cl, CH₃, Cl, BnO, F), (M-9322, Cl, CH₃, Cl, BnO,CF₃), (M-9323, Cl, CH₃, Cl, BnO, Br), (M-9324, Cl, CH₃, Cl, BnO, CH₃),(M-9325, Cl, CH₃, Cl, PhCH₂CH₂O, H), (M-9326, Cl, CH₃, Cl, PhCH₂CH₂O,Cl), (M-9327, Cl, CH₃, Cl, PhCH₂CH₂O, F), (M-9328, Cl, CH₃, Cl,PhCH₂CH₂O, CF₃), (M-9329, Cl, CH₃, Cl, PhCH₂CH₂O, Br), (M-9330, Cl, CH₃,Cl, PhCH₂CH₂O, CH₃), (M-9331, Cl, CH₃, Cl, CF₃O, H), (M-9332, Cl, CH₃,Cl, CF₃O, Cl), (M-9333, Cl, CH₃, Cl, CF₃O, F), (M-9334, Cl, CH₃, Cl,CF₃O, CF₃), (M-9335, Cl, CH₃, Cl, CF₃O, Br), (M-9336, Cl, CH₃, Cl, CF₃O,CH₃), (M-9337, Cl, CH₃, Cl, Ph, H), (M-9338, Cl, CH₃, Cl, Ph, Cl),(M-9339, Cl, CH₃, Cl, Ph, F), (M-9340, Cl, CH₃, Cl, Ph, CF₃), (M-9341,Cl, CH₃, Cl, Ph, Br), (M-9342, Cl, CH₃, Cl, Ph, CH₃), (M-9343, Cl, CH₃,Cl, 4-F-Ph, H), (M-9344, Cl, CH₃, Cl, 4-F-Ph, Cl), (M-9345, Cl, CH₃, Cl,4-F-Ph, F), (M-9346, Cl, CH₃, Cl, 4-F-Ph, CF₃), (M-9347, Cl, CH₃, Cl,4-F-Ph, Br), (M-9348, Cl, CH₃, Cl, 4-F-Ph, CH₃), (M-9349, Cl, CH₃, Cl,4-CF₃-Ph, H), (M-9350, Cl, CH₃, Cl, 4-CF₃-Ph, Cl), (M-9351, Cl, CH₃, Cl,4-CF₃-Ph, F), (M-9352, Cl, CH₃, Cl, 4-CF₃-Ph, CF₃), (M-9353, Cl, CH₃,Cl, 4-CF₃-Ph, Br), (M-9354, Cl, CH₃, Cl, 4-CF₃-Ph, CH₃), (M-9355, Cl,CH₃, Cl, 4-(Me)₂N-Ph, H), (M-9356, Cl, CH₃, Cl, 4-(Me)₂N-Ph, Cl),(M-9357, Cl, CH₃, Cl, 4-(Me)₂N-Ph, F), (M-9358, Cl, CH₃, Cl,4-(Me)₂N-Ph, CF₃), (M-9359, Cl, CH₃, Cl, 4-(Me)₂N-Ph, Br), (M-9360, Cl,CH₃, Cl, 4-(Me)₂N-Ph, CH₃), (M-9361, Cl, CH₃, Cl, 4-OH-Ph, H), (M-9362,Cl, CH₃, Cl, 4-OH-Ph, Cl), (M-9363, Cl, CH₃, Cl, 4-OH-Ph, F), (M-9364,Cl, CH₃, Cl, 4-OH-Ph, CF₃), (M-9365, Cl, CH₃, Cl, 4-OH-Ph, Br), (M-9366,Cl, CH₃, Cl, 4-OH-Ph, CH₃), (M-9367, Cl, CH₃, Cl, 3,4-di-F-Ph, H),(M-9368, Cl, CH₃, Cl, 3,4-di-F-Ph, Cl), (M-9369, Cl, CH₃, Cl,3,4-di-F-Ph, F), (M-9370, Cl, CH₃, Cl, 3,4-di-F-Ph, CF₃), (M-9371, Cl,CH₃, Cl, 3,4-di-F-Ph, Br), (M-9372, Cl, CH₃, Cl, 3,4-di-F-Ph, CH₃),(M-9373, Cl, CH₃, Cl, 4-COOH-Ph, H), (M-9374, Cl, CH₃, Cl, 4-COOH-Ph,Cl), (M-9375, Cl, CH₃, Cl, 4-COOH-Ph, F), (M-9376, Cl, CH₃, Cl,4-COOH-Ph, CF₃), (M-9377, Cl, CH₃, Cl, 4-COOH-Ph, Br), (M-9378, Cl, CH₃,Cl, 4-COOH-Ph, CH₃), (M-9379, Cl, CH₃, Cl, Bn, H), (M-9380, Cl, CH₃, Cl,Bn, Cl), (M-9381, Cl, CH₃, Cl, Bn, F), (M-9382, Cl, CH₃, Cl, Bn, CF₃),(M-9383, Cl, CH₃, Cl, Bn, Br), (M-9384, Cl, CH₃, Cl, Bn, CH₃), (M-9385,Cl, CH₃, Cl, 4-F-Bn, H), (M-9386, Cl, CH₃, Cl, 4-F-Bn, Cl), (M-9387, Cl,CH₃, Cl, 4-F-Bn, F), (M-9388, Cl, CH₃, Cl, 4-F-Bn, CF₃), (M-9389, Cl,CH₃, Cl, 4-F-Bn, Br), (M-9390, Cl, CH₃, Cl, 4-F-Bn, CH₃), (M-9391, Cl,CH₃, Cl, 2-Py, H), (M-9392, Cl, CH₃, Cl, 2-Py, Cl), (M-9393, Cl, CH₃,Cl, 2-Py, F), (M-9394, Cl, CH₃, Cl, 2-Py, CF₃), (M-9395, Cl, CH₃, Cl,2-Py, Br), (M-9396, Cl, CH₃, Cl, 2-Py, CH₃), (M-9397, Cl, CH₃, Cl, 3-Py,H), (M-9398, Cl, CH₃, Cl, 3-Py, Cl), (M-9399, Cl, CH₃, Cl, 3-Py, F),(M-9400, Cl, CH₃, Cl, 3-Py, CF₃), (M-9401, Cl, CH₃, Cl, 3-Py, Br),(M-9402, Cl, CH₃, Cl, 3-Py, CH₃), (M-9403, Cl, CH₃, Cl, 4-Py, H),(M-9404, Cl, CH₃, Cl, 4-Py, Cl), (M-9405, Cl, CH₃, Cl, 4-Py, F),(M-9406, Cl, CH₃, Cl, 4-Py, CF₃), (M-9407, Cl, CH₃, Cl, 4-Py, Br),(M-9408, Cl, CH₃, Cl, 4-Py, CH₃), (M-9409, Cl, CH₃, Cl, 2-Th, H),(M-9410, Cl, CH₃, Cl, 2-Th, Cl), (M-9411, Cl, CH₃, Cl, 2-Th, F),(M-9412, Cl, CH₃, Cl, 2-Th, CF₃), (M-9413, Cl, CH₃, Cl, 2-Th, Br),(M-9414, Cl, CH₃, Cl, 2-Th, CH₃), (M-9415, Cl, CH₃, Cl, 3-Th, H),(M-9416, Cl, CH₃, Cl, 3-Th, Cl), (M-9417, Cl, CH₃, Cl, 3-Th, F),(M-9418, Cl, CH₃, Cl, 3-Th, CF₃), (M-9419, Cl, CH₃, Cl, 3-Th, Br),(M-9420, Cl, CH₃, Cl, 3-Th, CH₃), (M-9421, Cl, CH₃, Cl, pyrrazol-2-yl,H), (M-9422, Cl, CH₃, Cl, pyrrazol-2-yl, Cl), (M-9423, Cl, CH₃, Cl,pyrrazol-2-yl, F), (M-9424, Cl, CH₃, Cl, pyrrazol-2-yl, CF₃), (M-9425,Cl, CH₃, Cl, pyrrazol-2-yl, Br), (M-9426, Cl, CH₃, Cl, pyrrazol-2-yl,CH₃), (M-9427, Cl, CH₃, Cl, pyrrazol-3-yl, H), (M-9428, Cl, CH₃, Cl,pyrrazol-3-yl, Cl), (M-9429, Cl, CH₃, Cl, pyrrazol-3-yl, F), (M-9430,Cl, CH₃, Cl, pyrrazol-3-yl, CF₃), (M-9431, Cl, CH₃, Cl, pyrrazol-3-yl,Br), (M-9432, Cl, CH₃, Cl, pyrrazol-3-yl, CH₃), (M-9433, Cl, CH₃, Cl,pyrimidin-2-yl, H), (M-9434, Cl, CH₃, Cl, pyrimidin-2-yl, Cl), (M-9435,Cl, CH₃, Cl, pyrimidin-2-yl, F), (M-9436, Cl, CH₃, Cl, pyrimidin-2-yl,CF₃), (M-9437, Cl, CH₃, Cl, pyrimidin-2-yl, Br), (M-9438, Cl, CH₃, Cl,pyrimidin-2-yl, CH₃), (M-9439, Cl, CH₃, Cl, pyrimidin-4-yl, H), (M-9440,Cl, CH₃, Cl, pyrimidin-4-yl, Cl), (M-9441, Cl, CH₃, Cl, pyrimidin-4-yl,F), (M-9442, Cl, CH₃, Cl, pyrimidin-4-yl, CF₃), (M-9443, Cl, CH₃, Cl,pyrimidin-4-yl, Br), (M-9444, Cl, CH₃, Cl, pyrimidin-4-yl, CH₃),(M-9445, Cl, CH₃, Cl, pyrimidin-5-yl, H), (M-9446, Cl, CH₃, Cl,pyrimidin-5-yl, Cl), (M-9447, Cl, CH₃, Cl, pyrimidin-5-yl, F), (M-9448,Cl, CH₃, Cl, pyrimidin-5-yl, CF₃), (M-9449, Cl, CH₃, Cl, pyrimidin-5-yl,Br), (M-9450, Cl, CH₃, Cl, pyrimidin-5-yl, CH₃), (M-9451, Cl, CH₃, Cl,HOOCCH₂CH₂CH₂, H), (M-9452, Cl, CH₃, Cl, HOOCCH₂CH₂CH₂, Cl), (M-9453,Cl, CH₃, Cl, HOOCCH₂CH₂CH₂, F), (M-9454, Cl, CH₃, Cl, HOOCCH₂CH₂CH₂,CF₃), (M-9455, Cl, CH₃, Cl, HOOCCH₂CH₂CH₂, Br), (M-9456, Cl, CH₃, Cl,HOOCCH₂CH₂CH₂, CH₃), (M-9457, Cl, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, H),(M-9458, Cl, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Cl), (M-9459, Cl, CH₃, Cl,HOOCCH₂CH₂CH₂CH₂, F), (M-9460, Cl, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, CF₃),(M-9461, Cl, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Br), (M-9462, Cl, CH₃, Cl,HOOCCH₂CH₂CH₂CH₂, CH₃), (M-9463, Cl, CH₃Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, H),(M-9464, Cl, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-9465, Cl, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-9466, Cl, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,CF₃), (M-9467, Cl, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-9468, Cl, CH₃,Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-9469, Cl, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-9470, Cl, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-9471, Cl, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-9472, Cl, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-9473, Cl, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-9474, Cl, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-9475, Cl, CH₃, Cl, MeOCH₂, H),(M-9476, Cl, CH₃, Cl, MeOCH₂, Cl), (M-9477, Cl, CH₃, Cl, MeOCH₂, F),(M-9478, Cl, CH₃, Cl, MeOCH₂, CF₃), (M-9479, Cl, CH₃, Cl, MeOCH₂, Br),(M-9480, Cl, CH₃, Cl, MeOCH₂, CH₃), (M-9481, Cl, CH₃, Cl, EtOCH₂, H),(M-9482, Cl, CH₃, Cl, EtOCH₂, Cl), (M-9483, Cl, CH₃, Cl, EtOCH₂, F),(M-9484, Cl, CH₃, Cl, EtOCH₂, CF₃), (M-9485, Cl, CH₃, Cl, EtOCH₂, Br),(M-9486, Cl, CH₃, Cl, EtOCH₂, CH₃), (M-9487, Cl, CH₃, Cl, EtOCH₂CH₂, H),(M-9488, Cl, CH₃, Cl, EtOCH₂CH₂, Cl), (M-9489, Cl, CH₃, Cl, EtOCH₂CH₂,F), (M-9490, Cl, CH₃, Cl, EtOCH₂CH₂, CF₃), (M-9491, Cl, CH₃, Cl,EtOCH₂CH₂, Br), (M-9492, Cl, CH₃, Cl, EtOCH₂CH₂, CH₃), (M-9493, Cl, CH₃,Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-9494, Cl, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, Cl),(M-9495, Cl, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, F), (M-9496, Cl, CH₃, Cl,MeOCH₂CH₂OCH₂CH₂, CF₃), (M-9497, Cl, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, Br),(M-9498, Cl, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-9499, Cl, CH₃, Cl,MeOCH₂CH₂, H), (M-9500, Cl, CH₃, Cl, MeOCH₂CH₂, Cl), (M-9501, Cl, CH₃,Cl, MeOCH₂CH₂, F), (M-9502, Cl, CH₃, Cl, MeOCH₂CH₂, CF₃), (M-9503, Cl,CH₃, Cl, MeOCH₂CH₂, Br), (M-9504, Cl, CH₃, Cl, MeOCH₂CH₂, CH₃), (M-9506,Cl, CH₃, Cl, HOCH₂, H), (M-9507, Cl, CH₃, Cl, HOCH₂, C), (M-9507, Cl,CH₃, Cl, HOCH₂, F), (M-9508, Cl, CH₃, Cl, HOCH₂, CF₃), (M-9509, Cl, CH₃,Cl, HOCH₂, Br), (M-9510, Cl, CH₃, Cl, HOCH₂, CH₃), (M-9511, Cl, CH₃, Cl,HOCH₂CH₂, H), (M-9512, Cl, CH₃, Cl, HOCH₂CH₂, Cl), (M-9513, Cl, CH₃, Cl,HOCH₂CH₂, F), (M-9514, Cl, CH₃, Cl, HOCH₂CH₂, CF₃), (M-9515, Cl, CH₃,Cl, HOCH₂CH₂, Br), (M-9516, Cl, CH₃, Cl, HOCH₂CH₂, CH₃), (M-9517, Cl,CH₃, Cl, HOCH₂CH₂CH₂, H), (M-9518, Cl, CH₃, Cl, HOCH₂CH₂CH₂, Cl),(M-9519, Cl, CH₃, Cl, HOCH₂CH₂CH₂, F), (M-9520, Cl, CH₃, Cl,HOCH₂CH₂CH₂, CF₃), (M-9521, Cl, CH₃, Cl, HOCH₂CH₂CH₂, Br), (M-9522, Cl,CH₃, Cl, HOCH₂CH₂CH₂, CH₃), (M-9523, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂, H),(M-9524, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Cl), (M-9525, Cl, CH₃, Cl,HOCH₂CH₂CH₂CH₂, F), (M-9526, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂, CF₃), (M-9527,Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-9528, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂,CH₃), (M-9529, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, H), (M-9530, Cl, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, Cl (M-9531, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, F),(M-9532, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-9533, Cl, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-9534, Cl, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-9535, Cl, CH₃, Cl, HOCH₂CH₂O CH₂CH₂, H), (M-9536, Cl, CH₃, Cl,HOCH₂CH₂OCH₂CH₂, Cl), (M-9537, Cl, CH₃, Cl, HOCH₂CH₂O CH₂CH₂, F),(M-9538, Cl, CH₃, Cl, HOCH₂CH₂O CH₂CH₂, CF₃), (M-9539, Cl, CH₃Cl,HOCH₂CH₂O CH₂CH₂, Br), (M-9540, Cl, CH₃, Cl, HOCH₂CH₂O CH₂CH₂, CH₃),(M-9541, Cl, CH₃, Cl, (Me)₂N, H), (M-9542, Cl, CH, Cl, (Me)₂N, Cl),(M-9543, Cl, CH₃, Cl, (Me)₂N, F), (M-9544, Cl, CH₃, Cl, (Me)₂N, CF₃),(M-9545, Cl, CH₃, Cl, (Me)₂N, Br), (M-9546, Cl, CH₃, Cl, (Me)₂N, CH₃),(M-9547, Cl, CH₃, Cl, piperidin-4-yl-methyl, H), (M-9548, Cl, CH₃, Cl,piperidin-4-yl-methyl, Cl), (M-9549, Cl, CH₃, Cl, piperidin-4-yl-methyl,F), (M-9550, Cl, CH₃, Cl, piperidin-4-yl-methyl, CF₃), (M-9551, Cl, CH₃,Cl, piperidin-4-yl-methyl, Br), (M-9552, Cl, CH₃, Cl,piperidin-4-yl-methyl, CH₃), (M-9553, Cl, CH₃, Cl, cyclohexylmethyl, H),(M-9554, Cl, CH₃, Cl, cyclohexylmethyl, Cl), (M-9555, Cl, CH₃, Cl,cyclohexylmethyl, F), (M-9556, Cl, CH₃, Cl, cyclohexylmethyl, CF₃),(M-9557, Cl, CH₃, Cl, cyclohexylmethyl, Br), (M-9558, Cl, CH₃, Cl,cyclohexylmethyl, CH₃), (M-9559, CH₃, H, H, H, H), (M-9560, CH₃, H, H,H, Cl), (M-9561, MeO, H, H, H, F), (M-9562, MeO, H, H, H, CF₃), (M-9563,CH₃, H, H, H, Br), (M-9564, CH₃, H, H, H, CH₃), (M-9565, MeO, H, H, F,H), (M-9566, CH₃, H, H, F, Cl), (M-9567, MeO, F, H, F, F), (M-9568, CH₃,H, H, F, CF₃), (M-9569, CH₃, H, H, F, Br), (M-9570, CH₃, H, H, F, CH₃),(M-9571, CH₃, H, H, Cl, H), (M-9572, MeO, F, H, H, i-Pr), (M-9573, CH₃,H, H, Cl, F), (M-9574, CH₃, H, H, Cl, CF₃), (M-9575, CH₃, H, H, Cl, Br),(M-9576, CH₃, H, H, Cl, CH₃), (M-9577, CH₃, H, H, CH₃, H), (M-9578, CH₃,H, H, CH₃, Cl), (M-9579, CH₃, H, H, CH₃, F), (M-9580, CH₃, H, H, CH₃,CF₃), (M-9581, CH₃, H, H, CH₃, Br), (M-9582, CH₃, H, H, CH₃, CH₃),(M-9583, CH₃, H, H, Et, H), (M-9584, CH₃, H, H, Et, Cl), (M-9585, CH₃,H, H, Et, F), (M-9586, CH₃, H, H, Et, CF₃), (M-9587, CH₃, H, H, Et, Br),(M-9588, CH₃, H, H, Et, CH₃), (M-9589, CH₃, H, H, n-Pr, H), (M-9590,CH₃, H, H, n-Pr, Cl), (M-9591, CH₃, H, H, n-Pr, F), (M-9592, CH₃, H, H,n-Pr, CF₃), (M-9593, CH₃, H, H, n-Pr, Br), (M-9594, CH₃, H, H, n-Pr,CH₃), (M-9595, CH₃, H, H, c-Pr, H), (M-9596, CH₃, H, H, c-Pr, Cl),(M-9597, CH₃, H, H, c-Pr, F), (M-9598, CH₃, H, H, c-Pr, CF₃), (M-9599,CH₃, H, H, c-Pr, Br), (M-9600, CH₃, H, H, c-Pr, CH₃), (M-9601, CH₃, H,H, i-Pr, H), (M-9602, CH₃, H, H, i-Pr, Cl), (M-9603, CH₃, H, H, i-Pr,F), (M-9604, CH₃, H, H, i-Pr, CF₃), (M-9605, CH₃, H, H, i-Pr, Br),(M-9606, CH₃, H, H, i-Pr, CH₃), (M-9607, CH₃, H, H, n-Bu, H), (M-9608,CH₃, H, H, n-Bu, Cl), (M-9609, CH₃, H, H, n-Bu, F), (M-9610, CH₃, H, H,n-Bu, CF₃), (M-9611, CH₃, H, H, n-Bu, Br), (M-9612, CH₃, H, H, n-Bu,CH₃), (M-9613, CH₃, H, H, i-Bu, H), (M-9614, CH₃, H, H, i-Bu, Cl),(M-9615, CH₃, H, H, i-Bu, F), (M-9616, CH₃, H, H, i-Bu, CF₃), (M-9617,CH₃, H, H, i-Bu, Br), (M-9618, CH₃, H, H, i-Bu, CH₃), (M-9619, CH₃, H,H, sec-Bu, H), (M-9620, CH₃, H, H, sec-Bu, Cl), (M-9621, CH₃, H, H,sec-Bu, F), (M-9622, CH₃, H, H, sec-Bu, CF₃), (M-9623, CH₃, H, H,sec-Bu, Br), (M-9624, CH₃, H, H, sec-Bu, CH₃), (M-9625, CH₃, H, H,n-Pen, H), (M-9626, CH₃, H, H, n-Pen, Cl), (M-9627, CH₃, H, H, n-Pen,F), (M-9628, CH₃, H, H, n-Pen, CF₃), (M-9629, CH₃, H, H, n-Pen, Br),(M-9630, CH₃, H, H, n-Pen, CH₃), (M-9631, CH₃, H, H, c-Pen, H), (M-9632,CH₃, H, H, c-Pen, Cl), (M-9633, CH₃, H, H, c-Pen, F), (M-9634, CH₃, H,H, c-Pen, CF₃), (M-9635, CH₃, H, H, c-Pen, Br), (M-9636, CH₃, H, H,c-Pen, CH₃), (M-9637, CH₃, H, H, n-Hex, H), (M-9638, CH₃, H, H, n-Hex,Cl), (M-9639, CH₃, H, H, n-Hex, F), (M-9640, CH₃, H, H, n-Hex, CF₃),(M-9641, CH₃, H, H, n-Hex, Br), (M-9642, CH₃, H, H, n-Hex, CH₃),(M-9643, CH₃, H, H, c-Hex, H), (M-9644, CH₃, H, H, c-Hex, Cl), (M-9645,CH₃, H, H, c-Hex, F), (M-9646, CH₃, H, H, c-Hex, CF₃), (M-9647, CH₃, H,H, c-Hex, Br), (M-9648, CH₃, H, H, c-Hex, CH₃), (M-9649, CH₃, H, H, OH,H), (M-9650, CH₃, H, H, OH, Cl), (M-9651, CH₃, H, H, OH, F), (M-9652,CH₃, H, H, OH, CF₃), (M-9653, CH₃, H, H, OH, Br), (M-9654, CH₃, H, H,OH, CH₃), (M-9655, CH₃, H, H, EtO, H), (M-9656, CH₃, H, H, EtO, Cl),(M-9657, CH₃, H, H, EtO, F), (M-9658, CH₃, H, H, EtO, CF₃), (M-9659,CH₃, H, H, EtO, Br), (M-9660, CH₃, H, H, EtO, CH₃), (M-9661, CH₃, H, H,n-PrO, H), (M-9662, CH₃, H, H, n-PrO, Cl), (M-9663, CH₃, H, H, n-PrO,F), (M-9664, CH₃, H, H, n-PrO, CF₃), (M-9665, CH₃, H, H, n-PrO, Br),(M-9666, CH₃, H, H, n-PrO, CH₃), (M-9667, CH₃, H, H, PhO, H), (M-9668,CH₃, H, H, PhO, Cl), (M-9669, CH₃, H, H, PhO, F), (M-9670, CH₃, H, H,PhO, CF₃), (M-9671, CH₃, H, H, PhO, Br), (M-9672, CH₃, H, H, PhO, CH₃),(M-9673, CH₃, H, H, BnO, H), (M-9674, CH₃, H, H, BnO, Cl), (M-9675, CH₃,H, H, BnO, F), (M-9676, CH₃, H, H, BnO, CF₃), (M-9677, CH₃, H, H, BnO,Br), (M-9678, CH₃, H, H, BnO, CH₃), (M-9679, CH₃, H, H, PhCH₂CH₂O, H),(M-9680, CH₃, H, H, PhCH₂CH₂O, Cl), (M-9681, CH₃, H, H, PhCH₂CH₂O, F),(M-9682, CH₃, H, H, PhCH₂CH₂O, CF₃), (M-9683, CH₃, H, H, PhCH₂CH₂O, Br),(M-9684, CH₃, H, H, PhCH₂CH₂O, CH₃), (M-9685, MeO, H, H, CF₃O, H),(M-9686, CH₃, H, H, CF₃O, Cl), (M-9687, CH₃, H, H, CF₃O, F), (M-9688,CH₃, H, H, CF₃O, CF₃), (M-9689, CH₃, H, H, CF₃O, Br), (M-9690, CH₃, H,H, CF₃O, CH₃), (M-9691, CH₃, H, H, Ph, H), (M-9692, CH₃, H, H, Ph, Cl),(M-9693, CH₃, H, H, Ph, F), (M-9694, CH₃, H, H, Ph, CF₃), (M-9695, CH₃,H, H, Ph, Br), (M-9696, CH₃, H, H, Ph, CH₃), (M-9697, CH₃, H, H, 4-F-Ph,H), (M-9698, CH₃, H, H, 4-F-Ph, Cl), (M-9699, CH₃, H, H, 4-F-Ph, F),(M-9700, CH₃, H, H, 4-F-Ph, CF₃), (M-9701, CH₃, H, H, 4-F-Ph, Br),(M-9702, CH₃, H, H, 4-F-Ph, CH₃), (M-9703, CH₃, H, H, 4-CF₃-Ph, H),(M-9704, CH₃, H, H, 4-CF₃-Ph, Cl), (M-9705, CH₃, H, H, 4-CF₃-Ph, F),(M-9706, CH₃, H, H, 4-CF₃-Ph, CF₃), (M-9707, CH₃, H, H, 4-CF₃-Ph, Br),(M-9708, CH₃, H, H, 4-CF,₃-Ph, CH₃), (M-9709, CH₃, H, H, 4-(Me)₂N-Ph,H), (M-9710, CH₃, H, H, 4-(Me)₂N-Ph, Cl), (M-9711, CH₃, H, H,4-(Me)₂N-Ph, F), (M-9712, CH₃, H, H, 4-(Me)₂N-Ph, CF₃), (M-9713, CH₃, H,H, 4-(Me)₂N-Ph, Br), (M-9714, CH₃, H, H, 4-(Me)₂N-Ph, CH₃), (M-9715,CH₃, H, H, 4-OH-Ph, H), (M-9716, CH₃, H, H, 4-OH-Ph, Cl), (M-9717, CH₃,H, H, 4-OH-Ph, F), (M-9718, CH₃, H, H, 4-OH-Ph, CF₃), (M-9719, CH₃, H,H, 4-OH-Ph, Br), (M-9720, CH₃, H, H, 4-OH-Ph, CH₃), (M-9721, CH₃, H, H,3,4-di-F-Ph, H), (M-9722, CH₃, H, H, 3,4-di-F-Ph, Cl), (M-9723, CH₃, H,H, 3,4-di-F-Ph, F), (M-9724, CH₃, H, H, 3,4-di-F-Ph, CF₃), (M-9725, CH₃,H, H, 3,4-di-F-Ph, Br), (M-9726, CH₃, H, H, 3,4-di-F-Ph, CH₃), (M-9727,CH₃, H, H, 4-COOH-Ph, H), (M-9728, CH₃, H, H, 4-COOH-Ph, Cl), (M-9729,CH₃, H, H, 4-COOH-Ph, F), (M-9730, CH₃, H, H, 4-COOH-Ph, CF₃), (M-9731,CH₃, H, H, 4-COOH-Ph, Br), (M-9732, CH₃, H, H, 4-COOH-Ph, CH₃), (M-9733,CH₃, H, H, Bn, H), (M-9734, CH₃, H, H, Bn, Cl), (M-9735, CH₃, H, H, Bn,F), (M-9736, CH₃, H, H, Bn, CF₃), (M-9737, CH₃, H, H, Bn, Br), (M-9738,CH₃, H, H, Bn, CH₃), (M-9739, CH₃, H, H, 4-F-Bn, H), (M-9740, CH₃, H, H,4-F-Bn, Cl), (M-9741, CH₃, H, H, 4-F-Bn, F), (M-9742, CH₃, H, H, 4-F-Bn,CF₃), (M-9743, CH₃, H, H, 4-F-Bn, Br), (M-9744, CH₃, H, H, 4-F-Bn, CH₃),(M-9745, CH₃, H, H, 2-Py, H), (M-9746, CH₃, H, H, 2-Py, Cl), (M-9747,CH₃, H, H, 2-Py, F), (M-9748, CH₃, H, H, 2-Py, CF₃), (M-9749, CH₃, H, H,2-Py, Br), (M-9750, CH₃, H, H, 2-Py, CH₃), (M-9751, CH₃, H, H, 3-Py, H),(M-9752, CH₃, H, H, 3-Py, Cl), (M-9753, CH₃, H, H, 3-Py, F), (M-9754,CH₃, H, H, 3-Py, CF₃), (M-9755, CH₃, H, H, 3-Py, Br), (M-9756, CH₃, H,H, 3-Py, CH₃), (M-9757, CH₃, H, H, 4-Py, H), (M-9758, CH₃, H, H, 4-Py,Cl), (M-9759, CH₃, H, H, 4-Py, F), (M-9760, CH₃, H, H, 4-Py, CF₃),(M-9761, CH₃, H, H, 4-Py, Br), (M-9762, CH₃, H, H, 4-Py, CH₃), (M-9763,CH₃, H, H, 2-Th, H), (M-9764, CH₃, H, H, 2-Th, Cl), (M-9765, CH₃, H, H,2-Th, F), (M-9766, CH₃, H, H, 2-Th, CF₃), (M-9767, CH₃, H, H, 2-Th, Br),(M-9768, CH₃, H, H, 2-Th, CH₃), (M-9769, CH₃, H, H, 3-Th, H), (M-9770,CH₃, H, H, 3-Th, Cl), (M9771, CH₃, H, H, 3-Th, F), (M-9772, CH₃, H, H,3-Th, CF₃), (M-9773, CH₃, H, H, 3-Th, Br), (M-9774, CH₃, H, H, 3-Th,CH₃), (M-9775, CH₃, H, H, pyrrazol-2-yl, H), (M-9776, CH₃, H, H,pyrrazol-2-yl, Cl), (M-9777, CH₃, H, H, pyrrazol-2-yl, F), (M-9778, CH₃,H, H, pyrrazol-2-yl, CF₃), (M-9779, CH₃, H, H, pyrrazol-2-yl, Br),(M-9780, CH₃, H, H, pyrrazol-2-yl, CH₃), (M-9781, CH₃, H, H,pyrrazol-3-yl, H), (M-9782, CH₃, H, H, pyrrazol-3-yl, Cl), (M-9783, CH₃,H, H, pyrrazol-3-yl, F), (M-9784, CH₃, H, H, pyrrazol-3-yl, CF₃),(M-9785, CH₃, H, H, pyrrazol-3-yl, Br), (M-9786, CH₃, H, H,pyrrazol-3-yl, CH₃), (M-9787, CH₃, H, H, pyrimidin-2-yl, H), (M-9788,CH₃, H, H, pyrimidin-2-yl, Cl), (M-9789, CH₃, H, H, pyrimidin-2-yl, F),(M-9790, CH₃, H, H, pyrimidin-2-yl, CF₃), (M-9791, CH₃, H, H,pyrimidin-2-yl, Br), (M-9792, CH₃, H, H, pyrimidin-2-yl, CH₃), (M-9793,CH₃, H, H, pyrimidin-4-yl, H), (M-9794, CH₃, H, H, pyrimidin-4-yl, Cl),(M-9795, CH₃, H, H, pyrimidin-4-yl, F), (M-9796, CH₃, H, H,pyrimidin-4-yl, CF₃), (M-9797, CH₃, H, H, pyrimidin-4-yl, Br), (M-9798,CH₃, H, H, pyrimidin-4-yl, CH₃), (M-9799, CH₃, H, H, pyrimidin-5-yl, H),(M-9800, CH₃, H, H, pyrimidin-5-yl, Cl), (M-9801, CH₃, H, H,pyrimidin-5-yl, F), (M-9802, CH₃, H, H, pyrimidin-5-yl, CF₃), (M-9803,CH₃, H, H, pyrimidin-5-yl, Br), (M-9804, CH₃, H, H, pyrimidin-5-yl,CH₃), (M-9805, CH₃, H, H, HOOCCH₂CH₂CH₂, H), (M-9806, CH₃, H, H,HOOCCH₂CH₂CH₂, Cl), (M-9807, CH₃, H, H, HOOCCH₂CH₂CH₂, F), (M-9808, CH₃,H, H, HOOCCH₂CH₂CH₂, CF₃), (M-9809, CH₃, H, H, HOOCCH₂CH₂CH₂, Br),(M-9810, CH₃, H, H, HOOCCH₂CH₂CH₂, CH₃), (M-9811, CH₃, H, H,HOOCCH₂CH₂CH₂CH₂, H), (M-9812, CH₃, H, H, HOOCCH₂CH₂CH₂CH₂, Cl),(M-9813, CH₃, H, H, HOOCCH₂CH₂CH₂CH₂, F), (M-9814, CH₃, H, H,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-9815, CH₃, H, H, HOOCCH₂CH₂CH₂CH₂, Br),(M-9816, CH₃, H, H, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-9817, CH₃H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-9818, CH₃, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl),(M-9819, CH₃, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-9820, CH₃, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-9821, CH₃, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-9822, CH₃, H, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-9823, CH₃, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-9824, CH₃, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-9825, CH₃, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-9826, CH₃, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-9827, CH₃, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-9828, CH₃, H, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-9829, CH₃, H, H, MeOCH₂, H), (M-9830,CH₃, H, H, MeOCH₂, Cl), (M-9831, CH₃, H, H, MeOCH₂, F), (M-9832, CH₃, H,H, MeOCH₂, CF₃), (M-9833, CH₃, H, H, MeOCH₂, Br), (M-9834, CH₃, H, H,MeOCH₂, CH₃), (M-9835, CH₃, H, H, EtOCH₂, H), (M-9836, CH₃, H, H,EtOCH₂, Cl), (M-9837, CH₃, H, H, EtOCH₂, F), (M-9838, CH₃, H, H, EtOCH₂,CF₃), (M-9839, CH₃, H, H, EtOCH₂, Br), (M-9840, CH₃, H, H, EtOCH₂, CH₃),(M-9841, CH₃, H, H, EtOCH₂CH₂, H), (M-9842, CH₃, H, H, EtOCH₂CH₂, Cl),(M-9843, CH₃, H, H, EtOCH₂CH₂, F), (M-9844, CH₃, H, H, EtOCH₂CH₂, CF₃),(M-9845, CH₃, H, H, EtOCH₂CH₂, Br), (M-9846, CH₃, H, H, EtOCH₂CH₂, CH₃),(M-9847, CH₃, H, H, MeOCH₂CH₂OCH₂CH₂, H), (M-9848, CH₃, H, H,MeOCH₂CH₂OCH₂CH₂, Cl), (M-9849, CH₃, H, H, MeOCH₂CH₂OCH₂CH₂, F),(M-9850, CH₃, H, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-9851, CH₃, H, H,MeOCH₂CH₂OCH₂CH₂, Br), (M-9852, CH₃, H, H, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-9853, CH₃, H, H, MeOCH₂CH₂, H), (M-9854, CH₃, H, H, MeOCH₂CH₂, Cl),(M-9855, CH₃, H, H, MeOCH₂CH₂, F), (M-9856, CH₃, H, H, MeOCH₂CH₂, CF₃),(M-9857, CH₃, H, H, MeOCH₂CH₂, Br), (M-9858, CH₃, H, H, MeOCH₂CH₂, CH₃),(M-9859, CH₃, H, H, HOCH₂, H), (M-9860, CH₃, H, H, HOCH₂, Cl), (M-9861,CH₃, H, H, HOCH₂, F), (M-9862, CH₃, H, H, HOCH₂, CF₃), (M-9863, CH₃, H,H, HOCH₂, Br), (M-9864, CH₃, H, H, HOCH₂, CH₃), (M-9865, CH₃, H, H,HOCH₂CH₂, H), (M-9866, CH₃, H, H, HOCH₂CH₂, Cl), (M-9867, CH₃, H, H,HOCH₂CH₂, F), (M-9868, CH₃, H, H, HOCH₂CH₂, CF₃), (M-9869, CH₃, H, H,HOCH₂CH₂, Br), (M-9870, CH₃, H, H, HOCH₂CH₂, CH₃), (M-9871, CH₃, H, H,HOCH₂CH₂CH₂, H), (M-9872, CH₃, H, H, HOCH₂CH₂CH₂, Cl), (M-9873, CH₃, H,H, HOCH₂CH₂CH₂, F), (M-9874, CH₃, H, H, HOCH₂CH₂CH₂, CF₃), (M-9875, CH₃,H, H, HOCH₂CH₂CH₂, Br), (M-9876, CH₃, H, H, HOCH₂CH₂CH₂, CH₃), (M-9877,CH₃, H, H, HOCH₂CH₂CH₂CH₂, H), (M-9878, CH₃, H, H, HOCH₂CH₂CH₂CH₂, Cl),(M-9879, CH₃, H, H, HOCH₂CH₂CH₂CH₂, F), (M-9880, CH₃H, H,HOCH₂CH₂CH₂CH₂, CF₃), (M-9881, CH₃H, H, HOCH₂CH₂CH₂CH₂Br), (M-9882, CH₃,H, H, HOCH₂CH₂CH₂CH₂, CH₃), (M-9883, CH₃, H, H, HOCH₂CH₂CH₂CH₂CH₂, H),(M-9884, CH₃H, H, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-9885, CH₃, H, H,HOCH₂CH₂CH₂CH₂CH₂, F), (M-9886, CH₃, H, H, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-9887, CH₃H, H, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-9888, CH₃, H, H,HOCH₂CH₂CH₂CH₂CH_(2,)CH₃), (M-9889, CH₃, H, H, HOCH₂CH₂O CH₂CH₂, H),(M-9890, CH₃, H, H, HOCH₂CH₂OCH₂CH₂, Cl), (M-9891, CH₃, H, H,HOCH₂CH₂OCH₂CH₂, F), (M-9892, CH₃, H, H, HOCH₂CH₂O CH₂CH₂, CF₃),(M-9893, CH₃, H, H, HOCH₂CH₂OCH₂CH₂, Br), (M-9894, CH₃, H, H,HOCH₂CH₂OCH₂CH₂, CH₃), (M-9895, CH₃, H, H, (Me)₂N, H), (M-9896, CH₃, H,H, (Me)₂N, Cl), (M-9897, CH₃, H, H, (Me)₂N, F), (M-9898, CH₃, H, H,(Me)₂N, CF₃), (M-9899, CH₃, H, H, (Me)₂N, Br), (M-9900, CH₃, H, H,(Me)₂N, CH₃), (M-9901, CH₃, H, H, piperidin-4-yl-methyl, H), (M-9902,CH₃, H, H, piperidin-4-yl-methyl, Cl), (M-9903, CH₃, H, H,piperidin-4-yl-methyl, F), (M-9904, CH₃, H, H, piperidin-4-yl-methyl,CF₃), (M-9905, CH₃, H, H, piperidin-4-yl-methyl, Br), (M-9906, CH₃, H,H, piperidin-4-yl-methyl, CH₃), (M-9907, CH₃, H, H, cyclohexylmethyl,H), (M-9908, CH₃, H, H, cyclohexylmethyl, Cl), (M-9909, CH₃, H, H,cyclohexylmethyl, F), (M-9910, CH₃, H, H, cyclohexylmethyl, CF₃),(M-9911, CH₃, H, H, cyclohexylmethyl, Br), (M-9912, CH₃, H, H,cyclohexylmethyl, CH₃), (M-9913, CH₃, H, F, H, H), (M-9914, CH₃, H, F,H, Cl), (M-9915, CH₃, H, F, H, F), (M-9916, CH₃, H, F, H, CF₃), (M-9917,CH₃, H, F, H, Br), (M-9918, CH₃, H, F, H, CH₃), (M-9919, CH₃, H, F, F,H), (M-9920, CH₃, H, F, F, Cl), (M-9921, CH₃, H, F, F, F), (M-9922, CH₃,H, F, F, CF₃), (M-9923, CH₃, H, F, F, Br), (M-9924, CH₃, H, F, F, CH₃),(M-9925, CH₃, H, F, Cl, H), (M-9926, CH₃, H, F, Cl, Cl), (M-9927, CH₃,H, F, Cl, F), (M-9928, CH₃, H, F, Cl, CF₃), (M-9929, CH₃, H, F, Cl, Br),(M-9930, CH₃, H, F, Cl, CH₃), (M-9931, CH₃, H, F, CH₃, H), (M-9932, CH₃,H, F, CH₃, Cl), (M-9933, CH₃, H, F, CH₃, F), (M-9934, CH₃, H, F, CH₃,CF₃), (M-9935, CH₃, H, F, CH₃, Br), (M-9936, CH₃, H, F, CH₃, CH₃),(M-9937, CH₃H, F, Et, H), (M-9938, CH₃, H, F, Et, Cl), (M-9939, CH₃, H,F, Et, F), (M-9940, CH₃, H, F, Et, CF₃), (M-9941, CH₃, H, F, Et, Br),(M-9942, CH₃, H, F, Et, CH₃), (M-9943, CH₃, H, F, n-Pr, H), (M-9944,CH₃, H, F, n-Pr, Cl), (M-9945, CH₃, H, F, n-Pr, F), (M-9946, CH₃, H, F,n-Pr, CF₃), (M-9947, CH₃, H, F, n-Pr, Br), (M-9948, CH₃, H, F, n-Pr,CH₃), (M-9949, CH₃, H, F, c-Pr, H), (M-9950, CH₃, H, F, c-Pr, Cl),(M-9951, CH₃, H, F, c-Pr, F), (M-9952, CH₃, H, F, c-Pr, CF₃), (M-9953,CH₃, H, F, c-Pr, Br), (M-9954, CH₃, H, F, c-Pr, CH₃), (M-9955, CH₃, H,F, i-Pr, H), (M-9956, CH₃, H, F, i-Pr, Cl), (M-9957, CH₃, H, F, i-Pr,F), (M-9958, CH₃, H, F, i-Pr, CF₃), (M-9959, CH₃, H, F, i-Pr, Br),(M-9960, CH₃, H, F, i-Pr, CH₃), (M-9961, CH₃, H, F, n-Bu, H), (M-9962,CH₃, H, F, n-Bu, Cl), (M-9963, CH₃, H, F, n-Bu, F), (M-9964, CH₃, H, F,n-Bu, CF₃), (M-9965, CH₃, H, F, n-Bu, Br), (M-9966, CH₃, H, F, n-Bu,CH₃), (M-9967, CH₃, H, F, i-Bu, H), (M-9968, CH₃, H, F, i-Bu, Cl),(M-9969, CH₃, H, F, i-Bu, F), (M-9970, CH₃, H, F, i-Bu, CF₃), (M-9971,CH₃, H, F, i-Bu, Br), (M-9972, CH₃, H, F, i-Bu, CH₃), (M-9973, CH₃, H,F, sec-Bu, H), (M-9974, CH₃, H, F, i-Bu, CH₃), (M-9973, CH₃H, F, sec-Bu,H), (M-9974, CH₃, H, F, sec-Bu, Cl), (M-9975, CH₃, H, F, sec-Bu, F),(M-9976, CH₃, H, F, sec-Bu, CF₃), (M-9977, CH₃, H, F, sec-Bu, Br),(M-9978, CH₃, H, F, sec-Bu, CH₃), (M-9979, CH₃, H, F, n-Pen, H),(M-9980, CH₃, H, F, n-Pen, Cl), (M-9981, CH₃, H, F, n-Pen, F), (M-9982,CH₃, H, F, n-Pen, CF₃), (M-9983, CH₃, H, F, n-Pen, Br), (M-9984, CH₃, H,F, n-Pen, CH₃), (M-9985, CH₃, H, F, c-Pen, H), (M-9986, CH₃, H, F,c-Pen, Cl), (M-9987, CH₃, H, F, c-Pen, F), (M-9988, CH₃, H, F, c-Pen,CF₃), (M-9989, CH₃, H, F, c-Pen, Br), (M-9990, CH₃, H, F, c-Pen, CH₃),(M-9991, CH₃, H, F, n-Hex, H), (M-9992, CH₃, H, F, n-Hex, Cl), (M-9993,CH₃, H, F, n-Hex, F), (M-9994, CH₃, H, F, n-Hex, CF₃), (M-9995, CH₃, H,F, n-Hex, Br), (M-9996, CH₃, H, F, n-Hex, CH₃), (M-9997, CH₃, H, F,c-Hex, H), (M-9998, CH₃, H, F, c-Hex, Cl), (M-9999, CH₃, H, F, c-Hex,F), (M-10000, CH₃, H, F, c-Hex, CF₃), (M-10001, CH₃, H, F, c-Hex, Br),(M-10002, CH₃, H, F, c-Hex, CH₃), (M-10003, CH₃, H, F, OH, H), (M-10004,CH₃, H, F, OH, Cl), (M-10005, CH₃, H, F, OH, F), (M-10006, CH₃, H, F,OH, CF₃), (M-10007, CH₃, H, F, OH, Br), (M-10008, CH₃, H, F, OH, CH₃),(M-10009, CH₃, H, F, EtO, H), (M-10010, CH₃, H, F, EtO, Cl), (M-10011,CH₃, H, F, EtO, F), (M-10012, CH₃, H, F, EtO, CF₃), (M-10013, CH₃, H, F,EtO, Br), (M-10014, CH₃, H, F, EtO, CH₃), (M-10015, CH₃, H, F, n-PrO,H), (M-10016, CH₃, H, F, n-PrO, Cl), (M-10017, CH₃, H, F, n-PrO, F),(M-10018, CH₃, H, F, n-PrO, CF₃), (M-10019, CH₃, H, F, n-PrO, Br),(M-10020, CH₃, H, F, n-PrO, CH₃), (M-10021, CH₃, H, F, PhO, H),(M-10022, CH₃, H, F, PhO, Cl), (M-10023, CH₃, H, F, PhO, F), (M-10024,CH₃, H, F, PhO, CF₃), (M-10025, CH₃, H, F, PhO, Br), (M-10026, CH₃, H,F, PhO, CH₃), (M-10027, CH₃, H, F, BnO, H), (M-10028, CH₃, H, F, BnO,Cl), (M-10029, CH₃, H, F, BnO, F), (M-10030, CH₃, H, F, BnO, CF₃),(M-10031, CH₃, H, F, BnO, Br), (M-10032, CH₃, H, F, BnO, CH₃), (M-10033,CH₃, H, F, PhCH₂CH₂O, H), (M-10034, CH₃, H, F, PhCH₂CH₂O, Cl), (M-10035,CH₃, H, F, PhCH₂CH₂O, F), (M-10036, CH₃, H, F, PhCH₂CH₂O, CF₃),(M-10037, CH₃, H, F, PhCH₂CH₂O, Br), (M-10038, CH₃, H, F, PhCH₂CH₂O,CH₃), (M-10039, CH₃, H, F, CF₃O, H), (M-10040, CH₃, H, F, CF₃O, Cl),(M-10041, CH₃, H, F, CF₃O, F), (M-10042, CH₃, H, F, CF₃O, CF₃),(M-10043, CH₃, H, F, CF₃O, Br), (M-10044, CH₃, H, F, CF₃O, CH₃),(M-10045, CH₃, H, F, Ph, H), (M-10046, CH₃, H, F, Ph, Cl), (M-10047,CH₃, H, F, Ph, F), (M-10048, CH₃, H, F, Ph, CF₃), (M-10049, CH₃, H, F,Ph, Br), (M-10050, CH₃, H, F, Ph, CH₃), (M-10051, CH₃, H, F, 4-F-Ph, H),(M-10052, CH₃, H, F, 4-F-Ph, Cl), (M-10053, CH₃, H, F, 4-F-Ph, F),(M-10054, CH₃, H, F, 4-F-Ph, CF₃), (M-10055, CH₃, H, F, 4-F-Ph, Br),(M-10056, CH₃, H, F, 4-F-Ph, CH₃), (M-10057, CH₃, H, F, 4-CF₃-Ph, H),(M-10058, CH₃, H, F, 4-CF₃-Ph, Cl), (M-10059, CH₃, H, F, 4-CF₃-Ph, F),(M-10060, CH₃, H, F, 4-CF₃-Ph, CF₃), (M-10061, CH₃, H, F, 4-CF₃-Ph, Br),(M-10062, CH₃, H, F, 4-CF₃-Ph, CH₃), (M-10063, CH₃, H, F, 4-(Me)₂N-Ph,H), (M-10064, CH₃, H, F, 4-(Me)₂N-Ph, Cl), (M-10065, CH₃, H, F,4-(Me)₂N-Ph, F), (M-10066, CH₃, H, F, 4-(Me)₂N-Ph, CF₃), (M-10067, CH₃,H, F, 4-(Me)₂N-Ph, Br), (M-10068, CH₃, H, F, 4-(Me)₂N-Ph, CH₃),(M-10069, CH₃, H, F, 4-OH-Ph, H), (M-10070, CH₃, H, F, 4-OH-Ph, Cl),(M-10071, CH₃, H, F, 4-OH-Ph, F), (M-10072, CH₃, H, F, 4-OH-Ph, CF₃),(M-10073, CH₃, H, F, 4-OH-Ph, Br), (M-10074, CH₃, H, F, 4-OH-Ph, CH₃),(M-10075, CH₃, H, F, 3,4-di-F-Ph, H), (M-10076, CH₃, H, F, 3,4-di-F-Ph,Cl), (M-10077, CH₃, H, F, 3,4-di-F-Ph, F), (M-10078, CH₃, H, F,3,4-di-F-Ph, CF₃), (M-10079, CH₃, H, F, 3,4-di-F-Ph, Br), (M-10080, CH₃,H, F, 3,4-di-F-Ph, CH₃), (M-10081, CH₃, H, F, 4-COOH-Ph, H), (M-10082,CH₃, H, F, 4-COOH-Ph, Cl), (M-10083, CH₃, H, F, 4-COOH-Ph, F), (M-10084,CH₃, H, F, 4-COOH-Ph, CF₃), (M-10085, CH₃, H, F, 4-COOH-Ph, Br),(M-10086, CH₃, H, F, 4-COOH-Ph, CH₃), (M-10087, CH₃, H, F, Bn, H),(M-10088, CH₃, H, F, Bn, Cl), (M-10089, CH₃, H, F, Bn, F), (M-10090,CH₃, H, F, Bn, CF₃), (M-10091, CH₃, H, F, Bn, Br), (M-10092, CH₃, H, F,Bn, CH₃), (M-10093, CH₃, H, F, 4-F-Bn, H), (M-10094, CH₃, H, F, 4-F-Bn,Cl), (M-10095, CH₃, H, F, 4-F-Bn, F), (M-10096, CH₃, H, F, 4-F-Bn, CF₃),(M-10097, CH₃, H, F, 4-F-Bn, Br), (M-10098, CH₃, H, F, 4-F-Bn, CH₃),(M-10099, CH₃, H, F, 2-Py, H), (M-10100, CH₃, H, F, 2-Py, Cl), (M-10101,CH₃, H, F, 2-Py, F), (M-10102, CH₃, H, F, 2-Py, CF₃), (M-10103, CH₃, H,F, 2-Py, Br), (M-10104, CH₃, H, F, 2-Py, CH₃), (M-10105, CH₃, H, F,3-Py, H), (M-10106, CH₃, H, F, 3-Py, Cl), (M-10107, CH₃, H, F, 3-Py, F),(M-10108, CH₃, H, F, 3-Py, CF₃), (M-10109, CH₃, H, F, 3-Py, Br),(M-10110, CH₃, H, F, 3-Py, CH₃), (M-10111, CH₃, H, F, 4-Py, H),(M-10112, CH₃, H, F, 4-Py, Cl), (M-10113, CH₃, H, F, 4-Py, F), (M-10114,CH₃, H, F, 4-Py, CF₃), (M-10115, CH₃, H, F, 4-Py, Br), (M-10116, CH₃, H,F, 4-Py, CH₃), (M-10117, CH₃, H, F, 2-Th, H), (M-10118, CH₃, H, F, 2-Th,Cl), (M-10119, CH₃, H, F, 2-Th, F), (M-10120, CH₃, H, F, 2-Th, CF₃),(M-10121, CH₃, H, F, 2-Th, Br), (M-10122, CH₃, H, F, 2-Th, CH₃),(M-10123, CH₃, H, F, 3-Th, H), (M-10124, CH₃, H, F, 3-Th, Cl), (M-10125,CH₃, H, F, 3-Th, F), (M-10126, CH₃, H, F, 3-Th, CF₃), (M-10127, CH₃, H,F, 3-Th, Br), (M-10128, CH₃, H, F, 3-Th, CH₃), (M-10129, CH₃, H, F,pyrrazol-2-yl, H), (M-10130, CH₃, H, F, pyrrazol-2-yl, Cl), (M-10131,CH₃, H, F, pyrrazol-2-yl, F), (M-10132, CH₃, H, F, pyrrazol-2-yl, CF₃),(M-10133, CH₃, H, F, pyrrazol-2-yl, Br), (M-10134, CH₃, H, F,pyrrazol-2-yl, CH₃), (M-10135, CH₃, H, F, pyrrazol-3-yl, H), (M-10136,CH₃, H, F, pyrrazol-3-yl, Cl), (M-10137, CH₃, H, F, pyrrazol-3-yl, F),(M-10138, CH₃, H, F, pyrrazol-3-yl, CF₃), (M-10139, CH₃, H, F,pyrrazol-3-yl, Br), (M-10140, CH₃, H, F, pyrrazol-3-yl, CH₃), (M-10141,CH₃, H, F, pyrimidin-2-yl, H), (M-10142, CH₃, H, F, pyrimidin-2-yl, Cl),(M-10143, CH₃, H, F, pyrimidin-2-yl, F), (M-10144, CH₃, H, F,pyrimidin-2-yl, CF₃), (M-10145, CH₃, H, F, pyrimidin-2-yl, Br),(M-10146, CH₃, H, F, pyrimidin-2-yl, CH₃), (M-10147, CH₃, H, F,pyrimidin-4-yl, H), (M-10148, CH₃, H, F, pyrimidin-4-yl, Cl), (M-10149,CH₃, H, F, pyrimidin-4-yl, F), (M-10150, CH₃, H, F, pyrimidin-4-yl,CF₃), (M-10151, CH₃, H, F, pyrimidin-4-yl, Br), (M-10152, CH₃, H, F,pyrimidin-4-yl, CH₃), (M-10153, CH₃, H, F, pyrimidin-5-yl, H), (M-10154,CH₃, H, F, pyrimidin-5-yl, Cl), (M-10155, CH₃, H, F, pyrimidin-5-yl, F),(M-10156, CH₃, H, F, pyrimidin-5-yl, CF₃), (M-10157, CH₃, H, F,pyrimidin-5-yl, Br), (M-10158, CH₃, H, F, pyrimidin-5-yl, CH₃),(M-10159, CH₃, H, F, HOOCCH₂CH₂CH₂, H), (M-10160, CH₃, H, F,HOOCCH₂CH₂CH₂, Cl), (M-10161, CH₃, H, F, HOOCCH₂CH₂CH₂, F), (M-10162,CH₃, H, F, HOOCCH₂CH₂CH₂, CF₃), (M-10163, CH₃, H, F, HOOCCH₂CH₂CH₂, Br),(M-10164, CH₃, H, F, HOOCCH₂CH₂CH₂, CH₃), (M-10165, CH₃, H, F,HOOCCH₂CH₂CH₂CH₂, H), (M-10166, CH₃, H, F, HOOCCH₂CH₂CH₂CH₂, Cl),(M-10167, CH₃, H, F, HOOCCH₂CH₂CH₂CH₂, F), (M-10168, CH₃, H, F,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-10169, CH₃, H, F, HOOCCH₂CH₂CH₂CH₂, Br),(M-10170, CH₃, H, F, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-10171, CH₃, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-10172, CH₃, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂,Cl), (M-10173, CH₃, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-10174, CH₃, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-10175, CH₃, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-10176, CH₃, H, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-10177, CH₃, H,F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-10178, CH₃, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-10179, CH₃, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-10180, CH₃, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-10181, CH₃, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-10182, CH₃, H, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-10183, CH₃, H, F, MeOCH₂, H),(M-10184, CH₃, H, F, MeOCH₂, Cl), (M-10185, CH₃, H, F, MeOCH₂, F),(M-10186, CH₃, H, F, MeOCH₂, CF₃), (M-10187, CH₃, H, F, MeOCH₂, Br),(M-10188, CH₃, H, F, MeOCH₂, CH₃), (M-10189, CH₃, H, F, EtOCH₂, H),(M-10190, CH₃, H, F, EtOCH₂, Cl), (M-10191, CH₃, H, F, EtOCH₂, F),(M-10192, CH₃, H, F, EtOCH₂, CF₃), (M-10193, CH₃, H, F, EtOCH₂, Br),(M-10194, CH₃, H, F, EtOCH₂, CH₃), (M-10195, CH₃, H, F, EtOCH₂CH₂, H),(M-10196, CH₃, H, F, EtOCH₂CH₂, Cl), (M-10197, CH₃, H, F, EtOCH₂CH₂, F),(M-10198, CH₃, H, F, EtOCH₂CH₂, CF₃), (M-10199, CH₃, H, F, EtOCH₂CH₂,Br), (M-10200, CH₃, H, F, EtOCH₂CH₂, CH₃), (M-10201, CH₃, H, F,MeOCH₂CH₂OCH₂CH₂, H), (M-10202, CH₃, H, F, MeOCH₂CH₂OCH₂CH₂, Cl),(M-10203, CH₃, H, F, MeOCH₂CH₂OCH₂CH₂, F), (M-10204, CH₃, H, F,MeOCH₂CH₂OCH₂CH₂, CF₃), (M-10205, CH₃, H, F, MeOCH₂CH₂OCH₂CH₂, Br),(M-10206, CH₃, H, F, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-10207, CH₃, H, F,MeOCH₂CH₂, H), (M-10208, CH₃, H, F, MeOCH₂CH₂, Cl), (M-10209, CH₃, H, F,MeOCH₂CH₂, F), (M-10210, CH₃, H, F, MeOCH₂CH₂, CF₃), (M-10211, CH₃, H,F, MeOCH₂CH₂, Br), (M-10212, CH₃, H, F, MeOCH₂CH₂, CH₃), (M-10213, CH₃,H, F, HOCH₂, H), (M-10214, CH₃, H, F, HOCH₂, Cl), (M-10215, CH₃, H, F,HOCH₂, F), (M-10216, CH₃, H, F, HOCH₂, CF₃), (M-10217, CH₃, H, F, HOCH₂,Br), (M-10218, CH₃, H, F, HOCH₂, CH₃), (M-10219, CH₃, H, F, HOCH₂CH₂,H), (M-10220, CH₃, H, F, HOCH₂CH₂, Cl), (M-10221, CH₃, H, F, HOCH₂CH₂,F), (M-10222, CH₃, H, F, HOCH₂CH₂, CF₃), (M-10223, CH₃, H, F, HOCH₂CH₂,Br), (M-10224, CH₃, H, F, HOCH₂CH₂, CH₃), (M-10225, CH₃, H, F,HOCH₂CH₂CH₂, H), (M-10226, CH₃, H, F, HOCH₂CH₂CH₂, Cl), (M-10227, CH₃,H, F, HOCH₂CH₂CH₂, F), (M-10228, CH₃, H, F, HOCH₂CH₂CH₂, CF₃), (M-10229,CH₃, H, F, HOCH₂CH₂CH₂, Br), (M-10230, CH₃, H, F, HOCH₂CH₂CH₂, CH₃),(M-10231, CH₃, H, F, HOCH₂CH₂CH₂CH₂, H), (M-10232, CH₃, H, F,HOCH₂CH₂CH₂CH₂, Cl), (M-10233, CH₃, H, F, HOCH₂CH₂CH₂CH₂, F), (M-10234,CH₃, H, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-10235, CH₃, H, F, HOCH₂CH₂CH₂CH₂,Br), (M-10236, CH₃, H, F, HOCH₂CH₂CH₂CH₂, CH₃), (M-10237, CH₃, H, F,HOCH₂CH₂CH₂CH₂CH₂, H), (M-10238, CH₃H, F, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-10239, CH₃, H, F, HOCH₂CH₂CH₂CH₂CH₂, F), (M-10240, CH₃, H, F,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-10241, CH₃H, F, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-10242, CH₃, H, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-10243, CH₃, H, F,HOCH₂CH₂OCH₂CH₂, H), (M-10244, CH₃, H, F, HOCH₂CH₂OCH₂CH₂, Cl),(M-10245, CH₃, H, F, HOCH₂CH₂OCH₂CH₂, F), (M-10246, CH₃, H, F,HOCH₂CH₂OCH₂CH₂, CF₃), (M-10247, CH₃, H, F, HOCH₂CH₂OCH₂CH₂, Br),(M-10248, CH₃, H, F, HOCH₂CH₂OCH₂CH₂, CH₃), (M-10249, CH₃, H, F, (Me)₂N,H), (M-10250, CH₃, H, F, (Me)₂N, Cl), (M-10251, CH₃, H, F, (Me)₂N, F),(M-10252, CH₃, H, F, (Me)₂N, CF₃), (M-10253, CH₃, H, F, (Me)₂N, Br),(M-10254, CH₃, H, F, (Me)₂N, CH₃), (M-10255, CH₃, H, F,piperidin-4-yl-methyl, H), (M-10256, CH₃, H, F, piperidin-4-yl-methyl,Cl), (M-10257, CH₃, H, F, piperidin-4-yl-methyl, F), (M-10258, CH₃, H,F, piperidin-4-yl-methyl, CF₃), (M-10259, CH₃, H, F,piperidin-4-yl-methyl, Br), (M-10260, CH₃, H, F, piperidin-4-yl-methyl,CH₃), (M-10261, CH₃, H, F, cyclohexylmethyl, H), (M-10262, CH₃, H, F,cyclohexylmethyl, Cl), (M-10263, CH₃, H, F, cyclohexylmethyl, F),(M-10264, CH₃, H, F, cyclohexylmethyl, CF₃), (M-10265, CH₃, H, F,cyclohexylmethyl, Br), (M-10266, CH₃, H, F, cyclohexylmethyl, CH₃),(M-10267, CH₃, H, Cl, H, H), (M-10268, CH₃, H, Cl, H, Cl), (M-10269,CH₃, H, Cl, H, F), (M-10270, CH₃, H, Cl, H, CF₃), (M-10271, CH₃, H, Cl,H, Br), (M-10272, CH₃, H, Cl, H, CH₃), (M-10273, CH₃, H, Cl, F, H),(M-10274, CH₃, H, Cl, F, Cl), (M-10275, CH₃, H, Cl, F, F), (M-10276,CH₃, H, Cl, F, CF₃), (M-10277, CH₃, H, Cl, F, Br), (M-10278, CH₃, H, Cl,F, CH₃), (M-10279, CH₃, H, Cl, Cl, H), (M-10280, CH₃, H, Cl, Cl, Cl),(M-10281, CH₃, H, Cl, Cl, F), (M-10282, CH₃, H, Cl, Cl, CF₃), (M-10283,CH₃, H, Cl, Cl, Br), (M-10284, CH₃, H, Cl, Cl, CH₃), (M-10285, CH₃, H,Cl, CH₃, H), (M-10286, CH₃, H, Cl, CH₃, Cl), (M-10287, CH₃, H, Cl, CH₃,F), (M-10288, CH₃, H, Cl, CH₃, CF₃), (M-10289, CH₃, H, Cl, CH₃, Br),(M-10290, CH₃, H, Cl, CH₃, CH₃), (M-10291, CH₃, H, Cl, Et, H), (M-10292,CH₃, H, Cl, Et, Cl), (M-10293, CH₃, H, Cl, Et, F), (M-10294, CH₃, H, Cl,Et, CF₃), (M-10295, CH₃, H, Cl, Et, Br), (M-10296, CH₃, H, Cl, Et, CH₃),(M-10297, CH₃, H, Cl, n-Pr, H), (M-10298, CH₃, H, Cl, n-Pr, Cl),(M-10299, CH₃, H, Cl, n-Pr, F), (M-10300, CH₃, H, Cl, n-Pr, CF₃),(M-10301, CH₃, H, Cl, n-Pr, Br), (M-10302, CH₃, H, Cl, n-Pr, CH₃),(M-10303, CH₃, H, Cl, c-Pr, H), (M-10304, CH₃, H, Cl, c-Pr, Cl),(M-10305, CH₃, H, Cl, c-Pr, F), (M-10306, CH₃, H, Cl, c-Pr, CF₃),(M-10307, CH₃, H, Cl, c-Pr, Br), (M-10308, CH₃, H, Cl, c-Pr, CH₃),(M-10309, CH₃, H, Cl, i-Pr, H), (M-10310, CH₃, H, Cl, i-Pr, Cl),(M-10311, CH₃, H, Cl, i-Pr, F), (M-10312, CH₃, H, Cl, i-Pr, CF₃),(M-10313, CH₃, H, Cl, i-Pr, Br), (M-10314, CH₃, H, Cl, i-Pr, CH₃),(M-10315, CH₃, H, Cl, n-Bu, H), (M-10316, CH₃, H, Cl, n-Bu, Cl),(M-10317, CH₃, H, Cl, n-Bu, F), (M-10318, CH₃, H, Cl, n-Bu, CF₃),(M-10319, CH₃, H, Cl, n-Bu, Br), (M-10320, CH₃, H, Cl, n-Bu, CH₃),(M-10321, CH₃, H, Cl, i-Bu, H), (M-10322, CH₃, H, Cl, i-Bu, Cl),(M-10323, CH₃, H, Cl, i-Bu, F), (M-10324, CH₃, H, Cl, i-Bu, CF₃),(M-10325, CH₃, H, Cl, i-Bu, Br), (M-10326, CH₃, H, Cl, i-Bu, CH₃),(M-10327, CH₃, H, Cl, sec-Bu, H), (M-10328, CH₃, H, Cl, sec-Bu, Cl),(M-10329, CH₃, H, Cl, sec-Bu, F), (M-10330, CH₃, H, Cl, sec-Bu, CF₃),(M-10331, CH₃, H, Cl, sec-Bu, Br), (M-10332, CH₃, H, Cl, sec-Bu, CH₃),(M-10333, CH₃, H, Cl, n-Pen, H), (M-10334, CH₃, H, Cl, n-Pen, Cl),(M-10335, CH₃, H, Cl, n-Pen, F), (M-10336, CH₃H, Cl, n-Pen, CF₃),(M-10337, CH₃, H, Cl, n-Pen, Br), (M-10338, CH₃, H, Cl, n-Pen, CH₃),(M-10339, CH₃, H, Cl, c-Pen, H), (M-10340, CH₃, H, Cl, c-Pen, Cl),(M-10341, CH₃, H, Cl, c-Pen, F), (M-10342, CH₃, H, Cl, c-Pen, CF₃),(M-10343, CH₃, H, Cl, c-Pen, Br), (M-10344, CH₃, H, Cl, c-Pen, CH₃),(M-10345, CH₃, H, Cl, n-Hex, H), (M-10346, CH₃, H, Cl, n-Hex, Cl),(M-10347, CH₃, H, Cl, n-Hex, F), (M-10348, CH₃, H, Cl, n-Hex, CF₃),(M-10349, CH₃, H, Cl, n-Hex, Br), (M-10350, CH₃, H, Cl, n-Hex, C₃),(M-10351, CH₃, H, Cl, c-Hex, H), (M-10352, CH₃, H, Cl, c-Hex, Cl),(M-10353, CH₃, H, Cl, c-Hex, F), (M-10354, CH₃, H, Cl, c-Hex, CF₃),(M-10355, CH₃, H, Cl, c-Hex, Br), (M-10356, CH₃, H, Cl, c-Hex, CH₃),(M-10357, CH₃, H, Cl, OH, H), (M-10358, CH₃, H, Cl, OH, Cl), (M-10359,CH₃, H, Cl, OH, F), (M-10360, CH₃, H, Cl, OH, CF₃), (M-10361, CH₃, H,Cl, OH, Br), (M-10362, CH₃, H, Cl, OH, CH₃), (M-10363, CH₃, H, Cl, EtO,H), (M-10364, CH₃, H, Cl, EtO, Cl), (M-10365, CH₃, H, Cl, EtO, F),(M-10366, CH₃, H, Cl, EtO, CF₃), (M-10367, CH₃, H, Cl, EtO, Br),(M-10368, CH₃, H, Cl, EtO, CH₃), (M-10369, CH₃, H, Cl, n-PrO, H),(M-10370, CH₃, H, Cl, n-PrO, Cl), (M-10371, CH₃, H, Cl, n-PrO, F),(M-10372, CH₃, H, Cl, n-PrO, CF₃), (M-10373, CH₃, H, Cl, n-PrO, Br),(M-10374, CH₃, H, Cl, n-PrO, CH₃), (M-10375, CH₃, H, Cl, PhO, H),(M-10376, CH₃, H, Cl, PhO, Cl), (M-10377, CH₃, H, Cl, PhO, F), (M-10378,CH₃, H, Cl, PhO, CF₃), (M-10379, CH₃, H, Cl, PhO, Br), (M-10380, CH₃, H,Cl, PhO, CH₃), (M-10381, CH₃, H, Cl, BnO, H), (M-10382, CH₃, H, Cl, BnO,Cl), (M-10383, CH₃, H, Cl, BnO, F), (H-10384, CH₃, H, Cl, BnO, CF₃),(M-10385, CH₃, H, Cl, BnO, Br), (M-10386, CH₃, H, Cl, BnO, CH₃),(M-10387, CH₃, H, Cl, PhCH₂CH₂O, H), (M-10388, CH₃, H, Cl, PhCH₂CH₂O,Cl), (M-10389, CH₃, H, Cl, PhCH₂CH₂O, F), (M-10390, CH₃, H, Cl,PhCH₂CH₂O, CF₃), (M-10391, CH₃, H, Cl, PhCH₂CH₂O, Br), (M-10392, CH₃, H,Cl, PhCH₂CH₂O, CH₃), (M-10393, CH₃, H, Cl, CF₃O, H), (M-10394, CH₃, H,Cl, CF₃O, Cl), (M-10395, CH₃, H, Cl, CF₃O, F), (M-10396, CH₃, H, Cl,CF₃O, CF₃), (M-10397, CH₃, H, Cl, CF₃O, Br), (M-10398, CH₃, H, Cl, CF₃O,CH₃), (M-10399, CH₃, H, Cl, Ph, H), (M-10400, CH₃, H, Cl, Ph, Cl),(M-10401, CH₃, H, Cl, Ph, F), (M-10402, CH₃, H, Cl, Ph, CF₃), (M-10403,CH₃, H, Cl, Ph, Br), (M-10404, CH₃, H, Cl, Ph, CH₃), (M-10405, CH₃, H,Cl, 4-F-Ph, H), (M-10406, CH₃, H, Cl, 4-F-Ph, Cl), (M-10407, CH₃, H, Cl,4-F-Ph, F), (M-10408, CH₃, H, Cl, 4-F-Ph, CF₃), (M-10409, CH₃, H, Cl,4-F-Ph, Br), (M-10410, CH₃, H, Cl, 4-F-Ph, CH₃), (M-10411, CH₃, H, Cl,4-CF₃-Ph, H), (M-10412, CH₃, H, Cl, 4-CF₃-Ph, Cl), (M-10413, CH₃, H, Cl,4-CF₃-Ph, F), (M-10414, CH₃, H, Cl, 4-CF₃-Ph, CF₃), (M-10415, CH₃, H,Cl, 4-CF₃-Ph, Br), (M-10416, CH₃, H, Cl, 4-CF₃-Ph, CH₃), (M-10417, CH₃,H, Cl, 4-(Me)₂N-Ph, H), (M-10418, CH₃, H, Cl, 4-(Me)₂N-Ph, Cl),(M-10419, CH₃, H, Cl, 4-(Me)₂N-Ph, F), (M-10420, CH₃, H, Cl,4-(Me)₂N-Ph, CF₃), (M-10421, CH₃, H, Cl, 4-(Me)₂N-Ph, Br), (M-10422,CH₃, H, Cl, 4-(Me)₂N-Ph, CH₃), (M-10423, CH₃, H, Cl, 4-OH-Ph, H),(M-10424, CH₃, H, Cl, 4-OH-Ph, Cl), (M-10425, CH₃, H, Cl, 4-OH-Ph, F),(M-10426, CH₃, H, Cl, 4-OH-Ph, CF₃), (M-10427, CH₃, H, Cl, 4-OH-Ph, Br),(M-10428, CH₃, H, Cl, 4-OH-Ph, CH₃), (M-10429, CH₃, H, Cl, 3,4-di-F-Ph,H), (M-10430, CH₃, H, Cl, 3,4-di-F-Ph, Cl), (M-10431, CH₃, H, Cl,3,4-di-F-Ph, F), (M-10432, CH₃, H, Cl, 3,4-di-F-Ph, CF₃), (M-10433, CH₃,H, Cl, 3,4-di-F-Ph, Br), (M-10434, CH₃, H, Cl, 3,4-di-F-Ph, CH₃),(M-10435, CH₃, H, Cl, 4-COOH-Ph, H), (M-10436, CH₃, H, Cl, 4-COOH-Ph,Cl), (M-10437, CH₃, H, Cl, 4-COOH-Ph, F), (M-10438, CH₃, H, Cl,4-COOH-Ph, CF₃), (M-10439, CH₃, H, Cl, 4-COOH-Ph, Br), (M-10440, CH₃, H,Cl, 4-COOH-Ph, CH₃), (M-10441, CH₃, H, Cl, Bn, H), (M-10442, CH₃, H, Cl,Bn, Cl), (M-10443, CH₃, H, Cl, Bn, F), (M-10444, CH₃, H, Cl, Bn, CF₃),(M-10445, CH₃, H, Cl, Bn, Br), (M-10446, CH₃, H, Cl, Bn, CH₃), (M-10447,CH₃, H, Cl, 4-F-Bn, H), (M-10448, CH₃, H, Cl, 4-F-Bn, Cl), (M-10449,CH₃, H, Cl, 4-F-Bn, F), (M-10450, CH₃, H, Cl, 4-F-Bn, CF₃), (M-10451,CH₃, H, Cl, 4-F-Bn, Br), (M-10452, CH₃, H, Cl, 4-F-Bn, CH₃), (M-10453,CH₃, H, Cl, 2-Py, H), (M-10454, CH₃, H, Cl, 2-Py, Cl), (M-10455, CH₃, H,Cl, 2-Py, F), (M-10456, CH₃, H, Cl, 2-Py, CF₃), (M-10457, CH₃, H, Cl,2-Py, Br), (M-10458, CH₃, H, Cl, 2-Py, CH₃), (M-10459, CH₃, H, Cl, 3-Py,H), (M-10460, CH₃, H, Cl, 3-Py, Cl), (M-10461, CH₃, H, Cl, 3-Py, F),(M-10462, CH₃, H, Cl, 3-Py, CF₃), (M-10463, CH₃, H, Cl, 3-Py, Br),(M-10464, CH₃, H, Cl, 3-Py, CH₃), (M-10465, CH₃, H, Cl, 4-Py, H),(M-10466, CH₃, H, Cl, 4-Py, Cl), (M-10467, CH₃, H, Cl, 4-Py, F),(M-10468, CH₃, H, Cl, 4-Py, CF₃), (M-10469, CH₃, H, Cl, 4-Py, Br),(M-10470, CH₃, H, Cl, 4-Py, CH₃), (M-10471, CH₃, H, Cl, 2-Th, H),(M-10472, CH₃, H, Cl, 2-Th, Cl), (M-10473, CH₃, H, Cl, 2-Th, F),(M-10474, CH₃, H, Cl, 2-Th, CF₃), (M-10475, CH₃, H, Cl, 2-Th, Br),(M-10476, CH₃, H, Cl, 2-Th, CH₃), (M-10477, CH₃, H, Cl, 3-Th, H),(M-10478, CH₃, H, Cl, 3-Th, Cl), (M-10479, CH₃, H, Cl, 3-Th, F),(M-10480, CH₃, H, Cl, 3-Th, CF₃), (M-10481, CH₃, H, Cl, 3-Th, Br),(M-10482, CH₃, H, Cl, 3-Th, CH₃), (M-10483, CH₃, H, Cl, pyrrazol-2-yl,H), (M-10484, CH₃, H, Cl, pyrrazol-2-yl, Cl), (M-10485, CH₃, H, Cl,pyrrazol-2-yl, F), (M-10486, CH₃, H, Cl, pyrrazol-2-yl, CF₃), (M-10487,CH₃, H, Cl, pyrrazol-2-yl, Br), (M-10488, CH₃, H, Cl, pyrrazol-2-yl,CH₃), (M-10489, CH₃, H, Cl, pyrrazol-3-yl, H), (M-10490, CH₃, H, Cl,pyrrazol-3-yl, Cl), (M-10491, CH₃, H, Cl, pyrrazol-3-yl, F), (M-10492,CH₃, H, Cl, pyrrazol-3-yl, CF₃), (M-10493, CH₃, H, Cl, pyrrazol-3-yl,Br), (M-10494, CH₃, H, Cl, pyrrazol-3-yl, CH₃), (M-10495, CH₃, H, Cl,pyrimidin-2-yl, H), (M-10496, CH₃, H, Cl, pyrimidin-2-yl, Cl), (M-10497,CH₃, H, Cl, pyrimidin-2-yl, F), (M-10498, CH₃, H, Cl, pyrimidin-2-yl,CF₃), (M-10499, CH₃, H, Cl, pyrimidin-2-yl, Br), (M-10500, CH₃, H, Cl,pyrimidin-2-yl, CH₃), (M-10501, CH₃, H, Cl, pyrimidin-4-yl, H),(M-10502, CH₃, H, Cl, pyrimidin-4-yl, Cl), (M-10503, CH₃, H, Cl,pyrimidin-4-yl, F), (M-10504, CH₃, H, Cl, pyrimidin-4-yl, CF₃),(M-10505, CH₃, H, Cl, pyrimidin-4-yl, Br), (M-10506, CH₃, H, Cl,pyrimidin-4-yl, CH₃), (M-10507, CH₃, H, Cl, pyrimidin-5-yl, H),(M-10508, CH₃, H, Cl, pyrimidin-5-yl, Cl), (M-10509, CH₃, H, Cl,pyrimidin-5-yl, F), (M-10510, CH₃, H, Cl, pyrimidin-5-yl, CF₃),(M-10511, CH₃, H, Cl, pyrimidin-5-yl, Br), (M-10512, CH₃, H, Cl,pyrimidin-5-yl, CH₃), (M-10513, CH₃, H, Cl, HOOCCH₂CH₂CH₂, H), (M-10514,CH₃, H, Cl, HOOCCH₂CH₂CH₂, Cl), (M-10515, CH₃, H, Cl, HOOCCH₂CH₂CH₂, F),(M-10516, CH₃, H, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-10517, CH₃, H, Cl,HOOCCH₂CH₂CH₂, Br), (M-10518, CH₃, H, Cl, HOOCCH₂CH₂CH₂, CH₃), (M-10519,CH₃, H, Cl, HOOCCH₂CH₂CH₂CH₂, H), (M-10520, CH₃, H, Cl,HOOCCH₂CH₂CH₂CH₂, Cl), (M-10521, CH₃, H, Cl, HOOCCH₂CH₂CH₂CH₂, F),(M-10522, CH₃, H, Cl, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-10523, CH₃, H, Cl,HOOCCH₂CH₂CH₂CH₂, Br), (M-10524, CH₃, H, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-10525, CH₃, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-10526, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-10527, CH₃, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,F), (M-10528, CH₃, H, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-10529, CH₃, H,Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-10530, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-10531, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-10532, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-10533, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-10534, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-10535, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-10536, CH₃, H, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-10537, CH₃, H, Cl, MeOCH₂, H),(M-10538, CH₃, H, Cl, MeOCH₂, Cl), (M-10539, CH₃, H, Cl, MeOCH₂, F),(M-10540, CH₃, H, Cl, MeOCH₂, CF₃), (M-10541, CH₃, H, Cl, MeOCH₂, Br),(M-10542, CH₃, H, Cl, MeOCH₂, CH₃), (M-10543, CH₃, H, Cl, EtOCH₂, H),(M-10544, CH₃, H, Cl, EtOCH₂, Cl), (M-10545, CH₃, H, Cl, EtOCH₂, F),(M-10546, CH₃, H, Cl, EtOCH₂, CF₃), (M-10547, CH₃, H, Cl, EtOCH₂, Br),(M-10548, CH₃, H, Cl, EtOCH₂, CH₃), (M-10549, CH₃, H, Cl, EtOCH₂CH₂, H),(M-10550, CH₃, H, Cl, EtOCH₂CH₂, Cl), (M-10551, CH₃, H, Cl, EtOCH₂CH₂,F), (M-10552, CH₃, H, Cl, EtOCH₂CH₂, CF₃), (M-10553, CH₃, H, Cl,EtOCH₂CH₂, Br), (M-10554, CH₃, H, Cl, EtOCH₂CH₂, CH₃), (M-10555, CH₃, H,Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-10556, CH₃, H, Cl, MeOCH₂CH₂OCH₂CH₂, Cl),(M-10557, CH₃, H, Cl, MeOCH₂CH₂OCH₂CH₂, F), (M-10558, CH₃, H, Cl,MeOCH₂CH₂OCH₂CH₂, CF₃), (M-10559, CH₃, H, Cl, MeOCH₂CH₂OCH₂CH₂, Br),(M-10560, CH₃, H, Cl, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-10561, CH₃, H, Cl,MeOCH₂CH₂, H), (M-10562, CH₃, H, Cl, MeOCH₂CH₂, Cl), (M-10563, CH₃, H,Cl, MeOCH₂CH₂, F), (M-10564, CH₃, H, Cl, MeOCH₂CH₂, CF₃), (M-10565, CH₃,H, Cl, MeOCH₂CH₂, Br), (M-10566, CH₃, H, Cl, MeOCH₂CH₂, CH₃), (M-10567,CH₃, H, Cl, HOCH₂, H), (M-10568, CH₃, H, Cl, HOCH₂, Cl), (M-10569, CH₃,H, Cl, HOCH₂, F), (M-10570, CH₃, H, Cl, HOCH₂, CF₃), (M-10571, CH₃, H,Cl, HOCH₂, Br), (M-10572, CH₃, H, Cl, HOCH₂, CH₃), (M-10573, CH₃, H, Cl,HOCH₂CH₂, H), (M-10574, CH₃, H, Cl, HOCH₂CH₂, Cl), (M10575, CH₃, H, Cl,HOCH₂CH₂, F), (M-10576, CH₃, H, Cl, HOCH₂CH₂, CF₃), (M-10577, CH₃, H,Cl, HOCH₂CH₂, Br), (M-10578, CH₃, H, Cl, HOCH₂CH₂, CH₃), (M-10579, CH₃,H, Cl, HOCH₂CH₂CH₂, H), (M-10580, CH₃, H, Cl, HOCH₂CH₂CH₂, Cl),(M-10581, CH₃, H, Cl, HOCH₂CH₂CH₂, F), (M-10582, CH₃, H, Cl,HOCH₂CH₂CH₂, CF₃), (M-10583, CH₃, H, Cl, HOCH₂CH₂CH₂, Br), (M-10584,CH₃, H, Cl, HOCH₂CH₂CH₂, CH₃), (M-10585, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂, H),(M-10586, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂, Cl), (M-10587, CH₃, H, Cl,HOCH₂CH₂CH₂CH₂, F), (M-10588, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂, CF₃),(M-10589, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-10590, CH₃, H, Cl,HOCH₂CH₂CH₂CH₂, CH₃), (M-10591, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, H),(M-10592, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-10593, CH₃, H, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-10594, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, CF₃),(M-10595, CH₃, H, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-10596, CH₃, H, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-10597, CH₃, H, Cl, HOCH₂CH₂OCH₂CH₂, H),(M-10598, CH₃, H, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-10599, CH₃, H, Cl,HOCH₂CH₂OCH₂CH₂, F), (M-10600, CH₃, H, Cl, HOCH₂CH₂OCH₂CH₂, CF₃),(M-10601, CH₃, H, Cl, HOCH₂CH₂O CH₂CH₂, Br), (M-10602, CH₃, H, Cl,HOCH₂CH₂OCH₂CH₂, CH₃), (M-10603, CH₃, H, Cl, (Me)₂N, H), (M-10604, CH₃,H, Cl, (Me)₂N, Cl), (M-10605, CH₃, H, Cl, (Me)₂N, F), (M-10606, CH₃, H,Cl, (Me)₂N, CF₃), (M-10607, CH₃, H, Cl, (Me)₂N, Br), (M-10608, CH₃, H,Cl, (Me)₂N, CH₃), (M-10609, CH₃, H, Cl, piperidin-4-yl-methyl, H),(M-10610, CH₃, H, Cl, piperidin-4-yl-methyl, Cl), piperidin-4-yl-methyl,CF₃), (M-10613, CH₃, H, Cl, piperidin-4-yl-methyl, Br), (M-10614, CH₃,H, Cl, piperidin-4-yl-methyl, CH₃), (M-10615, CH₃, H, Cl,cyclohexylmethyl, H), (M-10616, CH₃, H, Cl, cyclohexylmethyl, Cl),(M-10617, CH₃, H, Cl, cyclohexylmethyl, F), (M-10618, CH₃, H, Cl,cyclohexylmethyl, CF₃), (M-10619, CH₃, H, Cl, cyclohexylmethyl, Br),(M-10620, CH₃, H, Cl, cyclohexylmethyl, CH₃), (M-10621, CH₃, F, H, H,H), (M-10622, CH₃, F, H, H, Cl), (M-10623, CH₃, F, H, H, F), (M-10624,CH₃, F, H, H, CF₃), (M-10625, CH₃, F, H, H, Br), (M-10626, CH₃, F, H, H,CH₃), (M-10627, CH₃, F, H, F, H), (M-10628, CH₃, F, H, F, Cl), (M-10629,CH₃, F, H, F, F), (M-10630, CH₃, F, H, F, CF₃), (M-10631, CH₃, F, H, F,Br), (M-10632, CH₃, F, H, F, CH₃), (M-10633, CH₃, F, H, Cl, H),(M-10634, CH₃, F, H, Cl, Cl), (M-10635, CH₃, F, H, Cl, F), (M-10636,CH₃, F, H, Cl, CF₃), (M-10637, CH₃, F, H, Cl, Br), (M-10638, CH₃, F, H,Cl, CH₃), (M-10639, CH₃, F, H, CH₃, H), (M-10640, CH₃, F, H, CH₃, Cl),(M-10641, CH₃, F, H, CH₃, F), (M-10642, CH₃, F, H, CH₃, CF₃), (M-10643,CH₃, F, H, CH₃, Br), (M-10644, CH₃, F, H, CH₃, CH₃), (M-10645, CH₃, F,H, Et, H), (M-10646, CH₃, F, H, Et, Cl), (M-10647, CH₃, F, H, Et, F),(M-10648, CH₃, F, H, Et, CF₃), (M-10649, CH₃, F, H, Et, Br), (M-10650,CH₃, F, H, Et, CH₃), (M-10651, CH₃, F, H, n-Pr, H), (M-10652, CH₃, F, H,n-Pr, Cl), (M-10653, CH₃, F, H, n-Pr, F), (M-10654, CH₃, F, H, n-Pr,CF₃), (M-10655, CH₃, F, H, n-Pr, Br), (M-10656, CH₃, F, H, n-Pr, CH₃),(M-10657, CH₃, F, H, c-Pr, H), (M-10658, CH₃, F, H, c-Pr, Cl), (M-10659,CH₃, F, H, c-Pr, F), (M-10660, CH₃, F, H, c-Pr, CF₃), (M-10661, CH₃, F,H, c-Pr, Br), (M-10662, CH₃, F, H, c-Pr, CH₃), (M-10663, CH₃, F, H,i-Pr, H), (M-10664, CH₃, F, H, i-Pr, Cl), (M-10665, CH₃, F, H, i-Pr, F),(M-10666, CH₃, F, H, i-Pr, CF₃), (M-10667, CH₃, F, H, i-Pr, Br),(M-10668, CH₃, F, H, i-Pr, CH₃), (M-10669, CH₃, F, H, n-Bu, H),(M-10670, CH₃, F, H, n-Bu, Cl), (M-10671, CH₃, F, H, n-Bu, F), (M-10672,CH₃, F, H, n-Bu, CF₃), (M-10673, CH₃, F, H, n-Bu, Br), (M-10674, CH₃, F,H, n-Bu, CH₃), (M-10675, CH₃, F, H, i-Bu, H), (M-10676, CH₃, F, H, i-Bu,Cl), (M-10677, CH₃, F, H, i-Bu, F), (M-10678, CH₃, F, H, i-Bu, CF₃),(M-10679, CH₃, F, H, i-Bu, Br), (M-10680, CH₃, F, H, i-Bu, CH₃),(M-10681, CH₃, F, H, sec-Bu, H), (M-10682, CH₃, F, H, sec-Bu, Cl),(M-10683, CH₃, F, H, sec-Bu, F), (M-10684, CH₃, F, H, sec-Bu, CF₃),(M-10685, CH₃, F, H, sec-Bu, Br), (M-10686, CH₃, F, H, sec-Bu, CH₃),(M-10687, CH₃, F, H, n-Pen, H), (M-10688, CH₃, F, H, n-Pen, Cl),(M-10689, CH₃, F, H, n-Pen, F), (M-10690, CH₃, F, H, n-Pen, CF₃),(M-10691, CH₃, F, H, n-Pen, Br), (M-10692, CH₃, F, H, n-Pen, CH₃),(M-10693, CH₃, F, H, c-Pen, H), (M-10694, CH₃, F, H, c-Pen, Cl),(M-10695, CH₃, F, H, c-Pen, F), (M-10696, CH₃, F, H, c-Pen, CF₃),(M-10697, CH₃, F, H, c-Pen, Br), (M-10698, CH₃, F, H, c-Pen, CH₃),(M-10699, CH₃, F, H, n-Hex, H), (M-10700, CH₃, F, H, n-Hex, Cl),(M-10701, CH₃, F, H, n-Hex, F), (M-10702, CH₃, F, H, n-Hex, CF₃),(M-10703, CH₃, F, H, n-Hex, Br), (M-10704, CH₃, F, H, n-Hex, CH₃),(M-10705, CH₃, F, H, c-Hex, H), (M-10706, CH₃, F, H, c-Hex, Cl),(M-10707, CH₃, F, H, c-Hex, F), (M-10708, CH₃, F, H, c-Hex, CF₃),(M-10709, CH₃, F, H, c-Hex, Br), (M-10710, CH₃, F, H, c-Hex, CH₃),(M-10711, CH₃, F, H, OH, H), (M-10712, CH₃, F, H, OH, Cl), (M-10713,CH₃, F, H, OH, F), (M-10714, CH₃, F, H, OH, CF₃), (M-10715, CH₃, F, H,OH, Br), (M-10716, CH₃, F, H, OH, CH₃), (M-10717, CH₃, F, H, EtO, H),(M-10718, CH₃, F, H, EtO, Cl), (M-10719, CH₃, F, H, EtO, F), (M-10720,CH₃, F, H, EtO, CF₃), (M-10721, CH₃, F, H, EtO, Br), (M-10722, CH₃, F,H, EtO, CH₃), (M-10723, CH₃, F, H, n-PrO, H), (M-10724, CH₃, F, H,n-PrO, Cl), (M-10725, CH₃, F, H, n-PrO, F), (M-10726, CH₃, F, H, n-PrO,CF₃), (M-10727, CH₃, F, H, n-PrO, Br), (M-10728, CH₃, F, H, n-PrO, CH₃),(M-10729, CH₃, F, H, PhO, H), (M-10730, CH₃, F, H, PhO, Cl), (M-10731,CH₃, F, H, PhO, F), (M-10732, CH₃, F, H, PhO, CF₃), (M-10733, CH₃, F, H,PhO, Br), (M-10734, CH₃, F, H, PhO, CH₃), (M-10735, CH₃, F, H, BnO, H),(M-10736, CH₃, F, H, BnO, Cl), (M-10737, CH₃, F, H, BnO, F), (M-10738,CH₃, F, H, BnO, CF₃), (M-10739, CH₃, F, H, BnO, Br), (M-10740, CH₃, F,H, BnO, CH₃), (M-10741, CH₃, F, H, PhCH₂CH₂O, H), (M-10742, CH₃, F, H,PhCH₂CH₂O, Cl), (M-10743, CH₃, F, H, PhCH₂CH₂O, F), (M-10744, CH₃, F, H,PhCH₂CH₂O, CF₃), (M-10745, CH₃, F, H, PhCH₂CH₂O, Br), (M-10746, CH₃, F,H, PhCH₂CH₂O, CH₃), (M-10747, CH₃, F, H, CF₃O, H), (M-10748, CH₃, F, H,CF₃O, Cl), (M-10749, CH₃, F, H, CF₃O, F), (M-10750, CH₃, F, H, CF₃O,CF₃), (M-10751, CH₃, F, H, CF₃, Br), (M-10752, CH₃, F, H, CF₃O, CH₃),(M-10753, CH₃, F, H, Ph, H), (M-10754, CH₃, F, H, Ph, Cl), (M-10755,CH₃, F, H, Ph, F), (M-10756, CH₃, F, H, Ph, CF₃), (M-10757, CH₃, F, H,Ph, Br), (M-10758, CH₃, F, H, Ph, CH₃), (M-10759, CH₃, F, H, 4-F-Ph, H),(M-10760, CH₃, F, H, 4-F-Ph, Cl), (M-10761, CH₃, F, H, 4-F-Ph, F),(M-10762, CH₃, F, H, 4-F-Ph, CF₃), (M-10763, CH₃, F, H, 4-F-Ph, Br),(M-10764, CH₃, F, H, 4-F-Ph, CH₃), (M-10765, CH₃, F, H, 4-CF₃-Ph, H),(M-10766, CH₃, F, H, 4-CF₃-Ph, Cl), (M-10767, CH₃, F, H, 4-CF₃-Ph, F),(M-10768, CH₃, F, H, 4-CF₃-Ph, CF₃), (M-10769, CH₃, F, H, 4-CF₃-Ph, Br),(M-10770, CH₃, F, H, 4-CF₃-Ph, CH₃), (M-10771, CH₃, F, H, 4-(Me)₂N-Ph,H), (M-10772, CH₃, F, H, 4-(Me)₂N-Ph, Cl), (M-10773, CH₃, F, H,4-(Me)₂N-Ph, F), (M-10774, CH₃, F, H, 4-(Me)₂N-Ph, CF₃), (M-10775, CH₃,F, H, 4-(Me)₂N-Ph, Br), (M-10776, CH₃, F, H, 4-(Me)₂N-Ph, CH₃),(M-10777, CH₃, F, H, 4-OH-Ph, H), (M-10778, CH₃, F, H, 4-OH-Ph, Cl),(M-10779, CH₃, F, H, 4-OH-Ph, F), (M-10780, CH₃, F, H, 4-OH-Ph, CF₃),(M-10781, CH₃, F, H, 4-OH-Ph, Br), (M-10782, CH₃, F, H, 4-OH-Ph, CH₃),(M-10783, CH₃, F, H, 3,4-di-F-Ph, H), (M-10784, CH₃, F, H, 3,4-di-F-Ph,Cl), (M-10785, CH₃, F, H, 3,4-di-F-Ph, F), (M-10786, CH₃, F, H,3,4-di-F-Ph, CF₃), (M-10787, CH₃, F, H, 3,4-di-F-Ph, Br), (M-10788, CH₃,F, H, 3,4-di-F-Ph, CH₃), (M-10789, CH₃, F, H, 4-COOH-Ph, H), (M-10790,CH₃, F, H, 4-COOH-Ph, Cl), (M-10791, CH₃, F, H, 4-COOH-Ph, F), (M-10792,CH₃, F, H, 4-COOH-Ph, CF₃), (M-10793, CH₃, F, H, 4-COOH-Ph, Br),(M-10794, CH₃, F, H, 4-COOH-Ph, CH₃), (M-10795, CH₃, F, H, Bn, H),(M-10796, CH₃, F, H, Bn, Cl), (M-10797, CH₃, F, H, Bn, F), (M-10798,CH₃, F, H, Bn, CF₃), (M-10799, CH₃, F, H, Bn, Br), (M-10800, CH₃, F, H,Bn, CH₃), (M-10801, CH₃, F, H, 4-F-Bn, H), (M-10802, CH₃, F, H, 4-F-Bn,Cl), (M-10803, CH₃, F, H, 4-F-Bn, F), (M-10804, CH₃, F, H, 4-F-Bn, CF₃),(M-10805, CH₃, F, H, 4-F-Bn, Br), (M-10806, CH₃, F, H, 4-F-Bn, CH₃),(M-10807, CH₃, F, H, 2-Py, H), (M-10808, CH₃, F, H, 2-Py, Cl), (M-10809,CH₃, F, H, 2-Py, F), (M-10810, CH₃, F, H, 2-Py, CF₃), (M-10811, CH₃, F,H, 2-Py, Br), (M-10812, CH₃, F, H, 2-Py, CH₃), (M-10813, CH₃, F, H,3-Py, H), (M-10814, CH₃, F, H, 3-Py, Cl), (M-10815, CH₃, F, H, 3-Py, F),(M-10816, CH₃, F, H, 3-Py, CF₃), (M-10817, CH₃, F, H, 3-Py, Br),(M-10818, CH₃, F, H, 3-Py, CH₃), (M-10819, CH₃, F, H, 4-Py, H),(M-10820, CH₃, F, H, 4-Py, Cl), (M-10821, CH₃, F, H, 4-Py, F), (M-10822,CH₃, F, H, 4-Py, CF₃), (M-10823, CH₃, F, H, 4-Py, Br), (M-10824, CH₃, F,H, 4-Py, CH₃), (M-10825, CIT₃, F, H, 2-Th, H), (M-10826, CH₃, F, H,2-Th, Cl), (M-10827, CH₃, F, H, 2-Th, F), (M-10828, CH₃, F, H, 2-Th,CF₃), (M-10829, CH₃, F, H, 2-Th, Br), (M-10830, CH₃; F, H, 2-Th, CH₃),(M-10831, CH₃, F, H, 3-Th, H), (M-10832, CH₃, F, H, 3-Th, Cl), (M-10833,CH₃, F, H, 3-Th, F), (M-10834, CH₃, F, H, 3-Th, CF₃), (M-10835, CH₃, F,H, 3-Th, Br), (M-10836, CH₃, F, H, 3-Th, CH₃), (M-10837, CH₃, F, H,pyrrazol-2-yl, H), (M-10838, CH₃, F, H, pyrrazol-2-yl, Cl), (M-10839,CH₃, F, H, pyrrazol-2-yl, F), (M-10840, CH₃, F, H, pyrrazol-2-yl, CF₃),(M-10841, CH₃, F, H, pyrrazol-2-yl, Br), (M-10842, CH₃, F, H,pyrrazol-2-yl, CH₃), (M-10843, CH₃, F, H, pyrrazol-3-yl, H), (M-10844,CH₃, F, H, pyrrazol-3-yl, Cl), (M-10845, CH₃, F, H, pyrrazol-3-yl, F),(M-10846, CH₃, F, H, pyrrazol-3-yl, CF₃), (M-10847, CH₃, F, H,pyrrazol-3-yl, Br), (M-10848, CH₃, F, H, pyrrazol-3-yl, CH₃), (M-10849,CH₃, F, H, pyrimidin-2-yl, H), (M-10850, CH₃, F, H, pyrimidin-2-yl, Cl),(M-10851, CH₃, F, H, pyrimidin-2-yl, F), (M-10852, CH₃, F, H,pyrimidin-2-yl, CF₃), (M-10853, CH₃, F, H, pyrimidin-2-yl, Br),(M-10854, CH₃, F, H, pyrimidin-2-yl, CH₃), (M-10855, CH₃, F, H,pyrimidin-4-yl, H), (M-10856, CH₃, F, H, pyrimidin-4-yl, Cl), (M-10857,CH₃, F, H, pyrimidin-4-yl, F), (M-10858, CH₃, F, H, pyrimidin-4-yl,CF₃), (M-10859, CH₃, F, H, pyrimidin-4-yl, Br), (M-10860, CH₃, F, H,pyrimidin-4-yl, CH₃), (M-10861, CH₃, F, H, pyrimidin-5-yl, H), (M-10862,CH₃, F, H, pyrimidin-5-yl, Cl), (M-10863, CH₃, F, H, pyrimidin-5-yl, F),(M-10864, CH₃, F, H, pyrimidin-5-yl, CF₃), (M-10865, CH₃, F, H,pyrimidin-5-yl, Br), (M-10866, CH₃, F, H, pyrimidin-5-yl, CH₃),(M-10867, CH₃, F, H, HOOCCH₂CH₂CH₂, H), (M-10868, CH₃, F, H,HOOCCH₂CH₂CH₂, Cl), (M-10869, CH₃, F, H, HOOCCH₂CH₂CH₂, F), (M-10870,CH₃, F, H, HOOCCH₂CH₂CH₂, CF₃), (M-10871, CH₃, F, H, HOOCCH₂CH₂CH₂, Br),(M-10872, CH₃, F, H, HOOCCH₂CH₂CH₂, CH₃), (M-10873, CH₃, F, H,HOOCCH₂CH₂CH₂CH₂, H), (M-10874, CH₃, F, H, HOOCCH₂CH₂CH₂CH₂, Cl),(M-10875, CH₃, F, H, HOOCCH₂CH₂CH₂CH₂, F), (M-10876, CH₃, F, H,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-10877, CH₃, F, H, HOOCCH₂CH₂CH₂CH₂, Br),(M-10878, CH₃, F, H, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-10879, CH₃, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-10880, CH₃, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂,Cl), (M-10881, CH₃, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-10882, CH₃, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-10883, CH₃, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-10884, CH₃, F, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-10885, CH₃, F,H, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-10886, CH₃, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-10887, CH₃, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-10888, CH₃, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-10889, CH₃, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-10890, CH₃, F, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-10891, CH₃, F, H, MeOCH₂, H),(M-10892, CH₃, F, H, MeOCH₂, Cl), (M-10893, CH₃, F, H, MeOCH₂, F),(M-10894, CH₃, F, H, MeOCH₂, CF₃), (M-10895, CH₃, F, H, MeOCH₂, Br),(M-10896, CH₃, F, H, MeOCH₂, CH₃), (M-10897, CH₃, F, H, EtOCH₂, H),(M-10898, CH₃, F, H, EtOCH₂, Cl), (M-10899, CH₃, F, H, EtOCH₂, F),(M-10900, CH₃, F, H, EtOCH₂, CF₃), (M-10901, CH₃, F, H, EtOCH₂, Br),(M-10902, CH₃, F, H, EtOCH₂, CH₃), (M-10903, CH₃, F, H, EtOCH₂CH₂, H),(M-10904, CH₃, F, H, EtOCH₂CH₂, Cl), (M-10905, CH₃, F, H, EtOCH₂CH₂, F),(M-10906, CH₃, F, H, EtOCH₂CH₂, CF₃), (M-10907, CH₃, F, H, EtOCH₂CH₂,Br), (M-10908, CH₃, F, H, EtOCH₂CH₂, CH₃), (M-10909, CH₃, F, H,MeOCH₂CH₂OCH₂CH₂, H), (M-10910, CH₃, F, H, MeOCH₂CH₂OCH₂CH₂, Cl),(M-10911, CH₃, F, H, MeOCH₂CH₂OCH₂CH₂, F), (M-10912, CH₃, F, H,MeOCH₂CH₂OCH₂CH₂, CF₃), (M-10913, CH₃, F, H, MeOCH₂CH₂OCH₂CH₂, Br),(M-10914, CH₃, F, H, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-10915, CH₃, F, H,MeOCH₂CH₂, H), (M-10916, CH₃, F, H, MeOCH₂CH₂, Cl), (M-10917, CH₃, F, H,MeOCH₂CH₂, F), (M-10918, CH₃, F, H, MeOCH₂CH₂, CF₃), (M-10919, CH₃, F,H, MeOCH₂CH₂, Br), (M-10920, CH₃, F, H, MeOCH₂CH₂, CH₃), (M-10921, CH₃,F, H, HOCH₂, H), (M-10922, CH₃, F, H, HOCH₂, Cl), (M-10923, CH₃, F, H,HOCH₂, F), (M-10924, CH₃, F, H, HOCH₂, CF₃), (M-10925, CH₃, F, H, HOCH₂,Br), (M-10926, CH₃, F, H, HOCH₂, CH₃), (M-10927, CH₃, F, H, HOCH₂CH₂,H), (M-10928, CH₃, F, H, HOCH₂CH₂, Cl), (M-10929, CH₃, F, H, HOCH₂CH₂,F), (M-10930, CH₃, F, H, HOCH₂CH₂, CF₃), (M-10931, CH₃, F, H, HOCH₂CH₂,Br), (M-10932, CH₃, F, H, HOCH₂CH₂, CH₃), (M-10933, CH₃, F, H,HOCH₂CH₂CH₂, H), (M-10934, CH₃, F, H, HOCH₂CH₂CH₂, Cl), (M-10935, CH₃,F, H, HOCH₂CH₂CH₂, F), (M-10936, CH₃, F, H, HOCH₂CH₂CH₂, CF₃), (M-10937,CH₃, F, H, HOCH₂CH₂CH₂, Br), (M-10938, CH₃, F, H, HOCH₂CH₂CH₂, CH₃),(M-10939, CH₃, F, H, HOCH₂CH₂CH₂CH₂, H), (M-10940, CH₃, F, H,HOCH₂CH₂CH₂CH₂, Cl), (M-10941, CH₃, F, H, HOCH₂CH₂CH₂CH₂, F), (M-10942,CH₃, F, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-10943, CH₃, F, H, HOCH₂CH₂CH₂CH₂,Br), (M-10944, CH₃, F, H, HOCH₂CH₂CH₂CH₂, CH₃), (M-10945, CH₃, F, H,HOCH₂CH₂CH₂CH₂CH₂, H), (M-10946, CH₃, F, H, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-10947, CH₃, F, H, HOCH₂CH₂CH₂CH₂CH₂, F), (M-10948, CH₃, F, H,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-10949, CH₃, F, H, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-10950, CH₃, F, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-10951, CH₃, F, H,HOCH₂CH₂OCH₂CH₂, H), (M-10952, CH₃, F, H, HOCH₂CH₂OCH₂CH₂, Cl),(M-10953, CH₃, F, H, HOCH₂CH₂O CH₂CH₂, F), (M-10954, CH₃, F, H,HOCH₂CH₂OCH₂CH₂, CF₃), (M-10955, CH₃, F, H, HOCH₂CH₂OCH₂CH₂, Br),(M-10956, CH₃, F, H, HOCH₂CH₂OCH₂CH₂, CH₃), (M-10957, CH₃, F, H, (Me)₂N,H), (M-10958, CH₃, F, H, (Me)₂N, Cl), (M-10959, CH₃, F, H, (Me)₂N, F),(M-10960, CH₃, F, H, (Me)₂N, CF₃), (M-10961, CH₃, F, H, (Me)₂N, Br),(M-10962, CH₃, F, H, (Me)₂N, CH₃), (M-10963, CH₃, F, H,piperidin-4-yl-methyl, H), (M-10964, CH₃, F, H, piperidin-4-yl-methyl,Cl), (M-10965, CH₃, F, H, piperidin-4-yl-methyl, F), (M-10966, CH₃, F,H, piperidin-4-yl-methyl, CF₃), (M-10967, CH₃, F, H,piperidin-4-yl-methyl, Br), (M-10968, CH₃, F, H, piperidin-4-yl-methyl,CH₃), (M-10969, CH₃, F, H, cyclohexylmethyl, H), (M-10970, CH₃, F, H,cyclohexylmethyl, Cl), (M-10971, CH₃, F, H, cyclohexylmethyl, F),(M-10972, CH₃, F, H, cyclohexylmethyl, CF₃), (M-10973, CH₃, F, H,cyclohexylmethyl, Br), (M-10974, CH₃, F, H, cyclohexylmethyl, CH₃),(M-10975, CH₃, F, F, H, H), (M-10976, CH₃, F, F, H, Cl), (M-10977, CH₃,F, F, H, F), (M-10978, CH₃, F, F, H, CF₃), (M-10979, CH₃, F, F, H, Br),(M-10980, CH₃, F, F, H, CH₃), (M-10981, CH₃, F, F, F, H), (M-10982, CH₃,F, F, F, Cl), (M-10983, CH₃, F, F, F, F), (M-10984, CH₃, F, F, F, CF₃),(M-10985, CH₃, F, F, F, Br), (M-10986, CH₃, F, F, F, CH₃), (M-10987,CH₃, F, F, Cl, H), (M-10988, CH₃, F, F, Cl, Cl), (M-10989, CH₃, F, F,Cl, F), (M-10990, CH₃, F, F, Cl, CF₃), (M-10991, CH₃, F, F, Cl, Br),(M-10992, CH₃, F, F, Cl, CH₃), (M-10993, CH₃, F, F, CH₃, H), (M-10994,CH₃, F, F, CH₃, Cl), (M-10995, CH₃, F, F, CH₃, F), (M-10996, CH₃, F, F,CH₃, CF₃), (M-10997, CH₃, F, F, CH₃, Br), (M-10998, CH₃, F, F, CH₃,CH₃), (M-10999, CH₃, F, F, Et, H), (M-11000, CH₃, F, F, Et, Cl),(M-11001, CH₃, F, F, Et, F), (M-11002, CH₃, F, F, Et, CF₃), (M-11003,CH₃, F, F, Et, Br), (M-11004, CH,₃, F, F, Et, CH₃), (M-11005, CH₃, F, F,n-Pr, H), (M-11006, CH₃, F, F, n-Pr, Cl), (M-11007, CH₃, F, F, n-Pr, F),(M-11008, CH₃, F, F, n-Pr, CF₃), (M-11009, CH₃, F, F, n-Pr, Br),(M-11010, CH₃, F, F, n-Pr, CH₃), (M-11011, CH₃, F, F, c-Pr, H),(M-11012, CH₃, F, F, c-Pr, Cl), (M-11013, CH₃, F, F, c-Pr, F), (M-11014,CH₃, F, F, c-Pr, CF₃), (M-11015, CH₃, F, F, c-Pr, Br), (M-11016, CH₃, F,F, c-Pr, CH₃), (M-11017, CH₃, F, F, i-Pr, H), (M-11018, CH₃, F, F, i-Pr,Cl), (M-11019, CH₃, F, F, i-Pr, F), (M-11020, CH₃, F, F, i-Pr, CF₃),(M-11021, CH₃, F, F, i-Pr, Br), (M-11022, CH₃, F, F, i-Pr, CH₃),(M-11023, CH₃, F, F, n-Bu, H), (M-11024, CH₃, F, F, n-Bu, Cl), (M-11025,CH₃, F, F, n-Bu, F), (M-11026, CH₃, F, F, n-Bu, CF₃), (M-11027, CH₃, F,F, n-Bu, Br), (M-11028, CH₃, F, F, n-Bu, CH₃), (M-11029, CH₃, F, F,i-Bu, H), (M-11030, CH₃, F, F, i-Bu, Cl), (M-11031, CH₃, F, F, i-Bu, F),(M-11032, CH₃, F, F, i-Bu, CF₃), (M-11033, CH₃, F, F, i-Bu, Br),(M-11034, CH₃, F, F, i-Bu, CH₃), (M-11035, CH₃, F, F, sec-Bu, H),(M-11036, CH₃, F, F, sec-Bu, Cl), (M-11037, CH₃, F, F, sec-Bu, F),(M-11038, CH₃, F, F, sec-Bu, CF₃), (M-11039, CH₃, F, F, sec-Bu, Br),(M-11040, CH₃, F, F, sec-Bu, CH₃), (M-11041, CH₃, F, F, n-Pen, H),(M-11042, CH₃, F, F, n-Pen, Cl), (M-11043, CH₃, F, F, n-Pen, F),(M-11044, CH₃, F, F, n-Pen, CF₃), (M-11045, CH₃, F, F, n-Pen, Br),(M-11046, CH₃, F, F, n-Pen, CH₃), (M-11047, CH₃, F, F, c-Pen, H),(M-11048, CH₃, F, F, c-Pen, Cl), (M-11049, CH₃, F, F, c-Pen, F),(M-11050, CH₃, F, F, c-Pen, CF₃), (M-11051, CH₃, F, F, c-Pen, Br),(M-11052, CH₃, F, F, c-Pen, CH₃), (M-11053, CH₃, F, F, n-Hex, H),(M-11054, CH₃, F, F, n-Hex, Cl), (M-11055, CH₃, F, F, n-Hex, F),(M-11056, CH₃, F, F, n-Hex, CF₃), (M-11057, CH₃, F, F, n-Hex, Br),(M-11058, CH₃, F, F, n-Hex, CH₃), (M-11059, CH₃, F, F, c-Hex, H),(M-11060, CH₃, F, F, c-Hex, Cl), (M-11061, CH₃, F, F, c-Hex, F),(M-11062, CH₃, F, F, c-Hex, CF₃), (M-11063, CH₃, F, F, c-Hex, Br),(M-11064, CH₃, F, F, c-Hex, CH₃), (M-11065, CH₃, F, F, OH, H), (M-11066,CH₃, F, F, OH, Cl), (M-11067, CH₃, F, F, OH, F), (M-11068, CH₃, F, F,OH, CF₃), (M-11069, CH₃, F, F, OH, Br), (M-11070, CH₃, F, F, OH, CH₃),(M-11071, CH₃, F, F, EtO, H), (M-11072, CH₃, F, F, EtO, Cl), (M-11073,CH₃, F, F, EtO, F), (M-11074, CH₃, F, F, EtO, CF₃), (M-11075, CH₃, F, F,EtO, Br), (M-11076, CH₃, F, F, EtO, CH₃), (M-11077, CH₃, F, F, n-PrO,H), (M-11078, CH₃, F, F, n-PrO, Cl), (M-11079, CH₃, F, F, n-PrO, F),(M-11080, CH₃, F, F, n-PrO, CF₃), (M-11081, CH₃, F, F, n-PrO, Br),(M-11082, CH₃, F, F, n-PrO, CH₃), (M-11083, CH₃, F, F, PhO, H),(M-11084, CH₃, F, F, PhO, Cl), (M-11085, CH₃, F, F, PhO, F), (M-11086,CH₃, F, F, PhO, CF₃), (M-11087, CH₃, F, F, PhO, Br), (M-11088, CH₃, F,F, PhO, CH₃), (M-11089, CH₃, F, F, BnO, H), (M-11090, CH₃, F, F, BnO,Cl), (M-11091, CH₃, F, F, BnO, F), (M-11092, CH₃, F, F, BnO, CF₃),(M-11093, CH₃, F, F, BnO, Br), (M-11094, CH₃, F, F, BnO, CH₃), (M-11095,CH₃, F, F, PhCH₂CH₂O, H), (M-11096, CH₃, F, F, PhCH₂CH₂O, Cl), (M-11097,CH₃, F, F, PhCH₂CH₂O, F), (M-11098, CH₃, F, F, PhCH₂CH₂O, CF₃),(M-11099, CH₃, F, F, PhCH₂CH₂O, Br), (M-11100, CH₃, F, F, PhCH₂CH₂O,CH₃), (M-11101, CH₃, F, F, CF₃O, H), (M-11102, CH₃, F, F, CF₃O, Cl),(M-11103, CH₃, F, F, CF₃O, F), (M-11104, CH₁₃, F, F, CF₃O, CF₃),(M-11105, CH₃, F, F, CF₃O, Br), (M-11106, CH₃, F, F, CF₃O, CH₃),(M-11107, CH₃, F, F, Ph, H), (M-11108, CH₃, F, F, Ph, Cl), (M-11109,CH₃, F, F, Ph, F), (M-11110, CH₃, F, F, Ph, CF₃), (M-11111, CH₃, F, F,Ph, Br), (M-11112, CH₃, F, F, Ph, CH₃), (M-11113, CH₃, F, F, 4-F-Ph, H),(M-11114, CH₃, F, F, 4-F-Ph, Cl), (M-11115, CH₃, F, F, 4-F-Ph, F),(M-11116, CH₃, F, F, 4-F-Ph, CF₃), (M-11117, CH₃, F, F, 4-F-Ph, Br),(M-11118, CH₃, F, F, 4-F-Ph, CH₃), (M-11119, CH₃, F, F, 4-CF₃-Ph, H),(M-11120, CH₃, F, F, 4-CF₃-Ph, Cl), (M-11121, CH₃, F, F, 4-CF₃-Ph, F),(M-11122, CH₃, F, F, 4-CF₃-Ph, CF₃), (M-11123, CH₃, F, F, 4-CF₃-Ph, Br),(M-11124, CH₃, F, F, 4-CF₃-Ph, CH₃), (M-11125, CH₃, F, F, 4-(Me)₂N-Ph,H), (M-11126, CH₃, F, F, 4-(Me)₂N-Ph, Cl), (M-11127, CH₃, F, F,4-(Me)₂N-Ph, F), (M-11128, CH₃, F, F, 4-(Me)₂N-Ph, CF₃), (M-11129, CH₃,F, F, 4-(Me)₂N-Ph, Br), (M-11130, CH₃, F, F, 4-(Me)₂N-Ph, CH₃),(M-11131, CH₃, F, F, 4-OH-Ph, H), (M-11132, CH₃, F, F, 4-OH-Ph, Cl),(M-11133, CH₃, F, F, 4-OH-Ph, F), (M-11134, CH₃, F, F, 4-OH-Ph, CF₃),(M-11135, CH₃, F, F, 4-OH-Ph, Br), (M-11136, CH₃, F, F, 4-OH-Ph, CH₃),(M-11137, CH₃, F, F, 3,4-di-F-Ph, H), (M-11138, CH₃, F, F, 3,4-di-F-Ph,Cl), (M-11139, CH₃, F, F, 3,4-di-F-Ph, F), (M-11140, CH₃, F, F,3,4-di-F-Ph, CF₃), (M-11141, CH₃, F, F, 3,4-di-F-Ph, Br), (M-11142, CH₃,F, F, 3,4-di-F-Ph, CH₃), (M-11143, CH₃, F, F, 4-COOH-Ph, H), (M-11144,CH₃, F, F, 4-COOH-Ph, Cl), (M-11145, CH₃, F, F, 4-COOH-Ph, F), (M-11146,CH₃, F, F, 4-COOH-Ph, CF₃), (M-11147, CH₃, F, F, 4-COOH-Ph, Br),(M-11148, CH₃, F, F, 4-COOH-Ph, CH₃), (M-11149, CH₃, F, F, Bn, H),(M-11150, CH₃, F, F, Bn, Cl), (M-11151, CH₃, F, F, Bn, F), (M-11152,CH₃, F, F, Bn, CF₃), (M-11153, CH₃, F, F, Bn, Br), (M-11154, CH₃, F, F,Bn, CH₃), (M-11155, CH₃, F, F, 4-F-Bn, H), (M-11156, CH₃, F, F, 4-F-Bn,Cl), (M-11157, CH₃, F, F, 4-F-Bn, F), (M-11158, CH₃, F, F, 4-F-Bn, CF₃),(M-11159, CH₃, F, F, 4-F-Bn, Br), (M-11160, CH₃, F, F, 4-F-Bn, CH₃),(M-11161, CH₃, F, F, 2-Py, H), (M-11162, CH₃, F, F, 2-Py, Cl), (M-11163,CH₃, F, F, 2-Py, F), (M-11164, CH₃, F, F, 2-Py, CF₃), (M-11165, CH₃, F,F, 2-Py, Br), (M-11166, CH₃, F, F, 2-Py, CH₃), (M-11167, CH₃, F, F,3-Py, H), (M-11168, CH₃, F, F, 3-Py, Cl), (M-11169, CH₃, F, F, 3-Py, F),(M-11170, CH₃, F, F, 3-Py, CF₃), (M-11171, CH₃, F, F, 3-Py, Br),(M-11172, CH₃, F, F, 3-Py, CH₃), (M-11173, CH₃, F, F, 4-Py, H),(M-11174, CH₃, F, F, 4-Py, Cl), (M-11175, CH₃, F, F, 4-Py, F), (M-11176,CH₃, F, F, 4-Py, CF₃), (M-11177, CH₃, F, F, 4-Py, Br), (M-11178, CH₃, F,F, 4-Py, CH₃), (M-11179, CH₃, F, F, 2-Th, H), (M-11180, CH₃, F, F, 2-Th,Cl), (M-11181, CH₃, F, F, 2-Th, F), (M-11182, CH₃, F, F, 2-Th, CF₃),(M-11183, CH₃, F, F, 2-Th, Br), (M-11184, CH₃, F, F, 2-Th, CH₃),(M-11185, CH₃, F, F, 3-Th, H), (M-11186, CH₃, F, F, 3-Th, Cl), (M-11187,CH₃, F, F, 3-Th, F), (M-11188, CH₃, F, F, 3-Th, CF₃), (M-11189, CH₃, F,F, 3-Th, Br), (M-11190, CH₃, F, F, 3-Th, CH₃), (M-11191, CH₃, F, F,pyrrazol-2-yl, H), (M-11192, CH₃, F, F, pyrrazol-2-yl, Cl), (M-11193,CH₃, F, F, pyrrazol-2-yl, F), (M-11194, CH₃, F, F, pyrrazol-2-yl, CF₃),(M-11195, CH₃, F, F, pyrrazol-2-yl, Br), (M-11196, CH₃, F, F,pyrrazol-2-yl, CH₃), (M-11197, CH₃, F, F, pyrrazol-3-yl, H), (M-11198,CH₃, F, F, pyrrazol-3-yl, Cl), (M-11199, CH₃, F, F, pyrrazol-3-yl, F),(M-11200, CH₃, F, F, pyrrazol-3-yl, CF₃), (M-11201, CH₃, F, F,pyrrazol-3-yl, Br), (M-11202, CH₃, F, F, pyrrazol-3-yl, CH₃), (M-11203,CH₃, F, F, pyrimidin-2-yl, H), (M-11204, CH₃, F, F, pyrimidin-2-yl, Cl),(M-11205, CH₃, F, F, pyrimidin-2-yl, F), (M-11206, CH₃, F, F,pyrimidin-2-yl, CF₃), (M-11207, CH₃, F, F, pyrimidin-2-yl, Br),(M-11208, CH₃, F, F, pyrimidin-2-yl, CH₃), (M-11209, CH₃, F, F,pyrimidin-4-yl, H), (M-11210, CH₃, F, F, pyrimidin-4-yl, Cl), (M-11211,CH₃, F, F, pyrimidin-4-yl, F), (M-11212, CH₃, F, F, pyrimidin-4-yl,CF₃), (M-11213, CH₃, F, F, pyrimidin-4-yl, Br), (M-11214, CH₃, F, F,pyrimidin-4-yl, CH₃), (M-11215, CH₃, F, F, pyrimidin-5-yl, H), (M-11216,CH₃, F, F, pyrimidin-5-yl, Cl), (M-11217, CH₃, F, F, pyrimidin-5-yl, F),(M-11218, CH₃, F, F, pyrimidin-5-yl, CF₃), (M-11219, CH₃, F, F,pyrimidin-5-yl, Br), (M-11220, CH₃, F, F, pyrimidin-5-yl, CH₃),(M-11221, CH₃, F, F, HOOCCH₂CH₂CH₂, H), (M-11222, CH₃, F, F,HOOCCH₂CH₂CH₂, Cl), (M-11223, CH₃, F, F, HOOCCH₂CH₂CH₂, F), (M-11224,CH₃, F, F, HOOCCH₂CH₂CH₂, CF₃), (M-11225, CH₃, F, F, HOOCCH₂CH₂CH₂, Br),(M-11226, CH₃, F, F, HOOCCH₂CH₂CH₂, CH₃), (M-11227, CH₃, F, F,HOOCCH₂CH₂CH₂CH₂, H), (M-11228, CH₃, F, F, HOOCCH₂CH₂CH₂CH₂, Cl),(M-11229, CH₃, F, F, HOOCCH₂CH₂CH₂CH₂, F), (M-11230, CH₃, F, F,HOOCCH₂CH₂CH₂CH₂, CF₃), (M-11231, CH₃, F, F, HOOCCH₂CH₂CH₂CH₂, Br),(M-11232, CH₃, F, F, HOOCCH₂CH₂CH₂CH₂, CH₃), (M-11233, CH₃, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-11234, CH₃, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂,Cl), (M-11235, CH₃, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-11236, CH₃, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-11237, CH₃, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂,Br), (M-11238, CH₃, F, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-11239, CH₃, F,F, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-11240, CH₃, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-11241, CH₃, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-11242, CH₃, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-11243, CH₃, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-11244, CH₃, F, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-11245, CH₃, F, F, MeOCH₂, H),(M-11246, CH₃, F, F, MeOCH₂, Cl), (M-11247, CH₃, F, F, MeOCH₂, F),(M-11248, CH₃, F, F, MeOCH₂, CF₃), (M-11249, CH₃, F, F, MeOCH₂, Br),(M-11250, CH₃, F, F, MeOCH₂, CH₃), (M-11251, CH₃, F, F, EtOCH₂, H),(M-11252, CH₃, F, F, EtOCH₂, Cl), (M-11253, CH₃, F, F, EtOCH₂, F),(M-11254, CH₃, F, F, EtOCH₂, CF₃), (M-11255, CH₃, F, F, EtOCH₂, Br),(M-11256, CH₃, F, F, EtOCH₂, CH₃), (M-11257, CH₃, F, F, EtOCH₂CH₂, H),(M-11258, CH₃, F, F, EtOCH₂CH₂, Cl), (M-11259, CH₃, F, F, EtOCH₂CH₂, F),(M-11260, CH₃, F, F, EtOCH₂CH₂, CF₃), (M-11261, CH₃, F, F, EtOCH₂CH₂,Br), (M-11262, CH₃, F, F, EtOCH₂CH₂, CH₃), (M-11263, CH₃, F, F,MeOCH₂CH₂OCH₂CH₂, H), (M-11264, CH₃, F, F, MeOCH₂CH₂OCH₂CH₂, Cl),(M-11265, CH₃, F, F, MeOCH₂CH₂OCH₂CH₂, F), (M-11266, CH₃, F, F,MeOCH₂CH₂OCH₂CH₂, CF₃), (M-11267, CH₃, F, F, MeOCH₂CH₂OCH₂CH₂, Br),(M-11268, CH₃, F, F, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-11269, CH₃, F, F,MeOCH₂CH₂, H), (M-11270, CH₃, F, F, MeOCH₂CH₂, Cl), (M-11271, CH₃, F, F,MeOCH₂CH₂, F), (M-11272, CH₃, F, F, MeOCH₂CH₂, CF₃), (M-11273, CH₃, F,F, MeOCH₂CH₂, Br), (M-11274, CH₃, F, F, MeOCH₂CH₂, CH₃), (M-11275, CH₃,F, F, HOCH₂, H), (M-11276, CH₃, F, F, HOCH₂, Cl), (M-11277, CH₃, F, F,HOCH₂, F), (M-11278, CH₃, F, F, HOCH₂, CF₃), (M-11279, CH₃, F, F, HOCH₂,Br), (M-11280, CH₃, F, F, HOCH₂, CH₃), (M-11281, CH₃, F, F, HOCH₂CH₂,H), (M-11282, CH₃, F, F, HOCH₂CH₂, Cl), (M-11283, CH₃, F, F, HOCH₂CH₂,F), (M-11284, CH₃, F, F, HOCH₂CH₂, CF₃), (M-11285, CH₃, F, F, HOCH₂CH₂,Br), (M-11286, CH₃, F, F, HOCH₂CH₂, CH₃), (M-11287, CH₃, F, F,HOCH₂CH₂CH₂, H), (M-11288, CH₃, F, F, HOCH₂CH₂CH₂, Cl), (M-11289, CH₃,F, F, HOCH₂CH₂CH₂, F), (M-11290, CH₃, F, F, HOCH₂CH₂CH₂, CF₃), (M-11291,CH₃, F, F, HOCH₂CH₂CH₂, Br), (M-11292, CH₃, F, F, HOCH₂CH₂CH₂, CH₃),(M-11293, CH₃, F, F, HOCH₂CH₂CH₂CH₂, H), (M-11294, CH₃, F, F,HOCH₂CH₂CH₂CH₂, Cl), (M-11295, CH₃, F, F, HOCH₂CH₂CH₂CH₂, F), (M-11296,CH₃, F, F, HOCH₂CH₂CH₂CH₂, CF₃), (M-11297, CH₃, F, F, HOCH₂CH₂CH₂CH₂,Br), (M-11298, CH₃, F, F, HOCH₂CH₂CH₂CH₂, CH₃), (M-11299, CH₃, F, F,HOCH₂CH₂CH₂CH₂CH₂, H), (M-11300, CH₃, F, F, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-11301, CH₃, F, F, HOCH₂CH₂CH₂CH₂CH₂, F), (M-11302, CH₃, F, F,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-11303, CH₃, F, F, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-11304, CH₃, F, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-11305, CH₃, F, F,HOCH₂CH₂OCH₂CH₂, H), (M-11306, CH₃, F, F, HOCH₂CH₂OCH₂CH₂, Cl),(M-11307, CH₃, F, F, HOCH₂CH₂O CH₂CH₂, F), (M-11308, CH₃, F, F,HOCH₂CH₂O CH₂CH₂, CF₃), (M-11309, CH₃, F, F, HOCH₂CH₂O CH₂CH₂, Br),(M-11310, CH₃, F, F, HOCH₂CH₂OCH₂CH₂, CH₃), (M-11311, CH₃, F, F, (Me)₂N,H), (M-11312, CH₃, F, F, (Me)₂N, Cl), (M-11313, CH₃, F, F, (Me)₂N, F),(M-11314, CH₃, F, F, (Me)₂N, CF₃), (M-11315, CH₃, F, F, (Me)₂N, Br),(M-11316, CH₃, F, F, (Me)₂N, CH₃), (M-11317, CH₃, F, F,piperidin-4-yl-methyl, H), (M-11318, CH₃, F, F, piperidin-4-yl-methyl,Cl), (M-11319, CH₃, F, F, piperidin-4-yl-methyl, F), (M-11320, CH₃, F,F, piperidin-4-yl-methyl, CF₃), (M-11321, CH₃, F, F,piperidin-4-yl-methyl, Br), (M-11322, CH₃, F, F, piperidin-4-yl-methyl,CH₃), (M-11323, CH₃, F, F, cyclohexylmethyl, H), (M-11324, CH₃, F, F,cyclohexylmethyl, Cl), (M-11325, CH₃, F, F, cyclohexylmethyl, F),(M-11326, CH₃, F, F, cyclohexylmethyl, CF₃), (M-11327, CH₃, F, F,cyclohexylmethyl, Br), (M-11328, CH₃, F, F, cyclohexylmethyl, CH₃),(M-11329, CH₃, F, Cl, H, H), (M-11330, CH₃, F, Cl, H, Cl), (M-11331,CH₃, F, Cl, H, F), (M-11332, CH₃, F, Cl, H, CF₃), (M-11333, CH₃, F, Cl,H, Br), (M-11334, CH₃, F, Cl, H, CH₃), (M-11335, CH₃, F, Cl, F, H),(M-11336, CH₃, F, Cl, F, Cl), (M-11337, CH₃, F, Cl, F, F), (M-11338,CH₃, F, Cl, F, CF₃), (M-11339, CH₃, F, Cl, F, Br), (M-11340, CH₃, F, Cl,F, CH₃), (M-11341, CH₃, F, Cl, Cl, H), (M-11342, CH₃, F, Cl, Cl, Cl),(M-11343, CH₃, F, Cl, Cl, F), (M-11344, CH₃, F, Cl, Cl, CF₃), (M-11345,CH₃, F, Cl, Cl, Br), (M-11346, CH₃, F, Cl, Cl, CH₃), (M-11347, CH₃, F,Cl, CH₃, H), (M-11348, CH₃, F, Cl, CH₃, Cl), (M-11349, CH₃, F, Cl, CH₃,F), (M-11350, CH₃, F, Cl, CH₃, CF₃), (M-11351, CH₃, F, Cl, CH₃, Br),(M-11352, CH₃, F, Cl, CH₃, CH₃), (M-11353, CH₃, F, Cl, Et, H), (M-11354,CH₃, F, Cl, Et, Cl), (M-11355, CH₃, F, Cl, Et, F), (M-11356, CH₃, F, Cl,Et, CF₃), (M-11357, CH₃, F, Cl, Et, Br), (M-11358, CH₃, F, Cl, Et, CH₃),(M-11359, CH₃, F, Cl, n-Pr, H), (M-11360, CH₃, F, Cl, n-Pr, Cl),(M-11361, CH₃, F, Cl, n-Pr, F), (M-11362, CH₃, F, Cl, n-Pr, CF₃),(M-11363, CH₃, F, Cl, n-Pr, Br), (M-11364, CH₃, F, Cl, n-Pr, CH₃),(M-11365, CH₃, F, Cl, c-Pr, H), (M-11366, CH₃, F, Cl, c-Pr, Cl),(M-11367, CH₃, F, Cl, c-Pr, F), (M-11368, CH₃, F, Cl, c-Pr, CF₃),(M-11369, CH₃, F, Cl, c-Pr, Br), (M-11370, CH₃, F, Cl, c-Pr, CH₃),(M-11371, CH₃, F, Cl, i-Pr, H), (M-11372, CH₃, F, Cl, i-Pr, Cl),(M-11373, CH₃, F, Cl, i-Pr, F), (M-11374, CH₃, F, Cl, i-Pr, CF₃),(M-11375, CH₃, F, Cl, i-Pr, Br), (M-11376, CH₃, F, Cl, i-Pr, CH₃),(M-11377, CH₃, F, Cl, n-Bu, H), (M-11378, CH₃, F, Cl, n-Bu, Cl),(M-11379, CH₃, F, Cl, n-Bu, F), (M-11380, CH₃, F, Cl, n-Bu, CF₃),(M-11381, CH₃, F, Cl, n-Bu, Br), (M-11382, CH₃, F, Cl, n-Bu, CH₃),(M-11383, CH₃, F, Cl, i-Bu, H), (M-11384, CH₃, F, Cl, i-Bu, Cl),(M-11385, CH₃, F, Cl, i-Bu, F), (M-11386, CH₃, F, Cl, i-Bu, CF₃),(M-11387, CH₃, F, Cl, i-Bu, Br), (M-11388, CH₃, F, Cl, i-Bu, CH₃),(M-11389, CH₃, F, Cl, sec-Bu, H), (M-11390, CH₃, F, Cl, sec-Bu, Cl),(M-11391, CH₃, F, Cl, sec-Bu, F), (M-11392, CH₃, F, Cl, sec-Bu, CF₃),(M-11393, CH₃, F, Cl, sec-Bu, Br), (M-11394, CH₃, F, Cl, sec-Bu, CH₃),(M-11395, CH₃, F, Cl, n-Pen, H), (M-11396, CH₃, F, Cl, n-Pen, Cl),(M-11397, CH₃, F, Cl, n-Pen, F), (M-11398, CH₃, F, Cl, n-Pen, CF₃),(M-11399, CH₃, F, Cl, n-Pen, Br), (M-11400, CH₃, F, Cl, n-Pen, CH₃),(M-11401, CH₃, F, Cl, c-Pen, H), (M-11402, CH₃, F, Cl, c-Pen, Cl),(M-11403, CH₃, F, Cl, c-Pen, F), (M-11404, CH₃, F, Cl, c-Pen, CF₃),(M-11405, CH₃, F, Cl, c-Pen, Br), (M-11406, CH₃, F, Cl, c-Pen, CH₃),(M-11407, CH₃, F, Cl, n-Hex, H), (M-11408, CH₃, F, Cl, n-Hex, Cl),(M-11409, CH₃, F, Cl, n-Hex, F), (M-11410, CH₃, F, Cl, n-Hex, CF₃),(M-11411, CH₃, F, Cl, n-Hex, Br), (M-11412, CH₃, F, Cl, n-Hex, CH₃),(M-11413, CH₃, F, Cl, c-Hex, H), (M-11414, CH₃, F, Cl, c-Hex, Cl),(M-11415, CH₃, F, Cl, c-Hex, F), (M-11416, CH₃, F, Cl, c-Hex, CF₃),(M-11417, CH₃, F, Cl, c-Hex, Br), (M-11418, CH₃, F, Cl, c-Hex, CH₃),(M-11419, CH₃, F, Cl, OH, H), (M-11420, CH₃, F, Cl, OH, Cl), (M-11421,CH₃, F, Cl, OH, F), (M-11422, CH₃, F, Cl, OH, CF₃), (M-11423, CH₃, F,Cl, OH, Br), (M-11424, CH₃, F, Cl, OH, CH₃), (M-11425, CH₃, F, Cl, EtO,H), (M-11426, CH₃, F, Cl, EtO, Cl), (M-11427, CH₃, F, Cl, EtO, F),(M-11428, CH₃, F, Cl, EtO, CF₃), (M-11429, CH₃, F, Cl, EtO, Br),(M-11430, CH₃, F, Cl, EtO, CH₃), (M-11431, CH₃, F, Cl, n-PrO, H),(M-11432, CH₃, F, Cl, n-PrO, Cl), (M-11433, CH₃, F, Cl, n-PrO, F),(M-11434, CH₃, F, Cl, n-PrO, CF₃), (M-11435, CH₃, F, Cl, n-PrO, Br),(M-11436, CH₃, F, Cl, n-PrO, CH₃), (M-11437, CH₃, F, Cl, PhO, H),(M-11438, CH₃, F, Cl, PhO, Cl), (M-11439, CH₃, F, Cl, PhO, F), (M-11440,CH₃, F, Cl, PhO, CF₃), (M-11441, CH₃, F, Cl, PhO, Br), (M-11442, CH₃, F,Cl, PhO, CH₃), (M-11443, CH₃, F, Cl, BnO, H), (M-11444, CH₃, F, Cl, BnO,Cl), (M-11445, CH₃, F, Cl, BnO, F), (M-11446, CH₃, F, Cl, BnO, CF₃),(M-11447, CH₃, F, Cl, BnO, Br), (M-11448, CH₃, F, Cl, BnO, CH₃),(M-11449, CH₃, F, Cl, PhCH₂CH₂O, H), (M-11450, CH₃, F, Cl, PhCH₂CH₂O,Cl), (M-11451, CH₃, F, Cl, PhCH₂CH₂O, F), (M-11452, CH₃, F, Cl,PhCH₂CH₂O, CF₃), (M-11453, CH₃, F, Cl, PhCH₂CH₂O, Br), (M-11454, CH₃, F,Cl, PhCH₂CH₂O, CH₃), (M-11455, CH₃, F, Cl, CF₃O, H), (M-11456, CH₃, F,Cl, CF₃O, Cl), (M-11457, CH₃, F, Cl, CF₃O, F), (M-11458, CH₃, F, Cl,CF₃O, CF₃), (M-11459, CH₃, F, Cl, CF₃O, Br), (M-11460, CH₃, F, Cl, CF₃O,CH₃), (M-11461, CH₃, F, Cl, Ph, H), (M-11462, CH₃, F, Cl, Ph, Cl),(M-11463, CH₃, F, Cl, Ph, F), (M-11464, CH₃, F, Cl, Ph, CF₃), (M-11465,CH₃, F, Cl, Ph, Br), (M-11466, CH₃, F, Cl, Ph, CH₃), (M-11467, CH₃, F,Cl, 4-F-Ph, H), (M-11468, CH₃, F, Cl, 4-F-Ph, Cl), (M-11469, CH₃, F, Cl,4-F-Ph, F), (M-11470, CH₃, F, Cl, 4-F-Ph, CF₃), (M-11471, CH₃, F, Cl,4-F-Ph, Br), (M-11472, CH₃, F, Cl, 4-F-Ph, CH₃), (M-11473, CH₃, F, Cl,4-CF₃-Ph, H), (M-11474, CH₃, F, Cl, 4-CF₃-Ph, Cl), (M-11475, CH₃, F, Cl,4-CF₃-Ph, F), (M-11476, CH₃, F, Cl, 4-CF₃-Ph, CF₃), (M-11477, CH₃, F,Cl, 4-CF₃-Ph, Br), (M-11478, CH₃, F, Cl, 4-CF₃-Ph, CH₃), (M-11479, CH₃,F, Cl, 4-(Me)₂N-Ph, H), (M-11480, CH₃, F, Cl, 4-(Me)₂N-Ph, Cl),(M-11481, CH₃, F, Cl, 4-(Me)₂N-Ph, F), (M-11482, CH₃, F, Cl,4-(Me)₂N-Ph, CF₃), (M-11483, CH₃, F, Cl, 4-(Me)₂N-Ph, Br), (M-11484,CH₃, F, Cl, 4-(Me)₂N-Ph, CH₃), (M-11485, CH₃, F, Cl, 4-OH-Ph, H),(M-11486, CH₃, F, Cl, 4-OH-Ph, Cl), (M-11487, CH₃, F, Cl, 4-OH-Ph, F),(M-11488, CH₃, F, Cl, 4-OH-Ph, CF₃), (M-11489, CH₃, F, Cl, 4-OH-Ph, Br),(M-11490, CH₃, F, Cl, 4-OH-Ph, CH₃), (M-11491, CH₃, F, Cl, 3,4-di-F-Ph,H), (M-11492, CH₃, F, Cl, 3,4-di-F-Ph, Cl), (M-11493, CH₃, F, Cl,3,4-di-F-Ph, F), (M-11494, CH₃, F, Cl, 3,4-di-F-Ph, CF₃), (M-11495, CH₃,F, Cl, 3,4-di-F-Ph, Br), (M-11496, CH₃, F, Cl, 3,4-di-F-Ph, CH₃),(M-11497, CH₃, F, Cl, 4-COOH-Ph, H), (M-11498, CH₃, F, Cl, 4-COOH-Ph,Cl), (M-11499, CH₃, F, Cl, 4-COOH-Ph, F), (M-11500, CH₃, F, Cl,4-COOH-Ph, CF₃), (M-11501, CH₃, F, Cl, 4-COOH-Ph, Br), (M-11502, CH₃, F,Cl, 4-COOH-Ph, CH₃), (M-11503, CH₃, F, Cl, Bn, H), (M-11504, CH₃, F, Cl,Bn, Cl), (M-11505, CH₃, F, Cl, Bn, F), (M-11506, CH₃, F, Cl, Bn, CF₃),(M-11507, CH₃, F, Cl, Bn, Br), (M-11508, CH₃, F, Cl, Bn, CH₃), (M-11509,CH₃, F, Cl, 4-F-Bn, H), (M-11510, CH₃, F, Cl, 4-F-Bn, Cl), (M-11511,CH₃, F, Cl, 4-F-Bn, F), (M-11512, CH₃, F, Cl, 4-F-Bn, CF₃), (M-11513,CH₃, F, Cl, 4-F-Bn, Br), (M-11514, CH₃, F, Cl, 4-F-Bn, CH₃), (M-11515,CH₃, F, Cl, 2-Py, H), (M-11516, CH₃, F, Cl, 2-Py, Cl), (M-11517, CH₃, F,Cl, 2-Py, F), (M-11518, CH₃, F, Cl, 2-Py, CF₃), (M-11519, CH₃, F, Cl,2-Py, Br), (M-11520, CH₃, F, Cl, 2-Py, CH₃), (M-11521, CH₃, F, Cl, 3-Py,H), (M-11522, CH₃, F, Cl, 3-Py, Cl), (M-11523, CH₃, F, Cl, 3-Py, F),(M-11524, CH₃, F, Cl, 3-Py, CF₃), (M-11525, CH₃, F, Cl, 3-Py, Br),(M-11526, CH₃, F, Cl, 3-Py, CH₃), (M-11527, CH₃, F, Cl, 4-Py, H),(M-11528, CH₃, F, Cl, 4-Py, Cl), (M-11529, CH₃, F, Cl, 4-Py, F),(M-11530, CH₃, F, Cl, 4-Py, CF₃), (M-11531, CH₃, F, Cl, 4-Py, Br),(M-11532, CH₃, F, Cl, 4-Py, CH₃), (M-11533, CH₃, F, Cl, 2-Th, H),(M-11534, CH₃, F, Cl, 2-Th, Cl), (M-11535, CH₃, F, Cl, 2-Th, F),(M-11536, CH₃, F, Cl, 2-Th, CF₃), (M-11537, CH₃, F, Cl, 2-Th, Br),(M-11538, CH₃, F, Cl, 2-Th, CH₃), (M-11539, CH₃, F, Cl, 3-Th, H),(M-11540, CH₃, F, Cl, 3-Th, Cl), (M-11541, CH₃, F, Cl, 3-Th, F),(M-11542, CH₃, F, Cl, 3-Th, CF₃), (M-11543, CH₃, F, Cl, 3-Th, Br),(M-11544, CH₃, F, Cl, 3-Th, CH₃), (M-11545, CH₃, F, Cl, pyrrazol-2-yl,H), (M-11546, CH₃, F, Cl, pyrrazol-2-yl, Cl), (M-11547, CH₃, F, Cl,pyrrazol-2-yl, F), (M-11548, CH₃, F, Cl, pyrrazol-2-yl, CF₃), (M-11549,CH₃, F, Cl, pyrrazol-2-yl, Br), (M-11550, CH₃, F, Cl, pyrrazol-2-yl,CH₃), (M-11551, CH₃, F, Cl, pyrrazol-3-yl, H), (M-11552, CH₃, F, Cl,pyrrazol-3-yl, Cl), (M-11553, CH₃, F, Cl, pyrrazol-3-yl, F), (M-11554,CH₃, F, Cl, pyrrazol-3-yl, CF₃), (M-11555, CH₃, F, Cl, pyrrazol-3-yl,Br), (M-11556, CH₃, F, Cl, pyrrazol-3-yl, CH₃), (M-11557, CH₃, F, Cl,pyrimidin-2-yl, H), (M-11558, CH₃, F, Cl, pyrimidin-2-yl, Cl), (M-11559,CH₃, F, Cl, pyrimidin-2-yl, F), (M-11560, CH₃, F, Cl, pyrimidin-2-yl,CF₃), (M-11561, CH₃, F, Cl, pyrimidin-2-yl, Br), (M-11562, CH₃, F, Cl,pyrimidin-2-yl, CH₃), (M-11563, CH₃, F, Cl, pyrimidin-4-yl, H),(M-11564, CH₃, F, Cl, pyrimidin-4-yl, Cl), (M-11565, CH₃, F, Cl,pyrimidin-4-yl, F), (M-11566, CH₃, F, Cl, pyrimidin-4-yl, CF₃),(M-11567, CH₃, F, Cl, pyrimidin-4-yl, Br), (M-11568, CH₃, F, Cl,pyrimidin-4-yl, CH₃), (M-11569, CH₃, F, Cl, pyrimidin-5-yl, H),(M-11570, CH₃, F, Cl, pyrimidin-5-yl, Cl), (M-11571, CH₃, F, Cl,pyrimidin-5-yl, F), (M-11572, CH₃, F, Cl, pyrimidin-5-yl, CF₃),(M-11573, CH₃, F, Cl, pyrimidin-5-yl, Br), (M-11574, CH₃, F, Cl,pyrimidin-5-yl, CH₃), (M-11575, CH₃, F, Cl, HOOCCH₂CH₂CH₂, H), (M-11576,CH₃, F, Cl, HOOCCH₂CH₂CH₂, Cl), (M-11577, CH₃, F, Cl, HOOCCH₂CH₂CH₂, F),(M-11578, CH₃, F, Cl, HOOCCH₂CH₂CH₂, CF₃), (M-11579, CH₃, F, Cl,HOOCCH₂CH₂CH₂, Br), (M-11580, CH₃, F, Cl, HOOCCH₂CH₂CH₂, CH₃), (M-11581,CH₃, F, Cl, HOOCCH₂CH₂CH₂CH₂, H), (M-11582, CH₃, F, Cl,HOOCCH₂CH₂CH₂CH₂, Cl), (M-11583, CH₃, F, Cl, HOOCCH₂CH₂CH₂CH₂, F),(M-11584, CH₃, F, Cl, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-11585, CH₃, F, Cl,HOOCCH₂CH₂CH₂CH₂, Br), (M-11586, CH₃, F, Cl, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-11587, CH₃, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-11588, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-11589, CH₃, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,F), (M-11590, CH₃, F, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-11591, CH₃, F,Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-11592, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-11593, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-11594, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-11595, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-11596, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-11597, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-11598, CH₃, F, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-11599, CH₃, F, Cl, MeOCH₂, H),(M-11600, CH₃, F, Cl, MeOCH₂, Cl), (M-11601, CH₃, F, Cl, MeOCH₂, F),(M-11602, CH₃, F, Cl, MeOCH₂, CF₃), (M-11603, CH₃, F, Cl, MeOCH₂, Br),(M-11604, CH₃, F, Cl, MeOCH₂, CH₃), (M-11605, CH₃, F, Cl, EtOCH₂, H),(M-11606, CH₃, F, Cl, EtOCH₂, Cl), (M-11607, CH₃, F, Cl, EtOCH₂, F),(M-11608, CH₃, F, Cl, EtOCH₂, CF₃), (M-11609, CH₃, F, Cl, EtOCH₂, Br),(M-11610, CH₃, F, Cl, EtOCH₂, CH₃), (M-11611, CH₃, F, Cl, EtOCH₂CH₂, H),(M-11612, CH₃, F, Cl, EtOCH₂CH₂, Cl), (M-11613, CH₃, F, Cl, EtOCH₂CH₂,F), (M-11614, CH₃, F, Cl, EtOCH₂CH₂, CF₃), (M-11615, CH₃, F, Cl,EtOCH₂CH₂, Br), (M-11616, CH₃, F, Cl, EtOCH₂CH₂, CH₃), (M-11617, CH₃, F,Cl, MeOCH₂CH₂OCH₂CH₂, H), (M-11618, CH₃, F, Cl, MeOCH₂CH₂OCH₂CH₂, Cl),(M-11619, CH₃, F, Cl, MeOCH₂CH₂OCH₂CH₂, F), (M-11620, CH₃, F, Cl,MeOCH₂CH₂OCH₂CH₂, CF₃), (M-11621, CH₃, F, Cl, MeOCH₂CH₂OCH₂CH₂, Br),(M-11622, CH₃, F, Cl, MeOCH₂CH₂OCH₂CH₂, CH₃), (M-11623, CH₃, F, Cl,MeOCH₂CH₂, H), (M-11624, CH₃, F, Cl, MeOCH₂CH₂, Cl), (M-11625, CH₃, F,Cl, MeOCH₂CH₂, F), (M-11626, CH₃, F, Cl, MeOCH₂CH₂, CF₃), (M-11627, CH₃,F, Cl, MeOCH₂CH₂, Br), (M-11628, CH₃, F, Cl, MeOCH₂CH₂, CH₃), (M-11629,CH₃, F, Cl, HOCH₂, H), (M-11630, CH₃, F, Cl, HOCH₂, Cl), (M-11631, CH₃,F, Cl, HOCH₂, F), (M-11632, CH₃, F, Cl, HOCH₂, CF₃), (M-11633, CH₃, F,Cl, HOCH₂, Br), (M-11634, CH₃, F, Cl, HOCH₂, CH₃), (M-11635, CH₃, F, Cl,HOCH₂CH₂, H), (M-11636, CH₃, F, Cl, HOCH₂CH₂, Cl), (M-11637, CH₃, F, Cl,HOCH₂CH₂, F), (M-11638, CH₃, F, Cl, HOCH₂CH₂, CF₃), (M-11639, CH₃, F,Cl, HOCH₂CH₂, Br), (M-11640, CH₃, F, Cl, HOCH₂CH₂, CH₃), (M-11641, CH₃,F, Cl, HOCH₂CH₂CH₂, H), (M-11642, CH₃, F, Cl, HOCH₂CH₂CH₂, Cl),(M-11643, CH₃, F, Cl, HOCH₂CH₂CH₂, F), (M-11644, CH₃, F, Cl,HOCH₂CH₂CH₂, CF₃), (M-11645, CH₃, F, Cl, HOCH₂CH₂CH₂, Br), (M-11646,CH₃, F, Cl, HOCH₂CH₂CH₂, CH₃), (M-11647, CH₃, F, Cl, HOCH₂CH₂CH₂CH₂, H),(M-11648, CH₃, F, Cl, HOCH₂CH₂CH₂CH₂, Cl), (M-11649, CH₃, F, Cl,HOCH₂CH₂CH₂CH₂, F), (M-11650, CH₃, F, Cl, HOCH₂CH₂CH₂CH₂, CF₃),(M-11651, CH₃, F, Cl, HOCH₂CH₂CH₂CH₂, Br), (M-11652, CH₃, F, Cl,HOCH₂CH₂CH₂CH₂, CH₃), (M-11653, CH₃, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, H),(M-11654, CH₃, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-11655, CH₃, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, F), (M-11656, CH₃, F, Cl, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-11657, CH₃F, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br), (M-11658, CH₃, F, Cl,HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-11659, CH₃, F, Cl, HOCH₂CH₂OCH₂CH₂, H),(M-11660, CH₃, F, Cl, HOCH₂CH₂OCH₂CH₂, Cl), (M-11661, CH₃, F, Cl,HOCH₂CH₂O CH₂CH₂, F), (M-11662, CH₃, F, Cl, HOCH₂CH₂O CH₂CH₂, CF₃),(M-11663, CH₃, F, Cl, HOCH₂CH₂OCH₂CH₂, Br), (M-11664, CH₃, F, Cl,HOCH₂CH₂O CH₂CH₂, CH₃), (M-11665, CH₃, F, Cl, (Me)₂N, H), (M-11666, CH₃,F, Cl, (Me)₂N, Cl), (M-11667, CH₃, F, Cl, (Me)₂N, F), (M-11668, CH₃, F,Cl, (Me)₂N, CF₃), (M-11669, CH₃, F, Cl, (Me)₂N, Br), (M-11670, CH₃, F,Cl, (Me)₂N, CH₃), (M-11671, CH₃, F, Cl, piperidin-4-yl-methyl, H),(M-11672, CH₃, F, Cl, piperidin-4-yl-methyl, Cl), (M-11673, CH₃, F, Cl,piperidin-4-yl-methyl, F), (M-11674, CH₃, F, Cl, piperidin-4-yl-methyl,CF₃), (M-11675, CH₃, F, Cl, piperidin-4-yl-methyl, Br), (M-11676, CH₃,F, Cl, piperidin-4-yl-methyl, CH₃), (M-11677, CH₃, F, Cl,cyclohexylmethyl, H), (M-11678, CH₃, F, Cl, cyclohexylmethyl, Cl),(M-11679, CH₃, F, Cl, cyclohexylmethyl, F), (M-11680, CH₃, F, Cl,cyclohexylmethyl, CF₃), (M-11681, CH₃, F, Cl, cyclohexylmethyl, Br),(M-11682, CH₃, F, Cl, cyclohexylmethyl, CH₃), (M-11683, CH₃, CH₃, H, H,H), (M-11684, CH₃, CH₃, H, H, Cl), (M-11685, CH₃, CH₃, H, H, F),(M-11686, CH₃, CH₃, H, H, CF₃), (M-11687, CH₃, CH₃, H, H, Br), (M-11688,CH₃, CH₃, H, H, CH₃), (M-11689, CH₃, CH₃, H, F, H), (M-11690, CH₃, CH₃,H, F, Cl), (M-11691, CH₃, CH₃, H, F, F), (M-11692, CH₃, CH₃, H, F, CF₃),(M-11693, CH₃, CH₃, H, F, Br), (M-11694, CH₃, CH₃, H, F, CH₃), (M-11695,CH₃, CH₃, H, Cl, H), (M-11696, CH₃, CH₃, H, Cl, Cl), (M-11697, CH₃, CH₃,H, Cl, F), (M-11698, CH₃, CH₃, H, Cl, CF₃), (M-11699, CH₃, CH₃, H, Cl,Br), (M-11700, CH₃, CH₃, H, Cl, CH₃), (M-11701, CH₃, CH₃, H, CH₃, H),(M-11702, CH₃, CH₃, H, CH₃, Cl), (M-11703, CH₃, CH₃, H, CH₃, F),(M-11704, CH₃, CH₃, H, CH₃, CF₃), (M-11705, CH₃, CH₃, H, CH₃, Br),(M-11706, CH₃, CH₃, H, CH₃, CH₃), (M-11707, CH₃, CH₃, H, Et, H),(M-11708, CH₃, CH₃, H, Et, Cl), (M-11709, CH₃, CH₃, H, Et, F), (M-11710,CH₃, CH₃, H, Et, CF₃), (M-11711, CH₃, CH₃, H, Et, Br), (M-11712, CH₃,CH₃, H, Et, CH₃), (M-11713, CH₃, CH₃, H, n-Pr, H), (M-11714, CH₃, CH₃,H, n-Pr, Cl), (M-11715, CH₃, CH₃, H, n-Pr, F), (M-11716, CH₃, CH₃, H,n-Pr, CF₃), (M-11717, CH₃, CH₃, H, n-Pr, Br), (M-11718, CH₃, CH₃, H,n-Pr, CH₃), (M-11719, CH₃, CH₃, H, c-Pr, H), (M-11720, CH₃, CH₃, H,c-Pr, Cl), (M-11721, CH₃, CH₃, H, c-Pr, F), (M-11722, CH₃, CH₃, H, c-Pr,CF₃), (M-11723, CH₃, CH₃, H, c-Pr, Br), (M-11724, CH₃, CH₃, H, c-Pr,CH₃), (M-11725, CH₃, CH₃, H, i-Pr, H), (M-11726, CH₃, CH₃, H, i-Pr, Cl),(M-11727, CH₃, CH₃, H, i-Pr, F), (M-11728, CH₃, CH₃, H, i-Pr, CF₃),(M-11729, CH₃, CH₃, H, i-Pr, Br), (M-11730, CH₃, CH₃, H, i-Pr, CH₃),(M-11731, CH₃, CH₃, H, n-Bu, H), (M-11732, CH₃, CH₃, H, n-Bu, Cl),(M-11733, CH₃, CH₃, H, n-Bu, F), (M-11734, CH₃, CH₃, H, n-Bu, CF₃),(M-11735, CH₃, CH₃, H, n-Bu, Br), (M-11736, CH₃, CH₃, H, n-Bu, CH₃),(M-11737, CH₃, CH₃, H, i-Bu, H), (M-11738, CH₃, CH₃, H, i-Bu, Cl),(M-11739, CH₃, CH₃, H, i-Bu, F), (M-11740, CH₃, CH₃, H, i-Bu, CF₃),(M-11741, CH₃, CH₃, H, i-Bu, Br), (M-11742, CH₃, CH₃, H, i-Bu, CH₃),(M-11743, CH₃, CH₃, H, sec-Bu, H), (M-11744, CH₃, CH₃, H, sec-Bu, Cl),(M-11745, CH₃, CH₃, H, sec-Bu, F), (M-11746, CH₃, CH₃, H, sec-Bu; CF₃),(M-11747, CH₃, CH₃, H, sec-Bu, Br), (M-11748, CH₃, CH₃, H, sec-Bu, CH₃),(M-11749, CH₃, CH₃, H, n-Pen, H), (M-11750, CH₃, CH₃, H, n-Pen, Cl),(M-11751, CH₃, CH₃, H, n-Pen, F), (M-11752, CH₃, CH₃, H, n-Pen, CF₃),(M-11753, CH₃, CH₃, H, n-Pen, Br), (M-11754, CH₃, CH₃, H, n-Pen, CH₃),(M-11755, CH₃, CH₃, H, c-Pen, H), (M-11756, CH₃, CH₃, H, c-Pen, Cl),(M-11757, CH₃, CH₃, H, c-Pen, F), (M-11758, CH₃, CH₃, H, c-Pen, CF₃),(M-11759, CH₃, CH₃, H, c-Pen, Br), (M-11760, CH₃, CH₃, H, c-Pen, CH₃),(M-11761, CH₃, CH₃, H, n-Hex, H), (M-11762, CH₃, CH₃, H, n-Hex, Cl),(M-11763, CH₃, CH₃, H, n-Hex, F), (M-11764, CH₃, CH₃, H, n-Hex, CF₃),(M-11765, CH₃, CH₃, H, n-Hex, Br), (M-11766, CH₃, CH₃, H, n-Hex, CH₃),(M-11767, CH₃, CH₃, H, c-Hex, H), (M-11768, CH₃, CH₃, H, c-Hex, Cl),(M-11769, CH₃, CH₃, H, c-Hex, F), (M-11770, CH₃, CH₃, H, c-Hex, CF₃),(M-11771, CH₃, CH₃, H, c-Hex, Br), (M-11772, CH₃, CH₃, H, c-Hex, CH₃),(M-11773, CH₃, CH₃, H, OH, H), (M-11774, CH₃, CH₃, H, OH, Cl), (M-11775,CH₃, CH₃, H, OH, F), (M-11776, CH₃, CH₃, H, OH, CF₃), (M-11777, CH₃,CH₃, H, OH, Br), (M-11778, CH₃, CH₃, H, OH, CH₃), (M-11779, CH₃, CH₃, H,EtO, H), (M-11780, CH₃, CH₃, H, EtO, Cl), (M-11781, CH₃, CH₃, H, EtO,F), (M-11782, CH₃, CH₃, H, EtO, CF₃), (M-11783, CH₃, CH₃, H, EtO, Br),(M-11784, CH₃, CH₃, H, EtO, CH₃), (M-11785, CH₃, CH₃, H, n-PrO, H),(M-11786, CH₃, CH₃, H, n-PrO, Cl), (M-11787, CH₃, CH₃, H, n-PrO, F),(M-11788, CH₃, CH₃, H, n-PrO, CF₃), (M-11789, CH₃, CH₃, H, n-PrO, Br),(M-11790, CH₃, CH₃, H, n-PrO, CH₃), (M-11791, CH₃, CH₃, H, PhO, H),(M-11792, CH₃, CH₃, H, PhO, Cl), (M-11793, CH₃, CH₃, H, PhO, F),(M-11794, CH₃, CH₃, H, PhO, CF₃), (M-11795, CH₃, CH₃, H, PhO, Br),(M-11796, CH₃, CH₃, H, PhO, CH₃), (M-11797, CH₃, CH₃, H, BnO, H),(M-11798, CH₃, CH₃, H, BnO, Cl), (M-11799, CH₃, CH₃, H, BnO, F),(M-11800, CH₃, CH₃, H, BnO, CF₃), (M-11801, CH₃, CH₃, H, BnO, Br),(M-11802, CH₃, CH₃, H, BnO, CH₃), (M-11803, CH₃, CH₃, H, PhCH₂CH₂O, H),(M-11804, CH₃, CH₃, H, PhCH₂CH₂O, Cl), (M-11805, CH₃, CH₃, H, PhCH₂CH₂O,F), (M-11806, CH₃, CH₃, H, PhCH₂CH₂O, CF₃), (M-11807, CH₃, CH₃, H,PhCH₂CH₂O, Br), (M-11808, CH₃, CH₃, H, PhCH₂CH₂O, CH₃), (M-11809, CH₃,CH₃, H, CF₃O, H), (M-11810, CH₃, CH₃, H, CF₃O, Cl), (M-11811, CH₃, CH₃,H, CF₃O, F), (M-11812, CH₃, CH₃, H, CF₃O, CF₃), (M-11813, CH₃, CH₃, H,CF₃O, Br), (M-11814, CH₃, CH₃, H, CF₃O, CH₃), (M-11815, CH₃, CH₃, H, Ph,H), (M-11816, CH₃, CH₃, H, Ph, Cl), (M-11817, CH₃, CH₃, H, Ph, F),(M-11818, CH₃, CH₃, H, Ph, CF₃), (M-11819, CH₃, CH₃, H, Ph, Br),(M-11820, CH₃, CH₃, H, Ph, CH₃), (M-11821, CH₃, CH₃, H, 4-F-Ph, H),(M-11822, CH₃, CH₃, H, 4-F-Ph, Cl), (M-11823, CH₃, CH₃, H, 4-F-Ph, F),(M-11824, CH₃, CH₃, H, 4-F-Ph, CF₃), (M-11825, CH₃, CH₃, H, 4-F-Ph, Br),(M-11826, CH₃, CH₃, H, 4-F-Ph, CH₃), (M-11827, CH₃, CH₃, H, 4-CF₃-Ph,H), (M-11828, CH₃, CH₃, H, 4-CF₃-Ph, Cl), (M-11829, CH₃, CH₃, H,4-CF₃-Ph, F), (M-11830, CH₃, CH₃, H, 4-CF₃-Ph, CF₃), (M-11831, CH₃,CH₃H, 4-CF₃-Ph, Br), (M-11832, CH₃, CH₃, H, 4-CF₃-Ph, CH₃), (M-11833,CH₃, CH₃H, 4-(Me)₂N-Ph, H), (M-11834, CH₃, CH₃, H, 4-(Me)₂N-Ph, Cl),(M-11835, CH₃, CH₃, H, 4-(Me)₂N-Ph, F), (M-11836, CH₃, CH₃, H,4-(Me)₂N-Ph, CF₃), (M-11837, CH₃, CH₃, H, 4-(Me)₂N-Ph, Br), (M-11838,CH₃, CH₃, H, 4-(Me)₂N-Ph, CH₃), (M-11839, CH₃, CH₃, H, 4-OH-Ph, H),(M-11840, CH₃, CH₃, H, 4-OH-Ph, Cl), (M-11841, CH₃, CH₃, H, 4-OH-Ph, F),(M-11842, CH₃, CH₃, H, 4-OH-Ph, CF₃), (M-11843, CH₃, CH₃, H, 4-OH-Ph,Br), (M-11844, CH₃, CH₃, H, 4-OH-Ph, CH₃), (M-11845, CH₃, CH₃, H,3,4-di-F-Ph, H), (M-11846, CH₃, CH₃, H, 3,4-di-F-Ph, Cl), (M-11847, CH₃,CH₃, H, 3,4-di-F-Ph, F), (M-11848, CH₃, CH₃, H, 3,4-di-F-Ph, CF₃),(M-11849, CH₃, CH₃, H, 3,4-di-F-Ph, Br), (M-11850, CH₃, CH₃, H,3,4-di-F-Ph, CH₃), (M-11851, CH₃, CH₃, H, 4-COOH-Ph, H), (M-11852, CH₃,CH₃, H, 4-COOH-Ph, Cl), (M-11853, CH₃, CH₃, H, 4-COOH-Ph, F), (M-11854,CH₃, CH₃, H, 4-COOH-Ph, CF₃), (M-11855, CH₃, CH₃, H, 4-COOH-Ph, Br),(M-11856, CH₃, CH₃, H, 4-COOH-Ph, CH₃), (M-11857, CH₃, CH₃, H, Bn, H),(M-11858, CH₃, CH₃, H, Bn, Cl), (M-11859, CH₃, CH₃, H, Bn, F), (M-11860,CH₃, CH₃, H, Bn, CF₃), (M-11861, CH₃, CH₃, H, Bn, Br), (M-11862, CH₃,CH₃, H, Bn, CH₃), (M-11863, CH₃, CH₃, H, 4-F-Bn, H), (M-11864, CH₃, CH₃,H, 4-F-Bn, Cl), (M-11865, CH₃, CH3, H, 4-F-Bn, F), (M-11866, CH₃, CH₃,H, 4-F-Bn, CF₃), (M-11867, CH₃, CH₃, H, 4-F-Bn, Br), (M-11868, CH₃, CH₃,H, 4-F-Bn, CH₃), (M-11869, CH₃, CH₃, H, 2-Py, H), (M-11870, CH₃, CH₃, H,2-Py, Cl), (M-11871, CH₃CH₃H, 2-Py, F), (M-11872, CH₃CH₃H, 2-Py, CF₃),(M-11873, CH₃CH_(3,) H, 2-Py, Br), (M-11874, CH₃, CH₃, H, 2-Py, CH₃),(M-11875, CH₃, CH₃, H, 3-Py, H), (M-11876, CH₃, CH₃, H, 3-Py, Cl),(M-11877, CH₃, CH₃, H, 3-Py, F), (M-11878, CH₃, CH₃, H, 3-Py, CF₃),(M-11879, CH₃, CH₃, H, 3-Py, Br), (M-11880, CH₃, CH₃, H, 3-Py, CH₃),(M-11881, CH₃, CH₃, H, 4-Py, H), (M-11882, CH₃, CH₃, H, 4-Py, Cl),(M-11883, CH₃, CH₃, H, 4-Py, F), (M-11884, CH₃, CH₃, H, 4-Py, CF₃),(M-11885, CH₃, CH₃, H, 4-Py, Br), (M-11886, CH₃, CH3, H, 4-Py, CH₃),(M-11887, CH₃, CH₃, H, 2-Th, H), (M-11888, CH₃, CH₃, H, 2-Th, Cl),(M-11889, CH₃, CH₃, H, 2-Th, F), (M-11890, CH₃, CH₃, H, 2-Th, CF₃),(M-11891, CH₃, CH₃, H, 2-Th, Br), (M-11892, CH₃, CH₃, H, 2-Th, CH₃),(M-11893, CH₃, CH₃, H, 3-Th, H), (M-11894, CH₃, CH₃, H, 3-Th, Cl),(M-11895, CH₃, CH₃, H, 3-Th, F), (M-11896, CH₃, CH₃, H, 3-Th, CF₃),(M-11897, CH₃, CH₃, H, 3-Th, Br), (M-11898, CH₃, CH₃, H, 3-Th, CH₃),(M-11899, CH₃, CH₃, H, pyrrazol-2-yl, H), (M-11900, CH₃, CH₃, H,pyrrazol-2-yl, Cl), (M-11901, CH₃, CH₃, H, pyrrazol-2-yl, F), (M-11902,CH₃, CH₃, H, pyrrazol-2-yl, CF₃), (M-11903, CH₃, CH₃, H, pyrrazol-2-yl,Br), (M-11904, CH₃, CH₃, H, pyrrazol-2-yl, CH₃), (M-11905, CH₃, CH₃, H,pyrrazol-3-yl, H), (M-11906, CH₃, CH₃, H, pyrrazol-3-yl, Cl), (M-11907,CH₃, CH₃, H, pyrrazol-3-yl, F), (M-11908, CH₃, CH₃, H, pyrrazol-3-yl,CF₃), (M-11909, CH₃, CH₃, H, pyrrazol-3-yl, Br), (M-11910, CH₃, CH₃, H,pyrrazol-3-yl, CH₃), (M-11911, CH₃, CH₃, H, pyrimidin-2-yl, H),(M-11912, CH₃, CH₃, H, pyrimidin-2-yl, Cl), (M-11913, CH₃, CH₃, H,pyrimidin-2-yl, F), (M-11914, CH₃, CH₃, H, pyrimidin-2-yl, CF₃),(M-11915, CH₃, CH₃, H, pyrimidin-2-yl, Br), (M-11916, CH₃, CH₃, H,pyrimidin-2-yl, CH₃), (M-11917, CH₃, CH₃, H, pyrimidin-4-yl, H),(M-11918, CH₃, CH₃, H, pyrimidin-4-yl, Cl), (M-11919, CH₃, CH₃, H,pyrimidin-4-yl, F), (M-11920, CH₃, CH₃, H, pyrimidin-4-yl, CF₃),(M-11921, CH₃, CH₃, H, pyrimidin-4-yl, Br), (M-11922, CH₃, CH₃, H,pyrimidin-4-yl, CH₃), (M-11923, CH₃, CH₃, H, pyrimidin-5-yl, H),(M-11924, CH₃, CH₃, H, pyrimidin-5-yl, Cl), (M-11925, CH₃, CH₃, H,pyrimidin-5-yl, F), (M-11926, CH₃, CH₃, H, pyrimidin-5-yl, CF₃),(M-11927, CH₃, CH₃, H, pyrimidin-5-yl, Br), (M-11928, CH₃, CH₃, H,pyrimidin-5-yl, CH₃), (M-11929, CH₃, CH₃, H, HOOCCH₂CH₂CH₂, H),(M-11930, CH₃, CH₃, H, HOOCCH₂CH₂CH₂, Cl), (M-11931, CH₃, CH₃,H,HOOCCH₂CH₂CH₂, F), (M-11932, CH₃, CH₃, H, HOOCCH₂CH₂CH₂, CF₃),(M-11933, CH₃, CH₃, H, HOOCCH₂CH₂CH₂, Br), (M-11934, CH₃, CH₃, H,HOOCCH₂CH₂CH₂, CH₃), (M-11935, CH₃, CH₃, H, HOOCCH₂CH₂CH₂CH₂, H),(M-11936, CH₃, CH₃, H, HOOCCH₂CH₂CH₂CH₂, Cl), (M-11937, CH₃, CH₃, H,HOOCCH₂CH₂CH₂CH₂, F), (M-11938, CH₃, CH₃, H, HOOCCH₂CH₂CH₂CH₂, CF₃),(M-11939, CH₃, CH₃, H, HOOCCH₂CH₂CH₂CH₂, Br), (M-11940, CH₃, CH₃, H,HOOCCH₂CH₂CH₂CH₂, CH₃), (M-11941, CH₃, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, H),(M-11942, CH₃, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-11943, CH₃, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-11944, CH₃, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂,CF₃), (M-11945, CH₃, CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-11946, CH₃,CH₃, H, (Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-11947, CH₃, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-11948, CH₃, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-11949, CH₃, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-11950, CH₃, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-11951, CH₃, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-11952, CH₃, CH₃, H,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-11953, CH₃, CH₃, H, MeOCH₂, H),(M-11954, CH₃, CH₃, H, MeOCH₂, Cl), (M-11955, CH₃, CH₃, H, MeOCH₂, F),(M-11956, CH₃, CH₃, H, MeOCH₂, CF₃), (M-11957, CH₃, CH₃, H, MeOCH₂, Br),(M-11958, CH₃, CH₃, H, MeOCH₂, CH₃), (M-11959, CH₃, CH₃, H, EtOCH₂, H),(M-11960, CH₃, CH₃, H, EtOCH₂, Cl), (M-11961, CH₃, CH₃, H, EtOCH₂, F),(M-11962, CH₃, CH₃, H, EtOCH₂, CF₃), (M-11963, CH₃, CH₃, H, EtOCH₂, Br),(M-11964, CH₃, CH₃, H, EtOCH₂, CH₃), (M-11965, CH₃, CH₃, H, EtOCH₂CH₂,H), (M-11966, CH₃, CH₃, H, EtOCH₂CH₂, Cl), (M-11967, CH₃, CH₃, H,EtOCH₂CH₂, F), (M-11968, CH₃, CH₃, H, EtOCH₂CH₂, CF₃), (M-11969, CH₃,CH₃, H, EtOCH₂CH₂, Br), (M-11970, CH₃, CH₃, H, EtOCH₂CH₂, CH₃),(M-11971, CH₃, CH₃, H, MeOCH₂CH₂OCH₂CH₂, H), (M-11972, CH₃, CH₃, H,MeOCH₂CH₂OCH₂CH₂, Cl), (M-11973, CH₃, CH₃, H, MeOCH₂CH₂OCH₂CH₂, F),(M-11974, CH₃, CH₃, H, MeOCH₂CH₂OCH₂CH₂, CF₃), (M-11975, CH₃, CH₃, HMeOCH₂CH₂OCH₂CH₂, Br), (M-11976, CH₃, CH₃, H, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-11977, CH₃, CH₃, H, MeOCH₂CH₂, H), (M-11978, CH₃, CH₃, H, MeOCH₂CH₂,Cl), (M-11979, CH₃, CH₃, H, MeOCH₂CH₂, F), (M-11980, CH₃, CH₃, H,MeOCH₂CH₂, CF₃), (M-11981, CH₃, CH₃, H, MeOCH₂CH₂, Br), (M-11982, CH₃,CH₃, H, MeOCH₂CH₂, CH₃), (M-11983, CH₃, CH₃, H, HOCH₂, H), (M-11984,CH₃, CH₃, H, HOCH₂, Cl), (M-11985, CH₃, CH₃, H, HOCH₂, F), (M-11986,CH₃, CH₃, H, HOCH₂, CF₃), (M-11987, CH₃, CH₃, H, HOCH₂, Br), (M-11988,CH, CH₃, H, HOCH₂, CH₃), (M-11989, CH₃, CH₃, H, HOCH₂CH₂, H), (M-11990,CH₃, CH₃, H, HOCH₂CH₂, Cl), (M-11991, CH₃, CH₃, H, HOCH₂CH₂, F),(M-11992, CH₃, CH₃, H, HOCH₂CH₂, CF₃), (M-11993, CH₃, CH₃, H, HOCH₂CH₂,Br), (M-11994, CH₃, CH₃, H, HOCH₂CH₂, CH₃), (M-11995, CH₃, CH₃, H,HOCH₂CH₂CH₂, H), (M-11996, CH₃, CH₃, H, HOCH₂CH₂CH₂, Cl), (M-11997, CH₃,CH₃, H, HOCH₂CH₂CH₂, F), (M-11998, CH₃, CH₃, H, HOCH₂CH₂CH₂, CF₃),(M-11999, CH₃, CH₃, H, HOCH₂CH₂CH₂, Br), (M-12000, CH₃, CH₃, H,HOCH₂CH₂CH₂, CH₃), (M-12001, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂, H), (M-12002,CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂, Cl), (M-12003, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂,F), (M-12004, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂, CF₃), (M-12005, CH₃, CH₃, H,HOCH₂CH₂CH₂CH₂, Br), (M-12006, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂, CH₃),(M-12007, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, H), (M-12008, CH₃, CH₃, H,HOCH₂CH₂CH₂CH₂CH₂, Cl), (M-12009, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, F),(M-12010, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-12011, CH₃, CH₃, H,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-12012, CH₃, CH₃, H, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-12013, CH₃, CH₃, H, HOCH₂CH₂OCH₂CH₂, H), (M-12014, CH₃, CH₃, H,HOCH₂CH₂OCH₂CH₂, Cl), (M-12015, CH₃, CH₃H, HOCH₂CH₂OCH₂CH₂, F),(M-12016, CH₃, CH₃, H, HOCH₂CH₂OCH₂CH₂, CF₃), (M-12017, CH₃CH₃H,HOCH₂CH₂OCH₂CH₂, Br), (M-12018, CH₃, CH₃, H, HOCH₂CH₂OCH₂CH₂, CH₃),(M-12019, CH₃, CH₃, H, (Me)₂N, H), (M-12020, CH₃, CH₃, H, (Me)₂N, Cl),(M-12021, CH₃, CH₃, H, (Me)₂N, F), (M-12022, CH₃, CH₃, H, (Me)₂N, CF₃),(M-12023, CH₃, CH₃, H, (Me)₂N, Br), (M-12024, CH₃, CH₃, H, (Me)₂N, CH₃),(M-12025, CH₃, CH₃, H, piperidin-4-yl-methyl, H), (M-12026, CH₃, CH₃, H,piperidin-4-yl-methyl, Cl), (M-12027, CH₃, CH₃, H,piperidin-4-yl-methyl, F), (M-12028, CH₃, CH₃, H, piperidin-4-yl-methyl,CF₃), (M-12029, CH₃, CH₃, H, piperidin-4-yl-methyl, Br), (M-12030, CH₃,CH₃, H, piperidin-4-yl-methyl, CH₃), (M-12031, CH₃, CH₃, H,cyclohexylmethyl, H), (M-12032, CH₃, CH₃, H, cyclohexylmethyl, Cl),(M-12033, CH₃, CH₃, H, cyclohexylmethyl, F), (M-12034, CH₃, CH₃, H,cyclohexylmethyl, CF₃), (M-12035, CH₃, CH₃, H, cyclohexylmethyl, Br),(M-12036, CH₃, CH₃, H, cyclohexylmethyl, CH₃), (M-12037, CH₃, CH₃, F, H,H), (M-12038, CH₃, CH₃F, H, Cl), (M-12039, CH₃, CH₃, F, H, F), (M-12040,CH₃, CH₃, F, H, CF₃), (M-12041, CH₃, CH₃, F, H, Br), (M-12042, CH₃, CH₃,F, H, CH₃), (M-12043, CH₃, CH₃, F, F, H), (M-12044, CH₃, CH₃, F, F, Cl),(M-12045, CH₃, CH₃, F, F, F), (M-12046, CH₃, CH₃, F, F, CF₃), (M-12047,CH₃, CH₃, F, F, Br), (M-12048, CH₃, CH₃, F, F, CH₃), (M-12049, CH₃, CH₃,F, Cl, H), (M-12050, CH₃, CH₃, F, Cl Cl), (M-12051, CH₃, CH₃, F, Cl, F),(M-12052, CH₃, CH₃, F, Cl, CF₃), (M-12053, CH₃, CH₃, F, Cl, Br),(M-12054, CH₃, CH₃, F, Cl, CH₃), (M-12055, CH₃, CH₃, F, CH₃, H),(M-12056, CH₃, CH₃, F, CH₃, Cl), (M-12057, CH₃, CH₃, F, CH₃, F),(M-12058, CH₃, CH₃, F, CH₃, CF₃), (M-12059, CH₃, CH₃, F, CH₃, Br),(M-12060, CH₃, CH₃, F, CH₃, CH₃), (M-12061, CH₃, CH₃, F, Et, H),(M-12062, CH₃, CH₃, F, Et, Cl), (M-12063, CH₃, CH₃, F, Et, F), (M-12064,CH₃, CH₃, F, Et, CF₃), (M-12065, CH₃, CH₃, F, Et, Br), (M-12066, CH₃,CH₃, F, Et, CH₃), (M-12067, CH₃, CH₃, F, n-Pr, H), (M-12068, CH₃, CH₃,F, n-Pr, Cl), (M-12069, CH₃, CH₃, F, n-Pr, F), (M-12070, CH₃, CH₃, F,n-Pr, CF₃), (M-12071, CH₃, CH₃, F, n-Pr, Br), (M-12072, CH₃, CH₃, F,n-Pr, CH₃), (M-12073, CH₃, CH₃, F, c-Pr, H), (M-12074, CH₃, CH₃, F,c-Pr, Cl), (M-12075, CH₃, CH₃, F, c-Pr, F), (M-12076, CH₃, CH₃, F, c-Pr,CF₃), (M-12077, CH₃, CH₃, F, c-Pr, Br), (M-12078, CH₃, CH₃, F, c-Pr,CH₃), (M-12079, CH₃, CH₃, F, i-Pr, H), (M-12080, CH₃, CH₃, F, i-Pr, Cl),(M-12081, CH₃, CH₃, F, i-Pr, F), (M-12082, CH₃, CH₃, F, i-Pr, CF₃),(M-12083, CH₃, CH₃, F, i-Pr, Br), (M-12084, CH₃, CH₃, F, i-Pr, CH₃),(M-12085, CH₃, CH₃, F, n-Bu, H), (M-12086, CH₃, CH₃, F, n-Bu, Cl),(M-12087, CH₃, CH₃, F, n-Bu, F), (M-12088, CH₃, CH₃, F, n-Bu, CF₃),(M-12089, CH₃, CH₃, F, n-Bu, Br), (M-12090, CH₃, CH₃, F, n-Bu, CH₃),(M-12091, CH₃, CH₃, F, i-Bu, H), (M-12092, CH₃, CH₃, F, i-Bu, Cl),(M-12093, CH₃, CH₃, F, i-Bu, F), (M-12094, CH₃, CH₃, F, i-Bu, CF₃),(M-12095, CH₃, CH₃, F, i-Bu, Br), (M-12096, CH₃, CH₃, F, i-Bu, CH₃),(M-12097, CH₃, CH₃, F, sec-Bu, H), (M-12098, CH₃, CH₃, F, sec-Bu, Cl),(M-12099, CH₃, CH₃, F, sec-Bu, F), (M-12100, CH₃, CH₃, F, sec-Bu, CF₃),(M-12101, CH₃, CH₃, F, sec-Bu, Br), (M-12102, CH₃, CH₃, F, sec-Bu, CH₃),(M-12103, CH₃, CH₃, F, n-Pen, H), (M-12104, CH₃, CH₃, F, n-Pen, Cl),(M-12105, CH₃, CH₃, F, n-Pen, F), (M-12106, CH₃, CH₃, F, n-Pen, CF₃),(M-12107, CH₃, CH₃, F, n-Pen, Br), (M-12108, CH₃, CH₃, F, n-Pen, CH₃),(M-12109, CH₃, CH₃, F, c-Pen, H), (M-12110, CH₃, CH₃, F, c-Pen, Cl),(M-12111, CH₃, CH₃, F, c-Pen, F), (M-12112, CH₃, CH₃, F, c-Pen, CF₃),(M-12113, CH₃, CH₃, F, c-Pen, Br), (M-12114, CH₃, CH₃, F, c-Pen, CH₃),(M-12115, CH₃, CH₃, F, n-Hex, H), (M-12116, CH₃, CH₃, F, n-Hex, Cl),(M-12117, CH₃, CH₃, F, n-Hex, F), (M-12118, CH₃, CH₃, F, n-Hex, CF₃),(M-12119, CH₃, CH₃, F, n-Hex, Br), (M-12120, CH₃, CH₃, F, n-Hex, CH₃),(M-12121, CH₃, CH₃, F, c-Hex, H), (M-12122, CH₃, CH₃, F, c-Hex, Cl),(M-12123, CH₃, CH₃, F, c-Hex, F), (M-12124, CH₃, CH₃, F, c-Hex, CF₃),(M-12125, CH₃, CH₃, F, c-Hex, Br), (M-12126, CH₃, CH₃, F, c-Hex, CH₃),(M-12127, CH₃, CH₃, F, OH, H), (M-12128, CH₃, CH₃, F, OH, Cl), (M-12129,CH₃, CH₃, F, OH, F), (M-12130, CH₃, CH₃, F, OH, CF₃), (M-12131, CH₃,CH₃, F, OH, Br), (M-12132, CH₃, CH₃, F, OH, CH₃), (M-12133, CH₃, CH₃, F,EtO, H), (M-12134, CH₃, CH₃, F, EtO, Cl), (M-12135, CH₃, CH₃, F, EtO,F), (M-12136, CH₃, CH₃, F, EtO, CF₃), (M-12137, CH₃, CH₃, F, EtO, Br),(M-12138, CH₃, CH₃, F, EtO, CH₃), (M-12139, CH₃, CH₃, F, n-PrO, H),(M-12140, CH₃, CH₃, F, n-PrO, Cl), (M-12141, CH₃, CH₃, F, n-PrO, F),(M-12142, CH₃, CH₃, F, n-PrO, CF₃), (M-12143, CH₃, CH₃, F, n-PrO, Br),(M-12144, CH₃, CH₃, F, n-PrO, CH₃), (M-12145, CH₃, CH₃, F, PhO, H),(M-12146, CH₃, CH₃, F, PhO, Cl), (M-12147, CH₃, CH₃, F, PhO, F),(M-12148, CH₃, CH₃, F, PhO, CF₃), (M-12149, CH₃, CH₃, F, PhO, Br),(M-12150, CH₃, CH₃, F, PhO, CH₃), (M-12151, CH₃, CH₃, F, BnO, H),(M-12152, CH₃, CH₃, F, BnO, Cl), (M-12153, CH₃, CH₃, F, BnO, F),(M-12154, CH₃, CH₃, F, BnO, CF₃), (M-12155, CH₃, CH₃, F, BnO, Br),(M-12156, CH₃, CH₃, F, BnO, CH₃), (M-12157, CH₃, CH₃, F, PhCH₂CH₂O, H),(M-12158, CH₃, CH₃, F, PhCH₂CH₂O, Cl), (M-12159, CH₃, CH₃, F, PhCH₂CH₂O,F), (M-12160, CH₃, CH₃, F, PhCH₂CH₂O, CF₃), (M-12161, CH₃, CH₃, F,PhCH₂CH₂O, Br), (M-12162, CH₃, CH₃, F, PhCH₂CH₂O, CH₃), (M-12163, CH₃,CH₃, F, CF₃O, H), (M-12164, CH₃, CH₃, F, CF₃O, Cl), (M-12165, CH₃, CH₃,F, CF₃O, F), (M-12166, CH₃, CH₃, F, CF₃O, CF₃), (M-12167, CH₃, CH₃, F,CF₃O, Br), (M-12168, CH₃, CH₃, F, CF₃O, CH₃), (M-12169, CH₃, CH₃, F, Ph,H), (M-12170, CH₃, CH₃, F, Ph, Cl), (M-12171, CH₃, CH₃, F, Ph, F),(M-12172, CH₃, CH₃, F, Ph, CF₃), (M-12173, CH₃, CH₃, F, Ph, Br),(M-12174, CH₃, CH₃, F, Ph, CH₃), (M-12175, CH₃, CH₃, F, 4-F-Ph, H),(M-12176, CH₃, CH₃, F, 4-F-Ph, Cl), (M-12177, CH₃, CH₃, F, 4-F-Ph, F),(M-12178, CH₃, CH₃, F, 4-F-Ph, CF₃), (M-12179, CH₃, CH₃, F, 4-F-Ph, Br),(M-12180, CH₃, CH₃, F, 4-F-Ph, CH₃), (M-12181, CH₃, CH₃, F, 4-CF₃-Ph,H), (M-12182, CH₃, CH₃, F, 4-CF₃-Ph, Cl), (M-12183, CH₃, CH₃, F,4-CF₃-Ph, F), (M-12184, CH₃, CH₃, F, 4-CF₃-Ph, CF₃), (M-12185, CH₃, CH₃,F, 4-CF₃-Ph, Br), (M-12186, CH₃, CH₃, F, 4-CF₃-Ph, CH₃), (M-12187, CH₃,CH₃, F, 4-(Me)2N-Ph, H), (M-12188, CH₃, CH₃, F, 4-(Me)₂N-Ph, Cl),(M-12189, CH₃, CH₃, F, 4-(Me)₂N-Ph, F), (M-12190, CH₃, CH₃, F,4-(Me)₂N-Ph, CF₃), (M-12191, CH₃, CH₃, F, 4-(Me)₂N-Ph, Br), (M-12192,CH₃, CH₃, F, 4-(Me)₂N-Ph, CH₃), (M-12193, CH₃, CH₃, F, 4-OH-Ph, H),(M-12194, CH₃, CH₃, F, 4-OH-Ph, Cl), (M-12195, CH₃, CH₃, F, 4-OH-Ph, F),(M-12196, CH₃, CH₃, F, 4-OH-Ph, CF₃), (M-12197, CH₃, CH₃, F, 4-OH-Ph,Br), (M-12198, CH₃, CH₃, F, 4-OH-Ph, CH₃), (M-12199, CH₃, CH₃, F,3,4-di-F-Ph, H), (M-12200, CH₃, CH₃, F, 3,4-di-F-Ph, Cl), (M-12201, CH₃,CH₃, F, 3,4-di-F-Ph, F), (M-12202, CH₃, CH₃, F, 3,4-di-F-Ph, CF₃),(M-12203, CH₃, CH₃, F, 3,4-di-F-Ph, Br), (M-12204, CH₃, CH₃, F,3,4-di-F-Ph, CH₃), (M-12205, CH₃, CH₃, F, 4-COOH-Ph, H), (M-12206, CH₃,CH₃, F, 4-COOH-Ph, Cl), (M-12207, CH₃, CH₃, F, 4-COOH-Ph, F), (M-12208,CH₃, CH₃, F, 4-COOH-Ph, CF₃), (M-12209, CH₃, CH₃, F, 4-COOH-Ph, Br),(M-12210, CH₃, CH₃, F, 4-COOH-Ph, CH₃), (M-12211, CH₃, CH₃, F, Bn, H),(M-12212, CH₃, CH₃, F, Bn, Cl), (M-12213, CH₃, CH₃, F, Bn, F), (M-12214,CH₃, CH₃, F, Bn, CF₃), (M-12215, CH₃, CH₃, F, Bn, Br), (M-12216, CH₃,CH₃, F, Bn, CH₃), (M-12217, CH₃, CH₃, F, 4-F-Bn, H), (M-12218, CH₃, CH₃,F, 4-F-Bn, Cl), (M-12219, CH₃, CH₃, F, 4-F-Bn, F), (M-12220, CH₃, CH₃,F, 4-F-Bn, CF₃), (M-12221, CH₃, CH₃, F, 4-F-Bn, Br), (M-12222, CH₃, CH₃,F, 4-F-Bn, CH₃), (M-12223, CH₃, CH₃, F, 2-Py, H), (M-12224, CH₃, CH₃, F,2-Py, Cl), (M-12225, CH₃, CH₃, F, 2-Py, F), (M-12226, CH₃, CH₃, F, 2-Py,CF₃), (M-12227, CH₃, CH₃, F, 2-Py, Br), (M-12228, CH₃, CH₃, F, 2-Py,CH₃), (M-12229, CH₃, CH₃, F, 3-Py, H), (M-12230, CH₃, CH₃F, 3-Py, Cl),(M-12231, CH₃, CH₃, F, 3-Py, F), (M-12232, CH₃, CH₃, F, 3-Py, CF₃),(M-12233, CH₃, CH₃, F, 3-Py, Br), (M-12234, CH₃, CH₃, F, 3-Py, CH₃),(M-12235, CH₃, CH₃, F, 4-Py, H), (M-12236, CH₃, CH₃, F, 4-Py, Cl),(M-12237, CH₃, CH₃, F, 4-Py, F), (M-12238, CH₃, CH₃, F, 4-Py, CF₃),(M-12239, CH₃, CH₃, F, 4-Py, Br), (M-12240, CH₃, CH₃, F, 4-Py, CH₃),(M-12241, CH₃, CH₃, F, 2-Th, H), (M-12242, CH₃, CH₃, F, 2-Th, Cl),(M-12243, CH₃, CH₃, F, 2-Th, F), (M-12244, CH₃, CH₃, F, 2-Th, CF₃),(M-12245, CH₃, CH₃, F, 2-Th, Br), (M-12246, CH₃, CH₃, F, 2-Th, CH₃),(M-12247, CH₃, CH₃, F, 3-Th, H), (M-12248, CH₃, CH₃, F, 3-Th, Cl),(M-12249, CH₃, CH₃, F, 3-Th, F), (M-12250, CH₃, CH₃, F, 3-Th, CF₃),(M-12251, CH₃, CH₃, F, 3-Th, Br), (M-12252, CH₃, CH₃, F, 3-Th, CH₃),(M-12253, CH₃, CH₃, F, pyrrazol-2-yl, H), (M-12254, CH₃, CH₃, F,pyrrazol-2-yl, Cl), (M-12255, CH₃, CH₃, F, pyrrazol-2-yl, F), (M-12256,CH₃, CH₃, F, pyrrazol-2-yl, CF₃), (M-12257, CH₃, CH₃, F, pyrrazol-2-yl,Br), (M-12258, CH₃, CH₃, F, pyrrazol-2-yl, CH₃), (M-12259, CH₃, CH₃, F,pyrrazol-3-yl, H), (M-12260, CH₃, CH₃, F, pyrrazol-3-yl, Cl), (M-12261,CH₃, CH₃, F, pyrrazol-3-yl, F), (M-12262, CH₃, CH₃, F, pyrrazol-3-yl,CF₃), (M-12263, CH₃, CH₃, F, pyrrazol-3-yl, Br), (M-12264, CH₃, CH₃, F,pyrrazol-3-yl, CH₃), (M-12265, CH₃, CH₃, F, pyrimidin-2-yl, H),(M-12266, CH₃, CH₃, F, pyrimidin-2-yl, Cl), (M-12267, CH₃, CH₃, F,pyrimidin-2-yl, F), (M-12268, CH₃, CH₃, F, pyrimidin-2-yl, CF₃),(M-12269, CH₃, CH₃, F, pyrimidin-2-yl, Br), (M-12270, CH₃, CH₃, F,pyrimidin-2-yl, CH₃), (M-12271, CH₃, CH₃, F, pyrimidin-4-yl, H),(M-12272, CH₃, CH₃, F, pyrimidin-4-yl, Cl), (M-12273, CH₃, CH₃, F,pyrimidin-4-yl, F), (M-12274, CH₃, CH₃, F, pyrimidin-4-yl, CF₃),(M-12275, CH₃, CH₃, F, pyrimidin-4-yl, Br), (M-12276, CH₃, CH₃, F,pyrimidin-4-yl, CH₃), (M-12277, CH₃, CH₃, F, pyrimidin-5-yl, H),(M-12278, CH₃, CH₃, F, pyrimidin-5-yl, Cl), (M-12279, CH₃, CH₃, F,pyrimidin-5-yl, F), (M-12280, CH₃, CH₃, F, pyrimidin5-yl, CF₃),(M-12281, CH₃, CH₃, F, pyrimidin-5-yl, Br), (M-12282, CH₃, CH₃, F,pyrimidin-5-yl, CH₃), (M-12283, CH₃, CH₃, F, HOOCCH₂CH₂CH₂, H),(M-12284, CH₃, CH₃, F, HOOCCH₂CH₂CH₂, Cl), (M-12285, CH₃, CH₃, F,HOOCCH₂CH₂CH₂, F), (M-12286, CH₃, CH₃, F, HOOCCH₂CH₂CH₂, CF₃), (M-12287,CH₃, CH₃, F, HOOCCH₂CH₂CH₂, Br), (M-12288, CH₃, CH₃, F, HOOCCH₂CH₂CH₂,CH₃), (M-12289, CH₃, CH₃, F, HOOCCH₂CH₂CH₂CH_(2,) H), (M-12290, CH₃,CH₃, F, HOOCCH₂CH₂CH₂CH₂, Cl), (M-12291, CH₃, CH₃, F, HOOCCH₂CH₂CH₂CH₂,F), (M-12292, CH₃, CH₃, F, HOOCCH₂CH₂CH₂CH₂, CF₃), (M-12293, CH₃, CH₃,F, HOOCCH₂CH₂CH₂CH₂, Br), (M-12294, CH₃, CH₃, F, HOOCCH₂CH₂CH₂CH₂, CH₃),(M-12295, CH₃, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, H), (M-12296, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-12297, CH₃, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂,F), (M-12298, CH₃, CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-12299, CH₃,CH₃, F, (Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-12300, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂, CH₃), (M-12301, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-12302, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-12303, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-12304, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-12305, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-12306, CH₃, CH₃, F,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-12307, CH₃, CH₃, F, MeOCH₂, H),(M-12308, CH₃, CH₃, F, MeOCH₂, Cl), (M-12309, CH₃, CH₃, F, MeOCH₂, F),(M-12310, CH₃, CH₃, F, MeOCH₂, CF₃), (M-12311, CH₃, CH₃, F, MeOCH₂, Br),(M-12312, CH₃, CH₃, F, MeOCH₂, CH₃), (M-12313, CH₃, CH₃, F, EtOCH₂, H),(M-12314, CH₃, CH₃, F, EtOCH₂, Cl), (M-12315, CH₃, CH₃, F, EtOCH₂, F),(M-12316, CH₃, CH₃, F, EtOCH₂, CF₃), (M-12317, CH₃, CH₃, F, EtOCH₂, Br),(M-12318, CH₃, CH₃, F, EtOCH₂, CH₃), (M-12319, CH₃, CH₃, F, EtOCH₂CH₂,H), (M-12320, CH₃, CH₃, F, EtOCH₂CH₂, Cl), (M-12321, CH₃, CH₃, F,EtOCH₂CH₂, F), (M-12322, CH₃, CH₃, F, EtOCH₂CH₂, CF₃), (M-12323, CH₃,CH₃, F, EtOCH₂CH₂, Br), (M-12324, CH₃, CH₃, F, EtOCH₂CH₂, CH₃),(M-12325, CH₃, CH₃, F, MeOCH₂CH₂OCH₂CH₂, H), (M-12326, CH₃, CH₃, F,MeOCH₂CH₂OCH₂CH₂, Cl), (M-12327, CH₃, CH₃, F, MeOCH₂CH₂OCH₂CH₂, F),(M-12328, CH₃, CH₃, F, MeOCH₂CH₂CH₂CH₂, CF₃), (M-12329, CH₃, CH₃, F,MeOCH₂CH₂OCH₂CH₂, Br), (M-12330, CH₃, CH₃, F, MeOCH₂CH₂OCH₂CH₂, CH₃),(M-12331, CH₃, CH₃, F, MeOCH₂CH₂, H), (M-12332, CH₃, CH₃, F, MeOCH₂CH₂,Cl), (M-12333, CH₃, CH₃, F, MeOCH₂CH₂, F), (M-12334, CH₃, CH₃, F,MeOCH₂CH₂, CF₃), (M-12335, CH₃, CH₃, F, MeOCH₂CH₂, Br), (M-12336, CH₃,CH₃, F, MeOCH₂CH₂, CH₃), (M-12337, CH₃, CH₃, F, HOCH₂, H), (M-12338,CH₃, CH₃, F, HOCH₂, Cl), (M-12339, CH₃, CH₃, F, HOCH₂, F), (M-12340,CH₃, CH₃, F, HOCH₂, CF₃), (M-12341, CH₃, CH₃, F, HOCH₂, Br), (M-12342,CH₃, CH₃, F, HOCH₂, CH₃), (M-12343, CH₃, CH₃, F, HOCH₂CH₂, H), (M-12344,CH₃, CH₃, F, HOCH₂CH₂, Cl), (M-12345, CH₃, CH₃, F, HOCH₂CH₂, F),(M-12346, CH₃, CH₃, F, HOCH₂CH₂, CF₃), (M-12347, CH₃, CH₃, F, HOCH₂CH₂,Br), (M-12348, CH₃, CH₃, F, HOCH₂CH₂, CH₃), (M-12349, CH₃, CH₃, F,HOCH₂CH₂CH₂, H), (M-12350, CH₃, CH₃, F, HOCH₂CH₂CH₂, Cl), (M-12351, CH₃,CH₃, F, HOCH₂CH₂CH₂, F), (M-12352, CH₃, CH₃, F, HOCH₂CH₂CH₂, CF₃),(M-12353, CH₃, CH₃, F, HOCH₂CH₂CH₂, Br), (M-12354, CH₃, CH₃, F,HOCH₂CH₂CH₂, CH₃), (M-12355, CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂, H), (M-12356,CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂, Cl), (M-12357, CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂,F), (M-12358, CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂CF₃), (M-12359, CH₃, CH₃F,HOCH₂CH₂CH₂CH₂, Br), (M-12360, CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂, CH₃),(M-12361, CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, H), (M-12362, CH₃CH₃F,HOCH₂CH₂CH₂CH₂CH₂Cl), (M-12363, CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂F),(M-12364, CH₃, CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-12365, CH₃, CH₃, F,HOCH₂CH₂CH₂CH₂CH₂, Br), (M-12366, CH₃CH₃, F, HOCH₂CH₂CH₂CH₂CH₂, CH₃),(M-12367, CH₃, CH₃F, HOCH₂CH₂OCH₂CH₂, H), (M-12368, CH₃CH₃, F,HOCH₂CH₂OCH₂CH₂, Cl), (M-12369, CH₃CH₃F, HOCH₂CH₂OCH₂CH₂, (M-12370, CH₃,CH₃, F, HOCH₂CH₂OCH₂CH₂, CF₃), (M-12371, CH₃, CH₃, F, HOCH₂CH₂OCH₂CH₂,Br), (M-12372, CH₃CH₃, F, HOCH₂CH₂OCH₂CH₂, CH (M-12373, CH₃, CH₃, F,(Me)₂N, H), (M-12374, CH₃, CH₃, F, (Me)₂N, Cl), (M-12375, CH₃, CH₃, F,(Me)₂N, F), (M-12376, CH₃, CH₃, F, (Me)₂N, CF₃), (M-12377, CH₃, CH₃, F,(Me)₂N, Br), (M-12378, CH₃, CH₃, F, (Me)₂N, CH₃), (M-12379, CH₃, CH₃, F,piperidin-4-yl-methyl, H), (M-12380, CH₃, CH₃, F, piperidin-4-yl-methyl,Cl), (M-12381, CH₃, CH₃, F, piperidin-4-yl-methyl, F), (M-12382, CH₃,CH₃, F, piperidin-4-yl-methyl, CF₃), (M-12383, CH₃, CH₃, F,piperidin-4-yl-methyl, Br), (M-12384, CH₃, CH₃, F,piperidin-4-yl-methyl, CH₃), (M-12385, CH₃, CH₃, F, cyclohexylmethyl,H), (M-12386, CH₃, CH₃, F, cyclohexylmethyl, Cl), (M-12387, CH₃, CH₃, F,cyclohexylmethyl, F), (M-12388, CH₃, CH₃, F, cyclohexylmethyl, CF₃),(M-12389, CH₃, CH₃, F, cyclohexylmethyl, Br), (M-12390, CH₃, CH₃, F,cyclohexylmethyl, CH₃), (M-12391, CH₃, CH₃, Cl, H, H), (M-12392, CH₃,CH₃, Cl, H, Cl), (M-12393, CH₃, CH₃, Cl, H, F), (M-12394, CH₃, CH₃, Cl,H, CF₃), (M-12395, CH₃, CH₃, Cl, H, Br), (M-12396, CH₃, CH₃, Cl, H,CH₃), (M-12397, CH₃, CH₃, Cl, F, H), (M-12398, CH₃, CH₃, Cl, F, Cl),(M-12399, CH₃, CH₃, Cl, F, F), (M-12400, CH₃, CH₃, Cl, F, CF₃),(M-12401, CH₃, CH₃, Cl, F, Br), (M-12402, CH₃, CH₃, Cl, F, CH₃),(M-12403, CH₃, CH₃, Cl, Cl, H), (M-12404, CH₃, CH₃, Cl, Cl, Cl),(M-12405, CH₃, CH₃, Cl, Cl, F), (M-12406, CH₃, CH₃, Cl, Cl, CF₃),(M-12407, CH₃, CH₃, Cl, Cl, Br), (M-12408, CH₃, CH₃, Cl, Cl, CH₃),(M-12409, CH₃, CH₃, Cl, CH₃, H), (M-12410, CH₃, CH₃, Cl, CH₃, Cl),(M-12411, CH₃, CH₃, Cl, CH₃, F), (M-12412, CH₃, CH₃, Cl, CH₃, CF₃),(M-12413, CH₃, CH₃, Cl, CH₃, Br), (M-12414, CH₃, CH₃, Cl, CH₃, CH₃),(M-12415, CH₃, CH₃, Cl, Et, H), (M-12416, CH₃, CH₃, Cl, Et, Cl),(M-12417, CH₃, CH₃, Cl, Et, F), (M-12418, CH₃, CH₃, Cl, Et, CF₃),(M-12419, CH₃, CH₃, Cl, Et, Br), (M-12420, CH₃, CH₃, Cl, Et, CH₃),(M-12421, CH₃, CH₃, Cl, n-Pr, H), (M-12422, CH₃, CH₃, Cl, n-Pr, Cl),(M-12423, CH₃, CH₃, Cl, n-Pr, F), (M-12424, CH₃, CH₃, Cl, n-Pr, CF₃),(M-12425, CH₃, CH₃, Cl, n-Pr, Br), (M-12426, CH₃, CH₃, Cl, n-Pr, CH₃),(M-12427, CH₃, CH₃, Cl, c-Pr, H), (M-12428, CH₃, CH₃, Cl, c-Pr, Cl),(M-12429, CH₃, CH₃, Cl, c-Pr, F), (M-12430, CH₃, CH₃, Cl, c-Pr, CF₃),(M-12431, CH₃, CH₃, Cl, c-Pr, Br), (M-12432, CH₃, CH₃, Cl, c-Pr, CH₃),(M-12433, CH₃, CH₃, Cl, i-Pr, H), (M-12434, CH₃, CH₃, Cl, i-Pr, Cl),(M-12435, CH₃, CH₃, Cl, i-Pr, F), (M-12436, CH₃, CH₃, Cl, i-Pr, CF₃),(M-12437, CH₃, CH₃, Cl, i-Pr, Br ), (M-12438, CH₃, CH₃, Cl, i-Pr, CH₃),(M-12439, CH₃, CH₃, Cl, n-Bu, H), (M-124403, CH₃, Cl, n-Bu, Cl),(M-12441, CH₃, CH₃, Cl, n-Bu, F), (M-12442, CH₃, CH₃, Cl, n-Bu, CF₃),(M-12443, CH₃, CH₃, Cl, n-Bu, Br), (M-12444, CH₃, CH₃, Cl, n-Bu, CH₃),(M-12445, CH₃, CH₃, Cl, n-Bu, H), (M-12446, CH₃, CH₃, Cl, i-Bu, Cl),(M-12447, CH₃, CH₃, Cl, i-Bu, F), (M-12448, CH₃, C₃, Cl, i-Bu, CF₃),(M-12449, CH₃, CH₃, Cl, i-Bu, Br), (M-12450, CH₃, CH₃, Cl, i-Bu, CH₃),(M-12451, CH₃, CH₃, Cl, sec-Bu, H), (M-12452, CH₃, CH₃, Cl, sec-Bu, Cl),(M-12453, CH₃, CH₃, Cl, sec-Bu, F), (M-12454, CH₃, CH₃, Cl, sec-Bu,CF₃), (M-12455, CH₃, CH₃, Cl, sec-Bu, Br), (M-12456, CH₃, CH₃, Cl,sec-Bu, CH₃), (M-12457, CH₃, CH₃, Cl, n-Pen, H), (M-12458, CH₃, CH₃, Cl,n-Pen, Cl), (M-12459, CH₃, CH₃, Cl, n-Pen, F), (M-12460, CH₃, CH₃, Cl,n-Pen, CF₃), (M-12461, CH₃, CH₃, Cl, n-Pen, Br), (M-12462, CH₃, CH₃, Cl,n-Pen, CH₃), (M-12463, CH₃, CH₃, Cl, c-Pen, H), (M-12464, CH₃, CH₃, Cl,c-Pen, Cl), (M-12465, CH₃, CH₃, Cl, c-Pen, F), (M-12466, CH₃, CH₃, Cl,c-Pen, CF₃), (M-12467, CH₃, CH₃, Cl, c-Pen, Br), (M-12468, CH₃, CH₃, Cl,c-Pen, CH₃), (M-12469, CH₃, CH₃, Cl, n-Hex, ), (M-12470, CH₃, CH₃, Cl,n-Hex, Cl), (M-12471, CH₃, CH₃, Cl, n-Hex, F), (M-12472, CH₃, CH₃, Cl,n-Hex, CF₃), (M-12473, CH₃, CH₃, Cl, a-Hex, Br), (M-12474, CH₃, CH₃, Cl,n-Hex, CH₃), (M-12475, CH₃, CH₃, Cl, c-Hex, H), (M-12476, CH₃, CH₃, Cl,n-Hex, Cl), (M-12477, CH₃, CH₃, Cl, c-Hex, F), (M-12478, CH₃, CH₃, Cl,c-Hex, CF₃), (M-12479, CH₃, CH₃, Cl, c-Hex, Br), (M-12480, CH₃, CH₃, Cl,c-Hex, CH₃), (M-12481, CH₃, CH₃, Cl, OH, H), (M-12482, CH₃, CH₃, Cl, OH,Cl), (M-12483, CH₃, CH₃, Cl, OH, F), (M-12484, CH₃, CH₃, Cl, OH, CF₃),(M-12485, CH₃, CH₃, Cl, OH, Br), (M-12486, CH₃, CH₃, Cl, OH, CH₃),(M-12487, CH₃, CH₃, Cl, EtO, H), (M-12488, CH₃, CH₃, Cl, EtO, Cl),(M-12489, CH₃, CH₃, Cl, EtO, F), (M-12490, CH₃, CH₃, Cl, EtO, CF₃),(M-12491, CH₃, CH₃, Cl, EtO, Br), (M-12492, CH₃, CH₃, Cl, EtO, CH₃),(M-12493, CH₃, CH₃, Cl, n-PrO, H), (M-12494, CH₃, CH₃, Cl, n-PrO, Cl),(M-12495, CH₃, CH₃, Cl, n-PrO, F), (M-12496, CH₃, CH₃, Cl, n-PrO, CF₃),(M-12497, CH₃, CH₃, C, n-PrO, Br), (M-12498, CH₃, CH₃, Cl, n-PrO, CH₃),(M-12499, CH₃, CH₃, Cl, PhO, H), (M-12500, CH₃, CH₃, Cl, PhO, Cl),(M-12501, CH₃, CH₃, Cl, PhO, F), (M-12502, CH₃, CH₃, Cl, PhO, CF₃),(M-12503, CH₃, CH₃, Cl, PhO, Br), (M-12504, CH₃, CH₃, Cl, PhO, CH₃),(M-12505, CH₃, CH₃, Cl, BnO, H), (M-12506, CH₃, CH₃, Cl, BnO, Cl),(M-12507, CH₃, CH₃, Cl, BnO, F), (M-12508, CH₃, CH₃, Cl, BnO, CF₃),(M-12509, CH₃, CH₃, Cl, BnO, Br), (M-12510, CH₃, CH₃, Cl, BnO, CH₃),(M-12511, CH₃, CH₃, Cl, PhCH₂CH₂O, H), (M-12512, CH₃, CH₃, Cl,PhCH₂CH₂O, Cl), (M-12513, CH₃, CH₃, Cl, PhCH₂CH₂O, F), (M-12514, CH₃,CH₃, Cl, PhCH₂CH₂O, CF₃), (M-12515, CH₃, CH₃, Cl, PhCH₂CH₂O, Br),(M-12516, CH₃, CH₃, Cl, PhCH₂CH₂O, CH₃), (M-12517, CH₃, CH₃, Cl, CF₃O,H), (M-12518, CH₃, CH₃, Cl, CF₃O, Cl), (M-12519, CH₃, CH₃, Cl, CF₃O, F),(M-12520, CH₃, CH₃Cl, CF₃O, CF₃), (M-12521, CH₃CH₃, Cl, CF₃O, Br),(M-12522, CH₃, CH₃, Cl, CF₃O, CH₃), (M-12523, CH₃, CH₃, Cl, Ph, H),(M-12524, CH₃, CH₃, Cl, Ph, Cl), (M-12525, CH₃, CH₃, Cl, Ph, F),(M-12526, CH₃, CH₃, Cl, Ph, CF₃), (M-12527, CH₃, CH₃, Cl, Ph, Br),(M-12528, CH₃, CH₃, Cl, Ph, CH₃), (M-12529, CH₃, CH₃, Cl, 4-F-Ph, H),(M-12530, CH₃, CH₃, Cl, 4-F-Ph, Cl), (M-12531, CH₃, CH₃, Cl, 4-F-Ph, F),(M-12532, CH₃, CH₃, Cl, 4-F-Ph, CF₃), (M-12533, CH₃, CH₃, Cl, 4-F-Ph,Br), (M-12534, CH₃, CH₃, Cl, 4-F-Ph, CH₃), (M-12535, CH₃, CH₃, Cl,4-CF₃-Ph, H), (M-12536, CH₃, CH₃, Cl, 4-CF₃-Ph, Cl), (M-12537, CH₃, CH₃,Cl, 4-CF₃-Ph, F), (M-12538, CH₃, CH₃, Cl, 4-CF₃-Ph, CF₃), (M-12539, CH₃,CH₃, Cl, 4-CF₃-Ph, Br), (M-12540, CH₃, CH₃, Cl, 4-CF₃-Ph, CH₃),(M-12541, CH₃, CH₃, Cl, 4-(Me)₂N-Ph, H), (M-12542, CH₃, CH₃, Cl,4-(Me)₂N-Ph, Cl), (M-12543, CH₃, CH₃, Cl, 4-(Me)₂N-Ph, F), (M-12544,CH₃, CH₃, Cl, 4-(Me)₂N -Ph, CF₃), (M-12545, CH₃, CH₃, Cl, 4-(Me)₂N -Ph,Br), (M-12546, CH₃, CH₃, Cl, 4-(Me)₂N-Ph, CH₃), (M-12547, CH₃, CH₃, Cl,4-OH-Ph, H), (M-12548, CH₃, CH₃, Cl, 4-OH-Ph, Cl), (M-12549, CH₃, CH₃,Cl, 4-OH-Ph, F), (M-12550, CH₃, CH₃, Cl, 4-OH-Ph, CF₃), (M-12551, CH₃,CH₃, Cl, 4-OH-Ph, Br), (M-12552, CH₃, CH₃, Cl, 4-OH-Ph, CH₃), (M-12551,CH₃, CH₃, Cl, 3,4-di-F-Ph, H), (M-12554, CH₃, CH₃, Cl, 3,4-di-F-Ph, Cl),(M-12555, CH₃, CH₃, Cl, 3,4-di-F-Ph, F), (M-12556, CH₃, CH₃, Cl,3,4-di-F-Ph, CF₃), (M-12557, CH₃, CH₃, Cl, 3,4-di-F-Ph, Br), (M-12558,CH₃, CH₃, Cl, 3,4-di-F-Ph , CH₃), (M-12559, CH₃, CH₃, Cl, 4-COOH-Ph, H),(M-12560, CH₃, CH₃, Cl, 4-COOH-Ph, Cl), (M-12561, CH₃, CH₃, Cl, 4-COOH-Ph, F), (M-12562, CH₃, CH₃, Cl, 4-COOH -Ph, CF₃), (M-12563, CH₃, CH₃,Cl, 4-COOH-Ph, Br), (M-12564, CH₃, CH₃, Cl, 4-COOH-Ph, CH₃), (M-12565CH₃, CH₃, Cl, Bn, H), (M-12566, CH₃, CH₃, Cl, Bn, Cl), (M-12567, CH₃,CH₃, Cl, Bn, F), (M-12568, CH₃, CH₃, Cl, Bn, CF₃), (M-12569, CH₃, CH₃,Cl, Bn Br ), (M-12570, CH₃, CH₃, Cl, Bn, CH₃), (M-12571, CH₃, CH₃, Cl,4-F-Bn, H), (M-12572, CH₃, CH₃, Cl, 4-F-Bn, Cl), (M-12573, CH₃, CH₃, Cl,4-F-Bn, F), (M-12574, CH₃, CH₃, Cl, 4-F-Bn, CF₃), (M-12575, CH₃, CH₃,Cl, 4-F-Bn, Br), (M-12576, CH₃, CH₃, Cl, 4-F-Bn, CH₃), (M-12577, CH₃,CH₃, Cl, 2-Py, Br), (M-12578, CH₃, CH₃, Cl, 2-Py, Cl), (M-12579, CH₃,CH₃, Cl, 2-Py, F), (M-12580, CH₃, CH₃, Cl, 2-Py, CF₃), (M-12581, CH₃,CH₃, Cl, 2-Py, Br), (M-12582, CH₃, CH₃, Cl, 2-Py, CH₃), (M-12583, CH₃,CH₃, Cl, 3-Py, H), (M-12684, CH₃, CH₃, Cl, 3-Py, Cl), (M-12585, CH₃,CH₃, Cl, 3-Py, F), (M-12586, C₃, CH₃, Cl, 3-Py, CF₃), (M-12587, CH₃,CH₃, Cl, 3-Py, Br), (M-12588, CH₃, CH₃, Cl, 3-Py, CH₃), (M-12589, CH₃,CH₃, Cl, 4-Py, H), (M-12590, CH₃, CH₃, Cl, 4-Py, Cl), (M-12591, CH₃,CH₃, Cl, 4-Py, F), (M-12592, CH₃, CH₃, Cl, 4-Py, CF₃), (M-12593, CH₃,CH₃, Cl, 4-Py, Br), (M-12594, CH₃, CH₃, Cl, 4-Py, CH₃), (M-12595, CH₃,CH₃, Cl, 2-Th, H), (M-12596, CH₃, CH₃, Cl, 2-Th, Cl), (M-12597, CH₃,CH₃, Cl, 2-Th, F), (M-12598, CH₃, CH₃, Cl, 2-Th, CF₃), (M-12599, CH₃,CH₃, Cl, 2-Th, Br), (M-12600, CH₃, CH₃, Cl, 2-Th, CH₃), (M-12601, CH₃,CH₃, Cl, 3-Th, H), (M-12602, CH₃, CH₃, Cl, 3-Th, Cl), (M-12603, CH₃,CH₃, Cl, 3-Th, F), (M-12604, CH₃, CH₃, Cl, 3-Th, CF₃), (M-12605, CH₃,CH₃, Cl, 3-Th, Br), (M-12606, CH₃, CH₃, Cl, 3-Th, CH₃), (M-12607, CH₃,CH₃, Cl, pyrrazol-2-yl, H), (M-12608, CH₃, CH₃, Cl, pyrrazol-2-yl, Cl),(M-12609, CH₃, CH₃, Cl, pyrrazol-2-yl, F), (M-12610, CH₃, CH₃, Cl,pyrrazol-2-yl, CF₃), (M-12611, CH₃, CH₃, Cl, pyrrazol-2-yl, Br),(M-12612, CH₃, CH₃, Cl, pyrrazol-2-yl, CH₃), (M-12613, CH₃, CH₃, Cl,pyrrazol-3-yl, H), (M-12614, CH₃, CH₃, Cl, pyrrazol-3-yl, Cl), (M-12615,CH₃, CH₃, Cl, pyrrazol-3-yl, F), (M-12616, CH₃, CH₃, Cl, pyrrazol-3-yl,CF₃), (M-12617, CH₃, CH₃, Cl, pyrrazol-3-yl, Br), (M-12618, CH₃, CH₃,Cl, pyrrazol-3-yl, CH₃), (M-12619, CH₃, CH₃, Cl, pyrimidin-2-yl, H),(M-12620, CH₃, CH₃, Cl, pyrimidin-2-yl, Cl), (M-12621, CH₃, CH₃, Cl,pyrimidin-2-yl, F), (M-12622, CH₃, CH₃, Cl, pyrimidin-2-yl, CF₃),(M-12623, CH₃, CH₃, Cl, pyrimidin-2-yl, Br), (M-12624, CH₃, CH₃, Cl,pyrimidin-2-yl, CH₃), (M-12625, CH₃, CH₃, Cl, pyrimidin-4-yl, H),(M-12626, CH₃, CH₃, Cl, pyrimidin-4-yl, Cl), (M-12627, CH₃, CH₃, Cl,pyrimidin-4-yl, F), (M-12628, CH₃, CH₃, Cl, pyrimidin-4-yl, CF₃),(M-12629, CH₃, CH₃, Cl, pyrimidin-4-yl, Br), (M-12630, CH₃, CH₃, Cl,pyrimidin-4-yl, CH₃), (M-12631, CH₃, CH₃, Cl, pyrimidin-5-yl, H),(M-12632, CH₃, CH₃, Cl, pyrimidin-5-yl, Cl), (M-12633, CH₃, CH₃, Cl,pyrimidin-5-yl, F), (M-12634, CH₃, CH₃, Cl, pyrimidin-5-yl, CF₃),(M-12635, CH₃, CH₃, Cl, pyrimidin-5-yl, Br), (M-12636, CH₃, CH₃, Cl,pyrimidin-5-yl, CH₃), (M-12637, CH₃, CH₃, Cl, HOOCCH₂CH₂CH₂, H),(M-12638, CH₃, CH₃, Cl, HOOCCH₂CH₂CH₂, Cl), (M-12639, CH₃, CH₃, Cl,HOOCCH₂CH₂CH₂, F), (M-12640, CH₃, CH₃, Cl, HOOCCH₂CH₂CH_(2,) CF₃),(M-12641, CH₃, CH₃, Cl, HOOCCH₂CH₂CH₂, Br), (M-12642, CH₃, CH₃, Cl,HOOCCH₂CH₂CH₂, CH₃), (M-12643, CH₃, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, H),(M-12644, CH₃, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Cl), (M-12645, CH₃, CH₃, Cl,HOOCCH₂CH₂CH₂CH₂, F), (M-12646, CH₃, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, CF₃),(M-12647, CH₃, CH₃, Cl, HOOCCH₂CH₂CH₂CH₂, Br), (M-12648, CH₃, CH₃, Cl,HOOCCH₂CH₂CH₂CH₂, CH₃), (M-12649, CH₃, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,H), (M-12650, CH₃, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, Cl), (M-12651, CH₃,CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂, F), (M-12652, CH₃, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, CF₃), (M-12653, CH₃, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂, Br), (M-12654, CH₃, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂,CH₃), (M-12655, CH₃, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, H), (M-12656,CH₃, CH₃, Cl, (Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Cl), (M-12657, CH₃, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, F), (M-12658, CH₃, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-12659, CH₃, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, Br), (M-12660, CH₃, CH₃, Cl,(Me)₂NCOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-12661, CH₃, CH₃, Cl, MeOCH₂, H),(M-12662, CH₃, CH₃, Cl, MeOCH₂, Cl), (M-12663, CH₃, CH₃, Cl, MeOCH₂, F),(M-12664, CH₃, CH₃, Cl, MeOCH₂, CF₃), (M-12665, CH₃, CH₃, Cl, MeOCH₂,Br), (M-12666, CH₃, CH₃, Cl, MeOCH₂, CH₃), (M-12667, CH₃, CH₃, Cl,EtOCH₂, H), (M-12668, CH₃, CH₃, Cl, EtOCH₂, Cl), (M-12669, CH₃, CH₃, Cl,EtOCH₂, F), (M-12670, CH₃, CH₃, Cl, EtOCH₂, CF₃), (M-12671, CH₃, CH₃,Cl, EtOCH₂, Br), (M-12672, CH₃, CH₃, Cl, EtOCH₂, CH₃), (M-12673, CH₃,CH₃, Cl, EtOCH₂CH₂, H), (M-12674, CH₃, CH₃, Cl, EtOCH₂CH₂, Cl),(M-12675, CH₃, CH₃, Cl, EtOCH₂CH₂, F), (M-12676, CH₃, CH₃, Cl,EtOCH₂CH₂, CF₃), (M-12677, CH₃, CH₃, Cl, EtOCH₂CH₂, Br), (M-12678, CH₃,CH₃, Cl, EtOCH₂CH₂, CH₃), (M- 12679, CH₃, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, H),(M-12680, CH₃, CH₃, Cl, MeOCH₂CH₂OCH₂CH₂, Cl), (M-12681, CH₃, CH₃, Cl,MeOCH₂CH₂OCH₂CH₂, F), (M-12682, CH₃, CH₃Cl, MeOCH₂CH₂OCH₂CH₂, CF₃),(M-12683, CH₃CF₃, Cl, MeOCH₂CH₂OCH₂CH₂, Br), (M-12684, CH₃, CH₃, Cl,MeOCH₂CH₂OCH₂CH₂, CH₃), (M-12685, CH₃, CH₃, Cl, MeOCH₂CH₂, H), (M-12686,CH₃, C₃, Cl, MeOCH₂CH₂, Cl), (M-12687, CH₃, CH₃, Cl, MeOCH₂CH₂, F),(M-12688, CH₃, CH₃, Cl, MeOCH₂CH₂, CF₃), (M-12689, CH₃, CH₃, Cl,MeOCH₂CH₂, Br), (M-12690, CH₃, CH₃, Cl, MeOCH₂CH₂, CH₃), (M-12691, CH₃,CH₃, Cl, HOCH₂, H), (M-12692, CH₃, CH₃, Cl, HOCH₂, Cl), (M-12693, CH₃,CH₃, Cl, HOCH₂, F), (M-12694, CH₃, CH₃, Cl, HOCH₂, CF₃), (M-12695, CH₃,CH₃, Cl, HOCH₂, Br), (M-12696, CH₃, CH₃, Cl, HOCH₂, CH₃), (M-12697, CH₃,CH₃, Cl, HOCH₂CH₂, H), (M-12698, CH₃, CH₃, Cl, HOCH₂CH₂, Cl), (M-12699,CH₃, CH₃, Cl, HOCH₂CH₂, F), (M-12700, CH₃, CH₃, Cl, HOCH₂CH₂, CF₃),(M-12701, CH₃, CH₃, Cl, HOCH₂CH₂, Br), (M-12702, CH₃, CH₃, Cl, HOCH₂CH₂,CH₃), (M-12703, CH₃, CH₃, Cl, HOCH₂CH₂CH₂, H), (M-12704, CH₃, CH₃, Cl,HOCH₂CH₂CH₂, Cl), (M-12705, CH₃, CH₃, Cl, HOCH₂CH₂CH₂, F), (M-12706,CH₃, CH₃, Cl, HOCH₂CH₂CH₂, CF₃), (M-12707, CH₃, CH₃, Cl, HOCH₂CH₂CH₂,Br), (M-12708, CH₃, CH₃, Cl, HOCH₂CH₂CH₂, CH₃), (M-12709, CH₃, CH₃, Cl,HOCH₂CH₂CH₂CH₂, H), (M-12710, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Cl),(M-12711, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂, F), (M-12712, CH₃, CH₃, Cl,HOCH₂CH₂CH₂CH₂, CF₃), (M-12713, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂, Br),(M-12714, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂, CH₃), (M-12715, CH₃, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, H), (M-12716, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, Cl),(M-12717, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, F), (M-12718, CH₃, CH₃, Cl,HOCH₂CH₂CH₂CH₂CH₂, CF₃), (M-12719, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, Br),(M-12720, CH₃, CH₃, Cl, HOCH₂CH₂CH₂CH₂CH₂, CH₃), (M-12721, CH₃, CH₃, Cl,HOCH₂CH₂CH₂CH₂H), (M-12722, CH₃, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, Cl),(M-12723, CH₃, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, F), (M-12724, CH₃, CH₃, Cl,HOCH₂CH₂CH₂CH₂, CF₃), (M-12725, CH₃, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, Br),(M-12726, CH₃, CH₃, Cl, HOCH₂CH₂OCH₂CH₂, CH₃), (M-12727, CH₃, CH₃, Cl,(Me)₂N, H), (M-12728, CH₃, CH₃, Cl, (Me)₂N, Cl), (M-12729, CH₃, CH₃, Cl,(Me)₂N, F), (M-12730, CH₃, CH₃, Cl, (Me)₂N, CF₃), (M-12731, CH₃, CH₃,Cl, (Me)₂N, Br), (M-12732, CH₃, CH₃, Cl, (Me)₂N, CH₃), (M-12733, CH₃,CH₃, Cl, piperidin-4-yl-methyl, H), (M-12734, CH₃, CH₃, Cl,piperidin-4-yl-methyl, Cl), (M-12735, CH₃, CH₃, Cl,piperidin-4-yl-methyl, F), (M-12736, CH₃, CH₃, Cl,piperidin-4-yl-methyl, CF₃), (M-12737, CH₃, CH₃, Cl,piperidin-4-yl-methyl, Br), (M-12738, CH₃, CH₃, Cl,piperidin-4-yl-methyl, CH₃), (M-12739, CH₃, CH₃, Cl, cyclohexylmethyl,H), (M-12740, CH₃, CH₃, Cl, cyclohexylmethyl, Cl), (M-12741, CH₃, CH₃,Cl, cyclohexylmethyl, F), (M-12742, CH₃, CH₃, Cl, cyclohexylmethyl,CF₃), (M-12743, CH₃, CH₃, Cl, cyclohexylmethyl, Br), (M-12744, CH₃, CH₃,Cl, cyclohexylmethyl, CH₃), (M-12745, H, H, H, CF₃, H), (M-12746, H, H,H, CF₃, Cl), (M-12747, H, H, H, CF₃, F), (M-12748, H, H, H, CF₃, CF₃),(M-12749, H, H, H, CF₃, Br), (M-12750, H, H, H, CF₃, CH₃), (M-12751, H,H, F, CF₃, H), (M-12752, H, H, F, CF₃, Cl), (M-12753, H, H, F, CF₃, F),(M-12754, H, H, F, CF₃, CF₃), (M-12755, H, H, F, CF₃, Br), (M-12756, H,H, F, CF₃, CH₃), (M-12757, H, H, Cl, CF₃, H), (M-12758, H, H, Cl, CF₃,Cl), (M-12759, H, H, Cl, CF₃, F), (M-12760, H, H, Cl, CF₃, CF₃),(M-12761, H, H, Cl, CF₃, Br), (M-12762, H, H, Cl, CF₃, CH₃), (M-12763,H, F, H, CF₃, H), (M-12764, H, F, H, CF₃, Cl), (M-12765, H, F, H, CF₃,F), (M-12766, H, F, H, CF₃, CF₃), (M-12767, H, F, H, CF₃, Br), (M-12768,H, F, H, CF₃, CH₃), (M-12769, H, F, F, CF₃, H), (M-12770, H, F, F, CF₃,Cl), (M-12771, H, F, F, CF₃, F), (M-12772, H, F, F, CF₃, CF₃), (M-12773,H, F, F, CF₃, Br), (M-12774, H, F, F, CF₃, CH₃), (M-12775, H, F, Cl,CF₃, H), (M-12776, H, F, Cl, CF₃, Cl), (M-12777, H, F, Cl, CF₃, F),(M-12778, H, F, Cl, CF₃, CF₃), (M-12779, H, F, Cl, CF₃, Br), (M-12780,H, F, Cl, CF₃, CH₃), (M-12781, H, CH₃, H, CF₃, H), (M-12782, H, CH₃, H,CF₃, Cl), (M-12783, H, CH₃, H, CF₃, F), (M-12784, H, CH₃, H, CF₃, CF₃),(M-12785, H, CH₃, H, CF₃, Br), (M-12786, H, CH₃, H, CF₃, CH₃), (M-12787,H, CH₃, F, CF₃, H), (M-12788, H, CH₃, F, CF₃, Cl), (M-12789, H, CH₃, F,CF₃, F), (M-12790, H, CH₃, F, CF₃, CF₃), (M-12791, H, CH₃, F, CF₃, Br),(M-12792, H, CH₃, F, CF₃, CH₃), (M-12793, H, CH₃, Cl, CF₃, H), (M-12794,H, CH₃, Cl, CF₃, Cl), (M-12795, H, CH₃, Cl, CF₃, F), (M-12796, H, CH₃,Cl, CF₃, CF₃), (M-12797, H, CH₃, Cl, CF₃, Br), (M-12798, H, CH₃, Cl,CF₃, CH₃), (M-12799, F, H, H, CF₃, i-Pr), (M-12800, F, H, H, CF₃, Cl),(M-12801, F, H, H, CF₃, F), (M-12802, F, H, H, CF₃, CF₃), (M-12803, F,H, H, CF₃, Br), (M-12804, F, H, H, CF₃, CH₃), (M-12805, F, H, F, CF₃,H), (M-12806, F, H, F, CF₃, Cl), (M-12807, F, H, F, CF₃, F), (M-12808,F, H, F, CF₃, CF₃), (M-12809, F, H, F, CF₃, Br), (M-12810, F, H, F, CF₃,CH₃), (M-12811, F, H, CT, CF₃, H), (M-12812, F, H, Cl, CF₃, Cl),(M-12813, F, H, Cl, CF₃, F), (M-12814, F, H, Cl, CF₃, CF₃), (M-12815, F,H, Cl, CF₃, Br), (M-12816, F, H, Cl, CF₃, CH₃), (M-12817, F, F, H, CF₃,H), (M-12818, F, F, H, CF₃, Cl), (M-12819, F, F, H, CF₃, F), (M-12820,F, F, H, CF₃, CF₃), (M-12821, F, F, H, CF₃, Br), (M-12822, F, F, H, CF₃,CH₃), (M-12823, F, F, F, CF₃, H), (M-12824, F, F, F, CF₃, Cl), (M-12825,F, F, F, CF₃, F), (M-12826, F, F, F, CF₃, CF₃), (M-12827, F, F, F, CF₃,Br), (M-12828, F, F, F, CF₃, CH₃), (M-12829, F, F, Cl, CF₃, H),(M-12830, F, F, Cl, CF₃, Cl), (M-12831, F, F, Cl, CF₃, F), (M-12832, F,F, Cl, CF₃, CF₃), (M-12833, F, F, Cl, CF₃, Br), (M-12834, F, F, Cl, CF₃,CH₃), (M-12835, F, CH₃, H, CF₃, H), (M-12836, F, CH₃, H, CF₃, Cl),(M-12837, F, CH₃, H, CF₃, F), (M-12838, F, CH₃, H, CF₃, CF₃), (M-12839,F, CH₃, H, CF₃, Br), (M-12840, F, CH₃, H, CF₃, CH₃), (M-12841, F, CH₃,F, CF₃, H), (M-12842, F, CH₃, F, CF₃, Cl), (M-12843, F, CH₃, F, CF₃, F),(M-12844, F, CH₃, F, CF₃, CF₃), (M-12845, F, CH₃, F, CF₃, Br), (M-12846,F, CH₃, F, CF₃, CH₃), (M-12847, F, CH₃, Cl, CF₃, H), (M-12848, F, CH₃,Cl, CF₃, CT), (M-12849, F, CH₃, Cl, CF₃, F), (M-12850, F, CH₃, Cl, CF₃,CF₃), (M-12851, F, CH₃, Cl, CF₃, Br), (M-12852, F, CH₃, Cl, CF₃, CH₃),(M-12853, Cl, H, H, CF₃, i-Pr), (M-12854, Cl, H, H, CF₃, Cl), (M-12855,Cl, H, H, CF₃, F), (M-12856, Cl, H, H, CF₃, CF₃), (M-12857, Cl, H, H,CF₃, Br), (M-12858, Cl, H, H, CF₃, CH₃), (M-12859, Cl, H, F, CF₃, i-Pr),(M-12860, Cl, H, F, CF₃, Cl), (M-12861, Cl, H, F, CF₃, F), (M-12862, Cl,H, F, CF₃, CF₃), (M-12863, Cl, H, F, CF₃, Br), (M-12864, Cl, H, F, CF₃,CH₃), (M-12865, Cl, H, Cl, CF₃, H), (M-12866, Cl, H, Cl, CF₃, Cl),(M-12867, Cl, H, Cl, CF₃, F), (M-12868, Cl, H, Cl, CF₃, CF₃), (M-12869,Cl, H, Cl, CF₃, Br), (M-12870, Cl, H, Cl, CF₃, CH₃), (M-12871, Cl, F, H,CF₃, i-Pr), (M-12872, Cl, F, H, CF₃, Cl), (M-12873, Cl, F, H, CF₃, F),(M-12874, Cl, F, H, CF₃, CF₃), (M-12875, Cl, F, H, CF₃, Br), (M-12876,Cl, F, H, CF₃, CH₃), (M-12877, Cl, F, F, CF₃, H), (M-12878, Cl, F, F,CF₃, Cl), (M-12879, Cl, F, F, CF₃, F), (M-12880, Cl, F, F, CF₃, CF₃),(M-12881, Cl, F, F, CF₃, Br), (M-12882, Cl, F, F, CF₃, CH₃), (M-12883,Cl, F, Cl, CF₃, H), (M-12884, Cl, F, Cl, CF₃, Cl), (M-12885, Cl, F, Cl,CF₃, F), (M-12886, Cl, F, Cl, CF₃, CF₃), (M-12887, Cl, F, Cl, CF₃, Br),(M-12888, Cl, F, Cl, CF₃, CH₃), (M-12889, Cl, CH₃, H, CF₃, i-Pr),(M-12890, Cl, CH₃, H, CF₃, Cl), (M-12891, Cl, CH₃, H, CF₃, F), (M-12892,Cl, CH₃, H, CF₃, CF₃), (M-12893, Cl, CH₃, H, CF₃, Br), (M-12894, Cl,CH₃, H, CF₃, CH₃), (M-12895, Cl, CH₃, F, CF₃, i-Pr), (M-12896, Cl, CH₃,F, CF₃, Cl), (M-12897, Cl, CH₃, F, CF₃, F), (M-12898, Cl, CH₃, F, CF₃,CF₃), (M-12899, Cl, CH₃, F, CF₃, Br), (M-12900, Cl, CH₃, F, CF₃, CH₃),(M-12901, Cl, CH₃, Cl, CF₃, H), (M-12902, Cl, CH₃, Cl, CF₃, Cl),(M-12903, Cl, CH₃, Cl, CF₃, F), (M-12904, Cl, CH₃, Cl, CF₃, CF₃),(M-12905, Cl, CH₃, Cl, CF₃, Br), (M-12906, Cl, CH₃, Cl, CF₃, CH₃),(M-12907, CH₃, H, H, CF₃, i-Pr), (M-12908, CH₃, H, H, CF₃, Cl),(M-12909, CH₃, H, H, CF₃, F), (M-12910, CH₃, H, H, CF₃, CF₃), (M-12911,CH₃, H, H, CF₃, Br), (M-12912, CH₃, H, H, CF₃, CH₃), (M-12913, CH₃, H,F, CF₃, H), (M-12914, CH₃, H, F, CF₃, Cl), (M-12915, CH₃, H, F, CF₃, F),(M-12916, CH₃, H, F, CF₃, CF₃), (M-12917, CH₃, H, F, CF₃, Br), (M-12918,CH₃, H, F, CF₃, CH₃), (M-12919, CH₃, H, Cl, CF₃, H), (M-12920, CH₃, H,Cl, CF₃, Cl), (M-12921, CH₃, H, Cl, CF₃, F), (M-12922, CH₃, H, Cl, CF₃,CF₃), (M-12923, CH₃, H, Cl, CF₃, Br), (M-12924, CH₃, H, Cl, CF₃, CH₃),(M-12925, CH₃, F, H, CF₃, H), (M-12926, CH₃, F, H, CF₃, Cl), (M-12927,CH₃, F, H, CF₃, F), (M-12928, CH₃, F, H, CF₃, CF₃), (M-12929, CH₃, F, H,CF₃, Br), (M-12930, CH₃, F, H, CF₃, CH₃), (M-12931, CH₃, F, F, CF₃, H),(M-12932, CH₃, F, F, CF₃, Cl), (M-12933, CH₃, F, F, CF₃, F), (M-12934,CH₃, F, F, CF₃, CF₃), (M-12935, CH₃, F, F, CF₃, Br), (M-12936, CH₃, F,F, CF₃, CH₃), (M-12937, CH₃, F, Cl, CF₃, H), (M-12938, CH₃, F, Cl, CF₃,Cl), (M-12939, CH₃, F, Cl, CF₃, F), (M-12940, CH₃, F, Cl, CF₃, CF₃),(M-12941, CH₃, F, Cl, CF₃, Br), (M-12942, CH₃, F, Cl, CF₃, CH₃),(M-12943, CH₃, CH₃, H, CF₃H), (M-12944, CH₃, CH₃, CF₃, Cl),(M-12945,-CH₃, CH₃, H, CF₃, F), (M-12946, CH₃, CH₃, H, CF₃, CF₃),(M-12947, CH₃, CH₃, H, CF₃, Br), (M-12948, CH₃, CH₃, H, CF₃, CH₃),(M-12949, CH₃, CH₃, F, CF₃, H), (M-12950, CH₃, CH₃, F, CF₃, Cl),(M-12951, CH₃, CH₃, F, CF₃, F), (M-12952, CH₃, CH₃, F, CF₃, CF₃),(M-12953, CH₃, CH₃, F, CF₃, Br), (M-12954, CH₃, CH₃, F, CF₃, CH₃),(M-12955, CH₃, CH₃, Cl, CF₃, H), (M-12956, CH₃, CH₃, Cl, CF₃, Cl),(M-12957, CH₃, CH₃, Cl, CF₃, F), (M-12958, CH₃, CH₃, Cl, CF₃, CF₃),(M-12959, CH₃, CH₃, Cl, CF₃, Br), (M-12960, CH₃, CH₃, Cl, CF₃CH₃)

Test Examples Test Example 1 Isolation and Purification ofThrombopoietin (TPO)

Human TPO (hTPO) and murine TPO (mTPO) were purchased from R&D Systems.

Test Example 2 The Increasing Effect in Vitro of the MegakaryocyteColonies with the Compound (B-1)

We examined the ability of the compound in promoting differentiation ofhuman hematopoietic progenitor cells into mature megakaryocytes. Humanbone marrow cells (2.2×10⁵ cells) were plated in 3-cm dishes andcultured in methylcellulose in Iscove's Modified Dulbecco's medium inthe presence of 1% of the compound dissolved in 10% ethanol. Afterincubation at 37° C. for 7 days in the 5% CO₂ incubator, themegakaryocyte colonies were counted. The results are shown in FIG. 1.

Test Example 3 The Thrombopoietic Activity of the Compound (B-1)

The TPO dependent BaF/hTPOR cell line which was established byintroducing human TPO receptor (hTPOR) into BaF-B03 cells according toCollins et al (J. Cell. Physiol., 137:293-298 (1988)) was used to testthe thrombopoietic activity of the present compound. The DNA sequencesand encoded peptide sequences for human hTPOR have been described byVigon et al (Proc. Natl. Acad. Sci. USA, 89:5640-5644 (1992)). TPO dosenot have any ability to support proliferation of interlukin-3 dependentparental cell line BaF-B03. BAF/hTPOR cells were maintained in RPMImedium and WEHI-3B conditioned medium as a source of murineinterleukin-3 (IL-3). These cells were washed and resuspended in RPMImedium without a source of murine IL-3 and seeded into each well of96-well microtiter plates at a density of 5 X10⁴ cells per well in theabsence or presence of various concentration of hTPO or the presentcompound. After incubation at 37° C. for 20 hours in the 5% CO₂incubator, 10% WST-1 reagent (Takara Biomedicals, Japan) was added toeach wells and the cells were further incubated for 4 hours. Theabsorbance at 450 nm was measured and the results are shown in FIG. 2.Effect of the present compound on the growth of BAF/mTPOR cell linewhich was established by introducing murine TPO receptor (mTPOR) intoBAF-B03 cells is shown in FIG. 3. Table 8 exemplifies the ED₅₀ fortested compounds of the present invention, wherein the ED₅₀ is the halfconcentration of the concentration showing the maximum thrombopoieticactivity.

TABLE 33 Com- ED₅₀ pound No. (μM) A-1 0.117 A-2 0.066 A-3 0.218 A-40.124 A-5 0.984 A-6 0.248 A-8 0.529 A-9 0.504 A-10 0.365 A-11 0.0335A-14 0.017 A-17 0.864 A-18 0.132 A-19 0.170 A-20 0.610 A-23 0.337 A-240.288 A-25 0.150 A-26 0.098 A-27 0.193 A-28 0.099 A-29 0.289 A-30 0.274A-31 0.056 A-32 0.040 A-35 0.096 A-36 0.095 A-37 0.096 A-38 0.245 A-390.044 A-40 0.047 A-41 0.039 A-42 0.050 A-43 0.071 A-44 0.227 A-45 0.203A-46 0.263 A-47 0.512 A-48 0.473 A-49 0.116 A-50 0.113 A-51 0.568 A-520.425 A-54 0.065 A-55 0.037 A-56 0.066 A-57 0.019 A-58 0.497 A-59 0.164A-60 0.023 A-61 0.207 A-62 0.101 A-63 0.025 A-64 0.204 A-65 0.028 A-660.211 A-68 0.222 A-69 0.071 A-70 0.089 A-72 0.119 A-73 0.075 A-74 0.472A-75 0.073 A-76 0.205 A-77 0.110 A-78 0.408 A-79 0.410 A-80 0.066 A-810.071 A-82 0.199 A-83 0.077 A-84 0.023 A-85 0.026 A-86 0.243 A-87 0.710A-88 0.028 A-89 0.072 A-90 0.805 A-91 0.076 A-92 0.178 A-93 0.008 B-10.081 B-2 0.257 B-3 0.156 B-4 0.089 B-5 0.123 B-6 0.084 B-7 0.059 B-80.378 B-9 0.082 B-11 0.236 B-12 0.207 B-13 0.213 B-14 0.305 B-15 0.197B-16 0.182 B-17 0.244 B-18 0.15 B-19 0.15 B-20 0.425 B-25 0.367 B-260.346 B-27 0.707 B-28 0.565 B-29 0.181 B-30 0.177 B-31 0.178 B-32 0.123B-33 0.372 B-34 0.398 B-35 0.186 B-36 0.163 B-37 0.139 B-38 0.239 B-390.729 B-40 0.201 B-41 0.19 B-42 0.236 B-43 0.303 B-46 0.213 C-4 0.922D-1 0.276 F-1 0.174 F-2 0.144 F-3 0.198 G-1 0.261 G-2 0.299 G-3 0.430G-4 0.240 G-5 0.260 G-6 0.370 G-7 0.400 G-8 0.360 H-7 0.038 H-8 0.250J-11 0.311 J-12 0.107 J-13 0.116 J-14 0.036 J-15 0.011 K-1 0.189 K-20.975 K-3 0.693 K-5 0.403 K-6 0.077 K-10 0.475 K-11 0.373 K-12 0.208K-13 0.260 K-15 0.465 L-1 0.208 L-2 0.143 L-3 0.321 L-4 0.256

As shown in FIG. 1, addition of the compounds of the present inventioninduced forming megakaryocyte colonies and the number of coloniesincreased depending on the concentration of the compounds. This resultrevealed that the compounds of the present invention induced thedifferentiation of human bone marrow cells and produced megakaryocyteshaving ability of producing platelet.

The compound supported the proliferation of TPO-dependent BaF/hTPOR in adose-dependent manner as shown in FIG. 2. BaF/mTPOR expressing murineTPOR was not induced the proliferation by compounds as shown in FIG. 3.These results suggest that the compound of the present invention exertthe thrombopoietic activity by interacting with hTPOR because it isactive only in cells expressing hTPOR.

Formulation Example Formulation Example 1

Granules are prepared using the following ingredients.

Ingredients The compound represented by the formula (I) 10 mg Lactose700 mg  Corn starch 274 mg  HPC-L 16 mg 1000 mg 

The compound represented by the formula (I) and lactose are made passthrough a 60 mesh sieve. Corn starch is made pass through a 120 meshsieve. They are mixed by a twin shell blender. An aqueous solution ofHPC-L (low mucosity hydroxypropylcellulose) is added to the mixture andthe resulting mixture is kneaded, granulated (by the extrusion with poresize 0.5 to 1 mm mesh), and dried. The dried granules thus obtained aresieved by a swing sieve (12/60 mesh) to yield the granules.

Formulation 2

Powders for filling capsules are prepared using the followingingredients.

Ingredients The compound represented by the formula (I) 10 mg Lactose 79mg Corn starch 10 mg Magnesium stearate  1 mg 100 mg 

The compound represented by the formula (I) and lactose are made passthrough a 60 mesh sieve. Corn starch is made pass through a 120 meshsieve. These ingredients and magnesium stearate are mixed by a twinshell blender. 100 mg of the 10-fold trituration is filled into a No. 5hard gelatin capsule.

Formulation 3

Granules for filling capsules are prepared using the followingingredients.

Ingredients The compound represented by the formula (I) 15 mg Lactose 90mg Corn starch 42 mg HPC-L  3 mg 150 mg 

The compound represented by the formula (I) and lactose are made passthrough a 60 mesh sieve. Corn starch is made pass through a 120 meshsieve. After mixing them, an aqueous solution of HPC-L is added to themixture and the resulting mixture is kneaded, granulated, and dried.After the dried granules are lubricated, 150 mg of that are filled intoa No. 4 hard gelatin capsule.

Formulation 4

Tablets are prepared using the following ingredients.

Ingredients The compound represented by the formula (I) 10 mg Lactose 90mg Microcrystal cellulose 30 mg CMC-Na 15 mg Magnesium stearate  5 mg150 mg 

The compound represented by the formula (I), lactose, microcrystalcellulose, and CMC-Na (carboxymethylcellulose sodium salt) are made passthrough a 60 mesh sieve and then mixed. The resulting mixture is mixedwith magnesium stearate to obtain the mixed powder for the tabletformulation. The mixed powder is compressed to yield tablets of 150 mg.

Formulation 5

Intravenous formulations are prepared using the following ingredients.

Ingredients The compound represented by the formula (I) 100 mg

Saturated fattyacid glyceride 1000 ml

Usually a solution of ingredients above described is administeredintravenously to a patient by the speed of 1 ml/min.

INDUSTRIAL APPLICABILITY

The compounds of the present invention have thrombopoietin receptoragonism and are useful as the treating or preventing agent for hemopathyaccompanied with unusual count of platelet, for example,thrombocytopenia and the like

1. A compound represented by the general formula (III):

wherein R¹⁶ is a hydrogen atom, optionally substituted lower alkyl,carboxy, lower alkyloxycarbonyl, halogen atom, or optionally substitutedaminocarbonyl; R¹⁷, R¹⁸, R¹⁹, R²⁰, and R²¹ are each independently ahydrogen atom, optionally substituted lower alkyl by one or moresubstituent(s) selected from substituent group B, cycloalkyl, optionallysubstituted alkyoxy by one or more substituent(s) selected fromsubstituent group B, alkylthio, halogen atom, optionally substitutedphenyl by one or more halogen atoms, optionally substituted heteroarylby one or more halogen atoms, or optionally substituted nonaromaticheterocyclic group by one or more halogen atoms; substituent group Bconsists of hydroxy, alkyloxy, halogen atom, carboxy, loweralkyloxycarbonyl, aryloxycarbonyl, optionally substituted amino whereinthe substituent is an alkyl, phenyl, non-aromatic heterocyclic group, orheteroaryl; or R¹⁶ and R¹⁷ taken together may form —CH₂—, —CH₂CH₂—,—CH₂CH₂CH₂—, —OCH₂—, or —SCH₂—; R³¹ and R³² are each independently ahydrogen atom, lower alkyl, halogen atom, halo(lower)alkyl, loweralkyloxy, halo(lower)alkyloxy, or hydroxy; W³ is represented by theformula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthio, or halogen atom; R¹⁴ and R¹⁵ are each independently ahydrogen atom, or optionally substituted lower alkyl, optionallysubstituted lower alkenyl, optionally substituted lower alkynyl,optionally substituted cycloalkyl, optionally substituted aryl,optionally substituted aralkyl, optionally substituted heteroaryl,optionally substituted heteroarylalkyl, or optionally substitutednon-aromatic heterocyclic group, each substituted by one or moresubstituent(s) selected from substituent group A; substituent group Aconsists of a halogen atom, halo(lower)alkyl, optionally substitutedamino, carboxy, lower alkylthio, lower alkylsilyl, or lower alkyloxy;R²⁴ is a hydrogen atom or lower alkyl; R²⁵ is lower alkyl, optionallysubstituted aryl, or optionally substituted non-aromatic heterocyclicgroup; A³ is heteroaryl; or pharmaceutically acceptable salts thereof.2. A compound represented by the general formula (IV-A):

wherein R²⁷ is a hydrogen atom, C1-C3 alkyl, trifluoromethyl, or halogenatom; R²⁸, R²⁹, and R³⁰ are independently a hydrogen atom, optionallysubstituted lower alkyl by one or more substituent(s) selected fromsubstituent group B, cycloalkyl, optionally substituted alkyoxy by oneor more substituent(s) selected from substituent group B, alkylthio,halogen atom, optionally substituted phenyl by one or more halogenatoms, optionally substituted heteroaryl by one or more halogen atoms,or optionally substituted nonaromatic heterocyclic group by one or morehalogen atoms; substituent group B consists of hydroxy, alkyloxy,halogen atom, carboxy, lower alkyloxycarbonyl, aryloxycarbonyl,optionally substituted amino wherein the substituent is an alkyl,phenyl, non-aromatic heterocyclic group, or heteroaryl; R³¹ and R³² areeach independently a hydrogen atom, lower alkyl, halogen atom,halo(lower)alkyl, lower alkyloxy, halo(lower)alkyloxy, or hydroxy; W⁴ isa group represented by the formula:

wherein R¹³ is a hydrogen atom, lower alkyl, lower alkyloxy, loweralkylthie, or halogen atom; R¹⁴ and R¹⁵ are each independently ahydrogen atom, optionally substituted lower alkyl, optionallysubstituted lower alkenyl, optionally substituted lower alkynyl,optionally substituted cycloalkyl, optionally substituted aryl,optionally substituted aralkyl, optionally substituted heteroaryl,optionally substituted heteroarylalkyl, or optionally substitutednon-aromatic heterocyclic group, each substituted by one or moresubstituent(s) selected from substituent group A, substituent group Aconsists of a halogen atom, halo(lower)alkyl, optionally substitutedamino, carboxy, lower alkylthio, lower alkylsilyl, or lower alkyloxy;R²⁴ is a hydrogen atom or lower alkyl; or pharmaceutically acceptablesalts thereof.
 3. A pharmaceutical composition containing as the activeingredient a compound of any one of claims 1, or
 2. 4. A pharmaceuticalcomposition containing as the active ingredient a compound of any one ofclaims 1 or 2, which is exhibiting thrombopoietin receptor agon ism. 5.A pharmaceutical composition for platelet production modification,comprising at least one compound according to any one of claims 1 or 2and at least one of an excipient, binder, penetrant, disintegrator, orlubricant.
 6. A method for modifiering a platelet production of amammal, including a human, which comprises administration to said mammalof a compound of any one of claims 1 or 2 in a pharmaceuticallyeffective amount.